Reversal of Trimethyltin-Induced Learning and Memory Deficits by 3,5-Dicaffeoylquinic Acid.


:The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H. extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice. In several behavioral tests, namely, the Y-maze, passive avoidance, and Morris water maze (MWM) test, 3,5-diCQA significantly ameliorated learning and memory deficits. After the behavioral tests, brain tissues from the mice were analyzed to characterize the basis of the neuroprotective effect. Acetylcholine (ACh) levels increased, whereas the activity of acetylcholinesterase (AChE) decreased upon administration of 3,5-diCQA. In addition, 3,5-diCQA effectively protected against an increase in malondialdehyde (MDA) content, an increase in the oxidized glutathione (GSH) ratio, and a decline of total superoxide dismutase (SOD) level. 3,5-diCQA may prevent neuronal apoptosis through the protection of mitochondrial activities and the repression of apoptotic signaling molecules such as p-Akt, BAX, and p-tau (Ser 404).


Oxid Med Cell Longev


Kang JY,Park SK,Guo TJ,Ha JS,Lee DS,Kim JM,Lee U,Kim DO,Heo HJ




Has Abstract


2016-01-01 00:00:00










  • Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity.

    abstract::Surgical intervention is currently the only option for an abdominal aortic aneurysm (AAA), preventing its rupture and sudden death of a patient. Therefore, it is crucial to determine the pathogenic mechanisms of this disease for the development of effective pharmacological therapies. Oxidative stress is said to be one...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Kopacz A,Werner E,Grochot-Przęczek A,Klóska D,Hajduk K,Neumayer C,Józkowicz A,Piechota-Polanczyk A

    更新日期:2020-06-16 00:00:00

  • Regulation of System xc(-) by Pharmacological Manipulation of Cellular Thiols.

    abstract::The cystine/glutamate exchanger (system xc (-)) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, system xc (-) can potentially cause excitotoxicity. However, through providing cystine to the cell, it regulates the levels of cellular glutathione (GSH), the main endogeno...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Albano R,Raddatz NJ,Hjelmhaug J,Baker DA,Lobner D

    更新日期:2015-01-01 00:00:00

  • Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.

    abstract::Accumulating evidence has demonstrated that oxidative stress is associated with depression. Our present study aimed at investigating the antidepressant effect and the possible mechanisms of curcumin (CUR) in chronic unpredictable mild stress- (CUMS-) induced depression model in rats. After exposure to CUMS for four we...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Liao D,Lv C,Cao L,Yao D,Wu Y,Long M,Liu N,Jiang P

    更新日期:2020-09-17 00:00:00

  • W196 and the β-Hairpin Motif Modulate the Redox Switch of Conformation and the Biomolecular Interaction Network of the Apoptosis-Inducing Factor.

    abstract::The human apoptosis-inducing factor (hAIF) is a moonlight flavoprotein involved in mitochondrial respiratory complex assembly and caspase-independent programmed cell death. These functions might be modulated by its redox-linked structural transition that enables hAIF to act as a NAD(H/+) redox sensor. Upon reduction w...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Romero-Tamayo S,Laplaza R,Velazquez-Campoy A,Villanueva R,Medina M,Ferreira P

    更新日期:2021-01-15 00:00:00

  • The antioxidant effects of a polyphenol-rich grape pomace extract in vitro do not correspond in vivo using exercise as an oxidant stimulus.

    abstract::Fruits, such as grapes, are essential food of the Mediterranean diet. Grape extracts have potent antioxidant and chemopreventive properties in vitro. Numerous studies have examined the effects of plant extract administration on redox status at rest in animals and humans but their results are controversial. However, th...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Veskoukis AS,Kyparos A,Nikolaidis MG,Stagos D,Aligiannis N,Halabalaki M,Chronis K,Goutzourelas N,Skaltsounis L,Kouretas D

    更新日期:2012-01-01 00:00:00

  • Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases.

    abstract::During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

    更新日期:2020-06-17 00:00:00

  • Erratum to "Long-Term Treatment of Native LDL Induces Senescence of Cultured Human Endothelial Cells".

    abstract::[This corrects the article DOI: 10.1155/2017/6487825.]. ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,已发布勘误


    authors: Oh ST,Park H,Yoon HJ,Yang SY

    更新日期:2017-01-01 00:00:00

  • Corrigendum to "Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal-Induced Injuries in Rat Pheochromocytoma Cells".

