Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes.

abstract：:This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephr...

journal_title：Oxidative medicine and cellular longevity

authors： Arellano-Buendía AS,Tostado-González M,García-Arroyo FE,Cristóbal-García M,Loredo-Mendoza ML,Tapia E,Sánchez-Lozada LG,Osorio-Alonso H

更新日期：2016-01-01 00:00:00

abstract：:Aging leads to a number of disadvantageous changes in the cardiovascular system. Deterioration of vascular homoeostasis with increase in oxidative stress, chronic low-grade inflammation, and impaired nitric oxide bioavailability results in endothelial dysfunction, increased vascular stiffness, and compromised arterial...

journal_title：Oxidative medicine and cellular longevity

authors： Rammos C,Totzeck M,Deenen R,Köhrer K,Kelm M,Rassaf T,Hendgen-Cotta UB

更新日期：2015-01-01 00:00:00

abstract：:Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y,...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos KC,Cury SS,Ferraz APCR,Corrente JE,Gonçalves BM,de Araújo Machado LH,Carvalho RF,de Melo Stevanato Nakamune AC,Fabro AT,Freire PP,Corrêa CR

更新日期：2018-04-10 00:00:00

abstract：:The present study discusses about the effects of a combination of probiotics able to stimulate the immune system of patients affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To this purpose, patients diagnosed according to Fukuda's criteria and treated with probiotics were analyzed by means of ...

journal_title：Oxidative medicine and cellular longevity

authors： Venturini L,Bacchi S,Capelli E,Lorusso L,Ricevuti G,Cusa C

更新日期：2019-11-23 00:00:00

abstract：:GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

journal_title：Oxidative medicine and cellular longevity

authors： Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

更新日期：2017-01-01 00:00:00

abstract：:Several lines of investigation have implicated oxidative stress in Parkinson's disease (PD) pathogenesis, but the mechanisms involved are still unclear. In this study, we characterized the involvement of NADPH oxidase (Nox), a multisubunit enzyme that catalyzes the reduction of oxygen, in the 6-hydroxydopamine- (6-OHD...

journal_title：Oxidative medicine and cellular longevity

authors： Hernandes MS,Café-Mendes CC,Britto LR

更新日期：2013-01-01 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been ...

journal_title：Oxidative medicine and cellular longevity

authors： Kong X,Liu CX,Wang GD,Yang H,Yao XM,Hua Q,Li XY,Zhang HM,Ma MZ,Su Q,Lv K

更新日期：2019-10-14 00:00:00

abstract：:Increased follicular atresia occurs with aging and results in reduced fecundity in laying chickens. Therefore, relieving follicular atresia of aging poultry is a crucial measure to maintain sustained high laying performance. As an antiaging agent, metformin was reported to play important roles in preventing aging in d...

journal_title：Oxidative medicine and cellular longevity

authors： Yao J,Ma Y,Zhou S,Bao T,Mi Y,Zeng W,Li J,Zhang C

更新日期：2020-11-26 00:00:00

abstract：Background/Aims:Obesity, which is related to increased oxidative stress in various tissues, is a risk factor for male infertility. Metformin is reported to have an antioxidant effect; however, the precise role of metformin in obesity-induced male infertility remains unknown. The current study is aimed at exploring the ...

journal_title：Oxidative medicine and cellular longevity

authors： Ye J,Luo D,Xu X,Sun M,Su X,Tian Z,Zhang M,Yu C,Guan Q

更新日期：2019-09-10 00:00:00

abstract：:Hydrogen sulfide (H2S), a toxic gaseous molecule, plays a physiological role in regulating homeostasis and cell signaling. H2S is produced from cysteine by enzymes, such as cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST). The...

journal_title：Oxidative medicine and cellular longevity

authors： Shefa U,Kim MS,Jeong NY,Jung J

更新日期：2018-02-04 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/4824371.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Song TY,Yang NC,Chen CL,Thi TLV

更新日期：2019-08-06 00:00:00

abstract：AIM:Ginkgolide B is a Ginkgo biloba leaf extract that has been identified as a natural platelet-activating factor receptor (PAFR) antagonist. We investigated the effect of ginkgolide B on high glucose-induced TLR4 activation in human umbilical vein endothelial cells (HUVECs). METHODS:Protein expression was analyzed by...

journal_title：Oxidative medicine and cellular longevity

authors： Chen K,Sun W,Jiang Y,Chen B,Zhao Y,Sun J,Gong H,Qi R

更新日期：2017-01-01 00:00:00

abstract：:There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessa...

journal_title：Oxidative medicine and cellular longevity

authors： Rosales-Corral S,Tan DX,Manchester L,Reiter RJ

更新日期：2015-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

journal_title：Oxidative medicine and cellular longevity

authors： Hsueh CY,Shao M,Cao W,Li S,Zhou L

更新日期：2019-04-16 00:00:00

abstract：:Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

journal_title：Oxidative medicine and cellular longevity

authors： Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

更新日期：2019-02-17 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter with a variety of cardiovascular protective effects. Sirtuin 3 (SIRT3) is closely related to mitochondrial function and oxidative stress. We found that NaHS increased SIRT3 expression in the preventive effect on isoproterenol- (ISO-) induced myocardial hypertrophy. We furthe...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Yu J,Chen Y,Liu L,Xu M,Sun L,Luo H,Wang Y,Meng G

