Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation In Vivo.


Background:Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure. Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury. Intravenous anesthetic propofol potent effects on free radical scavenging and protects livers against I/R injury. However, the role and mechanism of propofol-mediated hepatic protection in liver transplantation is poorly understood. The aim of this study was to evaluate the role of propofol postconditioning in the liver I/R injury after liver transplantation. Methods:Forty-eight rats were randomly divided into six groups: rats receiving either sham operation or orthotopic autologous liver transplantation (OALT) in the absence or presence of propofol (high dose and low dose) postconditioning or intralipid control or VAS2870 (Nox2 special inhibitor). Eight hours after OALT or sham operation, parameters of organ injury, oxidative stress, inflammation, and NADPH-associated proteins were assessed. Results:After OALT, severe liver pathological injury was observed that was associated with increases of serum AST and ALT, which were attenuated by propofol postconditioning. In addition, especially high dose of propofol postconditioning reduced TNF-α, IL-1β, IL-6, TLR4, and NF-κB inflammatory pathway, accompanied with decrease of neutrophil elastase activity, MPO activity, 8-isoprotane, p47phox and gp91phox protein expressions, and increase of SOD activity. Inhibition of Nox2 by VAS2870 conferred similar protective effects in liver transplantation. Conclusion:Liver transplantation leads to severe inflammation and oxidative stress with NADPH oxidase activation. Propofol postconditioning reduces liver I/R injury after liver transplantation partly via inhibiting NADPH oxidase Nox2 and the subsequent inflammation and oxidative stress.


Oxid Med Cell Longev


Yao W,Han X,Zhang Y,Guan J,Ge M,Chen C,Wu S,Chen J,Luo G,Huang P,Hei Z




Has Abstract


2018-10-28 00:00:00










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    abstract::In chronic heart failure (HF), some parameters of oxidative stress are correlated with disease severity. The aim of this study was to evaluate the importance of oxidative stress biomarkers in prognostic risk stratification (death and combined endpoint: heart transplantation or death). In 774 patients, aged 48-59 years...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Romuk E,Wojciechowska C,Jacheć W,Zemła-Woszek A,Momot A,Buczkowska M,Rozentryt P

    更新日期:2019-10-09 00:00:00

  • Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

    abstract::In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria ar...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


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  • Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice.

    abstract::As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand. While shungite is regarded as a natural source of fullerene, it remains poorly documented. Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-)...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Sajo MEJ,Kim CS,Kim SK,Shim KY,Kang TY,Lee KJ

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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhang J,Xia Y,Xu Z,Deng X

    更新日期:2016-01-01 00:00:00

  • Accelerated aging in major depression: the role of nitro-oxidative stress.

    abstract::Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD). The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature m...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


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    更新日期:2016-01-01 00:00:00

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    abstract::Organophosphate pesticides (OPs) are among the most widely used synthetic chemicals for the control of a wide variety of pests, and reactive oxygen species (ROS) caused by OPs may be involved in the toxicity of various pesticides. Previous studies have demonstrated that a reactivation of latent Epstein-Barr virus (EBV...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhao L,Xie F,Wang TT,Liu MY,Li JL,Shang L,Deng ZX,Zhao PX,Ma XM

    更新日期:2015-01-01 00:00:00

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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 已发布勘误


    authors: Zhang X,Fu Q,Xu L,Yang Y,Zhao W,Zhang Y,Mi W,Li H

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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Yang Y,Wang Y,Kong Y,Zhang X,Zhang H,Feng X,Wang Z,Gao P,Yan M,Bai L,Li F

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  • DHA Oral Supplementation Modulates Serum Epoxydocosapentaenoic Acid (EDP) Levels in Breast Cancer Patients.

    abstract:Introduction:The omega-3 polyunsaturated fatty acids, as docosahexaenoic acid (DHA), are considered mediators regulating the resolution of inflammation during cancer and may be associated with better outcomes. Epoxydocosapentaenoic acids (EDPs), metabolites of the DHA, are hypothesized to be responsible for some benefi...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Kim JM,Lee U,Kang JY,Park SK,Kim JC,Heo HJ

    更新日期:2020-11-28 00:00:00

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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Németh CE,Nemoda Z,Lőw P,Szabó P,Horváth EZ,Willaert A,Boel A,Callewaert BL,Coucke PJ,Colombi M,Bánhegyi G,Margittai É

    更新日期:2019-01-13 00:00:00

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    abstract::Fisetin, a known antioxidant, has been found to be cytotoxic against certain cell lines. However, the mechanism by which it inhibits tumor growth in vivo remains unexplored. Recently, we have demonstrated that Aflatoxin-B1 (AFB1) induced hepatocarcinogenesis is associated with activation of oxidative stress-inflammato...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Maurya BK,Trigun SK

    更新日期:2016-01-01 00:00:00

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    abstract::Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly malignant, recurrent, drug-resistant, and often diagnosed in the advanced stage. It is clear that early diagnosis and a better understanding of molecular mechanisms contributing to HCC progression is clinically urgent. Metabolic a...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: De Matteis S,Ragusa A,Marisi G,De Domenico S,Casadei Gardini A,Bonafè M,Giudetti AM

    更新日期:2018-11-04 00:00:00

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    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Katwal G,Baral D,Fan X,Weiyang H,Zhang X,Ling L,Xiong Y,Ye Q,Wang Y

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  • Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

    abstract::A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VI

    更新日期:2018-01-31 00:00:00

  • Metformin Protects against Oxidative Stress Injury Induced by Ischemia/Reperfusion via Regulation of the lncRNA-H19/miR-148a-3p/Rock2 Axis.

    abstract::Previous studies have shown that metformin not only is a hypoglycemic agent but also has neuroprotective effects. However, the mechanism of action of metformin in ischemic stroke is unclear. Oxidative stress is an important factor in the pathogenesis of cerebral ischemia-reperfusion injury. It has been reported that m...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zeng J,Zhu L,Liu J,Zhu T,Xie Z,Sun X,Zhang H

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  • Buyang Huanwu Decoction Exerts Cardioprotective Effects through Targeting Angiogenesis via Caveolin-1/VEGF Signaling Pathway in Mice with Acute Myocardial Infarction.

    abstract:Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

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  • Oxidative Stress in Poultry: Lessons from the Viral Infections.

    abstract::Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, both RNS and ROS are...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


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  • Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.

    abstract::The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Andreicuț AD,Fischer-Fodor E,Pârvu AE,Ţigu AB,Cenariu M,Pârvu M,Cătoi FA,Irimie A

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  • Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice.

    abstract::OVE26 mice are a widely used transgenic model of early-onset type 1 diabetes. These mice overexpress calmodulin in their pancreatic β cells, develop severe diabetes within the first weeks of life, and progress to severe diabetic complications including diabetic nephropathy and diabetic cardiomyopathy (DCM). To date, d...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Tang X,Jiang S,Zhang J,Zhou S,Zheng Y

    更新日期:2020-05-14 00:00:00