Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration.

abstract：:Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

journal_title：Oxidative medicine and cellular longevity

authors： He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

更新日期：2020-11-05 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a ce...

journal_title：Oxidative medicine and cellular longevity

authors： Büchter C,Zhao L,Havermann S,Honnen S,Fritz G,Proksch P,Wätjen W

更新日期：2015-01-01 00:00:00

abstract：:To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in bot...

journal_title：Oxidative medicine and cellular longevity

authors： Marciniak A,Walczyna B,Rajtar G,Marciniak S,Wojtak A,Lasiecka K

更新日期：2016-01-01 00:00:00

abstract：:We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo...

journal_title：Oxidative medicine and cellular longevity

authors： Huang Y,Zhao H,Cao K,Sun D,Yang Y,Liu C,Cui J,Cheng Y,Li B,Cai J,Gao F

更新日期：2016-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible lung disease of unknown etiology with limited survival. IPF incidence and prevalence increase significantly with aging, which is associated with an age-related accumulation of oxidative DNA damage. The Mutyh gene is involved in the base excision repair...

journal_title：Oxidative medicine and cellular longevity

authors： Sun Q,Chen J,Xu L,Kang J,Wu X,Ren Y,Nakabeppu Y,Wang Y

更新日期：2020-10-16 00:00:00

abstract：:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AE

更新日期：2014-01-01 00:00:00

abstract：:Methionine sulfoxide reductase B1 (MsrB1) is a member of the selenoprotein family, which contributes to the reduction of methionine sulfoxides produced from reactive oxygen species (ROS) by redox processes in energy pathways. However, few studies have examined the role of MsrB1 in human hepatocellular carcinoma (HCC)....

journal_title：Oxidative medicine and cellular longevity

authors： He Q,Li H,Meng F,Sun X,Feng X,Chen J,Li L,Liu J

更新日期：2018-05-10 00:00:00

abstract：:Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated w...

journal_title：Oxidative medicine and cellular longevity

authors： Baldim JL,de Alcântara BGV,Domingos ODS,Soares MG,Caldas IS,Novaes RD,Oliveira TB,Lago JHG,Chagas-Paula DA

更新日期：2017-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/5031926.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Hong YA,Yang KJ,Jung SY,Park KC,Choi H,Oh JM,Lee SJ,Chang YK,WheePark C,Yang CW,Kim SY,Hwang HS

更新日期：2017-01-01 00:00:00

abstract：:Increased follicular atresia occurs with aging and results in reduced fecundity in laying chickens. Therefore, relieving follicular atresia of aging poultry is a crucial measure to maintain sustained high laying performance. As an antiaging agent, metformin was reported to play important roles in preventing aging in d...

journal_title：Oxidative medicine and cellular longevity

authors： Yao J,Ma Y,Zhou S,Bao T,Mi Y,Zeng W,Li J,Zhang C

更新日期：2020-11-26 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：:In an attempt to better understand the pathogen-host interaction between invading Mycoplasma ovipneumoniae (M. ovipneumoniae) and sheep airway epithelial cells, biological effects and possible molecular mechanism of capsular polysaccharide of M. ovipneumoniae (CPS) in the induction of cell apoptosis were explored usin...

journal_title：Oxidative medicine and cellular longevity

authors： Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

更新日期：2017-01-01 00:00:00

abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

journal_title：Oxidative medicine and cellular longevity

authors： Kim HM,Cho BR

更新日期：2013-01-01 00:00:00

abstract：:This study aims at investigating the radioprotective effect of ethanol extract from Ji-Xue-Teng (JXT, Spatholobus suberectus) on radiation-induced hematopoietic alteration and oxidative stress in the liver. Mice were exposed to a single acute γ-radiation for the whole body at the dose of 6.0 Gy, then subjected to admi...

journal_title：Oxidative medicine and cellular longevity

authors： Dong XZ,Wang YN,Tan X,Liu P,Guo DH,Yan C

更新日期：2018-10-28 00:00:00

abstract：:Oxidative stress (OS), a common intracellular phenomenon induced by excess reactive oxygen species (ROS) generation, has been shown to be associated with mammalian ovarian follicular development blockage and granulosa cell (GC) impairment. However, the mechanism involved in these effects remains unknown, and the effec...

journal_title：Oxidative medicine and cellular longevity

authors： Du X,Li Q,Cao Q,Wang S,Liu H,Li Q

更新日期：2019-11-04 00:00:00

abstract：:Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its ...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Z,Zhang S,Xiao Y,Zhang W,Wu S,Qin T,Yue Y,Qian W,Li L

更新日期：2020-02-17 00:00:00

abstract：:Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage. Unfortunately, no specific drugs have been found that effectively prevent and treat RIRI. Curcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities invol...

