Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.

abstract：:The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained ...

journal_title：Oxidative medicine and cellular longevity

authors： de Giffoni de Carvalho JT,da Silva Baldivia D,Leite DF,de Araújo LCA,de Toledo Espindola PP,Antunes KA,Rocha PS,de Picoli Souza K,Dos Santos EL

更新日期：2019-08-25 00:00:00

abstract：:Systemic inflammation often induces neuroinflammation and disrupts neural functions, ultimately causing cognitive impairment. Furthermore, neuronal inflammation is the key cause of many neurological conditions. It is particularly important to develop effective neuroprotectants to prevent and control inflammatory brain...

journal_title：Oxidative medicine and cellular longevity

authors： Li Y,Liu T,Li Y,Han D,Hong J,Yang N,He J,Peng R,Mi X,Kuang C,Zhou Y,Han Y,Shi C,Li Z,Guo X

更新日期：2020-09-22 00:00:00

abstract：:The widely used herbicide atrazine (ATR) can cause many adverse effects including immunotoxicity, but the underlying mechanisms are not fully understood. The current study investigated the role of oxidative stress and calcium homeostasis in ATR-induced immunotoxicity in mice. ATR at doses of 0, 100, 200, or 400 mg/kg ...

journal_title：Oxidative medicine and cellular longevity

authors： Gao S,Wang Z,Zhang C,Jia L,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial dysfunction is associated with macrophage damage, but the role of mitochondrial fission in macrophage cholesterol metabolism is not fully understood. In this study, we explored the influences of miR-9 and mitochondrial fission on macrophage viability and cholesterol metabolism. Macrophages were incubated...

journal_title：Oxidative medicine and cellular longevity

authors： Xin T,Lu C,Zhang J,Wen J,Yan S,Li C,Zhang F,Zhang J

更新日期：2020-11-01 00:00:00

abstract：:Non-thermal plasma (NTP), an ionized gas generated at ambient pressure and temperature, has been an emerging technology for medical applications. Through controlled delivery of reactive oxygen and nitrogen species (ROS/RNS), NTP can elicit hormetic cellular responses, thus stimulating broad therapeutic effects. To ena...

journal_title：Oxidative medicine and cellular longevity

authors： Lin A,Biscop E,Breen C,Butler SJ,Smits E,Bogaerts A

更新日期：2020-12-03 00:00:00

abstract：:Organophosphate pesticides (OPs) are among the most widely used synthetic chemicals for the control of a wide variety of pests, and reactive oxygen species (ROS) caused by OPs may be involved in the toxicity of various pesticides. Previous studies have demonstrated that a reactivation of latent Epstein-Barr virus (EBV...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao L,Xie F,Wang TT,Liu MY,Li JL,Shang L,Deng ZX,Zhao PX,Ma XM

更新日期：2015-01-01 00:00:00

abstract：:Accumulating evidence has demonstrated that oxidative stress is associated with depression. Our present study aimed at investigating the antidepressant effect and the possible mechanisms of curcumin (CUR) in chronic unpredictable mild stress- (CUMS-) induced depression model in rats. After exposure to CUMS for four we...

journal_title：Oxidative medicine and cellular longevity

authors： Liao D,Lv C,Cao L,Yao D,Wu Y,Long M,Liu N,Jiang P

更新日期：2020-09-17 00:00:00

abstract：:GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

journal_title：Oxidative medicine and cellular longevity

authors： Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group, n = 97) and RA patients (n = 173). RA patients were...

journal_title：Oxidative medicine and cellular longevity

authors： Costa NT,Veiga Iriyoda TM,Kallaur AP,Delongui F,Alfieri DF,Lozovoy MA,Amin RB,Delfino VD,Dichi I,Simão AN

更新日期：2016-01-01 00:00:00

abstract：:In metabolic diseases, the increased reactive oxygen species (ROS) represents one of the pathogenic mechanisms for vascular disease probably by promoting vascular smooth muscle cell (SMC) proliferation that contributes to the development of arterial remodeling and stenosis, hypertension, and atherosclerosis. Therefore...

journal_title：Oxidative medicine and cellular longevity

authors： López-Acosta O,de Los Angeles Fortis-Barrera M,Barrios-Maya MA,Ramírez AR,Aguilar FJA,El-Hafidi M

更新日期：2018-12-23 00:00:00

abstract：:This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephr...

