Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats.

abstract：:Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP). The redox properties of both Hem12p and Tkl1p from Saccharomyces cerevisiae were investigated using proteom...

journal_title：Oxidative medicine and cellular longevity

authors： McDonagh B,Pedrajas JR,Padilla CA,Bárcena JA

更新日期：2013-01-01 00:00:00

abstract：:Essential oils of some aromatic plants provide an effective nonmedicinal option to control liver fibrosis. Mentha piperita L. essential oil (MPEO) have been reported to possess protective effects against hepatotoxicity. However, its effect against liver fibrosis remains unknown. The present study investigated the anti...

journal_title：Oxidative medicine and cellular longevity

authors： Ogaly HA,Eltablawy NA,Abd-Elsalam RM

更新日期：2018-04-19 00:00:00

abstract：:Tau, a microtubule-associated protein expressed in mature neurons, interacts with tubulin to promote the assembly and stabilization of microtubules. However, abnormally hyperphosphorylated tau dissociates from microtubules and self-aggregates. Tau aggregates, including paired helical filaments and neurofibrillary tang...

journal_title：Oxidative medicine and cellular longevity

authors： Shin SJ,Park YH,Jeon SG,Kim S,Nam Y,Oh SM,Lee YY,Moon M

更新日期：2020-06-30 00:00:00

abstract：Background:Amino acids (AAs) in cerebrospinal fluid (CSF) play a pivotal role in cerebral ischemia (CI). BuChang NaoXinTong Capsules (BNC) are widely prescribed in Chinese medicine for the treatment of cerebrovascular and cardiovascular diseases. Methods:In order to investigate the therapeutic effects and pharmacologi...

journal_title：Oxidative medicine and cellular longevity

authors： Xu J,Liu X,Luo L,Tang L,Guo N,Liu M,Li H,Zhang F,Zhang Y,Li D,Zhao Y,Wu H,Yang H

更新日期：2019-03-20 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/6838921.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Songia P,Porro B,Chiesa M,Myasoedova V,Alamanni F,Tremoli E,Poggio P

更新日期：2017-01-01 00:00:00

abstract：:Considering the various pharmacological activities of epigallocatechin-3-O-gallate (EGCG) including anticancer, and anti-inflammatory, antidiabetic, and so forth, relatively less attention has been paid to the antiaging effect of EGCG on primary cells. In this study, the preventive effects of EGCG against serial passa...

journal_title：Oxidative medicine and cellular longevity

authors： Han DW,Lee MH,Kim B,Lee JJ,Hyon SH,Park JC

更新日期：2012-01-01 00:00:00

abstract：:NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and progression. NRF2 and HERs confer cancers with resistance to several t...

journal_title：Oxidative medicine and cellular longevity

authors： Kankia IH,Khalil HS,Langdon SP,Moult PR,Bown JL,Deeni YY

更新日期：2017-01-01 00:00:00

abstract：:Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be...

journal_title：Oxidative medicine and cellular longevity

authors： Picone P,Nuzzo D,Caruana L,Scafidi V,Di Carlo M

更新日期：2014-01-01 00:00:00

abstract：:Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randoml...

journal_title：Oxidative medicine and cellular longevity

authors： Dkhil MA,Al-Quraishy S,Aref AM,Othman MS,El-Deib KM,Abdel Moneim AE

更新日期：2013-01-01 00:00:00

abstract：:The regulation on calcium oxalate (CaOx) crystallization and protective effect on human proximal tubular epithelial cells (HK-2) of four green tea polysaccharides (TPSs) with molecular weights of 10.88 (TPS0), 8.16 (TPS1), 4.82 (TPS2), and 2.3 kDa (TPS3) were comparatively studied. XRD, Fourier transform infrared spec...

journal_title：Oxidative medicine and cellular longevity

authors： Liu H,Sun XY,Wang FX,Ouyang JM

更新日期：2020-05-12 00:00:00

abstract：:Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia caused by mutations in endoglin (ENG; HHT1) or activin receptor-like kinase (ALK1; HHT2) genes, coding for transforming growth factor-β (TGF-β) superfamily receptors. We demonstrated previously that endoglin and ALK1 interact with endothelial NO synth...

journal_title：Oxidative medicine and cellular longevity

authors： Jerkic M,Sotov V,Letarte M

更新日期：2012-01-01 00:00:00

abstract：:Balkan endemic nephropathy (BEN) represents a chronic tubulointerstitial nephropathy which is followed by the progression of kidney fibrosis to end-stage kidney failure. The critical involvement of poisons in food (aristolochic acid (AA), ochratoxin, and heavy metals) and selenium deficiency are among nutritive factor...

journal_title：Oxidative medicine and cellular longevity

authors： Veljković A,Hadži-Đokić J,Sokolović D,Čukuranović R,Čukuranović-Kokoris J,Bašić D,Đorđević B,Stojanović M,Šmelcerović A,Kocić G

更新日期：2020-08-18 00:00:00

abstract：:Oxidative stress reflects an imbalance between oxidants and antioxidants in favor of the oxidants capable of evoking tissue damage. Like hydrogen sulfide (H2S) and nitric oxide (NO), carbon monoxide (CO) is an endogenous gaseous mediator recently implicated in the physiology of the gastrointestinal (GI) tract. CO is p...

journal_title：Oxidative medicine and cellular longevity

authors： Korbut E,Brzozowski T,Magierowski M

更新日期：2020-04-15 00:00:00

abstract：:The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression. Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death an...

