Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats.

abstract：:Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticanc...

journal_title：Oxidative medicine and cellular longevity

authors： Li K,Zheng Q,Chen X,Wang Y,Wang D,Wang J

更新日期：2018-10-16 00:00:00

abstract：:Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from...

journal_title：Oxidative medicine and cellular longevity

authors： Del Campo A,Jaimovich E,Tevy MF

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS:The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Lau RC,Bennett RD

更新日期：2017-01-01 00:00:00

abstract：:Low back pain (LBP) is the leading cause of disability in the elderly. Intervertebral disc degeneration (IDD) was considered as the main cause for LBP. Degeneration of cartilaginous endplate was a crucial harmful factor during the initiation and development of IDD. Oxidative stress was implicated in IDD. However, the ...

journal_title：Oxidative medicine and cellular longevity

authors： Chen K,Lv X,Li W,Yu F,Lin J,Ma J,Xiao D

更新日期：2017-01-01 00:00:00

abstract：:Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Gaspar RS,Trostchansky A,Paes AM

更新日期：2016-01-01 00:00:00

abstract：:This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary ...

journal_title：Oxidative medicine and cellular longevity

authors： Moreto F,de Oliveira EP,Manda RM,Burini RC

更新日期：2014-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical event...

journal_title：Oxidative medicine and cellular longevity

authors： Angeloni C,Prata C,Dalla Sega FV,Piperno R,Hrelia S

更新日期：2015-01-01 00:00:00

abstract：:Viruses play an important role in cancerogenesis. It is estimated that approximately 20% of all cancers are linked to infectious agents. The viral genes modulate the physiological machinery of infected cells that lead to cell transformation and development of cancer. One of the important adoptive responses by the canc...

journal_title：Oxidative medicine and cellular longevity

authors： Mushtaq M,Darekar S,Kashuba E

更新日期：2016-01-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is a Ca+2-permeable channel expressed on neuronal and nonneuronal cells, known as an oxidative stress sensor. It plays a protective role in bacterial infection, and recent findings indicate that this receptor modulates monocyte populations in mice with malaria; however,...

journal_title：Oxidative medicine and cellular longevity

authors： Pereira DMS,Teixeira SA,Murillo O,Peixoto EPM,Araújo MC,Sousa NCF,Monteiro-Neto V,Calixto JB,Cunha TM,Marinho CRF,Muscará MN,Fernandes ES

更新日期：2019-05-16 00:00:00

abstract：:In the present study, we demonstrated that bone marrow mesenchymal stem cells (BMSCs) of the 3rd passage displayed the senescence-associated phenotypes characterized with increased activity of SA-β-gal, altered autophagy, and increased G1 cell cycle arrest, ROS production, and expression of p53 and p21Cip1/Waf1 compar...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang M,Du Y,Lu R,Shu Y,Zhao W,Li Z,Zhang Y,Liu R,Yang T,Luo S,Gao M,Zhang Y,Zhang G,Liu J,Lu Y

更新日期：2016-01-01 00:00:00

abstract：:Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be...

journal_title：Oxidative medicine and cellular longevity

authors： Picone P,Nuzzo D,Caruana L,Scafidi V,Di Carlo M

更新日期：2014-01-01 00:00:00

abstract：:We hypothesized that fibroblast growth factor-9 (FGF-9) would enhance angiogenesis via activating c-kit positive stem cells in the infarcted nondiabetic and diabetic heart. In brief, animals were divided into three groups: Sham, MI, and MI+FGF-9. Two weeks following MI or sham surgery, our data suggest that treatment ...

journal_title：Oxidative medicine and cellular longevity

authors： Singla D,Wang J

更新日期：2016-01-01 00:00:00

abstract：:Considering the various pharmacological activities of epigallocatechin-3-O-gallate (EGCG) including anticancer, and anti-inflammatory, antidiabetic, and so forth, relatively less attention has been paid to the antiaging effect of EGCG on primary cells. In this study, the preventive effects of EGCG against serial passa...

journal_title：Oxidative medicine and cellular longevity

authors： Han DW,Lee MH,Kim B,Lee JJ,Hyon SH,Park JC

更新日期：2012-01-01 00:00:00

abstract：AIM:Ginkgolide B is a Ginkgo biloba leaf extract that has been identified as a natural platelet-activating factor receptor (PAFR) antagonist. We investigated the effect of ginkgolide B on high glucose-induced TLR4 activation in human umbilical vein endothelial cells (HUVECs). METHODS:Protein expression was analyzed by...

journal_title：Oxidative medicine and cellular longevity

authors： Chen K,Sun W,Jiang Y,Chen B,Zhao Y,Sun J,Gong H,Qi R

更新日期：2017-01-01 00:00:00

abstract：:In plasma medicine, cold physical plasma delivers a delicate mixture of reactive components to cells and tissues. Recent studies suggested a beneficial role of cold plasma in wound healing. Yet, the biological processes related to the redox modulation via plasma are not fully understood. We here used the monocytic cel...

