当前位置： SCI文献检索 > Oxidative Medicine and Cellular Longevity期刊下所有文献 > Long-Term Treatment of Native LDL Induces Senescence of Cultured Human Endothelial Cells.

Long-Term Treatment of Native LDL Induces Senescence of Cultured Human Endothelial Cells.

Abstract：

:The study aimed to evaluate whether the treatment of primary cultured human endothelial cells with native low-density lipoprotein (nLDL) could induce their senescence and to uncover some of the putative mechanisms involved. For this purpose, human umbilical vein endothelial cells (HUVECs) were subcultured and/or continuously cultured with nLDL (0, 2, 5, and 10 μg protein/mL), for up to 9 days. The results indicated that nLDL inhibited the proliferation of HUVECs by arresting the cell cycle at G1 phase. The G1-arrested cells showed increase in cytosolic senescence-associated-β-galactosidase (SA-β-Gal) activity, a biomarker of cellular senescence. The causative factor of the cellular senescence was nLDL itself and not oxidized LDL (oxLDL), since blocking LDL receptor (LDLR) with the anti-LDLR antibody opposed the nLDL-induced increase of SA-β-Gal activity and decrease of cellular proliferation. In addition, nLDL-induced cellular senescence by inhibiting the phosphorylation of pRb (G1 arrest) via p53 as well as p16 signal transduction pathways. G1 phase arrest of the senescent cells was not overcome by nLDL removal from the culture medium. Moreover, the nLDL-treated cells produced reactive oxygen species (ROS) dose- and time-dependently. These results suggested, for the first time, that long-term treatment of nLDL could induce the premature senescence of endothelial cells.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Oh ST,Park H,Yoon HJ,Yang SY

doi

10.1155/2017/6487825

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

6487825

eissn

1942-0900

issn

1942-0994

journal_volume

2017

pub_type

杂志文章

相关文献

Oxidative Medicine and Cellular Longevity文献大全
  • Pu-erh Tea Ameliorates Atherosclerosis Associated with Promoting Macrophage Apoptosis by Reducing NF-κB Activation in ApoE Knockout Mice.

    abstract：:We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE-/-) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean prop...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/3197829

    authors： Xiao Y,He M,Liang X,She J,He L,Liu Y,Zou J,Yuan Z

    更新日期：2018-08-23 00:00:00

  • Higher Urinary Levels of 8-Hydroxy-2'-deoxyguanosine Are Associated with a Worse RANKL/OPG Ratio in Postmenopausal Women with Osteopenia.

    abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/6038798

    authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

    更新日期：2016-01-01 00:00:00

  • hCLOCK Causes Rho-Kinase-Mediated Endothelial Dysfunction and NF-κB-Mediated Inflammatory Responses.

    abstract：BACKGROUND:The human Circadian Locomotor Output Cycle protein Kaput (CLOCK) gene was originally discovered as a regulator of essential human daily rhythms. This seemingly innocuous gene was then found to be associated with a multitude of human malignancies, via several biochemical pathways. We aimed to further investig...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2015/671839

    authors： Tang X,Guo D,Lin C,Shi Z,Qian R,Fu W,Liu J,Li X,Fan L

    更新日期：2015-01-01 00:00:00

  • Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice.

    abstract：:As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pres...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.4161/oxim.3.1.10094

    authors： Li L,Obinata M,Hori K

    更新日期：2010-01-01 00:00:00

  • Fish Scale Collagen Peptides Protect against CoCl2/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.

    abstract：:Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/9703609

    authors： Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

    更新日期：2017-01-01 00:00:00

  • Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena.

    abstract：:Mesenchymal stem cells (MSCs) have shown beneficial effects in the treatment of abdominal aortic aneurysm (AAA). Nonetheless, the biological properties of adipose-derived MSCs (ASCs) from patients with AAA (AAA-ASCs) remain unclear. This study is aimed at investigating the properties of cell phenotype and function of ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/1305049

    authors： Huang X,Zhang H,Liang X,Hong Y,Mao M,Han Q,He H,Tao W,Jiang G,Zhang Y,Li X

    更新日期：2019-11-25 00:00:00

  • Integrated Metabolomic and Lipidomic Analysis Reveals the Neuroprotective Mechanisms of Bushen Tiansui Formula in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.

