Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid.

abstract：:The human apoptosis-inducing factor (hAIF) is a moonlight flavoprotein involved in mitochondrial respiratory complex assembly and caspase-independent programmed cell death. These functions might be modulated by its redox-linked structural transition that enables hAIF to act as a NAD(H/+) redox sensor. Upon reduction w...

journal_title：Oxidative medicine and cellular longevity

authors： Romero-Tamayo S,Laplaza R,Velazquez-Campoy A,Villanueva R,Medina M,Ferreira P

更新日期：2021-01-15 00:00:00

abstract：:Hyperglycemia-induced stress in the brain of patients with diabetes triggers the disruption of blood-brain barrier (BBB), leading to diverse neurological diseases including stroke and dementia. Recently, the role of microRNA becomes an interest in the research for deciphering the mechanism of brain endothelial cell da...

journal_title：Oxidative medicine and cellular longevity

authors： Song J,Yoon SR,Kim OY

更新日期：2017-01-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder characterized by movement alterations caused by reduced dopaminergic neurotransmission in the nigrostriatal pathway, presumably by oxidative stress (OS). MPP(+) intrastriatal injection leads to the overproduction of free radicals (FR). The increasing formation of FR ...

journal_title：Oxidative medicine and cellular longevity

authors： Rubio-Osornio M,Gorostieta-Salas E,Montes S,Pérez-Severiano F,Rubio C,Gómez C,Ríos C,Guevara J

更新日期：2015-01-01 00:00:00

abstract：:Many groups of Gram-negative bacteria cause diseases that are harmful to sheep. Toll-like receptor 4 (TLR4), which is critical for detecting Gram-negative bacteria by the innate immune system, is activated by lipopolysaccharide (LPS) to initiate inflammatory responses and oxidative stress. Oxidation intermediates are ...

journal_title：Oxidative medicine and cellular longevity

authors： Deng S,Yu K,Zhang B,Yao Y,Wang Z,Zhang J,Zhang X,Liu G,Li N,Liu Y,Lian Z

更新日期：2015-01-01 00:00:00

abstract：:Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immun...

journal_title：Oxidative medicine and cellular longevity

authors： Luck C,DeMarco VG,Mahmood A,Gavini MP,Pulakat L

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to examine exercise-related genes in articular cartilage identified through bioinformatics analysis to dissect the potential signaling pathway involved in mechanical stimulation in osteoarthritis (OA). To this end, we evaluated the GSE74898 dataset from the Gene Expression Omnibus database fo...

journal_title：Oxidative medicine and cellular longevity

authors： Yang Y,Wang Y,Kong Y,Zhang X,Zhang H,Feng X,Wang Z,Gao P,Yan M,Bai L,Li F

更新日期：2020-05-23 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are key transmembrane proteins leading to reactive oxygen species (ROS) overproduction. However, the detailed roles of NOXs in retinal pigment epithelial (RPE) cell metabolic stress induced by Earle's balanced salt solution (EBSS) through starvation r...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang Y,Ren S,Gu Y,Wang J,Liu Z,Zhang Z

更新日期：2018-07-29 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regu...

journal_title：Oxidative medicine and cellular longevity

authors： Chu Q,Zhang S,Chen M,Han W,Jia R,Chen W,Zheng X

更新日期：2019-02-25 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00

abstract：:Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) i...

journal_title：Oxidative medicine and cellular longevity

authors： Carreira BP,Santos DF,Santos AI,Carvalho CM,Araújo IM

更新日期：2015-01-01 00:00:00

abstract：Background:Oxidized human DNA or plasmid DNAs containing human ribosomal genes can easily penetrate into the breast cancer cells MCF7 and stimulate the adaptive response induction. Plasmid DNA containing a CMV promoter, gene EGFP, and the insertion of the human ribosomal genes can be expressed. A hypothesis is proposed...

journal_title：Oxidative medicine and cellular longevity

authors： Kozhina EA,Ershova ES,Okorokova NA,Veiko VP,Malinovskaya EM,Sergeeva VA,Konkova MS,Kutsev SI,Veiko NN,Kostyuk SV

更新日期：2019-11-03 00:00:00

abstract：Objective:The aim of this study was to establish a 3T3-L1 adipocyte model and ApoE-/- mouse model of intermittent hypoxia (IH) composite abnormal glucose metabolism (AGM) in vitro and in vivo and explore their synergistic damage effect leading to atherosclerosis (AS) and the influence of SREBP-1 signaling molecule-rela...

journal_title：Oxidative medicine and cellular longevity

authors： Ma L,Zhang J,Qiao Y,Sun X,Mao T,Lei S,Zheng Q,Liu Y

更新日期：2019-02-04 00:00:00

abstract：:Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been...

journal_title：Oxidative medicine and cellular longevity

authors： Tatzber F,Pursch E,Resch U,Pfragner R,Holasek S,Lindschinger M,Cvirn G,Wonisch W

更新日期：2017-01-01 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast cancer cells media...

