当前位置： SCI文献检索 > Oxidative Medicine and Cellular Longevity期刊下所有文献 > Resveratrol inhibits phenotype modulation by platelet derived growth factor-bb in rat aortic smooth muscle cells.

Resveratrol inhibits phenotype modulation by platelet derived growth factor-bb in rat aortic smooth muscle cells.

Abstract：

:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of platelet derived growth factor-bb (PDGF-bb) in rat aortic vascular smooth muscle cells (RAOSMCs). Treatment of RAOSMCs with resveratrol showed dose-dependent inhibition of PDGF-bb-stimulated proliferation. Resveratrol treatment inhibited this phenotype change and disassembly of actin filaments and maintained the expression of contractile phenotype-related proteins such as calponin and smooth muscle actin-alpha in comparison with only PDGF-bb stimulated RAOSMC. Although PDGF stimulation elicited strong and detectable Akt and mTOR phosphorylations lasting for several hours, Akt activation was much weaker when PDGF was used with resveratrol. In contrast, resveratrol only slightly inhibited phosphorylations of 42/44 MAPK and p38 MAPK. In conclusion, RAOSMC dedifferentiation, phenotype, and proliferation rate were inhibited by resveratrol via interruption of the balance of Akt, 42/44MAPK, and p38MAPK pathway activation stimulated by PDGF-bb.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

doi

10.1155/2014/572430

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

572430

eissn

1942-0900

issn

1942-0994

journal_volume

2014

pub_type

杂志文章

相关文献

Oxidative Medicine and Cellular Longevity文献大全
  • Oxidative Stress Markers and Their Dynamic Changes in Patients after Acute Ischemic Stroke.

    abstract：:We have focused on determining the range of oxidative stress biomarkers and their dynamic changes in patients at different time points after the acute ischemic stroke (AIS). 82 patients with AIS were involved in our study and were tested: within 24 h from the onset of the attack (group A); at 7-day follow-up (group B)...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/9761697

    authors： Žitňanová I,Šiarnik P,Kollár B,Chomová M,Pazderová P,Andrezálová L,Ježovičová M,Koňariková K,Laubertová L,Krivošíková Z,Slezáková L,Turčáni P

    更新日期：2016-01-01 00:00:00

  • Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.

    abstract：:The infiltration of red blood cells into atheromatous plaques is implicated in atherogenesis. Inside the lesion, hemoglobin (Hb) is oxidized to ferri- and ferrylHb which exhibit prooxidant and proinflammatory activities. Cystathione gamma-lyase- (CSE-) derived H2S has been suggested to possess various antiatherogenic ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/3812568

    authors： Potor L,Nagy P,Méhes G,Hendrik Z,Jeney V,Pethő D,Vasas A,Pálinkás Z,Balogh E,Gyetvai Á,Whiteman M,Torregrossa R,Wood ME,Olvasztó S,Nagy P,Balla G,Balla J

    更新日期：2018-01-21 00:00:00

  • The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway.

    abstract：:Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have be...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2019/5470470

    authors： Aquila G,Marracino L,Martino V,Calabria D,Campo G,Caliceti C,Rizzo P

    更新日期：2019-05-02 00:00:00

  • Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia.

    abstract：Background/Aims:Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal hormone levels in peripheral blood and poor-quality oocytes. PCOS is a pathophysiological syndrome caused by chronic inflammation and oxidative stress. The aim of this study was to investigate the mechanism of melatonin ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/8218650

    authors： Yu K,Wang RX,Li MH,Sun TC,Zhou YW,Li YY,Sun LH,Zhang BL,Lian ZX,Xue SG,Liu YX,Deng SL

    更新日期：2019-10-20 00:00:00

  • Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway.

    abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regu...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/4825949

    authors： Chu Q,Zhang S,Chen M,Han W,Jia R,Chen W,Zheng X

    更新日期：2019-02-25 00:00:00

  • Oxidative Stress and Microvascular Alterations in Diabetic Retinopathy: Future Therapies.

    abstract：:Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin. However, patients' metabolic control is inadequate in a high percentage of them and a major cause of chronic diseases like diabetic retinopathy. Approximately 15% of patients have some degree of diabetic retinopathy when diabetes i...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2019/4940825

    authors： Rodríguez ML,Pérez S,Mena-Mollá S,Desco MC,Ortega ÁL

    更新日期：2019-11-11 00:00:00

  • The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling.

    abstract：:Lung cancer is a leading cause of cancer death worldwide, and non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancer, which is highly metastatic, leading to the poor survival rate of patients. We recently reported that 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), a phenoxyphenol, exerts antihepatoma eff...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/5167292

    authors： Liu W,Wu CY,Lu MJ,Chuang YJ,Tsai EM,Leu S,Lin IL,Ko CJ,Chiu CC,Chang WT

    更新日期：2020-01-07 00:00:00

  • Cultivation and Immortalization of Human B-Cells Producing a Human Monoclonal IgM Antibody Binding to MDA-LDL: Further Evidence for Formation of Atherogenic MDA-LDL Adducts in Humans In Vivo.

