Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases.

Abstract:

:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.

journal_name

Oxid Med Cell Longev

authors

Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

doi

10.1155/2020/2128513

subject

Has Abstract

pub_date

2020-06-17 00:00:00

pages

2128513

eissn

1942-0900

issn

1942-0994

journal_volume

2020

pub_type

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