Role of the Nrf2-ARE pathway in liver diseases.

abstract：:As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pres...

journal_title：Oxidative medicine and cellular longevity

authors： Li L,Obinata M,Hori K

更新日期：2010-01-01 00:00:00

abstract：:Organic cations (OCs) are substances of endogenous (e.g. dopamine, choline) or exogenous (e.g. drugs like cimetidine) origin that are positively charged at physiological pH. Since many of these compounds can not pass the cell membrane freely, their transport in our out of cells must be mediated by specific transport s...

journal_title：Oxidative medicine and cellular longevity

authors： Faria A,Monteiro R,Pestana D,Freitas Vd,Mateus N,Azevedo I,Calhau C

更新日期：2009-11-01 00:00:00

abstract：:Endothelial injury plays a critical role in the pathogenesis of cardiovascular disorders and metabolic-associated vascular complications which are the leading cause of death worldwide. However, the mechanism underlying endothelial dysfunction is not completely understood. The study is aimed at investigating the role o...

journal_title：Oxidative medicine and cellular longevity

authors： Liu N,Li Y,Nan W,Zhou W,Huang J,Li R,Zhou L,Hu R

更新日期：2020-10-02 00:00:00

abstract：:Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone gro...

journal_title：Oxidative medicine and cellular longevity

authors： You Z,Sun J,Xie F,Chen Z,Zhang S,Chen H,Liu F,Li L,Chen G,Song Y,Xuan Y,Zheng G,Xin Y

更新日期：2017-01-01 00:00:00

abstract：:Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans. However, the mechanism underlying this effec...

journal_title：Oxidative medicine and cellular longevity

authors： Meng F,Li J,Rao Y,Wang W,Fu Y

更新日期：2018-02-18 00:00:00

abstract：:Stem cells derived from elderly donors or harvested by repeated subculture exhibit a marked decrease in proliferative capacity and multipotency, which not only compromises their therapeutic potential but also raises safety concerns for regenerative medicine. NANOG-a well-known core transcription factor-plays an import...

journal_title：Oxidative medicine and cellular longevity

authors： Liu F,Shi J,Zhang Y,Lian A,Han X,Zuo K,Liu M,Zheng T,Zou F,Liu X,Jin M,Mu Y,Li G,Su G,Liu J

更新日期：2019-12-04 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) is an alpha- and gamma-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the gamma-secretase, presenilin, have been implicated in familial Alzheimer's dis...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang T,Mi Z,Schor NF

更新日期：2009-09-01 00:00:00

abstract：:Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typi...

journal_title：Oxidative medicine and cellular longevity

authors： Passaro A,Vigna GB,Romani A,Sanz JM,Cavicchio C,Bonaccorsi G,Valacchi G,Cervellati C

更新日期：2018-11-05 00:00:00

abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2015-01-01 00:00:00

abstract：:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...

journal_title：Oxidative medicine and cellular longevity

authors： Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

更新日期：2014-01-01 00:00:00

abstract：:Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies curcumin as a neuroprotectant against hemin-induced damage in primary cultures of cerebellar granule neurons (CGNs) of rats. Hemin, the oxidized form of heme, is a highly reactive compound that induces cellular injury. Pretreatmen...

journal_title：Oxidative medicine and cellular longevity

authors： González-Reyes S,Guzmán-Beltrán S,Medina-Campos ON,Pedraza-Chaverri J

更新日期：2013-01-01 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of Commiphora molmol resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH4Cl-) induced hyperammonemic rats, with an emphasis on the glutama...

journal_title：Oxidative medicine and cellular longevity

authors： Mahmoud AM,Alqahtani S,Othman SI,Germoush MO,Hussein OE,Al-Basher G,Khim JS,Al-Qaraawi MA,Al-Harbi HM,Fadel A,Allam AA

更新日期：2017-01-01 00:00:00

abstract：:Ganoderma lucidum, mushroom used for centuries by Asian peoples as food supplement, has been shown interesting biological activities, including over the Central Nervous System. Besides, these mushroom bioactive compounds present antioxidant and anti-inflammatory activities. On the side, binge drinking paradigm consist...

journal_title：Oxidative medicine and cellular longevity

authors： Nascimento CP,Luz DA,da Silva CCS,Malcher CMR,Fernandes LMP,Dalla Santa HS,Gomes ARQ,Monteiro MC,Ribeiro CHMA,Fontes-Júnior EA,Maia CSF

