Redox Stimulation of Human THP-1 Monocytes in Response to Cold Physical Plasma.

Abstract:

:In plasma medicine, cold physical plasma delivers a delicate mixture of reactive components to cells and tissues. Recent studies suggested a beneficial role of cold plasma in wound healing. Yet, the biological processes related to the redox modulation via plasma are not fully understood. We here used the monocytic cell line THP-1 as a model to test their response to cold plasma in vitro. Intriguingly, short term plasma treatment stimulated cell growth. Longer exposure only modestly compromised cell viability but apparently supported the growth of cells that were enlarged in size and that showed enhanced metabolic activity. A significantly increased mitochondrial content in plasma treated cells supported this notion. On THP-1 cell proteome level, we identified an increase of protein translation with key regulatory proteins being involved in redox regulation (hypoxia inducible factor 2α), differentiation (retinoic acid signaling and interferon inducible factors), and cell growth (Yin Yang 1). Regulation of inflammation is a key element in many chronic diseases, and we found a significantly increased expression of the anti-inflammatory heme oxygenase 1 (HMOX1) and of the neutrophil attractant chemokine interleukin-8 (IL-8). Together, these results foster the view that cold physical plasma modulates the redox balance and inflammatory processes in wound related cells.

journal_name

Oxid Med Cell Longev

authors

Bekeschus S,Schmidt A,Bethge L,Masur K,von Woedtke T,Hasse S,Wende K

doi

10.1155/2016/5910695

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

5910695

eissn

1942-0900

issn

1942-0994

journal_volume

2016

pub_type

杂志文章
  • Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries.

    abstract::Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/5967434

    authors: Yan C,Zhang X,Miao J,Yuan H,Liu E,Liang T,Li Q

    更新日期:2020-01-28 00:00:00

  • Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats.

    abstract::Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies curcumin as a neuroprotectant against hemin-induced damage in primary cultures of cerebellar granule neurons (CGNs) of rats. Hemin, the oxidized form of heme, is a highly reactive compound that induces cellular injury. Pretreatmen...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/801418

    authors: González-Reyes S,Guzmán-Beltrán S,Medina-Campos ON,Pedraza-Chaverri J

    更新日期:2013-01-01 00:00:00

  • Reactive Oxygen Species from NADPH Oxidase and Mitochondria Participate in the Proliferation of Aortic Smooth Muscle Cells from a Model of Metabolic Syndrome.

    abstract::In metabolic diseases, the increased reactive oxygen species (ROS) represents one of the pathogenic mechanisms for vascular disease probably by promoting vascular smooth muscle cell (SMC) proliferation that contributes to the development of arterial remodeling and stenosis, hypertension, and atherosclerosis. Therefore...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/5835072

    authors: López-Acosta O,de Los Angeles Fortis-Barrera M,Barrios-Maya MA,Ramírez AR,Aguilar FJA,El-Hafidi M

    更新日期:2018-12-23 00:00:00

  • Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-κB Activation in ApoE Knockout Mice.

    abstract::We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE-/-) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean prop...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/3197829

    authors: Xiao Y,He M,Liang X,She J,He L,Liu Y,Zou J,Yuan Z

    更新日期:2018-08-23 00:00:00

  • Redox regulation in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results from the death of upper and lower motor neurons. Due to a lack of effective treatment, it is imperative to understand the underlying mechanisms and processes involved in disease progression. Regulations in cellular reduction/oxidation (red...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/408681

    authors: Parakh S,Spencer DM,Halloran MA,Soo KY,Atkin JD

    更新日期:2013-01-01 00:00:00

  • Fish Scale Collagen Peptides Protect against CoCl2/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.

    abstract::Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/9703609

    authors: Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

    更新日期:2017-01-01 00:00:00

  • Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments.

    abstract::2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascu...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/4973239

    authors: Ling S,Xu JW

    更新日期:2016-01-01 00:00:00

  • Antioxidant Properties of Amazonian Fruits: A Mini Review of In Vivo and In Vitro Studies.

    abstract::Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2019/8204129

    authors: Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

    更新日期:2019-02-17 00:00:00

  • Role of Diet and Nutritional Supplements in Parkinson's Disease Progression.

