Propofol Protects Rat Cardiomyocytes from Anthracycline-Induced Apoptosis by Regulating MicroRNA-181a In Vitro and In Vivo.

abstract：:In the present study, we demonstrated that bone marrow mesenchymal stem cells (BMSCs) of the 3rd passage displayed the senescence-associated phenotypes characterized with increased activity of SA-β-gal, altered autophagy, and increased G1 cell cycle arrest, ROS production, and expression of p53 and p21Cip1/Waf1 compar...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang M,Du Y,Lu R,Shu Y,Zhao W,Li Z,Zhang Y,Liu R,Yang T,Luo S,Gao M,Zhang Y,Zhang G,Liu J,Lu Y

更新日期：2016-01-01 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Metabolic syndrome is becoming commoner due to a rise in obesity rates among adults. Generally speaking, a person with metabolic syndrome is twice as likely to develop cardiovascular disease and five times as likely to develop diabetes as someone without metabolic syndrome. Increasing oxidative stress in metabolic syn...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang P,Tian B

更新日期：2014-01-01 00:00:00

abstract：:Metabolic disorders are severe and chronic impairments of the health of many people and represent a challenge for the society as a whole that has to deal with an ever-increasing number of affected individuals. Among common metabolic disorders are Alzheimer's disease, obesity, and type 2 diabetes. These disorders do no...

journal_title：Oxidative medicine and cellular longevity

authors： Rigotto G,Basso E

更新日期：2019-06-16 00:00:00

abstract：:Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Ma...

journal_title：Oxidative medicine and cellular longevity

authors： Fujimoto C,Yamasoba T

更新日期：2014-01-01 00:00:00

abstract：Objective:Oxidized cholesterol derivatives are compounds with proven atherogenic and mutagenic effects. However, little is known about the effect of oxidized plant sterol derivatives (oxyphytosterols), whose structure is similar to the one of oxycholesterols. Our previous studies indicate that they have a similar profi...

journal_title：Oxidative medicine and cellular longevity

authors： Wielkoszyński T,Zalejska-Fiolka J,Strzelczyk JK,Owczarek AJ,Cholewka A,Kokoszczyk K,Stanek A

更新日期：2020-06-08 00:00:00

abstract：:Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage. Unfortunately, no specific drugs have been found that effectively prevent and treat RIRI. Curcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities invol...

journal_title：Oxidative medicine and cellular longevity

authors： Wang ZH,Deng LH,Chi CW,Wang H,Huang YY,Zheng Q

更新日期：2020-11-12 00:00:00

abstract：:Endothelial dysfunction tends to be the initial indicator in proinflammatory state and macro- and microvascular complications, such as atherosclerosis and cardiovascular diseases. It has been shown that certain compounds in diet can generate beneficial effects on cardiovascular disease due to its interactions with end...

journal_title：Oxidative medicine and cellular longevity

authors： Stromsnes K,Mas-Bargues C,Gambini J,Gimeno-Mallench L

更新日期：2020-08-06 00:00:00

abstract：:Three cosmetically important skin lightening agents, hydroquinone (HQ), kojic acid (KA), and niacinamide (NA), consume the bulk of successful skin lightening ingredients in cosmetic applications. However, the mechanisms by which these ingredients work are still unclear. In this study, melanocytes and keratinocytes wer...

journal_title：Oxidative medicine and cellular longevity

authors： Gruber JV,Holtz R

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/5031926.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Hong YA,Yang KJ,Jung SY,Park KC,Choi H,Oh JM,Lee SJ,Chang YK,WheePark C,Yang CW,Kim SY,Hwang HS

更新日期：2017-01-01 00:00:00

abstract：:Redox status changes during an annual training cycle in young and adult track and field athletes and possible differences between the two age groups were assessed. Forty-six individuals (24 children and 22 adults) were assigned to four groups: trained adolescents, (TAD, N = 13), untrained adolescents (UAD, N = 11), tr...

journal_title：Oxidative medicine and cellular longevity

authors： Zalavras A,Fatouros IG,Deli CK,Draganidis D,Theodorou AA,Soulas D,Koutsioras Y,Koutedakis Y,Jamurtas AZ

更新日期：2015-01-01 00:00:00

abstract：:The neuroendocrine functions of the pineal affect a wide variety of glandular and nervous system processes. Beside melatonin (MEL), the pineal gland secretes and expresses certain proteins essential for various physiological functions. It has been suggested that the pineal gland may also have an antioxidant role due t...

journal_title：Oxidative medicine and cellular longevity

authors： Bharti VK,Srivastava RS

更新日期：2009-04-01 00:00:00

abstract：Objectives:Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery. Method...

journal_title：Oxidative medicine and cellular longevity

authors： Li CX,Wang HW,Jiang WJ,Li GC,Zhang YD,Luo CH,Li XC

更新日期：2020-02-27 00:00:00

abstract：:Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

journal_title：Oxidative medicine and cellular longevity

authors： Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

更新日期：2017-01-01 00:00:00

abstract：:Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Gaspar RS,Trostchansky A,Paes AM

