Bisphenol A and Its Analogues in Chinese Total Diets: Contaminated Levels and Risk Assessment.


:Bisphenol A (BPA) and its analogues (BPs) are suspected posing potential endocrine disrupting properties. They might migrate into foodstuffs through food packaging materials or contaminated water and soil. Dietary exposure is of paramount importance way for human health. European Food Safety Authority (EFSA) lowered the value of tolerable daily intake (TDI) from 50 μg/kg bw/day (d) to a temporary (t) TDI (t-TDI) of 4 μg/kg bw/d. In this study, the Chinese total dietary samples were analyzed for assessing the exposure risk of BPs by diets. BPA, bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) were found in 12 kinds of food samples except for bisphenol B (BPB). A deterministic approach was used to calculate the dietary intakes of 4 kinds of compounds. For different age and gender groups, the exposure levels of BPA (178.440-403.672 ng/kg bw/d) was the highest, followed by BPS (21.372-52.112 ng/kg bw/d), BPF (20.641-50.507 ng/kg bw/d), and BPAF (0.434-1.210 ng/kg bw/d). Based on the t-TDI set by EFSA (4 μg/kg bw/d for BPA), the BPs through dietary intake pose low risks on the Chinese general population even summarization exposure levels of different BPs. However, human can be exposed to multiple endocrine disrupting chemicals rather than BPs alone; combined exposure risks should be further considered.


Oxid Med Cell Longev


Yao K,Zhang J,Yin J,Zhao Y,Shen J,Jiang H,Shao B




Has Abstract


2020-12-17 00:00:00










  • Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties.

    abstract::Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigat...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

    更新日期:2018-10-21 00:00:00

  • Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival.

    abstract::As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among wh...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Cao Q,Liu Z,Xiong Y,Zhong Z,Ye Q

    更新日期:2020-11-19 00:00:00

  • Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase-1.

    abstract::Metabolic diseases, such as insulin resistance, type II diabetes, and obesity, are associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of metabolic diseases, agents and...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Son Y,Lee JH,Chung HT,Pae HO

    更新日期:2013-01-01 00:00:00

  • Oxidized LDL Disrupts Metabolism and Inhibits Macrophage Survival by Activating a miR-9/Drp1/Mitochondrial Fission Signaling Pathway.

    abstract::Mitochondrial dysfunction is associated with macrophage damage, but the role of mitochondrial fission in macrophage cholesterol metabolism is not fully understood. In this study, we explored the influences of miR-9 and mitochondrial fission on macrophage viability and cholesterol metabolism. Macrophages were incubated...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Xin T,Lu C,Zhang J,Wen J,Yan S,Li C,Zhang F,Zhang J

    更新日期:2020-11-01 00:00:00

  • Oxidative Stress Regulation on Endothelial Cells by Hydrophilic Astaxanthin Complex: Chemical, Biological, and Molecular Antioxidant Activity Evaluation.

    abstract::An imbalance in the reactive oxygen species (ROS) homeostasis is involved in the pathogenesis of oxidative stress-related diseases. Astaxanthin, a xanthophyll carotenoid with high antioxidant capacities, has been shown to prevent the first stages of oxidative stress. Here, we evaluate the antioxidant capacities of ast...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zuluaga M,Barzegari A,Letourneur D,Gueguen V,Pavon-Djavid G

    更新日期:2017-01-01 00:00:00

  • Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.

    abstract::A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VI

    更新日期:2018-01-31 00:00:00

  • Protective Effect of Astragaloside IV on High Glucose-Induced Endothelial Dysfunction via Inhibition of P2X7R Dependent P38 MAPK Signaling Pathway.

    abstract::Vascular endothelial dysfunction is associated with increased mortality in patients with diabetes. Astragaloside IV (As-IV) is a bioactive saponin with therapeutic potential as an anti-inflammatory and antiendothelial dysfunction. However, the underlying mechanism for how As-IV ameliorated endothelial dysfunction is s...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Leng B,Li C,Sun Y,Zhao K,Zhang L,Lu ML,Wang HX

    更新日期:2020-09-14 00:00:00

  • Blueberry Extracts as a Novel Approach to Prevent Ozone-Induced Cutaneous Inflammasome Activation.

    abstract::The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environmen...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Pambianchi E,Ferrara F,Pecorelli A,Woodby B,Grace M,Therrien JP,Lila MA,Valacchi G

    更新日期:2020-08-13 00:00:00

  • Effect of novel marine nutraceuticals on IL-1α-mediated TNF-α release from UVB-irradiated human melanocyte-derived cells.