journal_title：Oxidative medicine and cellular longevity

authors： Leone A,Roca MS,Ciardiello C,Costantini S,Budillon A

更新日期：2017-01-01 00:00:00

abstract：:Methionine sulfoxide reductase B1 (MsrB1) is a member of the selenoprotein family, which contributes to the reduction of methionine sulfoxides produced from reactive oxygen species (ROS) by redox processes in energy pathways. However, few studies have examined the role of MsrB1 in human hepatocellular carcinoma (HCC)....

journal_title：Oxidative medicine and cellular longevity

authors： He Q,Li H,Meng F,Sun X,Feng X,Chen J,Li L,Liu J

更新日期：2018-05-10 00:00:00

abstract：:Mitochondria are the primary site of cellular energy generation and reactive oxygen species (ROS) accumulation. Elevated ROS levels are detrimental to normal cell function and have been linked to the pathogenesis of neurodegenerative disorders such as Down's syndrome (DS) and Alzheimer's disease (AD). RCAN1 is abundan...

journal_title：Oxidative medicine and cellular longevity

authors： Peiris H,Dubach D,Jessup CF,Unterweger P,Raghupathi R,Muyderman H,Zanin MP,Mackenzie K,Pritchard MA,Keating DJ

更新日期：2014-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduc...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou Y,Yan H,Guo M,Zhu J,Xiao Q,Zhang L

更新日期：2013-01-01 00:00:00

abstract：:The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear f...

journal_title：Oxidative medicine and cellular longevity

authors： Fuyuno Y,Uchi H,Yasumatsu M,Morino-Koga S,Tanaka Y,Mitoma C,Furue M

更新日期：2018-02-14 00:00:00

abstract：:Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its maintenance. Here we prop...

journal_title：Oxidative medicine and cellular longevity

authors： Farooq MA,Pracheil TM,Dong Z,Xiao F,Liu Z

更新日期：2013-01-01 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been ...

journal_title：Oxidative medicine and cellular longevity

authors： Kong X,Liu CX,Wang GD,Yang H,Yao XM,Hua Q,Li XY,Zhang HM,Ma MZ,Su Q,Lv K

更新日期：2019-10-14 00:00:00

abstract：:Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticanc...

journal_title：Oxidative medicine and cellular longevity

authors： Li K,Zheng Q,Chen X,Wang Y,Wang D,Wang J

更新日期：2018-10-16 00:00:00

abstract：:Mitochondrial dysfunctions caused by oxidative stress are currently regarded as the main cause of aging. Accumulation of mutations and deletions of mtDNA is a hallmark of aging. So far, however, there is no evidence that most studied oxygen radicals are directly responsible for mutations of mtDNA. Oxidative damages to...

journal_title：Oxidative medicine and cellular longevity

authors： Panov AV,Dikalov SI

更新日期：2020-09-08 00:00:00

abstract：:We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS). 82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B)...

journal_title：Oxidative medicine and cellular longevity

authors： Žitňanová I,Šiarnik P,Kollár B,Chomová M,Pazderová P,Andrezálová L,Ježovičová M,Koňariková K,Laubertová L,Krivošíková Z,Slezáková L,Turčáni P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and...

journal_title：Oxidative medicine and cellular longevity

authors： Longato L,Ripp K,Setshedi M,Dostalek M,Akhlaghi F,Branda M,Wands JR,de la Monte SM

更新日期：2012-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration. Pathogenetic mechanisms, triggered by β-amyloid (Aβ) accumulation, include oxidative stress, derived from energy homeostasis deregulation and involving mitochondria and peroxisomes. We here addressed the oxida...

journal_title：Oxidative medicine and cellular longevity

authors： Porcellotti S,Fanelli F,Fracassi A,Sepe S,Cecconi F,Bernardi C,Cimini A,Cerù MP,Moreno S

更新日期：2015-01-01 00:00:00

abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

journal_title：Oxidative medicine and cellular longevity

authors： Kim HM,Cho BR

更新日期：2013-01-01 00:00:00

abstract：:There is little research on how cooking and digestion affect the anti-inflammatory activity of culinary herbs. Thus, the aim of this paper was to investigate this activity following cooking and in vitro digestion of the common culinary herbs, rosemary, sage, and thyme, and the relationship between their anti-inflammat...

journal_title：Oxidative medicine and cellular longevity

authors： Chohan M,Naughton DP,Jones L,Opara EI

更新日期：2012-01-01 00:00:00

abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

更新日期：2019-03-26 00:00:00

abstract：:Although Tamoxifen (TAM) is one of the most widely used drugs in managing breast cancer, many women still relapse after long-term therapy. Caffeic acid phenethyl ester (CAPE) is a polyphenolic compound present in many medicinal plants and in propolis. The present study examined the effect of CAPE on TAM cytotoxicity i...

journal_title：Oxidative medicine and cellular longevity

authors： Motawi TK,Abdelazim SA,Darwish HA,Elbaz EM,Shouman SA

更新日期：2016-01-01 00:00:00

abstract：:Fisetin, a known antioxidant, has been found to be cytotoxic against certain cell lines. However, the mechanism by which it inhibits tumor growth in vivo remains unexplored. Recently, we have demonstrated that Aflatoxin-B1 (AFB1) induced hepatocarcinogenesis is associated with activation of oxidative stress-inflammato...

journal_title：Oxidative medicine and cellular longevity

authors： Maurya BK,Trigun SK

更新日期：2016-01-01 00:00:00