更新日期：2016-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) production in hepatic ischemia-reperfusion injury (IRI) is a complex process where multiple cellular and molecular pathways are involved. Few of those molecular pathways are under the direct influence of SIRT3 and its downstream mediators. SIRT3 plays a major role in the mechanism of IRI,...

journal_title：Oxidative medicine and cellular longevity

authors： Katwal G,Baral D,Fan X,Weiyang H,Zhang X,Ling L,Xiong Y,Ye Q,Wang Y

更新日期：2018-11-13 00:00:00

abstract：:The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy f...

journal_title：Oxidative medicine and cellular longevity

authors： Barquilha CN,Santos NJ,Monção CCD,Barbosa IC,Lima FO,Justulin LA,Pértega-Gomes N,Felisbino SL

更新日期：2020-01-20 00:00:00

abstract：:The infiltration of red blood cells into atheromatous plaques is implicated in atherogenesis. Inside the lesion, hemoglobin (Hb) is oxidized to ferri- and ferrylHb which exhibit prooxidant and proinflammatory activities. Cystathione gamma-lyase- (CSE-) derived H2S has been suggested to possess various antiatherogenic ...

journal_title：Oxidative medicine and cellular longevity

authors： Potor L,Nagy P,Méhes G,Hendrik Z,Jeney V,Pethő D,Vasas A,Pálinkás Z,Balogh E,Gyetvai Á,Whiteman M,Torregrossa R,Wood ME,Olvasztó S,Nagy P,Balla G,Balla J

更新日期：2018-01-21 00:00:00

abstract：:We recently showed that activated Ras proteins are localized to the plasma membrane and in the nucleus in wild-type cells growing exponentially on glucose, while in the hxk2Δ strain they accumulated mainly in mitochondria. An aberrant accumulation of activated Ras in these organelles was previously reported and correl...

journal_title：Oxidative medicine and cellular longevity

authors： Amigoni L,Martegani E,Colombo S

更新日期：2013-01-01 00:00:00

abstract：:Hemolytic diseases are characterized by an accelerated breakdown of red blood cells (RBCs) and the release of hemoglobin (Hb). Following, RBC lysis Hb oxidation occurs with the formation of different redox states of Hb (metHb and ferrylHb) and the release of heme. ferrylHb is unstable and decomposes to metHb with the ...

journal_title：Oxidative medicine and cellular longevity

authors： Nyakundi BB,Erdei J,Tóth A,Balogh E,Nagy A,Nagy B Jr,Novák L,Bognár L,Paragh G,Kappelmayer J,Jeney V

更新日期：2020-04-25 00:00:00

abstract：:Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,He Z,Shen X,Xu X,Fan J,Wu S,Zhang D

更新日期：2012-01-01 00:00:00

abstract：:There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessa...

journal_title：Oxidative medicine and cellular longevity

authors： Rosales-Corral S,Tan DX,Manchester L,Reiter RJ

更新日期：2015-01-01 00:00:00

abstract：:Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin ...

journal_title：Oxidative medicine and cellular longevity

authors： Ben Yehuda Greenwald M,Frušić-Zlotkin M,Soroka Y,Ben Sasson S,Bitton R,Bianco-Peled H,Kohen R

更新日期：2017-01-01 00:00:00

abstract：:The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity and prevention of systemic autoimmunity, the thymus is the first organ of the body that...

journal_title：Oxidative medicine and cellular longevity

authors： Barbouti A,Vasileiou PVS,Evangelou K,Vlasis KG,Papoudou-Bai A,Gorgoulis VG,Kanavaros P

更新日期：2020-02-05 00:00:00

abstract：:The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes. The generation and release of ROS in the fo...

journal_title：Oxidative medicine and cellular longevity

authors： Giardino G,Cicalese MP,Delmonte O,Migliavacca M,Palterer B,Loffredo L,Cirillo E,Gallo V,Violi F,Pignata C

更新日期：2017-01-01 00:00:00

abstract：:Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-ED...

journal_title：Oxidative medicine and cellular longevity

authors： Chiazza F,Chegaev K,Rogazzo M,Cutrin JC,Benetti E,Lazzarato L,Fruttero R,Collino M

更新日期：2015-01-01 00:00:00

abstract：:The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environmen...

journal_title：Oxidative medicine and cellular longevity

authors： Pambianchi E,Ferrara F,Pecorelli A,Woodby B,Grace M,Therrien JP,Lila MA,Valacchi G

更新日期：2020-08-13 00:00:00

abstract：:In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria ar...

journal_title：Oxidative medicine and cellular longevity

authors： Li N,Stojanovski S,Maechler P

更新日期：2012-01-01 00:00:00

abstract：:In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomal β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of V...

journal_title：Oxidative medicine and cellular longevity

authors： Zarrouk A,Vejux A,Nury T,El Hajj HI,Haddad M,Cherkaoui-Malki M,Riedinger JM,Hammami M,Lizard G

更新日期：2012-01-01 00:00:00

abstract：Aims:The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in db/db mice and to identify the protective mechanisms of this therapy. Methods:db/db mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously...

journal_title：Oxidative medicine and cellular longevity

authors： Papinska AM,Rodgers KE

更新日期：2018-10-23 00:00:00