    abstract::UV-induced inflammation and reactive oxygen species formation are involved in the development of melanoma. Natural products like 5β-scymnol and CO(2)-supercritical fluid extract (CO(2)-SFE) of mussel oil contain anti-inflammatory and antioxidant properties that may aid in reducing the deleterious effects of UV radiati...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Muthusamy V,Hodges LD,Macrides TA,Boyle GM,Piva TJ

    更新日期:2011-01-01 00:00:00

  • The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes.

    abstract::UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

    更新日期:2020-02-12 00:00:00

  • Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes.

    abstract::Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typi...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Passaro A,Vigna GB,Romani A,Sanz JM,Cavicchio C,Bonaccorsi G,Valacchi G,Cervellati C

    更新日期:2018-11-05 00:00:00

  • Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE.

    abstract::Oxidative stress (OS) and neuronal apoptosis are major pathological processes after hypoxic-ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to CSF1 receptor (CSF1R), has been shown to reduce neuronal loss after hypoxic-ischemia- (HI-) induced brain injury. In the present study, we hypothesiz...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Hu X,Li S,Doycheva DM,Huang L,Lenahan C,Liu R,Huang J,Gao L,Tang J,Zuo G,Zhang JH

    更新日期:2020-10-07 00:00:00

  • Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro.

    abstract::Tau, a microtubule-associated protein expressed in mature neurons, interacts with tubulin to promote the assembly and stabilization of microtubules. However, abnormally hyperphosphorylated tau dissociates from microtubules and self-aggregates. Tau aggregates, including paired helical filaments and neurofibrillary tang...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Shin SJ,Park YH,Jeon SG,Kim S,Nam Y,Oh SM,Lee YY,Moon M

    更新日期:2020-06-30 00:00:00

  • In Vivo Pharmacological and Anti-inflammatory Evaluation of Xerophyte Plantago sempervirens Crantz.

    abstract::Known for centuries throughout the world, Plantago species have long been used as traditional herbal remedies for many diseases related to inflammatory conditions of the skin, respiratory and digestive tract, or even malignancy. This study is aimed first at investigating the in vitro antioxidant and regenerative effec...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Farcaș AD,Moț AC,Pârvu AE,Toma VA,Popa MA,Mihai MC,Sevastre B,Roman I,Vlase L,Pârvu M

    更新日期:2019-06-02 00:00:00

  • Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells.

    abstract::Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are key transmembrane proteins leading to reactive oxygen species (ROS) overproduction. However, the detailed roles of NOXs in retinal pigment epithelial (RPE) cell metabolic stress induced by Earle's balanced salt solution (EBSS) through starvation r...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhang Y,Ren S,Gu Y,Wang J,Liu Z,Zhang Z

    更新日期:2018-07-29 00:00:00

  • Oxidative Stress in the Muscles of the Fish Nile Tilapia Caused by Zinc Oxide Nanoparticles and Its Modulation by Vitamins C and E.

    abstract::The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

    更新日期:2018-04-05 00:00:00

  • Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity.

    abstract::Balkan endemic nephropathy (BEN) represents a chronic tubulointerstitial nephropathy which is followed by the progression of kidney fibrosis to end-stage kidney failure. The critical involvement of poisons in food (aristolochic acid (AA), ochratoxin, and heavy metals) and selenium deficiency are among nutritive factor...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Veljković A,Hadži-Đokić J,Sokolović D,Čukuranović R,Čukuranović-Kokoris J,Bašić D,Đorđević B,Stojanović M,Šmelcerović A,Kocić G

    更新日期:2020-08-18 00:00:00

  • Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.

    abstract::The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Li S,Hong M,Tan HY,Wang N,Feng Y

    更新日期:2016-01-01 00:00:00

  • The Emerging Role of Senescence in Ocular Disease.

    abstract::Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses. An important role for senescence has been shown for a number of pathophysiological conditions that include cardiovascular disease, pulmonary fibrosis, and diseases of the skin. However, whether senescence con...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Sreekumar PG,Hinton DR,Kannan R

    更新日期:2020-03-09 00:00:00

  • Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-κB Activation in ApoE Knockout Mice.

    abstract::We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE-/-) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean prop...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Xiao Y,He M,Liang X,She J,He L,Liu Y,Zou J,Yuan Z

    更新日期:2018-08-23 00:00:00

  • Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway.

    abstract::Approximately 90% of male diabetes mellitus patients have varying degrees of testicular dysfunction. The molecular mechanism underlying diabetes-induced testicular damage has not been thoroughly elucidated. In this research, we sought to determine the influence of metformin (Met) on diabetes-induced testicular injury ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Liu Y,Yang Z,Kong D,Zhang Y,Yu W,Zha W

