Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer's Disease, Diabetes, and Obesity.

abstract：:Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone gro...

journal_title：Oxidative medicine and cellular longevity

authors： You Z,Sun J,Xie F,Chen Z,Zhang S,Chen H,Liu F,Li L,Chen G,Song Y,Xuan Y,Zheng G,Xin Y

更新日期：2017-01-01 00:00:00

abstract：:Some iron chelators display significant anticancer activity that may involve ferritin degradation either in proteasomes or in lysosomes, and the latter might involve ferritinophagy with a period. However, the correlation of ferritinophagy with anticancer activity of iron chelator was not fully determined. Revealing th...

journal_title：Oxidative medicine and cellular longevity

authors： Huang T,Sun Y,Li Y,Wang T,Fu Y,Li C,Li C

更新日期：2018-08-05 00:00:00

abstract：:The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies are presented. Special attention is paid to issues of use of carnosine in neurologic and mental diseases, in alcoholism as...

journal_title：Oxidative medicine and cellular longevity

authors： Prokopieva VD,Yarygina EG,Bokhan NA,Ivanova SA

更新日期：2016-01-01 00:00:00

abstract：Introduction:The omega-3 polyunsaturated fatty acids, as docosahexaenoic acid (DHA), are considered mediators regulating the resolution of inflammation during cancer and may be associated with better outcomes. Epoxydocosapentaenoic acids (EDPs), metabolites of the DHA, are hypothesized to be responsible for some benefi...

journal_title：Oxidative medicine and cellular longevity

authors： Molfino A,Amabile MI,Lionetto L,Spagnoli A,Ramaccini C,De Luca A,Simmaco M,Monti M,Muscaritoli M

更新日期：2019-03-05 00:00:00

abstract：:Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer's disease (AD) in the clinic; however, the mechanisms underlying its effects remain largely unknown. In this study, we used a rat AD model to study the effects of BSTSF on cognitive performance,...

journal_title：Oxidative medicine and cellular longevity

authors： Yi M,Zhang C,Zhang Z,Yi P,Xu P,Huang J,Peng W

更新日期：2020-06-19 00:00:00

abstract：:Although Tamoxifen (TAM) is one of the most widely used drugs in managing breast cancer, many women still relapse after long-term therapy. Caffeic acid phenethyl ester (CAPE) is a polyphenolic compound present in many medicinal plants and in propolis. The present study examined the effect of CAPE on TAM cytotoxicity i...

journal_title：Oxidative medicine and cellular longevity

authors： Motawi TK,Abdelazim SA,Darwish HA,Elbaz EM,Shouman SA

更新日期：2016-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：Aims:The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in db/db mice and to identify the protective mechanisms of this therapy. Methods:db/db mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously...

journal_title：Oxidative medicine and cellular longevity

authors： Papinska AM,Rodgers KE

更新日期：2018-10-23 00:00:00

abstract：:Eugenia dysenterica ex DC Mart. (Myrtaceae), popularly known as "cagaita," is a Brazilian plant rich in polyphenols and other antioxidant compounds. Aiming to evaluate the potential use of cagaita in pathologies involving oxidative stress, such as neurodegenerative disorders, this study investigated its antioxidant po...

journal_title：Oxidative medicine and cellular longevity

authors： Thomaz DV,Peixoto LF,de Oliveira TS,Fajemiroye JO,da Silva Neri HF,Xavier CH,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

更新日期：2018-09-19 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might ...

journal_title：Oxidative medicine and cellular longevity

authors： Petruk G,Del Giudice R,Rigano MM,Monti DM

更新日期：2018-08-02 00:00:00

abstract：:Stem cells derived from elderly donors or harvested by repeated subculture exhibit a marked decrease in proliferative capacity and multipotency, which not only compromises their therapeutic potential but also raises safety concerns for regenerative medicine. NANOG-a well-known core transcription factor-plays an import...

journal_title：Oxidative medicine and cellular longevity

authors： Liu F,Shi J,Zhang Y,Lian A,Han X,Zuo K,Liu M,Zheng T,Zou F,Liu X,Jin M,Mu Y,Li G,Su G,Liu J

更新日期：2019-12-04 00:00:00

abstract：:Systemic inflammation often induces neuroinflammation and disrupts neural functions, ultimately causing cognitive impairment. Furthermore, neuronal inflammation is the key cause of many neurological conditions. It is particularly important to develop effective neuroprotectants to prevent and control inflammatory brain...

journal_title：Oxidative medicine and cellular longevity

authors： Li Y,Liu T,Li Y,Han D,Hong J,Yang N,He J,Peng R,Mi X,Kuang C,Zhou Y,Han Y,Shi C,Li Z,Guo X