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:It has been known that cardiac surgery induces an oxidative stress. The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support. Total antioxidant capacity...

journal_title：Oxidative medicine and cellular longevity

authors： Kunt AS,Andac MH

更新日期：2012-01-01 00:00:00

abstract：:Organic cations (OCs) are substances of endogenous (e.g. dopamine, choline) or exogenous (e.g. drugs like cimetidine) origin that are positively charged at physiological pH. Since many of these compounds can not pass the cell membrane freely, their transport in our out of cells must be mediated by specific transport s...

journal_title：Oxidative medicine and cellular longevity

authors： Faria A,Monteiro R,Pestana D,Freitas Vd,Mateus N,Azevedo I,Calhau C

更新日期：2009-11-01 00:00:00

abstract：:We aimed to evaluate the cardioprotective effect and mechanism of propofol in anthracycline-induced cardiomyocyte apoptosis. We selected the rat myocardial cell line, H9c2, and primary cardiomyocytes for in vitro study. The cardiomyocytes were treated with vehicle, Adriamycin® (ADM), propofol, or a combination of ADM ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao H,Zhang X,Zheng Y,Li Y,Wang X,Hu N,Zhou P,Wang K

更新日期：2018-04-18 00:00:00

abstract：:Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis that bone morphogenetic protein 4 (BMP4) m...

journal_title：Oxidative medicine and cellular longevity

authors： Yang X,Niu N,Liang C,Wu MM,Tang LL,Wang QS,Lou J,Song BL,Zheng WW,Ma HP,Zhang ZR

更新日期：2020-10-28 00:00:00

abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%. However, the disease mechanism remains unclear, and no effective treatment is available. Paricalcitol has been reported to be effective in animal models of kidney injury. We hypoth...

journal_title：Oxidative medicine and cellular longevity

authors： Bae E,Kim JH,Jung MH,Jang SJ,Lee TW,Jung S,Lee S,Jang HN,Chang SH,Park DJ

更新日期：2020-11-23 00:00:00

abstract：:The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group, n = 97) and RA patients (n = 173). RA patients were...

journal_title：Oxidative medicine and cellular longevity

authors： Costa NT,Veiga Iriyoda TM,Kallaur AP,Delongui F,Alfieri DF,Lozovoy MA,Amin RB,Delfino VD,Dichi I,Simão AN

更新日期：2016-01-01 00:00:00

abstract：:Tau, a microtubule-associated protein expressed in mature neurons, interacts with tubulin to promote the assembly and stabilization of microtubules. However, abnormally hyperphosphorylated tau dissociates from microtubules and self-aggregates. Tau aggregates, including paired helical filaments and neurofibrillary tang...

journal_title：Oxidative medicine and cellular longevity

authors： Shin SJ,Park YH,Jeon SG,Kim S,Nam Y,Oh SM,Lee YY,Moon M

更新日期：2020-06-30 00:00:00

abstract：Background:Amino acids (AAs) in cerebrospinal fluid (CSF) play a pivotal role in cerebral ischemia (CI). BuChang NaoXinTong Capsules (BNC) are widely prescribed in Chinese medicine for the treatment of cerebrovascular and cardiovascular diseases. Methods:In order to investigate the therapeutic effects and pharmacologi...

journal_title：Oxidative medicine and cellular longevity

authors： Xu J,Liu X,Luo L,Tang L,Guo N,Liu M,Li H,Zhang F,Zhang Y,Li D,Zhao Y,Wu H,Yang H

更新日期：2019-03-20 00:00:00

abstract：:Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast cancer cells media...

journal_title：Oxidative medicine and cellular longevity

authors： Villalpando-Rodriguez GE,Blankstein AR,Konzelman C,Gibson SB

更新日期：2019-09-17 00:00:00

abstract：:Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear. Accumulating studies also indicate that uric acid has both pro- and antioxidant properties. We postulated that hyperuricemia impairs the function of glomerular podocytes, resulting in albuminuria. Hyperuricemic model w...

journal_title：Oxidative medicine and cellular longevity

authors： Asakawa S,Shibata S,Morimoto C,Shiraishi T,Nakamura T,Tamura Y,Kumagai T,Hosoyamada M,Uchida S

更新日期：2017-01-01 00:00:00

abstract：:Cardiolipin interacts with many proteins of the mitochondrial inner membrane and, together with cytochrome C and creatine kinase, activates them. It can be considered as an integrating factor for components of the mitochondrial respiratory chain, which provides for an efficient transfer of electrons and protons. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Shilovsky GA,Zverkov OA,Seliverstov AV,Ashapkin VV,Putyatina TS,Rubanov LI,Lyubetsky VA

更新日期：2019-10-24 00:00:00