Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities.

abstract：:Oxidative stress (OS), a common intracellular phenomenon induced by excess reactive oxygen species (ROS) generation, has been shown to be associated with mammalian ovarian follicular development blockage and granulosa cell (GC) impairment. However, the mechanism involved in these effects remains unknown, and the effec...

journal_title：Oxidative medicine and cellular longevity

authors： Du X,Li Q,Cao Q,Wang S,Liu H,Li Q

更新日期：2019-11-04 00:00:00

abstract：:The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular...

journal_title：Oxidative medicine and cellular longevity

authors： Palacios J,Cifuentes F,Valderrama JA,Benites J,Ríos D,González C,Chiong M,Cartes-Saavedra B,Lafourcade C,Wyneken U,González P,Owen GI,Pardo F,Sobrevia L,Buc Calderon P

更新日期：2016-01-01 00:00:00

abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Hong M,Tan HY,Wang N,Feng Y

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a great socioeconomic burden in the aging society. Compelling evidence demonstrates that molecular change characteristics for AD, such as oxidative stress and amyloid β (Aβ) oligomerization, precede by decades the onset of clinical dementia and that the...

journal_title：Oxidative medicine and cellular longevity

authors： Wojsiat J,Zoltowska KM,Laskowska-Kaszub K,Wojda U

更新日期：2018-01-31 00:00:00

abstract：:Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses. An important role for senescence has been shown for a number of pathophysiological conditions that include cardiovascular disease, pulmonary fibrosis, and diseases of the skin. However, whether senescence con...

journal_title：Oxidative medicine and cellular longevity

authors： Sreekumar PG,Hinton DR,Kannan R

更新日期：2020-03-09 00:00:00

abstract：:Methamphetamine (MA) leads to cardiac and pulmonary toxicity expressed as increases in inflammatory responses and oxidative stress. However, some interactions may exist between oxidative stress and endoplasmic reticulum stress (ERS). The current study is designed to investigate if both oxidative stress and ERS are inv...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Y,Gu YH,Liu M,Bai Y,Liang LY,Wang HL

更新日期：2017-01-01 00:00:00

abstract：:Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from...

journal_title：Oxidative medicine and cellular longevity

authors： Del Campo A,Jaimovich E,Tevy MF

更新日期：2016-01-01 00:00:00

abstract：:Obesity- or diabetes-induced oxidative stress is discussed as a major risk factor for DNA damage. Vitamin E and many polyphenols exhibit antioxidative activities with consequences on epigenetic regulation of inflammation and DNA repair. The present study investigated the counteraction of oxidative stress by vitamin E ...

journal_title：Oxidative medicine and cellular longevity

authors： Zappe K,Pointner A,Switzeny OJ,Magnet U,Tomeva E,Heller J,Mare G,Wagner KH,Knasmueller S,Haslberger AG

更新日期：2018-03-22 00:00:00

abstract：:Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66Shc adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis by providing oxidativ...

journal_title：Oxidative medicine and cellular longevity

authors： Pérez H,Finocchietto PV,Alippe Y,Rebagliati I,Elguero ME,Villalba N,Poderoso JJ,Carreras MC

更新日期：2018-03-12 00:00:00

abstract：:We present the spatiotemporal metabolic differentiation of yeast cell subpopulations from upper, lower, and margin regions of colonies of different ages, based on comprehensive transcriptomic analysis. Furthermore, the analysis was extended to include smaller cell subpopulations identified previously by microscopy wit...

journal_title：Oxidative medicine and cellular longevity

authors： Wilkinson D,Maršíková J,Hlaváček O,Gilfillan GD,Ježková E,Aaløkken R,Váchová L,Palková Z

更新日期：2018-01-11 00:00:00

abstract：:Background. Rutin is a natural nutraceutical that is a promising compound for the prevention of UV-induced metabolic changes in skin cells. The aim of this study was to examine the effects of rutin on redox and endocannabinoid systems, as well as proinflammatory and proapoptotic processes, in UV-irradiated fibroblasts...

journal_title：Oxidative medicine and cellular longevity

authors： Gęgotek A,Rybałtowska-Kawałko P,Skrzydlewska E

更新日期：2017-01-01 00:00:00

abstract：:The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

journal_title：Oxidative medicine and cellular longevity

authors： Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

更新日期：2015-01-01 00:00:00

abstract：:Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results,...

journal_title：Oxidative medicine and cellular longevity

authors： Ashour AE,Sayed-Ahmed MM,Abd-Allah AR,Korashy HM,Maayah ZH,Alkhalidi H,Mubarak M,Alhaider A

更新日期：2012-01-01 00:00:00

abstract：:Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional curcumin (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wis...

journal_title：Oxidative medicine and cellular longevity

authors： Boarescu PM,Chirilă I,Bulboacă AE,Bocșan IC,Pop RM,Gheban D,Bolboacă SD

更新日期：2019-05-07 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/5031926.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Hong YA,Yang KJ,Jung SY,Park KC,Choi H,Oh JM,Lee SJ,Chang YK,WheePark C,Yang CW,Kim SY,Hwang HS

更新日期：2017-01-01 00:00:00

abstract：:With recent insight into the mechanisms involved in diseases, such as cardiovascular disease, cancer, stroke, neurodegenerative diseases, and diabetes, more efficient modes of treatment are now being assessed. Traditional medicine including the use of natural products is widely practiced around the world, assuming tha...