    abstract：:Bushen Tiansui Formula (BSTSF) is a traditional Chinese medicine prescription. It has been widely applied to treat Alzheimer's disease (AD) in the clinic; however, the mechanisms underlying its effects remain largely unknown. In this study, we used a rat AD model to study the effects of BSTSF on cognitive performance,...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/5243453

    authors： Yi M,Zhang C,Zhang Z,Yi P,Xu P,Huang J,Peng W

    更新日期：2020-06-19 00:00:00

  • Oxidative stresses and mitochondrial dysfunction in age-related hearing loss.

    abstract：:Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Ma...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2014/582849

    authors： Fujimoto C,Yamasoba T

    更新日期：2014-01-01 00:00:00

  • Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome.

    abstract：:Chrysanthellum americanum L. (Vatke) is a medicinal plant from the Compositae family used in west-African traditional medicine, known for its flavonoid and saponin richness and for its strong antioxidant potential. In the present study, we assessed the effects of Chrysanthellum americanum polyphenolic extract in the p...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/3492767

    authors： Cojocariu R,Ciobica A,Balmus IM,Guenne S,Trifan A,Stanciu C,Hrițcu L,Lefter R

    更新日期：2019-08-14 00:00:00

  • Glutathione as a Biomarker in Parkinson's Disease: Associations with Aging and Disease Severity.

    abstract：:Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/9409363

    authors： Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

    更新日期：2016-01-01 00:00:00

  • Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.

    abstract：:Accumulating evidence has demonstrated that oxidative stress is associated with depression. Our present study aimed at investigating the antidepressant effect and the possible mechanisms of curcumin (CUR) in chronic unpredictable mild stress- (CUMS-) induced depression model in rats. After exposure to CUMS for four we...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/9268083

    authors： Liao D,Lv C,Cao L,Yao D,Wu Y,Long M,Liu N,Jiang P

    更新日期：2020-09-17 00:00:00

  • A novel contrast-induced acute kidney injury model based on the 5/6-nephrectomy rat and nephrotoxicological evaluation of iohexol and iodixanol in vivo.

    abstract：:Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media. Proper animal models of CI-AKI can help understand the mechanisms involved and prevent the disorder. We used the 5/6-nephrectomized (NE) rat to develop a CI-AKI model and to evaluate di...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/427560

    authors： Liu TQ,Luo WL,Tan X,Fang Y,Chen J,Zhang H,Yu XF,Cai JR,Ding XQ

    更新日期：2014-01-01 00:00:00

  • Corrigendum to "Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress".

    abstract：:[This corrects the article DOI: 10.1155/2017/3027109.]. ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 已发布勘误

    doi：10.1155/2017/1083618

    authors： Nawrocka D,Kornicka K,Szydlarska J,Marycz K

    更新日期：2017-01-01 00:00:00

  • Cytotoxic, Antioxidant, and Metabolic Enzyme Inhibitory Activities of Euphorbia cyparissias Extracts.

    abstract：:Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipa...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/9835167

    authors： Alonazi M,Horchani H,Alwhibi M,Ben Bacha A

    更新日期：2020-10-29 00:00:00

  • The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease.

    abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2015/604658

    authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

    更新日期：2015-01-01 00:00:00

  • Polyphenols in exercise performance and prevention of exercise-induced muscle damage.

    abstract：:Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2013/825928

    authors： Malaguti M,Angeloni C,Hrelia S

    更新日期：2013-01-01 00:00:00

  • Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients.

    abstract：:Ascorbate requiring Fe2+/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in the endomembranes of fibroblasts from arterial tortuosity syndrome (AT...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/8156592

    authors： Németh CE,Nemoda Z,Lőw P,Szabó P,Horváth EZ,Willaert A,Boel A,Callewaert BL,Coucke PJ,Colombi M,Bánhegyi G,Margittai É

    更新日期：2019-01-13 00:00:00

  • Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications.

    abstract：:During pregnancy, the adaptive changes in uterine circulation and the formation of the placenta are essential for the growth of the fetus and the well-being of the mother. The steroid hormone estrogen plays a pivotal role in this adaptive process. An insufficient blood supply to the placenta due to uteroplacental dysf...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2019/9194269

    authors： Hu XQ,Song R,Zhang L

    更新日期：2019-02-10 00:00:00

  • Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.

    abstract：:Hydrogen sulfide (H2S) is a gasotransmitter with a variety of cardiovascular protective effects. Sirtuin 3 (SIRT3) is closely related to mitochondrial function and oxidative stress. We found that NaHS increased SIRT3 expression in the preventive effect on isoproterenol- (ISO-) induced myocardial hypertrophy. We furthe...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/9396089

    authors： Zhang J,Yu J,Chen Y,Liu L,Xu M,Sun L,Luo H,Wang Y,Meng G

    更新日期：2018-12-17 00:00:00

  • Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis.