journal_title：Oxidative medicine and cellular longevity

authors： Wang ZH,Deng LH,Chi CW,Wang H,Huang YY,Zheng Q

更新日期：2020-11-12 00:00:00

abstract：:Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify ...

journal_title：Oxidative medicine and cellular longevity

authors： Malaguti M,Angeloni C,Hrelia S

更新日期：2013-01-01 00:00:00

abstract：:The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation. Intense exercise (28 m/min at a ...

journal_title：Oxidative medicine and cellular longevity

authors： Tang Y,Li J,Gao C,Xu Y,Li Y,Yu X,Wang J,Liu L,Yao P

更新日期：2016-01-01 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) aft...

journal_title：Oxidative medicine and cellular longevity

authors： Gaastra B,Glazier J,Bulters D,Galea I

更新日期：2017-01-01 00:00:00

abstract：:Essential oils of some aromatic plants provide an effective nonmedicinal option to control liver fibrosis. Mentha piperita L. essential oil (MPEO) have been reported to possess protective effects against hepatotoxicity. However, its effect against liver fibrosis remains unknown. The present study investigated the anti...

journal_title：Oxidative medicine and cellular longevity

authors： Ogaly HA,Eltablawy NA,Abd-Elsalam RM

更新日期：2018-04-19 00:00:00

abstract：:Mitochondria are the primary site of cellular energy generation and reactive oxygen species (ROS) accumulation. Elevated ROS levels are detrimental to normal cell function and have been linked to the pathogenesis of neurodegenerative disorders such as Down's syndrome (DS) and Alzheimer's disease (AD). RCAN1 is abundan...

journal_title：Oxidative medicine and cellular longevity

authors： Peiris H,Dubach D,Jessup CF,Unterweger P,Raghupathi R,Muyderman H,Zanin MP,Mackenzie K,Pritchard MA,Keating DJ

更新日期：2014-01-01 00:00:00

abstract：:Aging leads to a number of disadvantageous changes in the cardiovascular system. Deterioration of vascular homoeostasis with increase in oxidative stress, chronic low-grade inflammation, and impaired nitric oxide bioavailability results in endothelial dysfunction, increased vascular stiffness, and compromised arterial...

journal_title：Oxidative medicine and cellular longevity

authors： Rammos C,Totzeck M,Deenen R,Köhrer K,Kelm M,Rassaf T,Hendgen-Cotta UB

更新日期：2015-01-01 00:00:00

abstract：Objective:Oxidized cholesterol derivatives are compounds with proven atherogenic and mutagenic effects. However, little is known about the effect of oxidized plant sterol derivatives (oxyphytosterols), whose structure is similar to the one of oxycholesterols. Our previous studies indicate that they have a similar profi...

journal_title：Oxidative medicine and cellular longevity

authors： Wielkoszyński T,Zalejska-Fiolka J,Strzelczyk JK,Owczarek AJ,Cholewka A,Kokoszczyk K,Stanek A

更新日期：2020-06-08 00:00:00

abstract：:The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes. The generation and release of ROS in the fo...

journal_title：Oxidative medicine and cellular longevity

authors： Giardino G,Cicalese MP,Delmonte O,Migliavacca M,Palterer B,Loffredo L,Cirillo E,Gallo V,Violi F,Pignata C

更新日期：2017-01-01 00:00:00

abstract：:There is accumulating evidence that blood pressure (BP) control significantly reduces the risk of future cardiovascular events in patients with essential hypertension. However, strict BP control is often difficult to maintain, and half of hypertensive patients fail to attain BP goals on single-drug therapy. Therefore,...

journal_title：Oxidative medicine and cellular longevity

authors： Bekki H,Yamamoto K,Sone M,Homma T,Nakata M,Nohara M,Fukami K,Okuda S,Yamagishi S

更新日期：2010-09-01 00:00:00

abstract：:Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose ...

journal_title：Oxidative medicine and cellular longevity

authors： Gun A,Ozer MK,Bilgic S,Kocaman N,Ozan G

更新日期：2016-01-01 00:00:00

abstract：:Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters...

journal_title：Oxidative medicine and cellular longevity

authors： Tasca KI,Caleffi JT,Correa CR,Gatto M,Tavares FC,Camargo CC,Sartori A,Biasin M,de Souza LDR

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The human Circadian Locomotor Output Cycle protein Kaput (CLOCK) gene was originally discovered as a regulator of essential human daily rhythms. This seemingly innocuous gene was then found to be associated with a multitude of human malignancies, via several biochemical pathways. We aimed to further investig...

journal_title：Oxidative medicine and cellular longevity

authors： Tang X,Guo D,Lin C,Shi Z,Qian R,Fu W,Liu J,Li X,Fan L

更新日期：2015-01-01 00:00:00