    更新日期:2019-11-28 00:00:00

  • Purified Astaxanthin from Haematococcus pluvialis Promotes Tissue Regeneration by Reducing Oxidative Stress and the Secretion of Collagen In Vitro and In Vivo.

    abstract::Intracellular reactive apoptosis and reactive oxygen species (ROS) play a crucial role in ultraviolet- (UV-) induced inflammation and aging reaction in human dermal tissues. This study determines the mechanism by which Haematococcus pluvialis extracts (HPE) and purified astaxanthin (HPA) to promote skin regeneration i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Chou HY,Ma DL,Leung CH,Chiu CC,Hour TC,Wang HD

    更新日期:2020-08-03 00:00:00

  • Induction of mitochondrial changes associated with oxidative stress on very long chain fatty acids (C22:0, C24:0, or C26:0)-treated human neuronal cells (SK-NB-E).

    abstract::In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomal β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of V...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zarrouk A,Vejux A,Nury T,El Hajj HI,Haddad M,Cherkaoui-Malki M,Riedinger JM,Hammami M,Lizard G

    更新日期:2012-01-01 00:00:00

  • Cyclosporine A Promotes Bone Remodeling in LPS-Related Inflammation via Inhibiting ROS/ERK Signaling: Studies In Vivo and In Vitro.

    abstract::In some inflammatory diseases of bone, osteogenesis and osteoclasis are uncoupled and the balance is usually tipped resulting in bone destruction. The underlying mechanism of osteogenic dysfunction in inflammation still needs further study. This study is aimed at investigating the effects of cyclosporine A (CsA) on bo...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhao Y,Gao J,Zhang Y,Gan X,Yu H

    更新日期:2021-01-07 00:00:00

  • Oxidative stress contributes to endothelial dysfunction in mouse models of hereditary hemorrhagic telangiectasia.

    abstract::Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia caused by mutations in endoglin (ENG; HHT1) or activin receptor-like kinase (ALK1; HHT2) genes, coding for transforming growth factor-β (TGF-β) superfamily receptors. We demonstrated previously that endoglin and ALK1 interact with endothelial NO synth...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Jerkic M,Sotov V,Letarte M

    更新日期:2012-01-01 00:00:00

  • Preparation, Biosafety, and Cytotoxicity Studies of a Newly Tumor-Microenvironment-Responsive Biodegradable Mesoporous Silica Nanosystem Based on Multimodal and Synergistic Treatment.

    abstract::Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

    更新日期:2020-11-05 00:00:00

  • Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades.

    abstract::Inhibition of either P2Y12 receptor or the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome provides cardioprotective effects. Here, we investigate whether direct NLRP3 inflammasome inhibition exerts additive effects on myocardial protection induced by the ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Penna C,Aragno M,Cento AS,Femminò S,Russo I,Bello FD,Chiazza F,Collotta D,Alves GF,Bertinaria M,Zicola E,Mercurio V,Medana C,Collino M,Pagliaro P

    更新日期:2020-08-03 00:00:00

  • Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction.

    abstract::Endothelial dysfunction tends to be the initial indicator in proinflammatory state and macro- and microvascular complications, such as atherosclerosis and cardiovascular diseases. It has been shown that certain compounds in diet can generate beneficial effects on cardiovascular disease due to its interactions with end...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Stromsnes K,Mas-Bargues C,Gambini J,Gimeno-Mallench L

    更新日期:2020-08-06 00:00:00

  • Inhibitory Effect of Ursolic Acid on Ultraviolet B Radiation-Induced Oxidative Stress and Proinflammatory Response-Mediated Senescence in Human Skin Dermal Fibroblasts.

    abstract::Ultraviolet radiation is an environmental carcinogenic agent that enhances inflammation and immunological reactions in the exposed human skin cells leading to oxidative photoaging of the epidermal and dermal segment. In the present study, we investigated the protective role of ursolic acid (UA) against ultraviolet B (...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Samivel R,Nagarajan RP,Subramanian U,Khan AA,Masmali A,Almubrad T,Akhtar S

    更新日期:2020-06-15 00:00:00

  • Metabolomic Analysis Reveals That the Mechanism of Astaxanthin Improves the Osteogenic Differentiation Potential in Bone Marrow Mesenchymal Stem Cells.

    abstract::At present, little research has been done on the metabolic phenotype of the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. In this study, the effect of astaxanthin on improving osteogenic differentiation potential of mesenchymal stem cells was studied by metabolomics. Results showed that L-methioni...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhao G,Zhong H,Rao T,Pan Z

    更新日期:2020-03-25 00:00:00