    abstract::[This corrects the article DOI: 10.1155/2017/4824371.]. ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 已发布勘误


    authors: Song TY,Yang NC,Chen CL,Thi TLV

    更新日期:2019-08-06 00:00:00

  • Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation.

    abstract::The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environmen...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Pambianchi E,Ferrara F,Pecorelli A,Woodby B,Grace M,Therrien JP,Lila MA,Valacchi G

    更新日期:2020-08-13 00:00:00

  • Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

    abstract::Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both pa...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Ho YS,Zhao FY,Yeung WF,Wong GT,Zhang HQ,Chang RC

    更新日期:2020-02-13 00:00:00

  • Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats.

    abstract::Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immun...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Luck C,DeMarco VG,Mahmood A,Gavini MP,Pulakat L

    更新日期:2017-01-01 00:00:00

  • Soy Isoflavones Ameliorate Metabolic and Immunological Alterations of Ovariectomy in Female Wistar Rats: Antioxidant and Estrogen Sparing Potential.

    abstract::Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolis...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Abdelrazek HMA,Mahmoud MMA,Tag HM,Greish SM,Eltamany DA,Soliman MTA

    更新日期:2019-01-10 00:00:00

  • Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE.

    abstract::Oxidative stress (OS) and neuronal apoptosis are major pathological processes after hypoxic-ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to CSF1 receptor (CSF1R), has been shown to reduce neuronal loss after hypoxic-ischemia- (HI-) induced brain injury. In the present study, we hypothesiz...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Hu X,Li S,Doycheva DM,Huang L,Lenahan C,Liu R,Huang J,Gao L,Tang J,Zuo G,Zhang JH

    更新日期:2020-10-07 00:00:00

  • Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.

    abstract::Methanol extracts of Momordica charantia L. fruits are extensively studied for their antiaging activities. A new cucurbitane-type triterpenoid (1) and nine other known compounds (2-10) were isolated, and their structures were determined according to their spectroscopic characteristics and chemical derivatization. Biol...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Cao X,Sun Y,Lin Y,Pan Y,Farooq U,Xiang L,Qi J

    更新日期:2018-03-25 00:00:00

  • Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes.

    abstract::The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear f...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Fuyuno Y,Uchi H,Yasumatsu M,Morino-Koga S,Tanaka Y,Mitoma C,Furue M

    更新日期:2018-02-14 00:00:00

  • The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling.

    abstract::Lung cancer is a leading cause of cancer death worldwide, and non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancer, which is highly metastatic, leading to the poor survival rate of patients. We recently reported that 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), a phenoxyphenol, exerts antihepatoma eff...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Liu W,Wu CY,Lu MJ,Chuang YJ,Tsai EM,Leu S,Lin IL,Ko CJ,Chiu CC,Chang WT

    更新日期:2020-01-07 00:00:00

  • Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.

    abstract::GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,随机对照试验


    authors: Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

    更新日期:2017-01-01 00:00:00

  • Functional Interactions between BKCaα-Subunit and Annexin A5: Implications in Apoptosis.

    abstract::Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca2+-activated potassium channel (BKCaα), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the ou...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Brazier SP,Telezhkin V,Kemp PJ

    更新日期:2016-01-01 00:00:00

  • Formation and Detection of Highly Oxidized Hemoglobin Forms in Biological Fluids during Hemolytic Conditions.

    abstract::Hemolytic diseases are characterized by an accelerated breakdown of red blood cells (RBCs) and the release of hemoglobin (Hb). Following, RBC lysis Hb oxidation occurs with the formation of different redox states of Hb (metHb and ferrylHb) and the release of heme. ferrylHb is unstable and decomposes to metHb with the ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Nyakundi BB,Erdei J,Tóth A,Balogh E,Nagy A,Nagy B Jr,Novák L,Bognár L,Paragh G,Kappelmayer J,Jeney V

    更新日期:2020-04-25 00:00:00

  • Oxidative Stress Regulation on Endothelial Cells by Hydrophilic Astaxanthin Complex: Chemical, Biological, and Molecular Antioxidant Activity Evaluation.