journal_title：Oxidative medicine and cellular longevity

authors： Villalpando-Rodriguez GE,Blankstein AR,Konzelman C,Gibson SB

更新日期：2019-09-17 00:00:00

abstract：:Reversible myocardial ischemia/reperfusion (I/R) or ischemic preconditioning (IPC) is associated with an immediate genomic response; IPC-induced immediate early genes are associated with reduced infarct size. Because the immediate early response gene X-1 (IEX-1) plays a central role in cell apoptosis, we examine wheth...

journal_title：Oxidative medicine and cellular longevity

authors： Xu MJ,Cai Y,Qu A,Shyy JY,Li W,Wang X

更新日期：2017-01-01 00:00:00

abstract：:Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,He Z,Shen X,Xu X,Fan J,Wu S,Zhang D

更新日期：2012-01-01 00:00:00

abstract：:Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Ma...

journal_title：Oxidative medicine and cellular longevity

authors： Fujimoto C,Yamasoba T

更新日期：2014-01-01 00:00:00

abstract：:An optimisation of extraction towards an increased antioxidant capacity and the study on the extracts' composition by HPLC-ESI-Q-TOF-MS were performed on different organs of a rarely studied plant: Rheum cordatum Losinsk (Polygonaceae) growing in Kazakhstan. More than 20 compounds from anthraquinones and phenolics wer...

journal_title：Oxidative medicine and cellular longevity

authors： Zhumashova G,Kukula-Koch W,Koch W,Baj T,Sayakova G,Shukirbekova A,Głowniak K,Sakipova Z

更新日期：2019-11-16 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：Objective:Cholesterol oxidation products have an established proatherogenic and cytotoxic effect. An increased exposure to these substances may be associated with the development of atherosclerosis and cancers. Relatively little, though, is known about the effect of phytosterol oxidation products, although phytosterols...

journal_title：Oxidative medicine and cellular longevity

authors： Wielkoszyński T,Zalejska-Fiolka J,Strzelczyk JK,Owczarek AJ,Cholewka A,Krawczyk A,Stanek A

更新日期：2019-11-15 00:00:00

abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2015-01-01 00:00:00

abstract：:Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its ...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Z,Zhang S,Xiao Y,Zhang W,Wu S,Qin T,Yue Y,Qian W,Li L

更新日期：2020-02-17 00:00:00

abstract：:Vagus nerve stimulation (VNS) has been shown to attenuate ischemia-reperfusion (I/R) injury in multiple organs. The present study aimed at investigating whether VNS could exert protective effects against I/R injury in the skeletal muscle. Male Sprague-Dawley rats were randomly divided into 3 groups: the control, I/R, ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang Y,Li H,Wang M,Meng G,Wang Z,Deng J,Wang M,Zhang Q,Yang S,Jiang H

更新日期：2019-02-28 00:00:00

abstract：SCOPE:To determine whether doses of quercetin in the range of serum concentrations exert any effect on triacylglycerol accumulation in maturing preadipocytes and mature adipocytes. The influence on the expression of adipogenic markers as well as on gene expression and activity of enzymes involved in triacylglycerol met...

journal_title：Oxidative medicine and cellular longevity

authors： Eseberri I,Miranda J,Lasa A,Churruca I,Portillo MP

更新日期：2015-01-01 00:00:00

abstract：:Previous studies have shown that metformin not only is a hypoglycemic agent but also has neuroprotective effects. However, the mechanism of action of metformin in ischemic stroke is unclear. Oxidative stress is an important factor in the pathogenesis of cerebral ischemia-reperfusion injury. It has been reported that m...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng J,Zhu L,Liu J,Zhu T,Xie Z,Sun X,Zhang H

更新日期：2019-12-16 00:00:00

abstract：:Organophosphate pesticides (OPs) are among the most widely used synthetic chemicals for the control of a wide variety of pests, and reactive oxygen species (ROS) caused by OPs may be involved in the toxicity of various pesticides. Previous studies have demonstrated that a reactivation of latent Epstein-Barr virus (EBV...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao L,Xie F,Wang TT,Liu MY,Li JL,Shang L,Deng ZX,Zhao PX,Ma XM

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group, n = 97) and RA patients (n = 173). RA patients were...

journal_title：Oxidative medicine and cellular longevity

authors： Costa NT,Veiga Iriyoda TM,Kallaur AP,Delongui F,Alfieri DF,Lozovoy MA,Amin RB,Delfino VD,Dichi I,Simão AN

更新日期：2016-01-01 00:00:00

abstract：:We aimed to evaluate the cardioprotective effect and mechanism of propofol in anthracycline-induced cardiomyocyte apoptosis. We selected the rat myocardial cell line, H9c2, and primary cardiomyocytes for in vitro study. The cardiomyocytes were treated with vehicle, Adriamycin® (ADM), propofol, or a combination of ADM ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao H,Zhang X,Zheng Y,Li Y,Wang X,Hu N,Zhou P,Wang K

更新日期：2018-04-18 00:00:00

abstract：:We hypothesized that fibroblast growth factor-9 (FGF-9) would enhance angiogenesis via activating c-kit positive stem cells in the infarcted nondiabetic and diabetic heart. In brief, animals were divided into three groups: Sham, MI, and MI+FGF-9. Two weeks following MI or sham surgery, our data suggest that treatment ...

journal_title：Oxidative medicine and cellular longevity

authors： Singla D,Wang J

更新日期：2016-01-01 00:00:00