当前位置： SCI文献检索 > Oxidative Medicine and Cellular Longevity期刊下所有文献 > Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs.

Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs.

Abstract：

AIM:Ginkgolide B is a Ginkgo biloba leaf extract that has been identified as a natural platelet-activating factor receptor (PAFR) antagonist. We investigated the effect of ginkgolide B on high glucose-induced TLR4 activation in human umbilical vein endothelial cells (HUVECs). METHODS:Protein expression was analyzed by immunoblotting. Small-interfering RNA (siRNA) was used to knock down PAFR and TLR4 expression. RESULTS:Ginkgolide B suppressed the expression of TLR4 and MyD88 that was induced by high glucose. Ginkgolide B also reduced the levels of platelet endothelial cell adhesion molecule-1, interleukin-6, and monocyte chemotactic protein 1. Further, we examined the association between PAFR and TLR4 by coimmunoprecipitation. The result showed that high glucose treatment caused the binding of PAFR and TLR4, whereas ginkgolide B abolished this binding. The functional analysis indicated that PAFR siRNA treatment reduced TLR4 expression, and TLR4 siRNA treatment decreased PAFR expression in high glucose-treated HUVECs, further supporting the coimmunoprecipitation data. Ginkgolide B inhibited the phosphorylation of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) and p38 mitogen-activated protein kinase (MAPK). CONCLUSION:Ginkgolide B exerted protective effects by inhibiting the TLR4-mediated inflammatory response in high glucose-treated endothelial cells. The mechanism of action of ginkgolide B might be associated with inhibition of the JAK2/STAT3 and p38 MAPK phosphorylation.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Chen K,Sun W,Jiang Y,Chen B,Zhao Y,Sun J,Gong H,Qi R

doi

10.1155/2017/9371602

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

9371602

eissn

1942-0900

issn

1942-0994

journal_volume

2017

pub_type

杂志文章

相关文献

Oxidative Medicine and Cellular Longevity文献大全
  • Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages.

    abstract：:Many groups of Gram-negative bacteria cause diseases that are harmful to sheep. Toll-like receptor 4 (TLR4), which is critical for detecting Gram-negative bacteria by the innate immune system, is activated by lipopolysaccharide (LPS) to initiate inflammatory responses and oxidative stress. Oxidation intermediates are ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2015/359315

    authors： Deng S,Yu K,Zhang B,Yao Y,Wang Z,Zhang J,Zhang X,Liu G,Li N,Liu Y,Lian Z

    更新日期：2015-01-01 00:00:00

  • Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena.

    abstract：:Mesenchymal stem cells (MSCs) have shown beneficial effects in the treatment of abdominal aortic aneurysm (AAA). Nonetheless, the biological properties of adipose-derived MSCs (ASCs) from patients with AAA (AAA-ASCs) remain unclear. This study is aimed at investigating the properties of cell phenotype and function of ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/1305049

    authors： Huang X,Zhang H,Liang X,Hong Y,Mao M,Han Q,He H,Tao W,Jiang G,Zhang Y,Li X

    更新日期：2019-11-25 00:00:00

  • Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.

    abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2016/4234061

    authors： Li S,Hong M,Tan HY,Wang N,Feng Y

    更新日期：2016-01-01 00:00:00

  • Buyang Huanwu Decoction Exerts Cardioprotective Effects through Targeting Angiogenesis via Caveolin-1/VEGF Signaling Pathway in Mice with Acute Myocardial Infarction.

    abstract：Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/4275984

    authors： Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

    更新日期：2019-04-16 00:00:00

  • Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury.

    abstract：:Ischemia-reperfusion (I/R) injury caused by acute myocardial infarction (AMI) can initiate a strong inflammatory response. Polymorphonuclear cells (PMNs) are the most important inflammatory cells. Our previous studies found that the calcium-sensing receptor (CaSR) regulates the proinflammatory effects of PMNs. However...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2021/3010548

    authors： Zhai TY,Cui BH,Zhou Y,Xu XY,Zou L,Lin X,Zhu XS,Zhang SW,Xie WL,Cheng YY,Sun YH

    更新日期：2021-01-12 00:00:00

  • Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.

    abstract：:Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign lipid storage to so-called second hit of inflammation activation. Isoquercitrin (IQ) is widely present flavonoid but its effects on hepatic lipid metabolism remain unknown. We used free fatty acids (FFA) induced lipid overl...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/313602

    authors： Hassan W,Rongyin G,Daoud A,Ding L,Wang L,Liu J,Shang J

    更新日期：2014-01-01 00:00:00

  • Multiorgan Development of Oxidative and Nitrosative Stress in LPS-Induced Endotoxemia in C57Bl/6 Mice: DHE-Based In Vivo Approach.

    abstract：:Detection of free radicals in tissues is challenging. Most approaches rely on incubating excised sections or homogenates with reagents, typically at supraphysiologic oxygen tensions, to finally detect surrogate, nonspecific end products. In the present work, we explored the potential of using intravenously (i.v.) inje...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/7838406

    authors： Proniewski B,Kij A,Sitek B,Kelley EE,Chlopicki S

    更新日期：2019-05-22 00:00:00

  • LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis.

    abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/4010764

    authors： Kong X,Liu CX,Wang GD,Yang H,Yao XM,Hua Q,Li XY,Zhang HM,Ma MZ,Su Q,Lv K

    更新日期：2019-10-14 00:00:00

  • Corrigendum to "Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress".

    abstract：:[This corrects the article DOI: 10.1155/2017/3027109.]. ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 已发布勘误

    doi：10.1155/2017/1083618

    authors： Nawrocka D,Kornicka K,Szydlarska J,Marycz K

    更新日期：2017-01-01 00:00:00

  • Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

    abstract：:In an attempt to better understand the pathogen-host interaction between invading Mycoplasma ovipneumoniae (M. ovipneumoniae) and sheep airway epithelial cells, biological effects and possible molecular mechanism of capsular polysaccharide of M. ovipneumoniae (CPS) in the induction of cell apoptosis were explored usin...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/6175841

    authors： Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

    更新日期：2017-01-01 00:00:00

  • The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease.

    abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2015/604658

    authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

    更新日期：2015-01-01 00:00:00

  • Chronic NOS Inhibition Affects Oxidative State and Antioxidant Response Differently in the Kidneys of Young Normotensive and Hypertensive Rats.

    abstract：:Deficiency of nitric oxide (NO) and oxidative stress can be a cause, a consequence, or, more often, a potentiating factor for hypertension and hypertensive renal disease. Both NO and superoxide anions are radical molecules that interact with each other, leading to oxidative damage of such organs as the kidney. In the ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/5349398

    authors： Majzunova M,Kvandova M,Berenyiova A,Balis P,Dovinova I,Cacanyiova S

    更新日期：2019-11-22 00:00:00

  • Evidence of a Redox-Dependent Regulation of Immune Responses to Exercise-Induced Inflammation.

    abstract：:We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either plac...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/2840643

    authors： Sakelliou A,Fatouros IG,Athanailidis I,Tsoukas D,Chatzinikolaou A,Draganidis D,Jamurtas AZ,Liacos C,Papassotiriou I,Mandalidis D,Stamatelopoulos K,Dimopoulos MA,Mitrakou A

    更新日期：2016-01-01 00:00:00

  • The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling.

    abstract：:Lung cancer is a leading cause of cancer death worldwide, and non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancer, which is highly metastatic, leading to the poor survival rate of patients. We recently reported that 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), a phenoxyphenol, exerts antihepatoma eff...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/5167292

    authors： Liu W,Wu CY,Lu MJ,Chuang YJ,Tsai EM,Leu S,Lin IL,Ko CJ,Chiu CC,Chang WT

    更新日期：2020-01-07 00:00:00

  • The Tryptophan Pathway Targeting Antioxidant Capacity in the Placenta.

    abstract：:The placenta plays a vital role in fetal development during pregnancy. Dysfunction of the placenta can be caused by oxidative stress and can lead to abnormal fetal development. Preventing oxidative stress of the placenta is thus an important measure to ensure positive birth outcomes. Research shows that tryptophan and...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2018/1054797

    authors： Xu K,Liu G,Fu C

    更新日期：2018-07-22 00:00:00

  • Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats.

    abstract：:Platelet-rich plasma (PRP) has grown as an attractive biologic instrument in regenerative medicine for its powerful healing properties. It is considered as a source of growth factors that may induce tissue repairing and improve fibrosis. This product has proven its efficacy in multiple studies, but its effect on cispl...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/9658230

    authors： Salem N,Helmi N,Assaf N

    更新日期：2018-07-18 00:00:00

  • Xanthine Oxidoreductase-Derived Reactive Species: Physiological and Pathological Effects.

    abstract：:Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species. In addition to this housekeeping function, mammalian XOR is a physiological source of superoxide ion, hydrogen peroxide, and nitric oxide, which can fu...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2016/3527579

    authors： Battelli MG,Polito L,Bortolotti M,Bolognesi A

    更新日期：2016-01-01 00:00:00

  • Transplantation of Bone Marrow Mesenchymal Stem Cells Prevents Radiation-Induced Artery Injury by Suppressing Oxidative Stress and Inflammation.

    abstract：:The present study aims to explore the protective effect of human bone marrow mesenchymal stem cells (hBMSCs) on radiation-induced aortic injury (RIAI). hBMSCs were isolated and cultured from human bone marrow. Male C57/BL mice were irradiated with a dose of 18-Gy 6MV X-ray and randomly treated with either vehicle or h...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/5942916

    authors： Shen Y,Jiang X,Meng L,Xia C,Zhang L,Xin Y

    更新日期：2018-02-28 00:00:00

  • Resveratrol prevents dendritic cell maturation in response to advanced glycation end products.

    abstract：:Advanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence. Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2013/574029

    authors： Buttari B,Profumo E,Facchiano F,Ozturk EI,Segoni L,Saso L,Riganò R

    更新日期：2013-01-01 00:00:00

  • Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta.

