当前位置： SCI文献检索 > Oxidative Medicine and Cellular Longevity期刊下所有文献 > REGγ Contributes to Regulation of Hemoglobin and Hemoglobin δ Subunit.

REGγ Contributes to Regulation of Hemoglobin and Hemoglobin δ Subunit.

Abstract：

:Hemoglobin (Hb) is a family of proteins in red blood cells responsible for oxygen transport and vulnerable for oxidative damage. Hemoglobin δ subunit (HBD), a member of Hb family, is normally expressed by cells of erythroid lineage. Expression of Hb genes has been previously reported in nonerythroid and hematopoietic stem cells. Here, we report that Hb and HBD can be degraded via REGγ proteasome in hemopoietic tissues and nonerythroid cells. For this purpose, bone marrow, liver, and spleen hemopoietic tissues from REGγ+/+ and REGγ-/- mice and stable REGγ knockdown cells were evaluated for the degradation of Hb and HBD via REGγ. Western blot and immunohistochemical analyses exhibited downregulation of Hb in REGγ wild-type mouse tissues. This was validated by dynamic analysis following blockade of de novo synthesis of proteins with CHX. Degradation of HBD only occurred in REGγ WT cells but not in REGγN151Y, a dominant-negative REGγ mutant cell. Notably, downregulation of HBD was found in HeLa shN cells with stimulation of phenylhydrazine, an oxidation inducer, suggesting that the REGγ proteasome may target oxidatively damaged Hbs. In conclusion, our findings provide important implications for the degradation of Hb and HBD in hemopoietic tissues and nonerythroid cells via the REGγ proteasome.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Zuo Q,Cheng S,Huang W,Bhatti MZ,Xue Y,Zhang Y,Zhang B,Li L,Wu L,Fu J,Chen J,Li X

doi

10.1155/2017/7295319

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

7295319

eissn

1942-0900

issn

1942-0994

journal_volume

2017

pub_type

杂志文章

相关文献

Oxidative Medicine and Cellular Longevity文献大全
  • Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

    abstract：:Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both pa...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2020/9641904

    authors： Ho YS,Zhao FY,Yeung WF,Wong GT,Zhang HQ,Chang RC

    更新日期：2020-02-13 00:00:00

  • Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy.

    abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2015/938475

    authors： Turrini E,Ferruzzi L,Fimognari C

    更新日期：2015-01-01 00:00:00

  • Dexmedetomidine Attenuates Orthotopic Liver Transplantation-Induced Acute Gut Injury via α 2-Adrenergic Receptor-Dependent Suppression of Oxidative Stress.

    abstract：:Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. R...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/9426368

    authors： Lv P,Chen T,Liu P,Zheng L,Tian J,Tan F,Chen J,Deng Y,Li J,Cai J,Chi X

    更新日期：2019-11-11 00:00:00

  • Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

    abstract：:In an attempt to better understand the pathogen-host interaction between invading Mycoplasma ovipneumoniae (M. ovipneumoniae) and sheep airway epithelial cells, biological effects and possible molecular mechanism of capsular polysaccharide of M. ovipneumoniae (CPS) in the induction of cell apoptosis were explored usin...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/6175841

    authors： Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

    更新日期：2017-01-01 00:00:00

  • Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.

    abstract：:Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticanc...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/1915828

    authors： Li K,Zheng Q,Chen X,Wang Y,Wang D,Wang J

    更新日期：2018-10-16 00:00:00

  • Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.

    abstract：:GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,随机对照试验

    doi：10.1155/2017/5608287

    authors： Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

    更新日期：2017-01-01 00:00:00

  • Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently.

    abstract：:We conducted quantitative cellular respiration analysis on samples taken from human breast cancer (HBC) and human colorectal cancer (HCC) patients. Respiratory capacity is not lost as a result of tumor formation and even though, functionally, complex I in HCC was found to be suppressed, it was not evident on the prote...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/1372640

    authors： Koit A,Shevchuk I,Ounpuu L,Klepinin A,Chekulayev V,Timohhina N,Tepp K,Puurand M,Truu L,Heck K,Valvere V,Guzun R,Kaambre T

    更新日期：2017-01-01 00:00:00

  • Apocynin and Diphenyleneiodonium Induce Oxidative Stress and Modulate PI3K/Akt and MAPK/Erk Activity in Mouse Embryonic Stem Cells.

