Antifibrogenic Influence of Mentha piperita L. Essential Oil against CCl4-Induced Liver Fibrosis in Rats.

abstract：:Cardiac fibroblasts (CFs) are a critical cell population responsible for myocardial extracellular matrix homeostasis. After stimulation by myocardial infarction (MI), CFs transdifferentiate into cardiac myofibroblasts (CMFs) and play a fundamental role in the fibrotic healing response. Transient receptor potential ank...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Sun X,Wu H,Yu P,Wang X,Jiang Z,Gao E,Chen J,Li,Qiu C,Song B,Chen K,He K,Yang D,Yang Y

更新日期：2019-05-14 00:00:00

abstract：:Picroside II, from the herb Picrorhiza scrophulariiflora Pennell, has antioxidant and anti-inflammatory activities. However, its function on severe acute pancreatitis (SAP) and molecular mechanism remains unknown. The effects of picroside II on the SAP induced by cerulean were investigated. SAP rats were treated with ...

journal_title：Oxidative medicine and cellular longevity

authors： Piao X,Liu B,Guo L,Meng F,Gao L

更新日期：2017-01-01 00:00:00

abstract：:Redox status changes during an annual training cycle in young and adult track and field athletes and possible differences between the two age groups were assessed. Forty-six individuals (24 children and 22 adults) were assigned to four groups: trained adolescents, (TAD, N = 13), untrained adolescents (UAD, N = 11), tr...

journal_title：Oxidative medicine and cellular longevity

authors： Zalavras A,Fatouros IG,Deli CK,Draganidis D,Theodorou AA,Soulas D,Koutsioras Y,Koutedakis Y,Jamurtas AZ

更新日期：2015-01-01 00:00:00

abstract：:Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans. However, the mechanism underlying this effec...

journal_title：Oxidative medicine and cellular longevity

authors： Meng F,Li J,Rao Y,Wang W,Fu Y

更新日期：2018-02-18 00:00:00

abstract：:Oxidative stress induced by long-term glucocorticoid (GC) use weakens the repair capacity of bone tissue. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase (NOX) is a superoxide-generating enzyme that plays an important role in regulating bone metabolism. To clarify the role of nonphagocytic NO...

journal_title：Oxidative medicine and cellular longevity

authors： Bai SC,Xu Q,Li H,Qin YF,Song LC,Wang CG,Cui WH,Zheng Z,Yan DW,Li ZJ,Li D,Wan X,Zhang HF

更新日期：2019-03-27 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and is associated with high mortality and poor prognosis. Thus, the primary aim of the present study was to determine whether glycine could (1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and (2) downregulate mitochondria-mediated autop...

journal_title：Oxidative medicine and cellular longevity

authors： Cai CC,Zhu JH,Ye LX,Dai YY,Fang MC,Hu YY,Pan SL,Chen S,Li PJ,Fu XQ,Lin ZL

更新日期：2019-02-06 00:00:00

abstract：:As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pres...

journal_title：Oxidative medicine and cellular longevity

authors： Li L,Obinata M,Hori K

更新日期：2010-01-01 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Known for centuries throughout the world, Plantago species have long been used as traditional herbal remedies for many diseases related to inflammatory conditions of the skin, respiratory and digestive tract, or even malignancy. This study is aimed first at investigating the in vitro antioxidant and regenerative effec...

journal_title：Oxidative medicine and cellular longevity

authors： Farcaș AD,Moț AC,Pârvu AE,Toma VA,Popa MA,Mihai MC,Sevastre B,Roman I,Vlase L,Pârvu M

更新日期：2019-06-02 00:00:00

abstract：:Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury. The liver has high capacity for producing glutathione and is a key organ in modulating local and ...

journal_title：Oxidative medicine and cellular longevity

authors： Shang Y,Siow YL,Isaak CK,O K

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and decreased mtDNA copy number. Current wisdom indicates that mt...

journal_title：Oxidative medicine and cellular longevity

authors： Quan Y,Xin Y,Tian G,Zhou J,Liu X

更新日期：2020-03-26 00:00:00

abstract：:The liver is a central organ that performs a wide range of functions such as detoxification and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly susceptible to oxidative stress. It is well documented that liver diseases including hepatitis, fibrosis, cirrhosis, and hepatocellular ...