    abstract：:MicroRNAs are short (21-23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reporte...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2016/6021934

    authors： Giudice A,D'Arena G,Crispo A,Tecce MF,Nocerino F,Grimaldi M,Rotondo E,D'Ursi AM,Scrima M,Galdiero M,Ciliberto G,Capunzo M,Franci G,Barbieri A,Bimonte S,Montella M

    更新日期：2016-01-01 00:00:00

  • MitoTEMPO Prevents Oxalate Induced Injury in NRK-52E Cells via Inhibiting Mitochondrial Dysfunction and Modulating Oxidative Stress.

    abstract：:As one of the major risks for urolithiasis, hyperoxaluria can be caused by genetic defect or dietary intake. And high oxalate induced renal epithelial cells injury is related to oxidative stress and mitochondrial dysfunction. Here, we investigated whether MitoTEMPO, a mitochondria-targeted antioxidant, could protect a...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/7528090

    authors： Zhang J,Wang Q,Xu C,Lu Y,Hu H,Qin B,Wang Y,He D,Li C,Yu X,Wang S,Liu J

    更新日期：2017-01-01 00:00:00

  • Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells.

    abstract：:This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B. serrata was perform...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/2504305

    authors： Bertocchi M,Isani G,Medici F,Andreani G,Tubon Usca I,Roncada P,Forni M,Bernardini C

    更新日期：2018-06-25 00:00:00

  • Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence.

    abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%. However, the disease mechanism remains unclear, and no effective treatment is available. Paricalcitol has been reported to be effective in animal models of kidney injury. We hypoth...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/7627934

    authors： Bae E,Kim JH,Jung MH,Jang SJ,Lee TW,Jung S,Lee S,Jang HN,Chang SH,Park DJ

    更新日期：2020-11-23 00:00:00

  • Role of Diet and Nutritional Supplements in Parkinson's Disease Progression.

    abstract：OBJECTIVES:The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS:The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/6405278

    authors： Mischley LK,Lau RC,Bennett RD

    更新日期：2017-01-01 00:00:00

  • Roles of TRP Channels in Neurological Diseases.

    abstract：:Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the ce...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2020/7289194

    authors： Wang R,Tu S,Zhang J,Shao A

    更新日期：2020-09-04 00:00:00

  • Antioxidant and Neuroprotective Properties of Eugenia dysenterica Leaves.

    abstract：:Eugenia dysenterica ex DC Mart. (Myrtaceae), popularly known as "cagaita," is a Brazilian plant rich in polyphenols and other antioxidant compounds. Aiming to evaluate the potential use of cagaita in pathologies involving oxidative stress, such as neurodegenerative disorders, this study investigated its antioxidant po...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/3250908

    authors： Thomaz DV,Peixoto LF,de Oliveira TS,Fajemiroye JO,da Silva Neri HF,Xavier CH,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

    更新日期：2018-09-19 00:00:00

  • TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans.

    abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a ce...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2015/124357

    authors： Büchter C,Zhao L,Havermann S,Honnen S,Fritz G,Proksch P,Wätjen W

    更新日期：2015-01-01 00:00:00

  • Cultivation and Immortalization of Human B-Cells Producing a Human Monoclonal IgM Antibody Binding to MDA-LDL: Further Evidence for Formation of Atherogenic MDA-LDL Adducts in Humans In Vivo.

    abstract：:Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/6047142

    authors： Tatzber F,Pursch E,Resch U,Pfragner R,Holasek S,Lindschinger M,Cvirn G,Wonisch W

    更新日期：2017-01-01 00:00:00

  • Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway.

    abstract：:Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF-κB and TNF-α have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-κB and TNF-α remain unknown. Exosomes have been ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/9739258

    authors： Zhu B,Zhang L,Liang C,Liu B,Pan X,Wang Y,Zhang Y,Zhang Y,Xie W,Yan B,Liu F,Yip HK,Yu XY,Li Y

    更新日期：2019-04-08 00:00:00

  • The Utility of Ovotransferrin and Ovotransferrin-Derived Peptides as Possible Candidates in the Clinical Treatment of Cardiovascular Diseases.

    abstract：:Several of the most prevalent etiological factors which contribute towards global death rates are associated with cardiovascular diseases (CVDs), which include a range of conditions such as angina, rheumatic heart disease, and venous thrombosis. Extensive research has been conducted into the role played by oxidative s...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2017/6504518

    authors： Chen S,Jiang H,Peng H,Wu X,Fang J

    更新日期：2017-01-01 00:00:00