3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.

abstract：:[This corrects the article DOI: 10.1155/2020/9250512.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang X,Fu Q,Xu L,Yang Y,Zhao W,Zhang Y,Mi W,Li H

更新日期：2020-08-24 00:00:00

abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2015-01-01 00:00:00

abstract：:Vagus nerve stimulation (VNS) has been shown to attenuate ischemia-reperfusion (I/R) injury in multiple organs. The present study aimed at investigating whether VNS could exert protective effects against I/R injury in the skeletal muscle. Male Sprague-Dawley rats were randomly divided into 3 groups: the control, I/R, ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang Y,Li H,Wang M,Meng G,Wang Z,Deng J,Wang M,Zhang Q,Yang S,Jiang H

更新日期：2019-02-28 00:00:00

abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%. However, the disease mechanism remains unclear, and no effective treatment is available. Paricalcitol has been reported to be effective in animal models of kidney injury. We hypoth...

journal_title：Oxidative medicine and cellular longevity

authors： Bae E,Kim JH,Jung MH,Jang SJ,Lee TW,Jung S,Lee S,Jang HN,Chang SH,Park DJ

更新日期：2020-11-23 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：:Three cosmetically important skin lightening agents, hydroquinone (HQ), kojic acid (KA), and niacinamide (NA), consume the bulk of successful skin lightening ingredients in cosmetic applications. However, the mechanisms by which these ingredients work are still unclear. In this study, melanocytes and keratinocytes wer...

journal_title：Oxidative medicine and cellular longevity

authors： Gruber JV,Holtz R

更新日期：2013-01-01 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a ce...

journal_title：Oxidative medicine and cellular longevity

authors： Büchter C,Zhao L,Havermann S,Honnen S,Fritz G,Proksch P,Wätjen W

更新日期：2015-01-01 00:00:00

abstract：:Considering the various pharmacological activities of epigallocatechin-3-O-gallate (EGCG) including anticancer, and anti-inflammatory, antidiabetic, and so forth, relatively less attention has been paid to the antiaging effect of EGCG on primary cells. In this study, the preventive effects of EGCG against serial passa...

journal_title：Oxidative medicine and cellular longevity

authors： Han DW,Lee MH,Kim B,Lee JJ,Hyon SH,Park JC

更新日期：2012-01-01 00:00:00

abstract：:Oxidative stress (OS) and neuronal apoptosis are major pathological processes after hypoxic-ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to CSF1 receptor (CSF1R), has been shown to reduce neuronal loss after hypoxic-ischemia- (HI-) induced brain injury. In the present study, we hypothesiz...

journal_title：Oxidative medicine and cellular longevity

authors： Hu X,Li S,Doycheva DM,Huang L,Lenahan C,Liu R,Huang J,Gao L,Tang J,Zuo G,Zhang JH

更新日期：2020-10-07 00:00:00

abstract：Methods:The expression of CD86, CD206, and HIF-1α in the gastric mucosa was evaluated through immunohistochemistry. RAW 264.7 cells were cocultured with H. pylori at various multiplicities of infection (MOIs), and iNOS, CD86, Arg-1, CD206, and HIF-1α expression was detected by Western blot, PCR, and ELISA analyses. ROS...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,Rong J,Lai Y,Tao L,Yuan X,Shu X

更新日期：2020-12-08 00:00:00

abstract：:Ascorbate requiring Fe2+/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in the endomembranes of fibroblasts from arterial tortuosity syndrome (AT...

journal_title：Oxidative medicine and cellular longevity

authors： Németh CE,Nemoda Z,Lőw P,Szabó P,Horváth EZ,Willaert A,Boel A,Callewaert BL,Coucke PJ,Colombi M,Bánhegyi G,Margittai É

更新日期：2019-01-13 00:00:00

abstract：Introduction:The omega-3 polyunsaturated fatty acids, as docosahexaenoic acid (DHA), are considered mediators regulating the resolution of inflammation during cancer and may be associated with better outcomes. Epoxydocosapentaenoic acids (EDPs), metabolites of the DHA, are hypothesized to be responsible for some benefi...

journal_title：Oxidative medicine and cellular longevity

authors： Molfino A,Amabile MI,Lionetto L,Spagnoli A,Ramaccini C,De Luca A,Simmaco M,Monti M,Muscaritoli M

更新日期：2019-03-05 00:00:00

abstract：:Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,He Z,Shen X,Xu X,Fan J,Wu S,Zhang D

更新日期：2012-01-01 00:00:00

abstract：:Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipa...

journal_title：Oxidative medicine and cellular longevity

authors： Alonazi M,Horchani H,Alwhibi M,Ben Bacha A

更新日期：2020-10-29 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However, the specific effects of ISL on AP have not been determined. In this study, we aimed to investigate the protective effect of ISL on AP using ...