journal_title：Oxidative medicine and cellular longevity

authors： Bekeschus S,Schmidt A,Bethge L,Masur K,von Woedtke T,Hasse S,Wende K

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress (OS), a common intracellular phenomenon induced by excess reactive oxygen species (ROS) generation, has been shown to be associated with mammalian ovarian follicular development blockage and granulosa cell (GC) impairment. However, the mechanism involved in these effects remains unknown, and the effec...

journal_title：Oxidative medicine and cellular longevity

authors： Du X,Li Q,Cao Q,Wang S,Liu H,Li Q

更新日期：2019-11-04 00:00:00

abstract：:The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

journal_title：Oxidative medicine and cellular longevity

authors： Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

更新日期：2015-01-01 00:00:00

abstract：:Advanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence. Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to ...

journal_title：Oxidative medicine and cellular longevity

authors： Buttari B,Profumo E,Facchiano F,Ozturk EI,Segoni L,Saso L,Riganò R

更新日期：2013-01-01 00:00:00

abstract：:The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular...

journal_title：Oxidative medicine and cellular longevity

authors： Palacios J,Cifuentes F,Valderrama JA,Benites J,Ríos D,González C,Chiong M,Cartes-Saavedra B,Lafourcade C,Wyneken U,González P,Owen GI,Pardo F,Sobrevia L,Buc Calderon P

更新日期：2016-01-01 00:00:00

abstract：:Methionine sulfoxide reductase B1 (MsrB1) is a member of the selenoprotein family, which contributes to the reduction of methionine sulfoxides produced from reactive oxygen species (ROS) by redox processes in energy pathways. However, few studies have examined the role of MsrB1 in human hepatocellular carcinoma (HCC)....

journal_title：Oxidative medicine and cellular longevity

authors： He Q,Li H,Meng F,Sun X,Feng X,Chen J,Li L,Liu J

更新日期：2018-05-10 00:00:00

abstract：:The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group, n = 97) and RA patients (n = 173). RA patients were...

journal_title：Oxidative medicine and cellular longevity

authors： Costa NT,Veiga Iriyoda TM,Kallaur AP,Delongui F,Alfieri DF,Lozovoy MA,Amin RB,Delfino VD,Dichi I,Simão AN

更新日期：2016-01-01 00:00:00

abstract：Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

更新日期：2019-04-16 00:00:00

abstract：:NADPH oxidase (Nox) is considered a major source of reactive oxygen species (ROS) in the heart in normal and pathological conditions. However, the role of Nox in severe acute pancreatitis- (SAP-) associated cardiac injury remains unclear. Therefore, we aim to investigate the contribution of Nox to SAP-associated cardi...

journal_title：Oxidative medicine and cellular longevity

authors： Wen Y,Liu R,Lin N,Luo H,Tang J,Huang Q,Sun H,Tang L

更新日期：2019-05-09 00:00:00

abstract：:Type 2 diabetes (T2DM) and its complications constitute a major worldwide public health problem, with high rates of morbidity and mortality. Biomarkers for predicting the occurrence and development of the disease may therefore offer benefits in terms of early diagnosis and intervention. This review provides an overvie...

journal_title：Oxidative medicine and cellular longevity

authors： Bigagli E,Lodovici M

更新日期：2019-05-12 00:00:00

abstract：:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...

journal_title：Oxidative medicine and cellular longevity

authors： Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

更新日期：2014-01-01 00:00:00

abstract：:This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B. serrata was perform...

journal_title：Oxidative medicine and cellular longevity

authors： Bertocchi M,Isani G,Medici F,Andreani G,Tubon Usca I,Roncada P,Forni M,Bernardini C

更新日期：2018-06-25 00:00:00

abstract：:As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pres...

journal_title：Oxidative medicine and cellular longevity

authors： Li L,Obinata M,Hori K

更新日期：2010-01-01 00:00:00

abstract：:The study aimed to evaluate whether the treatment of primary cultured human endothelial cells with native low-density lipoprotein (nLDL) could induce their senescence and to uncover some of the putative mechanisms involved. For this purpose, human umbilical vein endothelial cells (HUVECs) were subcultured and/or conti...

journal_title：Oxidative medicine and cellular longevity

authors： Oh ST,Park H,Yoon HJ,Yang SY

更新日期：2017-01-01 00:00:00

abstract：:This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephr...

journal_title：Oxidative medicine and cellular longevity

authors： Arellano-Buendía AS,Tostado-González M,García-Arroyo FE,Cristóbal-García M,Loredo-Mendoza ML,Tapia E,Sánchez-Lozada LG,Osorio-Alonso H

更新日期：2016-01-01 00:00:00

abstract：:Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

journal_title：Oxidative medicine and cellular longevity

authors： Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

更新日期：2017-01-01 00:00:00