    abstract：:Reactive oxygen species (ROS) are important regulators of cellular functions. In embryonic stem cells, ROS are suggested to influence differentiation status. Regulated ROS formation is catalyzed primarily by NADPH-dependent oxidases (NOXs). Apocynin and diphenyleneiodonium are frequently used inhibitors of NOXs; howev...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/7409196

    authors： Kučera J,Binó L,Štefková K,Jaroš J,Vašíček O,Večeřa J,Kubala L,Pacherník J

    更新日期：2016-01-01 00:00:00

  • Neuroprotective effect of tea polyphenols on oxyhemoglobin induced subarachnoid hemorrhage in mice.

    abstract：:Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases. In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2013/743938

    authors： Mo H,Chen Y,Huang L,Zhang H,Li J,Zhou W

    更新日期：2013-01-01 00:00:00

  • hCLOCK Causes Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses.

    abstract：BACKGROUND:The human Circadian Locomotor Output Cycle protein Kaput (CLOCK) gene was originally discovered as a regulator of essential human daily rhythms. This seemingly innocuous gene was then found to be associated with a multitude of human malignancies, via several biochemical pathways. We aimed to further investig...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2015/671839

    authors： Tang X,Guo D,Lin C,Shi Z,Qian R,Fu W,Liu J,Li X,Fan L

    更新日期：2015-01-01 00:00:00

  • Corrigendum to "Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress".

    abstract：:[This corrects the article DOI: 10.1155/2017/3027109.]. ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 已发布勘误

    doi：10.1155/2017/1083618

    authors： Nawrocka D,Kornicka K,Szydlarska J,Marycz K

    更新日期：2017-01-01 00:00:00

  • LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis.

    abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/4010764

    authors： Kong X,Liu CX,Wang GD,Yang H,Yao XM,Hua Q,Li XY,Zhang HM,Ma MZ,Su Q,Lv K

    更新日期：2019-10-14 00:00:00

  • Efficacy of combination therapy with telmisartan plus amlodipine in patients with poorly controlled hypertension.

    abstract：:There is accumulating evidence that blood pressure (BP) control significantly reduces the risk of future cardiovascular events in patients with essential hypertension. However, strict BP control is often difficult to maintain, and half of hypertensive patients fail to attain BP goals on single-drug therapy. Therefore,...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.4161/oxim.3.5.13199

    authors： Bekki H,Yamamoto K,Sone M,Homma T,Nakata M,Nohara M,Fukami K,Okuda S,Yamagishi S

    更新日期：2010-09-01 00:00:00

  • Bisphenol A and Its Analogues in Chinese Total Diets: Contaminated Levels and Risk Assessment.

    abstract：:Bisphenol A (BPA) and its analogues (BPs) are suspected posing potential endocrine disrupting properties. They might migrate into foodstuffs through food packaging materials or contaminated water and soil. Dietary exposure is of paramount importance way for human health. European Food Safety Authority (EFSA) lowered t...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/8822321

    authors： Yao K,Zhang J,Yin J,Zhao Y,Shen J,Jiang H,Shao B

    更新日期：2020-12-17 00:00:00

  • Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway.

    abstract：:Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and is associated with high mortality and poor prognosis. Thus, the primary aim of the present study was to determine whether glycine could (1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and (2) downregulate mitochondria-mediated autop...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/4248529

    authors： Cai CC,Zhu JH,Ye LX,Dai YY,Fang MC,Hu YY,Pan SL,Chen S,Li PJ,Fu XQ,Lin ZL

    更新日期：2019-02-06 00:00:00

  • The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids.

    abstract：:Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated w...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/3789856

    authors： Baldim JL,de Alcântara BGV,Domingos ODS,Soares MG,Caldas IS,Novaes RD,Oliveira TB,Lago JHG,Chagas-Paula DA

    更新日期：2017-01-01 00:00:00

  • Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer.

    abstract：:Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of genes necessary to circumvent to hypoxic (low oxygen level) environments. In carcinogenesis, HIFs play a critical role. Indeed, HIF-1α has been validated as a promising target for novel cancer therapeutics, even as clinical i...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2019/8547846

    authors： Akanji MA,Rotimi D,Adeyemi OS

    更新日期：2019-08-14 00:00:00

  • Increased Oxidative Stress as a Selective Anticancer Therapy.

    abstract：:Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2015/294303

    authors： Liu J,Wang Z

    更新日期：2015-01-01 00:00:00

  • Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats.