journal_title：Oxidative medicine and cellular longevity

authors： Liu X,Zhu Q,Zhang M,Yin T,Xu R,Xiao W,Wu J,Deng B,Gao X,Gong W,Lu G,Ding Y

更新日期：2018-04-26 00:00:00

abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Hong M,Tan HY,Wang N,Feng Y

更新日期：2016-01-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter with a variety of cardiovascular protective effects. Sirtuin 3 (SIRT3) is closely related to mitochondrial function and oxidative stress. We found that NaHS increased SIRT3 expression in the preventive effect on isoproterenol- (ISO-) induced myocardial hypertrophy. We furthe...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Yu J,Chen Y,Liu L,Xu M,Sun L,Luo H,Wang Y,Meng G

更新日期：2018-12-17 00:00:00

abstract：:Oxidative stress is crucially involved in the pathogenesis of neurological diseases such as stroke and degenerative diseases. We previously demonstrated that platelet-derived growth factors (PDGFs) protected neurons from H2O2-induced oxidative stress and indicated the involvement of PI3K-Akt and MAP kinases as an unde...

journal_title：Oxidative medicine and cellular longevity

authors： Zheng LS,Ishii Y,Zhao QL,Kondo T,Sasahara M

更新日期：2013-01-01 00:00:00

abstract：:Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

journal_title：Oxidative medicine and cellular longevity

authors： Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

更新日期：2019-02-17 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is an upstream regulator of CaMKK-CaMKIV signaling cascade that activates various transcription factors, thereby regulating several cellular activities including, neuronal communication and immune response. Owing to the abnormal expression in cancer and neurodege...

journal_title：Oxidative medicine and cellular longevity

authors： Gupta P,Khan S,Fakhar Z,Hussain A,Rehman MT,AlAjmi MF,Islam A,Ahmad F,Hassan MI

更新日期：2020-07-16 00:00:00

abstract：:Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

更新日期：2016-01-01 00:00:00

abstract：:Inhibition of either P2Y12 receptor or the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome provides cardioprotective effects. Here, we investigate whether direct NLRP3 inflammasome inhibition exerts additive effects on myocardial protection induced by the ...

journal_title：Oxidative medicine and cellular longevity

authors： Penna C,Aragno M,Cento AS,Femminò S,Russo I,Bello FD,Chiazza F,Collotta D,Alves GF,Bertinaria M,Zicola E,Mercurio V,Medana C,Collino M,Pagliaro P

更新日期：2020-08-03 00:00:00

abstract：:Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer's disease (AD) in the clinic; however, the mechanisms underlying its effects remain largely unknown. In this study, we used a rat AD model to study the effects of BSTSF on cognitive performance,...

journal_title：Oxidative medicine and cellular longevity

authors： Yi M,Zhang C,Zhang Z,Yi P,Xu P,Huang J,Peng W

更新日期：2020-06-19 00:00:00

abstract：:The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities...

journal_title：Oxidative medicine and cellular longevity

authors： Andreicuț AD,Fischer-Fodor E,Pârvu AE,Ţigu AB,Cenariu M,Pârvu M,Cătoi FA,Irimie A

更新日期：2019-12-14 00:00:00

abstract：:Fungal immunomodulatory proteins (FIPs) are a class of small proteins that have been extensively studied for their immunomodulatory activities. In this study, two novel FIPs from Lentinus tigrinus were identified and named Fip-lti1 and Fip-lti2. The bioactive characteristics of Fip-lti1 and Fip-lti2 were compared to a...

journal_title：Oxidative medicine and cellular longevity

authors： Gao Y,Wáng Y,Wāng Y,Wu Y,Chen H,Yang R,Bao D

更新日期：2019-05-06 00:00:00

abstract：:In plasma medicine, cold physical plasma delivers a delicate mixture of reactive components to cells and tissues. Recent studies suggested a beneficial role of cold plasma in wound healing. Yet, the biological processes related to the redox modulation via plasma are not fully understood. We here used the monocytic cel...

journal_title：Oxidative medicine and cellular longevity

authors： Bekeschus S,Schmidt A,Bethge L,Masur K,von Woedtke T,Hasse S,Wende K

更新日期：2016-01-01 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Recent reports indicate that oxidative stress is involved in the pathobiology of acute spinal cord injury or compression myelopathy. We conducted an observational study to determine levels of oxidative stress markers in serum from 80 patients who underwent spinal surgery to treat neurological symptoms related to lumba...

journal_title：Oxidative medicine and cellular longevity

authors： Takahashi H,Aoki Y,Saito J,Nakajima A,Sonobe M,Akatsu Y,Taniguchi S,Yamada M,Koyama K,Akiyama Y,Shiga Y,Inage K,Orita S,Eguchi Y,Maki S,Furuya T,Akazawa T,Koda M,Yamazaki M,Ohtori S,Nakagawa K

更新日期：2020-12-24 00:00:00

abstract：:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

更新日期：2020-06-17 00:00:00