journal_title：Oxidative medicine and cellular longevity

authors： Shay J,Elbaz HA,Lee I,Zielske SP,Malek MH,Hüttemann M

更新日期：2015-01-01 00:00:00

abstract：:Hyperglycemia-induced stress in the brain of patients with diabetes triggers the disruption of blood-brain barrier (BBB), leading to diverse neurological diseases including stroke and dementia. Recently, the role of microRNA becomes an interest in the research for deciphering the mechanism of brain endothelial cell da...

journal_title：Oxidative medicine and cellular longevity

authors： Song J,Yoon SR,Kim OY

更新日期：2017-01-01 00:00:00

abstract：:This paper compiles the beneficial effects of cocoa polyphenols on human health, especially with regard to cardiovascular and inflammatory diseases, metabolic disorders, and cancer prevention. Their antioxidant properties may be responsible for many of their pharmacological effects, including the inhibition of lipid p...

journal_title：Oxidative medicine and cellular longevity

authors： Andújar I,Recio MC,Giner RM,Ríos JL

更新日期：2012-01-01 00:00:00

abstract：:Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of Commiphora molmol resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH4Cl-) induced hyperammonemic rats, with an emphasis on the glutama...

journal_title：Oxidative medicine and cellular longevity

authors： Mahmoud AM,Alqahtani S,Othman SI,Germoush MO,Hussein OE,Al-Basher G,Khim JS,Al-Qaraawi MA,Al-Harbi HM,Fadel A,Allam AA

更新日期：2017-01-01 00:00:00

abstract：:Our previous studies have shown Leptomycin B (LMB) is a promising antilung cancer drug. Epigallocatechin-3-gallate (EGCG) has antitumor properties but a debatable clinical application. The objective of this study is to evaluate the combination therapeutic effect of LMB and EGCG and its molecular mechanisms in human lu...

journal_title：Oxidative medicine and cellular longevity

authors： Cromie MM,Gao W

更新日期：2015-01-01 00:00:00

abstract：:Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms of ac...

journal_title：Oxidative medicine and cellular longevity

authors： Ucci M,Di Tomo P,Tritschler F,Cordone VGP,Lanuti P,Bologna G,Di Silvestre S,Di Pietro N,Pipino C,Mandatori D,Formoso G,Pandolfi A

更新日期：2019-01-30 00:00:00

abstract：:Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) i...

journal_title：Oxidative medicine and cellular longevity

authors： Carreira BP,Santos DF,Santos AI,Carvalho CM,Araújo IM

更新日期：2015-01-01 00:00:00

abstract：:Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries i...

journal_title：Oxidative medicine and cellular longevity

authors： Yan C,Zhang X,Miao J,Yuan H,Liu E,Liang T,Li Q

更新日期：2020-01-28 00:00:00

abstract：:Extracorporeal shock wave (ECSW) and adipose-derived mesenchymal stem cells (ADMSCs) have been recognized to have capacities of anti-inflammation and angiogenesis. We tested the hypothesis that ECSW and ADMSC therapy could attenuate ischemia-reperfusion- (IR-) induced thigh injury (femoral artery tightened for 6 h the...

journal_title：Oxidative medicine and cellular longevity

authors： Yin TC,Wu RW,Sheu JJ,Sung PH,Chen KH,Chiang JY,Hsueh SK,Chung WJ,Lin PY,Hsu SL,Chen CC,Chen CY,Shao PL,Yip HK

更新日期：2018-04-02 00:00:00

abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

journal_title：Oxidative medicine and cellular longevity

authors： Kim HM,Cho BR

更新日期：2013-01-01 00:00:00

abstract：:In the present study, we demonstrated that bone marrow mesenchymal stem cells (BMSCs) of the 3rd passage displayed the senescence-associated phenotypes characterized with increased activity of SA-β-gal, altered autophagy, and increased G1 cell cycle arrest, ROS production, and expression of p53 and p21Cip1/Waf1 compar...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang M,Du Y,Lu R,Shu Y,Zhao W,Li Z,Zhang Y,Liu R,Yang T,Luo S,Gao M,Zhang Y,Zhang G,Liu J,Lu Y

更新日期：2016-01-01 00:00:00

abstract：:There is little research on how cooking and digestion affect the anti-inflammatory activity of culinary herbs. Thus, the aim of this paper was to investigate this activity following cooking and in vitro digestion of the common culinary herbs, rosemary, sage, and thyme, and the relationship between their anti-inflammat...

journal_title：Oxidative medicine and cellular longevity

authors： Chohan M,Naughton DP,Jones L,Opara EI

更新日期：2012-01-01 00:00:00

abstract：:Ex vivo lung perfusion (EVLP) allows perfusion and reconditioning of retrieved lungs for organ transplantation. The Steen solution is specifically designed for this procedure but the mechanism through which it elicits its activity is still to be fully clarified. We speculated that Steen solution may encompass antioxid...

journal_title：Oxidative medicine and cellular longevity

authors： Carnevale R,Biondi-Zoccai G,Peruzzi M,De Falco E,Chimenti I,Venuta F,Anile M,Diso D,Cavarretta E,Marullo AG,Sartini P,Pignatelli P,Violi F,Frati G

更新日期：2014-01-01 00:00:00

abstract：:Recent studies have found that propofol may protect brain from cerebral ischemic-reperfusion injury. However, the underlying mechanism remains unclear. The effects of propofol were evaluated in HBVSMC after hypoxia/reoxygenation (H/R). Cell viability and levels of SOD, LDH, and MDA were measured. Apoptosis was detecte...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Xia Y,Xu Z,Deng X

更新日期：2016-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00