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Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice.

Abstract：

:As a member of peroxiredoxin (Prx) family, PrxIII has been demonstrated to play an important role in scavenging intracellular reactive oxygen species (ROS). Since PrxIII knockout mice exhibited oxidative stress in placentas resembling pathophysiologic changes in placentas of human pre-eclampsia, we measured blood pressure through the carotid artery and detected oxidative status by Western blotting in pregnant mice. We did not notice hypertension in pregnant PrxIII knockout mice as compared with wild-type littermates, although endothelin-1 was over-expressed in PrxIII-deficient placentas. Our results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Li L,Obinata M,Hori K

doi

10.4161/oxim.3.1.10094

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

71-3

issue

1

eissn

1942-0900

issn

1942-0994

pii

10094

journal_volume

3

pub_type

杂志文章

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