    abstract:OBJECTIVES:The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS:The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/6405278

    authors: Mischley LK,Lau RC,Bennett RD

    更新日期:2017-01-01 00:00:00

  • Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease.

    abstract::The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2015/842108

    authors: Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

    更新日期:2015-01-01 00:00:00

  • The Protective Role of Probiotics against Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide and a major global public health problem. With the rapid development of the economy, the incidence of CRC has increased linearly. Accumulating evidence indicates that changes in the gut microenvironment, such as undesirable changes ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/8884583

    authors: Ding S,Hu C,Fang J,Liu G

    更新日期:2020-12-09 00:00:00

  • Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats.

    abstract::Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear. Accumulating studies also indicate that uric acid has both pro- and antioxidant properties. We postulated that hyperuricemia impairs the function of glomerular podocytes, resulting in albuminuria. Hyperuricemic model w...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/3759153

    authors: Asakawa S,Shibata S,Morimoto C,Shiraishi T,Nakamura T,Tamura Y,Kumagai T,Hosoyamada M,Uchida S

    更新日期:2017-01-01 00:00:00

  • The potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female rats.

    abstract::Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randoml...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/741817

    authors: Dkhil MA,Al-Quraishy S,Aref AM,Othman MS,El-Deib KM,Abdel Moneim AE

    更新日期:2013-01-01 00:00:00

  • Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects.

    abstract::The advanced glycation end products (AGEs) are organic molecules formed in any living organisms with a great variety of structural and functional properties. They are considered organic markers of the glycation process. Due to their great heterogeneity, there is no specific test for their operational measurement. In t...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3818196

    authors: Perrone A,Giovino A,Benny J,Martinelli F

    更新日期:2020-03-18 00:00:00

  • The Degree of Helicobacter pylori Infection Affects the State of Macrophage Polarization through Crosstalk between ROS and HIF-1α.

    abstract:Methods:The expression of CD86, CD206, and HIF-1α in the gastric mucosa was evaluated through immunohistochemistry. RAW 264.7 cells were cocultured with H. pylori at various multiplicities of infection (MOIs), and iNOS, CD86, Arg-1, CD206, and HIF-1α expression was detected by Western blot, PCR, and ELISA analyses. ROS...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/5281795

    authors: Lu Y,Rong J,Lai Y,Tao L,Yuan X,Shu X

    更新日期:2020-12-08 00:00:00

  • The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism.

    abstract:Objectives:Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery. Method...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/3076131

    authors: Li CX,Wang HW,Jiang WJ,Li GC,Zhang YD,Luo CH,Li XC

    更新日期:2020-02-27 00:00:00

  • Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway.

    abstract::Escherichia coli (E. coli) is one of pathogens causing nosocomial pneumonia and could induce pulmonary excessive apoptosis. Although much has been learned about metabolic diseases induced by obesity, the information linking bacterial pneumonia to obesity is limited. Accordingly, we investigated the apoptosis of normal...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/1968539

    authors: Wang F,Zuo Z,Yang Z,Chen K,Fang J,Cui H,Shu G,Zhou Y,Geng Y,Ouyang P

    更新日期:2019-10-22 00:00:00

  • Preventive effects of epigallocatechin-3-O-gallate against replicative senescence associated with p53 acetylation in human dermal fibroblasts.

    abstract::Considering the various pharmacological activities of epigallocatechin-3-O-gallate (EGCG) including anticancer, and anti-inflammatory, antidiabetic, and so forth, relatively less attention has been paid to the antiaging effect of EGCG on primary cells. In this study, the preventive effects of EGCG against serial passa...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2012/850684

    authors: Han DW,Lee MH,Kim B,Lee JJ,Hyon SH,Park JC

    更新日期:2012-01-01 00:00:00

  • Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study.

    abstract::Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/9834803

    authors: Tasca KI,Caleffi JT,Correa CR,Gatto M,Tavares FC,Camargo CC,Sartori A,Biasin M,de Souza LDR

    更新日期:2017-01-01 00:00:00

  • NADPH Oxidase Deficiency: A Multisystem Approach.