    abstract：:Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/6047142

    authors： Tatzber F,Pursch E,Resch U,Pfragner R,Holasek S,Lindschinger M,Cvirn G,Wonisch W

    更新日期：2017-01-01 00:00:00

  • Resveratrol prevents dendritic cell maturation in response to advanced glycation end products.

    abstract：:Advanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence. Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2013/574029

    authors： Buttari B,Profumo E,Facchiano F,Ozturk EI,Segoni L,Saso L,Riganò R

    更新日期：2013-01-01 00:00:00

  • Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades.

    abstract：:Inhibition of either P2Y12 receptor or the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome provides cardioprotective effects. Here, we investigate whether direct NLRP3 inflammasome inhibition exerts additive effects on myocardial protection induced by the ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/9219825

    authors： Penna C,Aragno M,Cento AS,Femminò S,Russo I,Bello FD,Chiazza F,Collotta D,Alves GF,Bertinaria M,Zicola E,Mercurio V,Medana C,Collino M,Pagliaro P

    更新日期：2020-08-03 00:00:00

  • Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives.

    abstract：:Undiminishing actuality of enzyme modification for therapeutic purposes has been confirmed by application of modified enzymes in clinical practice and numerous research data on them. Intravenous injection of the superoxide dismutase-chondroitin sulfate-catalase (SOD-CHS-CAT) conjugate in preventive and medicative regi...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2016/3075695

    authors： Maksimenko AV

    更新日期：2016-01-01 00:00:00

  • Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer.

    abstract：:The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy f...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/2148562

    authors： Barquilha CN,Santos NJ,Monção CCD,Barbosa IC,Lima FO,Justulin LA,Pértega-Gomes N,Felisbino SL

    更新日期：2020-01-20 00:00:00

  • Increased Oxidative Damage of RNA in Early-Stage Nephropathy in db/db Mice.

    abstract：:To evaluate RNA oxidation in the early stage of diabetic nephropathy, we applied an accurate method based on isotope dilution high-performance liquid chromatography-triple quadruple mass spectrometry to analyze the oxidatively generated guanine nucleosides in renal tissue and urine from db/db mice of different ages. W...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/2353729

    authors： Wang WX,Luo SB,Jiang P,Xia MM,Hei AL,Mao YH,Li CB,Hu GX,Cai JP

    更新日期：2017-01-01 00:00:00

  • Exposure to Ti4Al4V Titanium Alloy Leads to Redox Abnormalities, Oxidative Stress, and Oxidative Damage in Patients Treated for Mandible Fractures.

    abstract：:Due to the high biotolerance, favourable mechanical properties, and osseointegration ability, titanium is the basic biomaterial used in maxillofacial surgery. The passive layer of titanium dioxide on the surface of the implant effectively provides anticorrosive properties, but it can be damaged, resulting in the relea...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/3714725

    authors： Borys J,Maciejczyk M,Antonowicz B,Krętowski A,Waszkiel D,Bortnik P,Czarniecka-Bargłowska K,Kocisz M,Szulimowska J,Czajkowski M,Waszkiewicz N,Zalewska A

    更新日期：2018-06-14 00:00:00

  • Intestinal oxidative state can alter nutrient and drug bioavailability.

    abstract：:Organic cations (OCs) are substances of endogenous (e.g. dopamine, choline) or exogenous (e.g. drugs like cimetidine) origin that are positively charged at physiological pH. Since many of these compounds can not pass the cell membrane freely, their transport in our out of cells must be mediated by specific transport s...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.4161/oxim.2.5.9769

    authors： Faria A,Monteiro R,Pestana D,Freitas Vd,Mateus N,Azevedo I,Calhau C

    更新日期：2009-11-01 00:00:00

  • 3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome.

    abstract：Background:Obesity is a growing epidemic with limited effective treatments and an important risk factor for several diseases such as metabolic syndrome (MetS). In this study, we aimed to investigate the effect of 3-amino-1,2,4-triazole (ATZ), an inhibitor of catalase and heme synthesis, in a murine model for MetS. Met...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/3025361

    authors： Nunes-Souza V,Dias-Júnior NM,Eleutério-Silva MA,Ferreira-Neves VP,Moura FA,Alenina N,Bader M,Rabelo LA

    更新日期：2020-04-13 00:00:00

  • Chidamide Inhibits Glioma Cells by Increasing Oxidative Stress via the miRNA-338-5p Regulation of Hedgehog Signaling.

    abstract：Objective:Chidamide has a broad spectrum of antitumor activity but its function on glioma remains unknown. The increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS) may control glioma risk by promoting its apoptosis and necrosis. Hedgehog pathway is crucial to glioma cell proliferation and contr...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/7126976

    authors： Zhou H,Han L,Wang H,Wei J,Guo Z,Li Z

    更新日期：2020-03-11 00:00:00

  • NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways.

    abstract：:We have demonstrated that neural progenitor cells (NPCs) protect endothelial cells (ECs) from oxidative stress. Since exosomes (EXs) can convey the benefit of parent cells through their carried microRNAs (miRs) and miR-210 is ubiquitously expressed with versatile functions, we investigated the role of miR-210 in the e...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/9397631

    authors： Liu H,Wang J,Chen Y,Chen Y,Ma X,Bihl JC,Yang Y

    更新日期：2017-01-01 00:00:00

  • Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs.