    abstract：:The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/3939540

    authors： Palacios J,Cifuentes F,Valderrama JA,Benites J,Ríos D,González C,Chiong M,Cartes-Saavedra B,Lafourcade C,Wyneken U,González P,Owen GI,Pardo F,Sobrevia L,Buc Calderon P

    更新日期：2016-01-01 00:00:00

  • Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin-Induced Cardiotoxicity.

    abstract：:Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application is limited by its cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) the chemical composition and antioxidant capacity of aqu...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/2935051

    authors： Dos Santos JM,Alfredo TM,Antunes KÁ,da Cunha JDSM,Costa EMA,Lima ES,Silva DB,Carollo CA,Schmitz WO,Boleti APA,Dos Santos EL,de Picoli Souza K

    更新日期：2018-06-28 00:00:00

  • Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway.

    abstract：:Systemic inflammation often induces neuroinflammation and disrupts neural functions, ultimately causing cognitive impairment. Furthermore, neuronal inflammation is the key cause of many neurological conditions. It is particularly important to develop effective neuroprotectants to prevent and control inflammatory brain...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/4751349

    authors： Li Y,Liu T,Li Y,Han D,Hong J,Yang N,He J,Peng R,Mi X,Kuang C,Zhou Y,Han Y,Shi C,Li Z,Guo X

    更新日期：2020-09-22 00:00:00

  • Sulfur Dioxide Enhances Endogenous Hydrogen Sulfide Accumulation and Alleviates Oxidative Stress Induced by Aluminum Stress in Germinating Wheat Seeds.

    abstract：:Aluminum ions are especially toxic to plants in acidic soils. Here we present evidences that SO2 protects germinating wheat grains against aluminum stress. SO2 donor (NaHSO3/Na2SO3) pretreatment at 1.2 mM reduced the accumulation of superoxide anion, hydrogen peroxide, and malondialdehyde, enhanced the activities of g...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2015/612363

    authors： Zhu DB,Hu KD,Guo XK,Liu Y,Hu LY,Li YH,Wang SH,Zhang H

    更新日期：2015-01-01 00:00:00

  • Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats.

    abstract：:Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneratio...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/7860650

    authors： Khan MS,Muhammad T,Ikram M,Kim MO

    更新日期：2019-11-07 00:00:00

  • PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model.

    abstract：:The clinical and experimental postcardiac arrest treatment has not reached therapeutic success. The present study investigated the effect of PD98059 (PD) in rats subjected to cardiac arrest (CA)/cardiopulmonary resuscitation (CPR). Experimental rats were divided randomly into 3 groups: sham, CA, and PD. The rats excep...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/3723762

    authors： Nguyen Thi PA,Chen MH,Li N,Zhuo XJ,Xie L

    更新日期：2016-01-01 00:00:00

  • Erratum to "Long-Term Treatment of Native LDL Induces Senescence of Cultured Human Endothelial Cells".

    abstract：:[This corrects the article DOI: 10.1155/2017/6487825.]. ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,已发布勘误

    doi：10.1155/2017/4576985

    authors： Oh ST,Park H,Yoon HJ,Yang SY

    更新日期：2017-01-01 00:00:00

  • Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome-Derived Platelet Hyperactivity.

    abstract：:Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative str...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2016/2423547

    authors： Gaspar RS,Trostchansky A,Paes AM

    更新日期：2016-01-01 00:00:00

  • Sex Differences in Progression of Diabetic Cardiomyopathy in OVE26 Type 1 Diabetic Mice.

    abstract：:OVE26 mice are a widely used transgenic model of early-onset type 1 diabetes. These mice overexpress calmodulin in their pancreatic β cells, develop severe diabetes within the first weeks of life, and progress to severe diabetic complications including diabetic nephropathy and diabetic cardiomyopathy (DCM). To date, d...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/6961348

    authors： Tang X,Jiang S,Zhang J,Zhou S,Zheng Y

    更新日期：2020-05-14 00:00:00

  • Evaluation of Binding of Rosmarinic Acid with Human Transferrin and Its Impact on the Protein Structure: Targeting Polyphenolic Acid-Induced Protection of Neurodegenerative Disorders.

    abstract：:Rosmarinic acid (RA) is a natural compound that is gaining wide popularity owing to its broad-spectrum biological activities. RA is known for its wide range of medicinal properties and therapeutic applications in a vast range of neurodegenerative disorders thus making it a vital natural compound. Human transferrin (hT...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/1245875

    authors： Shamsi A,Anwar S,Shahbaaz M,Mohammad T,Alajmi MF,Hussain A,Hassan I,Ahmad F,Islam A

    更新日期：2020-11-05 00:00:00

  • Mitochondrial-targeted two-photon fluorescent probes for zinc ions, H2O2, and thiols in living tissues.

    abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2013/323619

    authors： Kim HM,Cho BR

    更新日期：2013-01-01 00:00:00