    abstract::The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes. The generation and release of ROS in the fo...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4590127

    authors: Giardino G,Cicalese MP,Delmonte O,Migliavacca M,Palterer B,Loffredo L,Cirillo E,Gallo V,Violi F,Pignata C

    更新日期:2017-01-01 00:00:00

  • Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome-Derived Platelet Hyperactivity.

    abstract::Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative str...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2423547

    authors: Gaspar RS,Trostchansky A,Paes AM

    更新日期:2016-01-01 00:00:00

  • Buyang Huanwu Decoction Exerts Cardioprotective Effects through Targeting Angiogenesis via Caveolin-1/VEGF Signaling Pathway in Mice with Acute Myocardial Infarction.

    abstract:Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/4275984

    authors: Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

    更新日期:2019-04-16 00:00:00

  • Regulation of System xc(-) by Pharmacological Manipulation of Cellular Thiols.

    abstract::The cystine/glutamate exchanger (system xc (-)) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, system xc (-) can potentially cause excitotoxicity. However, through providing cystine to the cell, it regulates the levels of cellular glutathione (GSH), the main endogeno...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2015/269371

    authors: Albano R,Raddatz NJ,Hjelmhaug J,Baker DA,Lobner D

    更新日期:2015-01-01 00:00:00

  • Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.-Hill.

    abstract:UNLABELLED:Background. Duguetia furfuracea is popular plant used in popular medicine. Hypothesis/Purpose. This claim evaluated the phytochemical composition of the hydroethanolic extract (HEDF), fractions of Duguetia furfuracea, and antioxidant and antifungal activity. Methods. The chemical profile was carried out by H...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/7821051

    authors: Pinho FV,da Cruz LC,Rodrigues NR,Waczuk EP,Souza CE,Coutinho HD,da Costa JG,Athayde ML,Boligon AA,Franco JL,Posser T,de Menezes IR

    更新日期:2016-01-01 00:00:00

  • Dexmedetomidine Attenuates Orthotopic Liver Transplantation-Induced Acute Gut Injury via α 2-Adrenergic Receptor-Dependent Suppression of Oxidative Stress.

    abstract::Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. R...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9426368

    authors: Lv P,Chen T,Liu P,Zheng L,Tian J,Tan F,Chen J,Deng Y,Li J,Cai J,Chi X

    更新日期:2019-11-11 00:00:00

  • Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid.

    abstract::The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H. extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice. In several beha...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/6981595

    authors: Kang JY,Park SK,Guo TJ,Ha JS,Lee DS,Kim JM,Lee U,Kim DO,Heo HJ

    更新日期:2016-01-01 00:00:00

  • Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation.

    abstract::Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense. Tanshinone IIA has been recently revealed to act directly on neutrophils. Hence, we aimed at investigating whether Tanshinone IIA can protec...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/7916763

    authors: Liu X,He H,Huang T,Lei Z,Liu F,An G,Wen T

    更新日期:2016-01-01 00:00:00

  • Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats.

    abstract::Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was ind...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/1092015

    authors: Al-Rasheed NM,Al-Rasheed NM,Hasan IH,Al-Amin MA,Al-Ajmi HN,Mohamad RA,Mahmoud AM

    更新日期:2017-01-01 00:00:00

  • Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction.

    abstract::Endothelial dysfunction tends to be the initial indicator in proinflammatory state and macro- and microvascular complications, such as atherosclerosis and cardiovascular diseases. It has been shown that certain compounds in diet can generate beneficial effects on cardiovascular disease due to its interactions with end...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/2097096

    authors: Stromsnes K,Mas-Bargues C,Gambini J,Gimeno-Mallench L

    更新日期:2020-08-06 00:00:00

  • TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation.

    abstract::Transient receptor potential vanilloid 1 (TRPV1) is a Ca+2-permeable channel expressed on neuronal and nonneuronal cells, known as an oxidative stress sensor. It plays a protective role in bacterial infection, and recent findings indicate that this receptor modulates monocyte populations in mice with malaria; however,...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9451671

    authors: Pereira DMS,Teixeira SA,Murillo O,Peixoto EPM,Araújo MC,Sousa NCF,Monteiro-Neto V,Calixto JB,Cunha TM,Marinho CRF,Muscará MN,Fernandes ES

    更新日期:2019-05-16 00:00:00