更新日期：2020-07-30 00:00:00

abstract：:Extracorporeal shock wave (ECSW) and adipose-derived mesenchymal stem cells (ADMSCs) have been recognized to have capacities of anti-inflammation and angiogenesis. We tested the hypothesis that ECSW and ADMSC therapy could attenuate ischemia-reperfusion- (IR-) induced thigh injury (femoral artery tightened for 6 h the...

journal_title：Oxidative medicine and cellular longevity

authors： Yin TC,Wu RW,Sheu JJ,Sung PH,Chen KH,Chiang JY,Hsueh SK,Chung WJ,Lin PY,Hsu SL,Chen CC,Chen CY,Shao PL,Yip HK

更新日期：2018-04-02 00:00:00

abstract：:The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic ef...

journal_title：Oxidative medicine and cellular longevity

authors： Ficarra S,Russo A,Barreca D,Giunta E,Galtieri A,Tellone E

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to evaluate the properties of internal components of erythrocytes in chronic renal failure (CRF) patients undergoing hemodialysis (HD) in comparison to control subjects. For investigation of conformational state of hemoglobin and nonheme proteins (NHP) the maleimide spin label (MSL) in electr...

journal_title：Oxidative medicine and cellular longevity

authors： Pieniazek A,Gwozdzinski K

更新日期：2015-01-01 00:00:00

abstract：:The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generat...

journal_title：Oxidative medicine and cellular longevity

authors： Aune SE,Yeh ST,Kuppusamy P,Kuppusamy ML,Khan M,Angelos MG

更新日期：2013-01-01 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly malignant, recurrent, drug-resistant, and often diagnosed in the advanced stage. It is clear that early diagnosis and a better understanding of molecular mechanisms contributing to HCC progression is clinically urgent. Metabolic a...

journal_title：Oxidative medicine and cellular longevity

authors： De Matteis S,Ragusa A,Marisi G,De Domenico S,Casadei Gardini A,Bonafè M,Giudetti AM

更新日期：2018-11-04 00:00:00

abstract：:Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p < 0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69...

journal_title：Oxidative medicine and cellular longevity

authors： Pristov JB,Spasojevic I,Mikovic Z,Mandic V,Cerovic N,Spasic M

更新日期：2009-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is a common inflammatory bowel disease that can destroy the integrity of the colon and increase the risk of colorectal cancer. Oxidative stress is one of the critical pathogenic factors for UC, further impairing the entire affected colon. The Nrf2-ARE signaling pathway plays an important role i...

journal_title：Oxidative medicine and cellular longevity

authors： Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

更新日期：2018-05-20 00:00:00

abstract：:The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H. extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice. In several beha...

journal_title：Oxidative medicine and cellular longevity

authors： Kang JY,Park SK,Guo TJ,Ha JS,Lee DS,Kim JM,Lee U,Kim DO,Heo HJ

更新日期：2016-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66Shc adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis by providing oxidativ...

journal_title：Oxidative medicine and cellular longevity

authors： Pérez H,Finocchietto PV,Alippe Y,Rebagliati I,Elguero ME,Villalba N,Poderoso JJ,Carreras MC

更新日期：2018-03-12 00:00:00

abstract：:Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipa...

journal_title：Oxidative medicine and cellular longevity

authors： Alonazi M,Horchani H,Alwhibi M,Ben Bacha A

更新日期：2020-10-29 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of...

journal_title：Oxidative medicine and cellular longevity

authors： Paiva AA,Raposo HF,Wanschel AC,Nardelli TR,Oliveira HC

更新日期：2017-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible lung disease of unknown etiology with limited survival. IPF incidence and prevalence increase significantly with aging, which is associated with an age-related accumulation of oxidative DNA damage. The Mutyh gene is involved in the base excision repair...

journal_title：Oxidative medicine and cellular longevity

authors： Sun Q,Chen J,Xu L,Kang J,Wu X,Ren Y,Nakabeppu Y,Wang Y

更新日期：2020-10-16 00:00:00

abstract：:Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Gaspar RS,Trostchansky A,Paes AM

更新日期：2016-01-01 00:00:00

abstract：:Imbalance in prooxidant-antioxidant equilibrium plays an important role in the progression of osteoarthritis (OA). Postoperative rehabilitation significantly improves the functional activity of patients with OA. We aimed to assess the effect of the general 21-day postoperative rehabilitation on the oxidative stress ma...

journal_title：Oxidative medicine and cellular longevity

authors： Skrzep-Poloczek B,Poloczek J,Chełmecka E,Kazura W,Dulska A,Idzik M,Jochem J,Stygar D

更新日期：2020-09-24 00:00:00