    abstract::An imbalance in the reactive oxygen species (ROS) homeostasis is involved in the pathogenesis of oxidative stress-related diseases. Astaxanthin, a xanthophyll carotenoid with high antioxidant capacities, has been shown to prevent the first stages of oxidative stress. Here, we evaluate the antioxidant capacities of ast...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zuluaga M,Barzegari A,Letourneur D,Gueguen V,Pavon-Djavid G

    更新日期:2017-01-01 00:00:00

  • Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells.

    abstract::Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are key transmembrane proteins leading to reactive oxygen species (ROS) overproduction. However, the detailed roles of NOXs in retinal pigment epithelial (RPE) cell metabolic stress induced by Earle's balanced salt solution (EBSS) through starvation r...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhang Y,Ren S,Gu Y,Wang J,Liu Z,Zhang Z

    更新日期:2018-07-29 00:00:00

  • 3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome.

    abstract:Background:Obesity is a growing epidemic with limited effective treatments and an important risk factor for several diseases such as metabolic syndrome (MetS). In this study, we aimed to investigate the effect of 3-amino-1,2,4-triazole (ATZ), an inhibitor of catalase and heme synthesis, in a murine model for MetS. Met...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Nunes-Souza V,Dias-Júnior NM,Eleutério-Silva MA,Ferreira-Neves VP,Moura FA,Alenina N,Bader M,Rabelo LA

    更新日期:2020-04-13 00:00:00

  • Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury.

    abstract::Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury. The liver has high capacity for producing glutathione and is a key organ in modulating local and ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Shang Y,Siow YL,Isaak CK,O K

    更新日期:2016-01-01 00:00:00

  • Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats.

    abstract::Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneratio...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Khan MS,Muhammad T,Ikram M,Kim MO

    更新日期:2019-11-07 00:00:00

  • Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs.

    abstract:AIM:Ginkgolide B is a Ginkgo biloba leaf extract that has been identified as a natural platelet-activating factor receptor (PAFR) antagonist. We investigated the effect of ginkgolide B on high glucose-induced TLR4 activation in human umbilical vein endothelial cells (HUVECs). METHODS:Protein expression was analyzed by...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Chen K,Sun W,Jiang Y,Chen B,Zhao Y,Sun J,Gong H,Qi R

    更新日期:2017-01-01 00:00:00

  • Increased Oxidative Stress as a Selective Anticancer Therapy.

    abstract::Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Liu J,Wang Z

    更新日期:2015-01-01 00:00:00

  • Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase-1.

    abstract::Metabolic diseases, such as insulin resistance, type II diabetes, and obesity, are associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of metabolic diseases, agents and...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Son Y,Lee JH,Chung HT,Pae HO

    更新日期:2013-01-01 00:00:00

  • Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke.

    abstract::Cigarette smoking has been identified as a major risk factor for osteoporosis decades ago. Several studies have shown a direct relationship between cigarette smoking, decreased bone mineral density, and impaired fracture healing. However, the mechanisms behind impaired fracture healing and cigarette smoking are yet to...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Aspera-Werz RH,Ehnert S,Heid D,Zhu S,Chen T,Braun B,Sreekumar V,Arnscheidt C,Nussler AK

    更新日期:2018-11-06 00:00:00

  • Oxidative Stress Produced by Hyperthyroidism Status Induces the Antioxidant Enzyme Transcription through the Activation of the Nrf-2 Factor in Lymphoid Tissues of Balb/c Mice.

    abstract::Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3 and T4. Thyroid hormones exert pleiotropic actions on numerous tissues and induce an overall increase in metabolism, with an increase in energy demand and oxygen consumption. Therefore, the purpose of this study was to...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Costilla M,Macri Delbono R,Klecha A,Cremaschi GA,Barreiro Arcos ML

    更新日期:2019-06-02 00:00:00

  • Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains.

    abstract::The total lifespan of the yeast Saccharomyces cerevisiae may be divided into two phases: the reproductive phase, during which the cell undergoes mitosis cycles to produce successive buds, and the postreproductive phase, which extends from the last division to cell death. These phases may be regulated by a common mecha...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zadrag-Tecza R,Kwolek-Mirek M,Alabrudzińska M,Skoneczna A

    更新日期:2018-03-20 00:00:00