NADPH Oxidase Deficiency: A Multisystem Approach.

abstract：:Methanol extracts of Momordica charantia L. fruits are extensively studied for their antiaging activities. A new cucurbitane-type triterpenoid (1) and nine other known compounds (2-10) were isolated, and their structures were determined according to their spectroscopic characteristics and chemical derivatization. Biol...

journal_title：Oxidative medicine and cellular longevity

authors： Cao X,Sun Y,Lin Y,Pan Y,Farooq U,Xiang L,Qi J

更新日期：2018-03-25 00:00:00

abstract：:Recent reports indicate that oxidative stress is involved in the pathobiology of acute spinal cord injury or compression myelopathy. We conducted an observational study to determine levels of oxidative stress markers in serum from 80 patients who underwent spinal surgery to treat neurological symptoms related to lumba...

journal_title：Oxidative medicine and cellular longevity

authors： Takahashi H,Aoki Y,Saito J,Nakajima A,Sonobe M,Akatsu Y,Taniguchi S,Yamada M,Koyama K,Akiyama Y,Shiga Y,Inage K,Orita S,Eguchi Y,Maki S,Furuya T,Akazawa T,Koda M,Yamazaki M,Ohtori S,Nakagawa K

更新日期：2020-12-24 00:00:00

abstract：:Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM2.5-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM2.5-induced toxic effects, the current study explored the effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Y,Jin L,Chi Y,Yang J,Zhen Q,Wu H

更新日期：2019-12-07 00:00:00

abstract：:Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and is caused by mutations in the gene that encodes the cytoskeletal protein dystrophin. The treatment f...

journal_title：Oxidative medicine and cellular longevity

authors： Kuno A,Horio Y

更新日期：2016-01-01 00:00:00

abstract：:This study was conducted to assess the protective effect of extract of match (EM) on high-fat diet- (HFD-) induced cognitive deficits in male C57BL/6 mice. It was found that EM improved glucose tolerance status by measuring OGTT and IPGTT with HFD-induced mice. EM protected behavioral and memory dysfunction in Y-maze,...

journal_title：Oxidative medicine and cellular longevity

authors： Kim JM,Lee U,Kang JY,Park SK,Kim JC,Heo HJ

更新日期：2020-11-28 00:00:00

abstract：:Mitochondrial dysfunctions caused by oxidative stress are currently regarded as the main cause of aging. Accumulation of mutations and deletions of mtDNA is a hallmark of aging. So far, however, there is no evidence that most studied oxygen radicals are directly responsible for mutations of mtDNA. Oxidative damages to...

journal_title：Oxidative medicine and cellular longevity

authors： Panov AV,Dikalov SI

更新日期：2020-09-08 00:00:00

abstract：:Oxidative stress induced by long-term glucocorticoid (GC) use weakens the repair capacity of bone tissue. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase (NOX) is a superoxide-generating enzyme that plays an important role in regulating bone metabolism. To clarify the role of nonphagocytic NO...

journal_title：Oxidative medicine and cellular longevity

authors： Bai SC,Xu Q,Li H,Qin YF,Song LC,Wang CG,Cui WH,Zheng Z,Yan DW,Li ZJ,Li D,Wan X,Zhang HF

更新日期：2019-03-27 00:00:00

abstract：:Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF-κB and TNF-α have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-κB and TNF-α remain unknown. Exosomes have been ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu B,Zhang L,Liang C,Liu B,Pan X,Wang Y,Zhang Y,Zhang Y,Xie W,Yan B,Liu F,Yip HK,Yu XY,Li Y

更新日期：2019-04-08 00:00:00

abstract：:In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomal β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of V...

journal_title：Oxidative medicine and cellular longevity

authors： Zarrouk A,Vejux A,Nury T,El Hajj HI,Haddad M,Cherkaoui-Malki M,Riedinger JM,Hammami M,Lizard G

更新日期：2012-01-01 00:00:00

abstract：:Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of...

journal_title：Oxidative medicine and cellular longevity

authors： Liu J,Jia W,Hua RX,Zhu J,Zhang J,Yang T,Li P,Xia H,He J,Cheng J

更新日期：2019-06-25 00:00:00

abstract：:Equisetum ramosissimum, a genus of Equisetaceae, is a medicinal plant that can be separated into ethyl acetate (EA), dichloromethane (DM), n-hexane (Hex), methanol (MeOH), and water extracts. EA extract was known to have potent antioxidative properties, reducing power, DPPH scavenging activity, and metal ion chelating...

journal_title：Oxidative medicine and cellular longevity

authors： Li PH,Chiu YP,Shih CC,Wen ZH,Ibeto LK,Huang SH,Chiu CC,Ma DL,Leung CH,Chang YN,Wang HM

更新日期：2016-01-01 00:00:00

abstract：:In some inflammatory diseases of bone, osteogenesis and osteoclasis are uncoupled and the balance is usually tipped resulting in bone destruction. The underlying mechanism of osteogenic dysfunction in inflammation still needs further study. This study is aimed at investigating the effects of cyclosporine A (CsA) on bo...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Y,Gao J,Zhang Y,Gan X,Yu H

更新日期：2021-01-07 00:00:00

abstract：:Background. Increased oxidative stress is a well described feature of patients in hemodialysis. Their need for multiple blood transfusions and supplemental iron causes a significant iron overload that has recently been associated with increased oxidation of polyunsaturated lipids and accelerated aging due to DNA damag...