    abstract：Purpose:Oxidative stress induced by reduced blood circulation is a critical pathological damage to retinal ganglion cells (RGCs) in glaucoma. We previously showed that green tea extract (GTE) and its catechin constituents alleviate sodium iodate-induced retinal degeneration in rats. Here, we investigated the therapeuti...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/8407206

    authors： Yang Y,Xu C,Chen Y,Liang JJ,Xu Y,Chen SL,Huang S,Yang Q,Cen LP,Pang CP,Sun XH,Ng TK

    更新日期：2019-07-09 00:00:00

  • Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction.

    abstract：:Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional curcumin (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wis...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/7847142

    authors： Boarescu PM,Chirilă I,Bulboacă AE,Bocșan IC,Pop RM,Gheban D,Bolboacă SD

    更新日期：2019-05-07 00:00:00

  • Cytotoxic, Antioxidant, and Metabolic Enzyme Inhibitory Activities of Euphorbia cyparissias Extracts.

    abstract：:Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipa...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/9835167

    authors： Alonazi M,Horchani H,Alwhibi M,Ben Bacha A

    更新日期：2020-10-29 00:00:00

  • Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

    abstract：:In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria ar...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2012/740849

    authors： Li N,Stojanovski S,Maechler P

    更新日期：2012-01-01 00:00:00

  • Transcriptome Remodeling of Differentiated Cells during Chronological Ageing of Yeast Colonies: New Insights into Metabolic Differentiation.

    abstract：:We present the spatiotemporal metabolic differentiation of yeast cell subpopulations from upper, lower, and margin regions of colonies of different ages, based on comprehensive transcriptomic analysis. Furthermore, the analysis was extended to include smaller cell subpopulations identified previously by microscopy wit...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/4932905

    authors： Wilkinson D,Maršíková J,Hlaváček O,Gilfillan GD,Ježková E,Aaløkken R,Váchová L,Palková Z

    更新日期：2018-01-11 00:00:00

  • Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment.

    abstract：:Introduction. Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths. Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority. Metabolite quantitation is amenable to point-of-care analysis and can be performed...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2020/2930347

    authors： Goh YM,Antonowicz SS,Boshier P,Hanna GB

    更新日期：2020-02-21 00:00:00

  • Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity.

    abstract：:The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2019/3685264

    authors： de Giffoni de Carvalho JT,da Silva Baldivia D,Leite DF,de Araújo LCA,de Toledo Espindola PP,Antunes KA,Rocha PS,de Picoli Souza K,Dos Santos EL

    更新日期：2019-08-25 00:00:00

  • Low Dose of Genistein Alleviates Mono-(2-Ethylhexyl) Phthalate-Induced Fetal Testis Disorder Based on Organ Culture Model.

    abstract：:Mono-(2-ethylhexyl) phthalate (MEHP) and genistein have been classified as endocrine-disrupting chemicals (EDCs) which interfere with the differentiation and development of the male reproductive system. However, how these two EDCs would affect fetal rat testis development at a low dose was rarely studied. In this stud...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/4569268

    authors： Zhang TD,Ma YB,Li HC,Chong T,Wang ZM,Zhang LD

    更新日期：2020-05-27 00:00:00

  • Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction.

    abstract：:Obesity is a state of chronic low-level inflammation closely associated with oxidative stress. Childhood obesity is associated with endothelial dysfunction, inflammation, and oxidative stress markers individually. This study was aimed at determining the association between the biomarkers of inflammation, oxidative str...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/9604740

    authors： Selvaraju V,Ayine P,Fadamiro M,Babu JR,Brown M,Geetha T

    更新日期：2019-10-16 00:00:00

  • Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study.

    abstract：Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/1821969

    authors： Hsueh CY,Shao M,Cao W,Li S,Zhou L

    更新日期：2019-04-16 00:00:00

  • Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells.

    abstract：:This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B. serrata was perform...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/2504305

    authors： Bertocchi M,Isani G,Medici F,Andreani G,Tubon Usca I,Roncada P,Forni M,Bernardini C

    更新日期：2018-06-25 00:00:00

  • Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway.

    abstract：:Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/2153745

    authors： Hu M,Zou W,Wang CY,Chen X,Tan HY,Zeng HY,Zhang P,Gu HF,Tang XQ

    更新日期：2016-01-01 00:00:00