Abstract：
:Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells. ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants. In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
Fujimoto C,Yamasoba Tdoi
10.1155/2014/582849subject
Has Abstractpub_date
2014-01-01 00:00:00pages
582849eissn
1942-0900issn
1942-0994journal_volume
2014pub_type
杂志文章,评审abstract：:Xeroderma pigmentosum group A (XPA) is a genetic disorder in DNA nucleotide excision repair (NER) with severe neurological disorders, in which oxidative stress and disturbed melatonin metabolism may be involved. Herein we confirmed the diurnal variation of melatonin metabolites, oxidative stress markers, and antioxida...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2016/5741517
更新日期：2016-01-01 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2017/5031926.]. ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 已发布勘误
doi：10.1155/2017/1913954
更新日期：2017-01-01 00:00:00
abstract：:Doxorubicin (DOX) is a broad-spectrum antitumor drug while its use is limited due to its neurobiological side effects associated with depression. We investigated the neuroprotective efficacy of dl-3-n-butylphthalide (dl-NBP) against DOX-induced anxiety- and depression-like behaviors in rats. dl-NBP was given (30 mg/kg...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2018/9125601
更新日期：2018-08-16 00:00:00
abstract：:Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both pa...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
doi：10.1155/2020/9641904
更新日期：2020-02-13 00:00:00
abstract：:Cholestatic liver injury, due to obstruction of the biliary tract or genetic defects, is often accompanied by progressive inflammation and liver fibrosis. Methane-rich saline (MRS) has anti-inflammatory properties. However, whether MRS can provide protective effect in cholestatic liver injury is still unclear. In this...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/6565283
更新日期：2019-11-18 00:00:00
abstract：:Although the role of endothelium in varicose vein development is indisputable, the effect of the pathology on biological properties of endothelial cells remains unclear. Here we examined if the presence of varicose veins affects senescence of endothelial cells (HUVECs) and, if so, what will be the local and systemic o...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2016/2069290
更新日期：2016-01-01 00:00:00
abstract：:Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H2O2 production and its association with p(66Shc), FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were s...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2015/536456
更新日期：2015-01-01 00:00:00
abstract：:Many groups of Gram-negative bacteria cause diseases that are harmful to sheep. Toll-like receptor 4 (TLR4), which is critical for detecting Gram-negative bacteria by the innate immune system, is activated by lipopolysaccharide (LPS) to initiate inflammatory responses and oxidative stress. Oxidation intermediates are ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2015/359315
更新日期：2015-01-01 00:00:00
abstract：:Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP). The redox properties of both Hem12p and Tkl1p from Saccharomyces cerevisiae were investigated using proteom...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2013/932472
更新日期：2013-01-01 00:00:00
abstract：:Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
doi：10.1155/2018/1454936
更新日期：2018-08-02 00:00:00
abstract：:Stem cells derived from elderly donors or harvested by repeated subculture exhibit a marked decrease in proliferative capacity and multipotency, which not only compromises their therapeutic potential but also raises safety concerns for regenerative medicine. NANOG-a well-known core transcription factor-plays an import...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/4286213
更新日期：2019-12-04 00:00:00
abstract：OBJECTIVE:To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury. METHODS:36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (n = 12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2015/106836
更新日期：2015-01-01 00:00:00
abstract：:Few studies have associated the effects of changes in caloric intake and redox disturbances in the gastrointestinal tract. Therefore, the present study aimed at evaluating the hypercaloric diet consumption influence on the contractile reactivity of intestinal smooth muscle, morphology, and oxidative stress of rat ileu...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2018/6364821
更新日期：2018-10-25 00:00:00
abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/4010764
更新日期：2019-10-14 00:00:00
abstract：:Vagus nerve stimulation (VNS) has been shown to attenuate ischemia-reperfusion (I/R) injury in multiple organs. The present study aimed at investigating whether VNS could exert protective effects against I/R injury in the skeletal muscle. Male Sprague-Dawley rats were randomly divided into 3 groups: the control, I/R, ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/9208949
