NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice.

abstract：:Inflammation and oxidative stress are pivotal mechanisms for the pathogenesis of ischemia and reperfusion injury (IRI). Vagus nerve stimulation (VNS) may participate in maintaining oxidative homeostasis and response to external stimulus or injury. We investigated whether the in vivo VNS can protect the liver from IRI....

journal_title：Oxidative medicine and cellular longevity

authors： Xia H,Liu Z,Liang W,Zeng X,Yang Y,Chen P,Zhong Z,Ye Q

更新日期：2020-01-21 00:00:00

abstract：:The influence of a water-soluble [60] fullerene derivative containing five residues of 3-phenylpropionic acid and a chlorine addend appended to the carbon cage (F-828) on serum-starving human embryo lung diploid fibroblasts (HELFs) was studied. Serum deprivation evokes oxidative stress in HELFs. Cultivation of serum-s...

journal_title：Oxidative medicine and cellular longevity

authors： Ershova ES,Sergeeva VA,Tabakov VJ,Kameneva LA,Porokhovnik LN,Voronov II,Khakina EA,Troshin PA,Kutsev SI,Veiko NN,Kostyuk SV

更新日期：2016-01-01 00:00:00

abstract：:Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable model of human hyp...

journal_title：Oxidative medicine and cellular longevity

authors： Rubattu S,Stanzione R,Volpe M

更新日期：2016-01-01 00:00:00

abstract：:Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters...

journal_title：Oxidative medicine and cellular longevity

authors： Tasca KI,Caleffi JT,Correa CR,Gatto M,Tavares FC,Camargo CC,Sartori A,Biasin M,de Souza LDR

更新日期：2017-01-01 00:00:00

abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

journal_title：Oxidative medicine and cellular longevity

authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

更新日期：2015-01-01 00:00:00

abstract：:One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative st...

journal_title：Oxidative medicine and cellular longevity

authors： Kibel A,Lukinac AM,Dambic V,Juric I,Relatic KS

更新日期：2020-12-28 00:00:00

abstract：:This work reviews concepts regarding oxidative stress and the mechanisms by which endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys the relationships between oxidative stress, circadian rhythms, and retinal damage in humans, particularly those related to light and photodamage. In ...

journal_title：Oxidative medicine and cellular longevity

authors： Fanjul-Moles ML,López-Riquelme GO

更新日期：2016-01-01 00:00:00

abstract：:The human apoptosis-inducing factor (hAIF) is a moonlight flavoprotein involved in mitochondrial respiratory complex assembly and caspase-independent programmed cell death. These functions might be modulated by its redox-linked structural transition that enables hAIF to act as a NAD(H/+) redox sensor. Upon reduction w...

journal_title：Oxidative medicine and cellular longevity

authors： Romero-Tamayo S,Laplaza R,Velazquez-Campoy A,Villanueva R,Medina M,Ferreira P

更新日期：2021-01-15 00:00:00

abstract：:Cigarette smoking has been identified as a major risk factor for osteoporosis decades ago. Several studies have shown a direct relationship between cigarette smoking, decreased bone mineral density, and impaired fracture healing. However, the mechanisms behind impaired fracture healing and cigarette smoking are yet to...

journal_title：Oxidative medicine and cellular longevity

authors： Aspera-Werz RH,Ehnert S,Heid D,Zhu S,Chen T,Braun B,Sreekumar V,Arnscheidt C,Nussler AK

更新日期：2018-11-06 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is an upstream regulator of CaMKK-CaMKIV signaling cascade that activates various transcription factors, thereby regulating several cellular activities including, neuronal communication and immune response. Owing to the abnormal expression in cancer and neurodege...

journal_title：Oxidative medicine and cellular longevity

authors： Gupta P,Khan S,Fakhar Z,Hussain A,Rehman MT,AlAjmi MF,Islam A,Ahmad F,Hassan MI

更新日期：2020-07-16 00:00:00

abstract：:Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated...

journal_title：Oxidative medicine and cellular longevity

authors： Hu M,Zou W,Wang CY,Chen X,Tan HY,Zeng HY,Zhang P,Gu HF,Tang XQ

更新日期：2016-01-01 00:00:00

abstract：:Picroside II, from the herb Picrorhiza scrophulariiflora Pennell, has antioxidant and anti-inflammatory activities. However, its function on severe acute pancreatitis (SAP) and molecular mechanism remains unknown. The effects of picroside II on the SAP induced by cerulean were investigated. SAP rats were treated with ...

journal_title：Oxidative medicine and cellular longevity

authors： Piao X,Liu B,Guo L,Meng F,Gao L

更新日期：2017-01-01 00:00:00

abstract：:Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be...

journal_title：Oxidative medicine and cellular longevity

authors： Picone P,Nuzzo D,Caruana L,Scafidi V,Di Carlo M

更新日期：2014-01-01 00:00:00

abstract：:Hydroquinone (HQ) is widely used in food stuffs and is an occupational and environmental pollutant. Although the hepatotoxicity of HQ has been demonstrated both in vitro and in vivo, the prevention of HQ-induced hepatotoxicity has yet to be elucidated. In this study, we focused on the intervention effect of aqueous ex...

journal_title：Oxidative medicine and cellular longevity

authors： Gao Y,Tang H,Xiong L,Zou L,Dai W,Liu H,Hu G

更新日期：2018-11-18 00:00:00

abstract：:Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigat...

journal_title：Oxidative medicine and cellular longevity

authors： de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

更新日期：2018-10-21 00:00:00

abstract：:The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H. extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice. In several beha...

