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Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution.

Abstract：

:The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity and prevention of systemic autoimmunity, the thymus is the first organ of the body that exhibits age-associated degeneration/regression, termed "thymic involution." A hallmark of this early phenomenon is a progressive decline of thymic mass as well as a decreased output of naïve T cells, thus resulting in impaired immune response. Importantly, thymic involution has been recently linked with cellular senescence which is a stress response induced by various stimuli. Accumulation of senescent cells in tissues has been implicated in aging and a plethora of age-related diseases. In addition, several lines of evidence indicate that oxidative stress, a well-established trigger of senescence, is also involved in thymic involution, thus highlighting a possible interplay between oxidative stress, senescence, and thymic involution.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Barbouti A,Vasileiou PVS,Evangelou K,Vlasis KG,Papoudou-Bai A,Gorgoulis VG,Kanavaros P

doi

10.1155/2020/7986071

subject

Has Abstract

pub_date

2020-02-05 00:00:00

pages

7986071

eissn

1942-0900

issn

1942-0994

journal_volume

2020

pub_type

杂志文章,评审

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