更新日期：2019-02-28 00:00:00
abstract：:The ability to produce cold plasma at atmospheric pressure conditions was the basis for the rapid growth of plasma-related application areas in biomedicine. Plasma comprises a multitude of active components such as charged particles, electric current, UV radiation, and reactive gas species which can act synergisticall...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
doi：10.1155/2019/3873928
更新日期：2019-09-03 00:00:00
abstract：:The infiltration of red blood cells into atheromatous plaques is implicated in atherogenesis. Inside the lesion, hemoglobin (Hb) is oxidized to ferri- and ferrylHb which exhibit prooxidant and proinflammatory activities. Cystathione gamma-lyase- (CSE-) derived H2S has been suggested to possess various antiatherogenic ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2018/3812568
更新日期：2018-01-21 00:00:00
abstract：:Oleuropein (OP) is a bioactive compound derived from plants of the genus Oleaceae exhibiting antitumor properties in several human cancers, including non-small-cell lung cancer (NSCLC). Recent evidence suggests that OP has proapoptotic effects on NSCLC cells via the mitochondrial apoptotic pathway. However, the exact ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/8576961
更新日期：2019-07-22 00:00:00
abstract：:As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-)...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2017/7340143
更新日期：2017-01-01 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2020/9250512.]. ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 已发布勘误
doi：10.1155/2020/7059751
更新日期：2020-08-24 00:00:00
abstract：:The liver is a central organ that performs a wide range of functions such as detoxification and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly susceptible to oxidative stress. It is well documented that liver diseases including hepatitis, fibrosis, cirrhosis, and hepatocellular ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
doi：10.1155/2013/763257
更新日期：2013-01-01 00:00:00
abstract：:The aim of the study was to examine the effects of a polyphenolic powder from olive mill wastewater (OMWW) administered through drinking water, on chickens' redox status. Thus, 75 chickens were divided into three groups. Group A was given just drinking water, while groups B and C were given drinking water containing 2...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2017/8273160
更新日期：2017-01-01 00:00:00
abstract：:Reactive oxygen species (ROS) are generated by sperm metabolism. While, ROS are required for maturation, capacitation and acrosome reaction, they also modify many peroxidable cellular compounds. There is production of ROS during cryopreservation and frozen spermatozoa are highly sensitive to lipid peroxidation (LPO). ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.4161/oxim.2.3.8804
更新日期：2009-07-01 00:00:00
abstract：:Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the su...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2020/5963037
更新日期：2020-04-25 00:00:00
abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2018/6926712
更新日期：2018-04-05 00:00:00
abstract：:The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environmen...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2020/9571490
更新日期：2020-08-13 00:00:00
abstract：:Fungal immunomodulatory proteins (FIPs) are a class of small proteins that have been extensively studied for their immunomodulatory activities. In this study, two novel FIPs from Lentinus tigrinus were identified and named Fip-lti1 and Fip-lti2. The bioactive characteristics of Fip-lti1 and Fip-lti2 were compared to a...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/3139689
更新日期：2019-05-06 00:00:00
abstract：:Although a growing body of evidence suggests that plant polyphenols can modulate human immune responses, their simultaneous action on monocyte and neutrophil oxidative burst is currently poorly understood. Based on the hypothesis that various polyphenols contained in plant extracts might affect the oxidative burst of ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2014/764367
更新日期：2014-01-01 00:00:00
abstract：:This study was conducted to assess the protective effect of extract of match (EM) on high-fat diet- (HFD-) induced cognitive deficits in male C57BL/6 mice. It was found that EM improved glucose tolerance status by measuring OGTT and IPGTT with HFD-induced mice. EM protected behavioral and memory dysfunction in Y-maze,...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2020/8882763
更新日期：2020-11-28 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2017/6487825.]. ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,已发布勘误
doi：10.1155/2017/4576985
更新日期：2017-01-01 00:00:00