journal_title：Oxidative medicine and cellular longevity

authors： Kang JY,Park SK,Guo TJ,Ha JS,Lee DS,Kim JM,Lee U,Kim DO,Heo HJ

更新日期：2016-01-01 00:00:00

abstract：Objective:Atherogenic lipoproteins may impair vascular reactivity consecutively causing tissue damage in multiple organs via abnormal perfusion and excessive reactive oxygen species generation. We tested the hypothesis that chronic hypercholesterolemia causes endothelial dysfunction and cell loss in the retina. Method...

journal_title：Oxidative medicine and cellular longevity

authors： Zadeh JK,Zhutdieva MB,Laspas P,Yuksel C,Musayeva A,Pfeiffer N,Brochhausen C,Oelze M,Daiber A,Xia N,Li H,Gericke A

更新日期：2019-11-12 00:00:00

abstract：:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AE

更新日期：2014-01-01 00:00:00

abstract：:Some iron chelators display significant anticancer activity that may involve ferritin degradation either in proteasomes or in lysosomes, and the latter might involve ferritinophagy with a period. However, the correlation of ferritinophagy with anticancer activity of iron chelator was not fully determined. Revealing th...

journal_title：Oxidative medicine and cellular longevity

authors： Huang T,Sun Y,Li Y,Wang T,Fu Y,Li C,Li C

更新日期：2018-08-05 00:00:00

abstract：:Previous studies have shown that metformin not only is a hypoglycemic agent but also has neuroprotective effects. However, the mechanism of action of metformin in ischemic stroke is unclear. Oxidative stress is an important factor in the pathogenesis of cerebral ischemia-reperfusion injury. It has been reported that m...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng J,Zhu L,Liu J,Zhu T,Xie Z,Sun X,Zhang H

更新日期：2019-12-16 00:00:00

abstract：:Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. R...

journal_title：Oxidative medicine and cellular longevity

authors： Lv P,Chen T,Liu P,Zheng L,Tian J,Tan F,Chen J,Deng Y,Li J,Cai J,Chi X

更新日期：2019-11-11 00:00:00

abstract：:GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

journal_title：Oxidative medicine and cellular longevity

authors： Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

更新日期：2017-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is a flavonoid monomer with confirmed antioxidant activity. However, the specific effects of ISL on AP have not been determined. In this study, we aimed to investigate the protective effect of ISL on AP using ...

journal_title：Oxidative medicine and cellular longevity

authors： Liu X,Zhu Q,Zhang M,Yin T,Xu R,Xiao W,Wu J,Deng B,Gao X,Gong W,Lu G,Ding Y

更新日期：2018-04-26 00:00:00

abstract：Background:Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, and its incidence is increasing annually, but there is currently no specific drug for treating NAFLD. Shenling Baizhu powder (SL) is a safe herbal compound commonly used in clinical practice. Our previous research has shown...

journal_title：Oxidative medicine and cellular longevity

authors： Tang K,Deng Y,Zheng C,Nie H,Pan M,Chen R,Xie J,Yang Q,Zhang Y

更新日期：2020-06-08 00:00:00

abstract：:Fisetin, a known antioxidant, has been found to be cytotoxic against certain cell lines. However, the mechanism by which it inhibits tumor growth in vivo remains unexplored. Recently, we have demonstrated that Aflatoxin-B1 (AFB1) induced hepatocarcinogenesis is associated with activation of oxidative stress-inflammato...

journal_title：Oxidative medicine and cellular longevity

authors： Maurya BK,Trigun SK

更新日期：2016-01-01 00:00:00

abstract：:We examined in vitro antioxidant capacity of polyphenolic extract obtained from the wood of oak Quercus robur (QR), Robuvit, using TEAC (Trolox equivalent antioxidant capacity) method and the effect of its intake on markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity in plasma ...

journal_title：Oxidative medicine and cellular longevity

authors： Horvathova M,Orszaghova Z,Laubertova L,Vavakova M,Sabaka P,Rohdewald P,Durackova Z,Muchova J

更新日期：2014-01-01 00:00:00

abstract：:This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephr...

journal_title：Oxidative medicine and cellular longevity

authors： Arellano-Buendía AS,Tostado-González M,García-Arroyo FE,Cristóbal-García M,Loredo-Mendoza ML,Tapia E,Sánchez-Lozada LG,Osorio-Alonso H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Metabolic syndrome (MetS) has been associated with occurrence and prognosis of ischemic stroke. This study aimed to evaluate whether an association exists between MetS and early neurological deterioration (END) following acute ischemic stroke and the possible role inflammatory biomarkers play. METH...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang X,Sun Z,Ding C,Tang Y,Jiang X,Xie Y,Li C,Zhang L,Hu D,Li T,Xu G,Sheng L

更新日期：2016-01-01 00:00:00

abstract：:Ex vivo lung perfusion (EVLP) allows perfusion and reconditioning of retrieved lungs for organ transplantation. The Steen solution is specifically designed for this procedure but the mechanism through which it elicits its activity is still to be fully clarified. We speculated that Steen solution may encompass antioxid...

journal_title：Oxidative medicine and cellular longevity

authors： Carnevale R,Biondi-Zoccai G,Peruzzi M,De Falco E,Chimenti I,Venuta F,Anile M,Diso D,Cavarretta E,Marullo AG,Sartini P,Pignatelli P,Violi F,Frati G

更新日期：2014-01-01 00:00:00