journal_title：Oxidative medicine and cellular longevity

authors： Shin SM,Yang JH,Ki SH

更新日期：2013-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are generated by sperm metabolism. While, ROS are required for maturation, capacitation and acrosome reaction, they also modify many peroxidable cellular compounds. There is production of ROS during cryopreservation and frozen spermatozoa are highly sensitive to lipid peroxidation (LPO). ...

journal_title：Oxidative medicine and cellular longevity

authors： Cheema RS,Bansal AK,Bilaspuri GS

更新日期：2009-07-01 00:00:00

abstract：:Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Ma...

journal_title：Oxidative medicine and cellular longevity

authors： Fujimoto C,Yamasoba T

更新日期：2014-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is a common inflammatory bowel disease that can destroy the integrity of the colon and increase the risk of colorectal cancer. Oxidative stress is one of the critical pathogenic factors for UC, further impairing the entire affected colon. The Nrf2-ARE signaling pathway plays an important role i...

journal_title：Oxidative medicine and cellular longevity

authors： Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

更新日期：2018-05-20 00:00:00

abstract：:Since both O-GlcNAcylation and autophagy sense intracellular nutrient level, the alteration of those two pathways plays substantial roles in the progression of heart failure. Hence, determining the relationship between O-GlcNAcylation and autophagy is imperative to understand, prevent, and treat heart failure. However...

journal_title：Oxidative medicine and cellular longevity

authors： Yu H,Wen L,Mu Y

更新日期：2020-08-11 00:00:00

abstract：:Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. R...

journal_title：Oxidative medicine and cellular longevity

authors： Lv P,Chen T,Liu P,Zheng L,Tian J,Tan F,Chen J,Deng Y,Li J,Cai J,Chi X

更新日期：2019-11-11 00:00:00

abstract：:Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies. They...

journal_title：Oxidative medicine and cellular longevity

authors： Pichla M,Bartosz G,Sadowska-Bartosz I

更新日期：2020-10-13 00:00:00

abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Hong M,Tan HY,Wang N,Feng Y

更新日期：2016-01-01 00:00:00

abstract：:Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typi...

journal_title：Oxidative medicine and cellular longevity

authors： Passaro A,Vigna GB,Romani A,Sanz JM,Cavicchio C,Bonaccorsi G,Valacchi G,Cervellati C

更新日期：2018-11-05 00:00:00

abstract：:Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from...

journal_title：Oxidative medicine and cellular longevity

authors： Del Campo A,Jaimovich E,Tevy MF

更新日期：2016-01-01 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascu...

journal_title：Oxidative medicine and cellular longevity

authors： Ling S,Xu JW

更新日期：2016-01-01 00:00:00

abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

更新日期：2019-03-26 00:00:00

abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

journal_title：Oxidative medicine and cellular longevity

authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

更新日期：2015-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant s...

journal_title：Oxidative medicine and cellular longevity

authors： Gunawardena HP,Silva R,Sivakanesan R,Ranasinghe P,Katulanda P

更新日期：2019-08-05 00:00:00

abstract：Background:The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects. Aims:To assess the effect of ileal transposition (IT) and sham types of ...

journal_title：Oxidative medicine and cellular longevity

authors： Skrzep-Poloczek B,Stygar D,Sawczyn T,Romuk E,Chełmecka E,Poloczek J,Dulska A,Kazura W,Karcz KW

更新日期：2018-11-11 00:00:00

abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

journal_title：Oxidative medicine and cellular longevity

authors： Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

更新日期：2020-02-12 00:00:00

abstract：:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AE

更新日期：2014-01-01 00:00:00

abstract：Background:Renal fibrosis is a common pathological symptom of chronic kidney disease (CKD). Many studies support that mitochondrial dysfunction and endoplasmic reticulum (ER) stress are implicated in the pathogenesis of CKD. In our study, we investigated the benefits and underlying mechanisms of Mito-TEMPO on renal fib...

journal_title：Oxidative medicine and cellular longevity

authors： Liu Y,Wang Y,Ding W,Wang Y

更新日期：2018-03-25 00:00:00