journal_title：Oxidative medicine and cellular longevity

authors： Murillo-Ortiz B,Ramírez Emiliano J,Hernández Vázquez WI,Martínez-Garza S,Solorio-Meza S,Albarrán-Tamayo F,Ramos-Rodríguez E,Benítez-Bribiesca L

更新日期：2016-01-01 00:00:00

abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%. However, the disease mechanism remains unclear, and no effective treatment is available. Paricalcitol has been reported to be effective in animal models of kidney injury. We hypoth...

journal_title：Oxidative medicine and cellular longevity

authors： Bae E,Kim JH,Jung MH,Jang SJ,Lee TW,Jung S,Lee S,Jang HN,Chang SH,Park DJ

更新日期：2020-11-23 00:00:00

abstract：:The present study discusses about the effects of a combination of probiotics able to stimulate the immune system of patients affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To this purpose, patients diagnosed according to Fukuda's criteria and treated with probiotics were analyzed by means of ...

journal_title：Oxidative medicine and cellular longevity

authors： Venturini L,Bacchi S,Capelli E,Lorusso L,Ricevuti G,Cusa C

更新日期：2019-11-23 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of endothelial dysfunction, which is found to precede the development of diverse cardiovascular diseases (CVDs). The aim of this study was to observe the protective effects of PD against H2O2-induced oxidative stress injury (OSI) in human umbilical vein endo...

journal_title：Oxidative medicine and cellular longevity

authors： Qiao H,Chen H,Dong Y,Ma H,Zhao G,Tang F,Li Z

更新日期：2016-01-01 00:00:00

abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Hong M,Tan HY,Wang N,Feng Y

更新日期：2016-01-01 00:00:00

abstract：:Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies curcumin as a neuroprotectant against hemin-induced damage in primary cultures of cerebellar granule neurons (CGNs) of rats. Hemin, the oxidized form of heme, is a highly reactive compound that induces cellular injury. Pretreatmen...

journal_title：Oxidative medicine and cellular longevity

authors： González-Reyes S,Guzmán-Beltrán S,Medina-Campos ON,Pedraza-Chaverri J

更新日期：2013-01-01 00:00:00

abstract：:Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been...

journal_title：Oxidative medicine and cellular longevity

authors： Tatzber F,Pursch E,Resch U,Pfragner R,Holasek S,Lindschinger M,Cvirn G,Wonisch W

更新日期：2017-01-01 00:00:00

abstract：:Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae. The animals received either 10 μL of saline or a S. pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis...

journal_title：Oxidative medicine and cellular longevity

authors： Barichello T,Santos AL,Silvestre C,Generoso JS,Cipriano AL,Petronilho F,Dal-Pizzol F,Comim CM,Quevedo J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:It has been known that cardiac surgery induces an oxidative stress. The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support. Total antioxidant capacity...

journal_title：Oxidative medicine and cellular longevity

authors： Kunt AS,Andac MH

更新日期：2012-01-01 00:00:00

abstract：:One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative st...

journal_title：Oxidative medicine and cellular longevity

authors： Kibel A,Lukinac AM,Dambic V,Juric I,Relatic KS

更新日期：2020-12-28 00:00:00

abstract：:Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast cancer cells media...

journal_title：Oxidative medicine and cellular longevity

authors： Villalpando-Rodriguez GE,Blankstein AR,Konzelman C,Gibson SB

更新日期：2019-09-17 00:00:00

abstract：:Ischemia-reperfusion (IR) injury is directly related to the formation of reactive oxygen species (ROS), endothelial cell injury, increased vascular permeability, and the activation of neutrophils and platelets, cytokines, and the complement system. Several studies have confirmed the destructiveness of the toxic oxygen...

journal_title：Oxidative medicine and cellular longevity

authors： Ferrari RS,Andrade CF

更新日期：2015-01-01 00:00:00

abstract：:Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric ox...

journal_title：Oxidative medicine and cellular longevity

authors： Jung J,Na C,Huh Y

更新日期：2012-01-01 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the su...

journal_title：Oxidative medicine and cellular longevity

authors： Kang M,Cho JH,Kim TJ,Lee SM,Kim HJ,Coronado I,Yi DK,Kim DY

更新日期：2020-04-25 00:00:00

abstract：:Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was ind...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Rasheed NM,Al-Rasheed NM,Hasan IH,Al-Amin MA,Al-Ajmi HN,Mohamad RA,Mahmoud AM

更新日期：2017-01-01 00:00:00

abstract：:Many groups of Gram-negative bacteria cause diseases that are harmful to sheep. Toll-like receptor 4 (TLR4), which is critical for detecting Gram-negative bacteria by the innate immune system, is activated by lipopolysaccharide (LPS) to initiate inflammatory responses and oxidative stress. Oxidation intermediates are ...

journal_title：Oxidative medicine and cellular longevity

authors： Deng S,Yu K,Zhang B,Yao Y,Wang Z,Zhang J,Zhang X,Liu G,Li N,Liu Y,Lian Z

更新日期：2015-01-01 00:00:00

abstract：:Exposure to ionizing radiation alone (RI) or combined with traumatic tissue injury (CI) is a crucial life-threatening factor in nuclear and radiological events. In our laboratory, mice exposed to (60)Co-γ-photon radiation (9.5 Gy, 0.4 Gy/min, bilateral) followed by 15% total-body-surface-area skin wounds (R-W CI) or b...

journal_title：Oxidative medicine and cellular longevity

authors： Kiang JG,Zhai M,Liao PJ,Elliott TB,Gorbunov NV

更新日期：2014-01-01 00:00:00