    abstract：AIM:Ginkgolide B is a Ginkgo biloba leaf extract that has been identified as a natural platelet-activating factor receptor (PAFR) antagonist. We investigated the effect of ginkgolide B on high glucose-induced TLR4 activation in human umbilical vein endothelial cells (HUVECs). METHODS:Protein expression was analyzed by...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/9371602

    authors： Chen K,Sun W,Jiang Y,Chen B,Zhao Y,Sun J,Gong H,Qi R

    更新日期：2017-01-01 00:00:00

  • Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary.

    abstract：:Glucocorticoid (GC) production is physiologically regulated through a negative feedback loop mediated by the GC, which appear disrupted in several pathological conditions. The inability to perform negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in several diseases is associated with an overproductio...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/4156361

    authors： Prevatto JP,Torres RC,Diaz BL,Silva PMRE,Martins MA,Carvalho VF

    更新日期：2017-01-01 00:00:00

  • Short-Term Effects of Chlorpromazine on Oxidative Stress in Erythrocyte Functionality: Activation of Metabolism and Membrane Perturbation.

    abstract：:The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic ef...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/2394130

    authors： Ficarra S,Russo A,Barreca D,Giunta E,Galtieri A,Tellone E

    更新日期：2016-01-01 00:00:00

  • SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1α.

    abstract：:Reactive oxygen species (ROS) production in hepatic ischemia-reperfusion injury (IRI) is a complex process where multiple cellular and molecular pathways are involved. Few of those molecular pathways are under the direct influence of SIRT3 and its downstream mediators. SIRT3 plays a major role in the mechanism of IRI,...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2018/2976957

    authors： Katwal G,Baral D,Fan X,Weiyang H,Zhang X,Ling L,Xiong Y,Ye Q,Wang Y

    更新日期：2018-11-13 00:00:00

  • Malondialdehyde and Uric Acid as Predictors of Adverse Outcome in Patients with Chronic Heart Failure.

    abstract：:In chronic heart failure (HF), some parameters of oxidative stress are correlated with disease severity. The aim of this study was to evaluate the importance of oxidative stress biomarkers in prognostic risk stratification (death and combined endpoint: heart transplantation or death). In 774 patients, aged 48-59 years...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/9246138

    authors： Romuk E,Wojciechowska C,Jacheć W,Zemła-Woszek A,Momot A,Buczkowska M,Rozentryt P

    更新日期：2019-10-09 00:00:00

  • Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway.

    abstract：:Approximately 90% of male diabetes mellitus patients have varying degrees of testicular dysfunction. The molecular mechanism underlying diabetes-induced testicular damage has not been thoroughly elucidated. In this research, we sought to determine the influence of metformin (Met) on diabetes-induced testicular injury ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/5681701

    authors： Liu Y,Yang Z,Kong D,Zhang Y,Yu W,Zha W

    更新日期：2019-11-28 00:00:00

  • Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition.

    abstract：:Methionine sulfoxide reductase B1 (MsrB1) is a member of the selenoprotein family, which contributes to the reduction of methionine sulfoxides produced from reactive oxygen species (ROS) by redox processes in energy pathways. However, few studies have examined the role of MsrB1 in human hepatocellular carcinoma (HCC)....

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/5287971

    authors： He Q,Li H,Meng F,Sun X,Feng X,Chen J,Li L,Liu J

    更新日期：2018-05-10 00:00:00

  • The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats.

    abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/2745352

    authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

    更新日期：2019-03-26 00:00:00

  • Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats.

    abstract：Purpose:Oxidative stress induced by reduced blood circulation is a critical pathological damage to retinal ganglion cells (RGCs) in glaucoma. We previously showed that green tea extract (GTE) and its catechin constituents alleviate sodium iodate-induced retinal degeneration in rats. Here, we investigated the therapeuti...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/8407206

    authors： Yang Y,Xu C,Chen Y,Liang JJ,Xu Y,Chen SL,Huang S,Yang Q,Cen LP,Pang CP,Sun XH,Ng TK

    更新日期：2019-07-09 00:00:00

  • Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model.

    abstract：:To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in bot...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/4139851

    authors： Marciniak A,Walczyna B,Rajtar G,Marciniak S,Wojtak A,Lasiecka K

    更新日期：2016-01-01 00:00:00

  • Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme.

    abstract：:Oleuropein (OP) is a bioactive compound derived from plants of the genus Oleaceae exhibiting antitumor properties in several human cancers, including non-small-cell lung cancer (NSCLC). Recent evidence suggests that OP has proapoptotic effects on NSCLC cells via the mitochondrial apoptotic pathway. However, the exact ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/8576961

    authors： Antognelli C,Frosini R,Santolla MF,Peirce MJ,Talesa VN

    更新日期：2019-07-22 00:00:00

  • Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats.

    abstract：:Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immun...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/5724046

    authors： Luck C,DeMarco VG,Mahmood A,Gavini MP,Pulakat L

    更新日期：2017-01-01 00:00:00