Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis.

abstract：:Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable model of human hyp...

journal_title：Oxidative medicine and cellular longevity

authors： Rubattu S,Stanzione R,Volpe M

更新日期：2016-01-01 00:00:00

abstract：:Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

journal_title：Oxidative medicine and cellular longevity

authors： He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

更新日期：2020-11-05 00:00:00

abstract：:Hemoglobin (Hb) is a family of proteins in red blood cells responsible for oxygen transport and vulnerable for oxidative damage. Hemoglobin δ subunit (HBD), a member of Hb family, is normally expressed by cells of erythroid lineage. Expression of Hb genes has been previously reported in nonerythroid and hematopoietic ...

journal_title：Oxidative medicine and cellular longevity

authors： Zuo Q,Cheng S,Huang W,Bhatti MZ,Xue Y,Zhang Y,Zhang B,Li L,Wu L,Fu J,Chen J,Li X

更新日期：2017-01-01 00:00:00

abstract：:The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained ...

journal_title：Oxidative medicine and cellular longevity

authors： de Giffoni de Carvalho JT,da Silva Baldivia D,Leite DF,de Araújo LCA,de Toledo Espindola PP,Antunes KA,Rocha PS,de Picoli Souza K,Dos Santos EL

更新日期：2019-08-25 00:00:00

abstract：:This study was conducted to assess the protective effect of extract of match (EM) on high-fat diet- (HFD-) induced cognitive deficits in male C57BL/6 mice. It was found that EM improved glucose tolerance status by measuring OGTT and IPGTT with HFD-induced mice. EM protected behavioral and memory dysfunction in Y-maze,...

journal_title：Oxidative medicine and cellular longevity

authors： Kim JM,Lee U,Kang JY,Park SK,Kim JC,Heo HJ

更新日期：2020-11-28 00:00:00

abstract：:The aim of this study was to evaluate the properties of internal components of erythrocytes in chronic renal failure (CRF) patients undergoing hemodialysis (HD) in comparison to control subjects. For investigation of conformational state of hemoglobin and nonheme proteins (NHP) the maleimide spin label (MSL) in electr...

journal_title：Oxidative medicine and cellular longevity

authors： Pieniazek A,Gwozdzinski K

更新日期：2015-01-01 00:00:00

abstract：:Introduction. Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths. Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority. Metabolite quantitation is amenable to point-of-care analysis and can be performed...

journal_title：Oxidative medicine and cellular longevity

authors： Goh YM,Antonowicz SS,Boshier P,Hanna GB

更新日期：2020-02-21 00:00:00

abstract：:With recent insight into the mechanisms involved in diseases, such as cardiovascular disease, cancer, stroke, neurodegenerative diseases, and diabetes, more efficient modes of treatment are now being assessed. Traditional medicine including the use of natural products is widely practiced around the world, assuming tha...

journal_title：Oxidative medicine and cellular longevity

authors： Shay J,Elbaz HA,Lee I,Zielske SP,Malek MH,Hüttemann M

更新日期：2015-01-01 00:00:00

abstract：:The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generat...

journal_title：Oxidative medicine and cellular longevity

authors： Aune SE,Yeh ST,Kuppusamy P,Kuppusamy ML,Khan M,Angelos MG

更新日期：2013-01-01 00:00:00

abstract：:Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66Shc adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis by providing oxidativ...

journal_title：Oxidative medicine and cellular longevity

authors： Pérez H,Finocchietto PV,Alippe Y,Rebagliati I,Elguero ME,Villalba N,Poderoso JJ,Carreras MC

更新日期：2018-03-12 00:00:00

abstract：:Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing mo...

journal_title：Oxidative medicine and cellular longevity

authors： Hernández-Álvarez D,Mena-Montes B,Toledo-Pérez R,Pedraza-Vázquez G,López-Cervantes SP,Morales-Salazar A,Hernández-Cruz E,Lazzarini-Lechuga R,Vázquez-Cárdenas RR,Vilchis-DeLaRosa S,Posadas-Rodríguez P,Santín-Márquez R,Rosas-Carras

更新日期：2019-11-11 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been ...

journal_title：Oxidative medicine and cellular longevity

authors： Kong X,Liu CX,Wang GD,Yang H,Yao XM,Hua Q,Li XY,Zhang HM,Ma MZ,Su Q,Lv K

更新日期：2019-10-14 00:00:00

abstract：:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

更新日期：2020-06-17 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00

abstract：:The mechanisms underlying poor outcome following subarachnoid haemorrhage (SAH) are complex and multifactorial. They include early brain injury, spreading depolarisation, inflammation, oxidative stress, macroscopic cerebral vasospasm, and microcirculatory disturbances. Nrf2 is a global promoter of the antioxidant and ...

