Abstract:
:Cholestatic liver injury, due to obstruction of the biliary tract or genetic defects, is often accompanied by progressive inflammation and liver fibrosis. Methane-rich saline (MRS) has anti-inflammatory properties. However, whether MRS can provide protective effect in cholestatic liver injury is still unclear. In this study, Sprague-Dawley rats received bile duct ligation (BDL) to generate a cholestatic model followed by MRS treatment (10 mL/kg, ip treatment) every 12 h after the operation to explore the potential protective mechanism of MRS in cholestatic liver injury. We found that MRS effectively improved liver function, alleviated liver pathological damage, and localized infiltration of inflammatory cells. MRS treatment decreased the expression of hepatic fibrosis-associated proteins to alleviate liver fibrosis. Furthermore, MRS treatment suppressed the TLR4/NF-κB pathway and further reduced the levels of proinflammatory factors. Downregulation of NF-κB subsequently reduced the NLRP3 expression to inhibit pyroptosis. Our data indicated that methane treatment prevented cholestatic liver injury via anti-inflammatory properties that involved the TLR4/NF-κB/NLRP3 signaling pathway.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
Li Z,Chen D,Jia Y,Feng Y,Wang C,Tong Y,Cui R,Qu K,Liu C,Zhang Jdoi
10.1155/2019/6565283subject
Has Abstractpub_date
2019-11-18 00:00:00pages
6565283eissn
1942-0900issn
1942-0994journal_volume
2019pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1155/2015/124357
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abstract::[This corrects the article DOI: 10.1155/2017/6838921.]. ...
journal_title:Oxidative medicine and cellular longevity
pub_type: 杂志文章,已发布勘误
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