更新日期：2020-09-22 00:00:00

abstract：:Reactive oxygen species (ROS) are generated by sperm metabolism. While, ROS are required for maturation, capacitation and acrosome reaction, they also modify many peroxidable cellular compounds. There is production of ROS during cryopreservation and frozen spermatozoa are highly sensitive to lipid peroxidation (LPO). ...

journal_title：Oxidative medicine and cellular longevity

authors： Cheema RS,Bansal AK,Bilaspuri GS

更新日期：2009-07-01 00:00:00

abstract：Objective:Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated in...

journal_title：Oxidative medicine and cellular longevity

authors： Gericke A,Mann C,Zadeh JK,Musayeva A,Wolff I,Wang M,Pfeiffer N,Daiber A,Li H,Xia N,Prokosch V

更新日期：2019-12-29 00:00:00

abstract：:One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative st...

journal_title：Oxidative medicine and cellular longevity

authors： Kibel A,Lukinac AM,Dambic V,Juric I,Relatic KS

更新日期：2020-12-28 00:00:00

abstract：:Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify ...

journal_title：Oxidative medicine and cellular longevity

authors： Malaguti M,Angeloni C,Hrelia S

更新日期：2013-01-01 00:00:00

abstract：:Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases. In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and...

journal_title：Oxidative medicine and cellular longevity

authors： Mo H,Chen Y,Huang L,Zhang H,Li J,Zhou W

更新日期：2013-01-01 00:00:00

abstract：:The widely used herbicide atrazine (ATR) can cause many adverse effects including immunotoxicity, but the underlying mechanisms are not fully understood. The current study investigated the role of oxidative stress and calcium homeostasis in ATR-induced immunotoxicity in mice. ATR at doses of 0, 100, 200, or 400 mg/kg ...

journal_title：Oxidative medicine and cellular longevity

authors： Gao S,Wang Z,Zhang C,Jia L,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its ...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Z,Zhang S,Xiao Y,Zhang W,Wu S,Qin T,Yue Y,Qian W,Li L

更新日期：2020-02-17 00:00:00

abstract：Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

更新日期：2019-04-16 00:00:00

abstract：OBJECTIVES:The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS:The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Lau RC,Bennett RD

更新日期：2017-01-01 00:00:00

abstract：:Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to ox...

journal_title：Oxidative medicine and cellular longevity

authors： Tramutola A,Di Domenico F,Barone E,Perluigi M,Butterfield DA

更新日期：2016-01-01 00:00:00

abstract：:This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation with MRI findings. A multicenter prospective observational study was performed between March 201...

journal_title：Oxidative medicine and cellular longevity

authors： Negro S,Benders MJNL,Tataranno ML,Coviello C,de Vries LS,van Bel F,Groenendaal F,Longini M,Proietti F,Belvisi E,Buonocore G,Perrone S

更新日期：2018-06-28 00:00:00

abstract：:Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant s...

journal_title：Oxidative medicine and cellular longevity

authors： Gunawardena HP,Silva R,Sivakanesan R,Ranasinghe P,Katulanda P

更新日期：2019-08-05 00:00:00

abstract：:Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable model of human hyp...

journal_title：Oxidative medicine and cellular longevity

authors： Rubattu S,Stanzione R,Volpe M

更新日期：2016-01-01 00:00:00

abstract：:The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression. Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death an...

journal_title：Oxidative medicine and cellular longevity

authors： Leone A,Roca MS,Ciardiello C,Costantini S,Budillon A

更新日期：2017-01-01 00:00:00

abstract：:During pregnancy, the adaptive changes in uterine circulation and the formation of the placenta are essential for the growth of the fetus and the well-being of the mother. The steroid hormone estrogen plays a pivotal role in this adaptive process. An insufficient blood supply to the placenta due to uteroplacental dysf...

journal_title：Oxidative medicine and cellular longevity

authors： Hu XQ,Song R,Zhang L

更新日期：2019-02-10 00:00:00

abstract：:Ex vivo lung perfusion (EVLP) allows perfusion and reconditioning of retrieved lungs for organ transplantation. The Steen solution is specifically designed for this procedure but the mechanism through which it elicits its activity is still to be fully clarified. We speculated that Steen solution may encompass antioxid...

journal_title：Oxidative medicine and cellular longevity

authors： Carnevale R,Biondi-Zoccai G,Peruzzi M,De Falco E,Chimenti I,Venuta F,Anile M,Diso D,Cavarretta E,Marullo AG,Sartini P,Pignatelli P,Violi F,Frati G

更新日期：2014-01-01 00:00:00

abstract：:Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immun...

journal_title：Oxidative medicine and cellular longevity

authors： Luck C,DeMarco VG,Mahmood A,Gavini MP,Pulakat L

更新日期：2017-01-01 00:00:00