journal_title：Oxidative medicine and cellular longevity

authors： Zolnourian A,Galea I,Bulters D

更新日期：2019-05-02 00:00:00

abstract：:Serine-threonine kinase receptor-associated protein (STRAP) is a transforming growth factor β (TGF-β) receptor-interacting protein that has been implicated in both cell proliferation and cell death in response to various stresses. However, the precise roles of STRAP in these cellular processes are still unclear. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Manoharan R,Seong HA,Ha H

更新日期：2018-04-19 00:00:00

abstract：:Reactive oxygen species (ROS) are important regulators of cellular functions. In embryonic stem cells, ROS are suggested to influence differentiation status. Regulated ROS formation is catalyzed primarily by NADPH-dependent oxidases (NOXs). Apocynin and diphenyleneiodonium are frequently used inhibitors of NOXs; howev...

journal_title：Oxidative medicine and cellular longevity

authors： Kučera J,Binó L,Štefková K,Jaroš J,Vašíček O,Večeřa J,Kubala L,Pacherník J

更新日期：2016-01-01 00:00:00

abstract：:Fruits, such as grapes, are essential food of the Mediterranean diet. Grape extracts have potent antioxidant and chemopreventive properties in vitro. Numerous studies have examined the effects of plant extract administration on redox status at rest in animals and humans but their results are controversial. However, th...

journal_title：Oxidative medicine and cellular longevity

authors： Veskoukis AS,Kyparos A,Nikolaidis MG,Stagos D,Aligiannis N,Halabalaki M,Chronis K,Goutzourelas N,Skaltsounis L,Kouretas D

更新日期：2012-01-01 00:00:00

abstract：:The ability to produce cold plasma at atmospheric pressure conditions was the basis for the rapid growth of plasma-related application areas in biomedicine. Plasma comprises a multitude of active components such as charged particles, electric current, UV radiation, and reactive gas species which can act synergisticall...

journal_title：Oxidative medicine and cellular longevity

authors： Bernhardt T,Semmler ML,Schäfer M,Bekeschus S,Emmert S,Boeckmann L

更新日期：2019-09-03 00:00:00

abstract：SCOPE:To determine whether doses of quercetin in the range of serum concentrations exert any effect on triacylglycerol accumulation in maturing preadipocytes and mature adipocytes. The influence on the expression of adipogenic markers as well as on gene expression and activity of enzymes involved in triacylglycerol met...

journal_title：Oxidative medicine and cellular longevity

authors： Eseberri I,Miranda J,Lasa A,Churruca I,Portillo MP

更新日期：2015-01-01 00:00:00

abstract：:This paper compiles the beneficial effects of cocoa polyphenols on human health, especially with regard to cardiovascular and inflammatory diseases, metabolic disorders, and cancer prevention. Their antioxidant properties may be responsible for many of their pharmacological effects, including the inhibition of lipid p...

journal_title：Oxidative medicine and cellular longevity

authors： Andújar I,Recio MC,Giner RM,Ríos JL

更新日期：2012-01-01 00:00:00

abstract：:Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies. They...

journal_title：Oxidative medicine and cellular longevity

authors： Pichla M,Bartosz G,Sadowska-Bartosz I

更新日期：2020-10-13 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo...

journal_title：Oxidative medicine and cellular longevity

authors： Huang Y,Zhao H,Cao K,Sun D,Yang Y,Liu C,Cui J,Cheng Y,Li B,Cai J,Gao F

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/4824371.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Song TY,Yang NC,Chen CL,Thi TLV

更新日期：2019-08-06 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the su...

journal_title：Oxidative medicine and cellular longevity

authors： Kang M,Cho JH,Kim TJ,Lee SM,Kim HJ,Coronado I,Yi DK,Kim DY

更新日期：2020-04-25 00:00:00

abstract：:Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was ind...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Rasheed NM,Al-Rasheed NM,Hasan IH,Al-Amin MA,Al-Ajmi HN,Mohamad RA,Mahmoud AM

更新日期：2017-01-01 00:00:00

abstract：:Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, both RNS and ROS are...

journal_title：Oxidative medicine and cellular longevity

authors： Rehman ZU,Meng C,Sun Y,Safdar A,Pasha RH,Munir M,Ding C

更新日期：2018-12-10 00:00:00

abstract：:Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have be...

journal_title：Oxidative medicine and cellular longevity

authors： Aquila G,Marracino L,Martino V,Calabria D,Campo G,Caliceti C,Rizzo P

更新日期：2019-05-02 00:00:00

abstract：Background:Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure. Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury. Intravenous anesthetic propofol potent effects on free radical scaven...

journal_title：Oxidative medicine and cellular longevity

authors： Yao W,Han X,Zhang Y,Guan J,Ge M,Chen C,Wu S,Chen J,Luo G,Huang P,Hei Z

更新日期：2018-10-28 00:00:00