journal_title：Oxidative medicine and cellular longevity

authors： Arellano-Buendía AS,Tostado-González M,García-Arroyo FE,Cristóbal-García M,Loredo-Mendoza ML,Tapia E,Sánchez-Lozada LG,Osorio-Alonso H

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress plays a pathological role in the development of various diseases including diabetes, atherosclerosis, or cancer. Systemic oxidative stress results from an imbalance between oxidants derivatives production and antioxidants defenses. Reactive oxygen species (ROS) are generally considered to be detriment...

journal_title：Oxidative medicine and cellular longevity

authors： Le Lay S,Simard G,Martinez MC,Andriantsitohaina R

更新日期：2014-01-01 00:00:00

abstract：:Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign lipid storage to so-called second hit of inflammation activation. Isoquercitrin (IQ) is widely present flavonoid but its effects on hepatic lipid metabolism remain unknown. We used free fatty acids (FFA) induced lipid overl...

journal_title：Oxidative medicine and cellular longevity

authors： Hassan W,Rongyin G,Daoud A,Ding L,Wang L,Liu J,Shang J

更新日期：2014-01-01 00:00:00

abstract：:Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3 and T4. Thyroid hormones exert pleiotropic actions on numerous tissues and induce an overall increase in metabolism, with an increase in energy demand and oxygen consumption. Therefore, the purpose of this study was to...

journal_title：Oxidative medicine and cellular longevity

authors： Costilla M,Macri Delbono R,Klecha A,Cremaschi GA,Barreiro Arcos ML

更新日期：2019-06-02 00:00:00

abstract：:Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant-based lotions before sun exposure might ...

journal_title：Oxidative medicine and cellular longevity

authors： Petruk G,Del Giudice R,Rigano MM,Monti DM

更新日期：2018-08-02 00:00:00

abstract：:Cardiolipin interacts with many proteins of the mitochondrial inner membrane and, together with cytochrome C and creatine kinase, activates them. It can be considered as an integrating factor for components of the mitochondrial respiratory chain, which provides for an efficient transfer of electrons and protons. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Shilovsky GA,Zverkov OA,Seliverstov AV,Ashapkin VV,Putyatina TS,Rubanov LI,Lyubetsky VA

更新日期：2019-10-24 00:00:00

abstract：:Vascular endothelial dysfunction is associated with increased mortality in patients with diabetes. Astragaloside IV (As-IV) is a bioactive saponin with therapeutic potential as an anti-inflammatory and antiendothelial dysfunction. However, the underlying mechanism for how As-IV ameliorated endothelial dysfunction is s...

journal_title：Oxidative medicine and cellular longevity

authors： Leng B,Li C,Sun Y,Zhao K,Zhang L,Lu ML,Wang HX

更新日期：2020-09-14 00:00:00

abstract：:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AE

更新日期：2014-01-01 00:00:00

abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

journal_title：Oxidative medicine and cellular longevity

authors： Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

更新日期：2020-02-12 00:00:00

abstract：Introduction:The omega-3 polyunsaturated fatty acids, as docosahexaenoic acid (DHA), are considered mediators regulating the resolution of inflammation during cancer and may be associated with better outcomes. Epoxydocosapentaenoic acids (EDPs), metabolites of the DHA, are hypothesized to be responsible for some benefi...

journal_title：Oxidative medicine and cellular longevity

authors： Molfino A,Amabile MI,Lionetto L,Spagnoli A,Ramaccini C,De Luca A,Simmaco M,Monti M,Muscaritoli M

更新日期：2019-03-05 00:00:00

abstract：:A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies. As red blood cells (RBCs) participate in NO formation in the bloodstream, the aim of this study was to outline the metabolic profile of L-arginine (Arg)/NO pathway and of oxidati...

journal_title：Oxidative medicine and cellular longevity

authors： Porro B,Eligini S,Veglia F,Lualdi A,Squellerio I,Fiorelli S,Giovannardi M,Chiorino E,Dalla Cia A,Crisci M,Werba JP,Tremoli E,Cavalca V

更新日期：2014-01-01 00:00:00

abstract：:Glucocorticoid (GC) production is physiologically regulated through a negative feedback loop mediated by the GC, which appear disrupted in several pathological conditions. The inability to perform negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in several diseases is associated with an overproductio...

journal_title：Oxidative medicine and cellular longevity

authors： Prevatto JP,Torres RC,Diaz BL,Silva PMRE,Martins MA,Carvalho VF

更新日期：2017-01-01 00:00:00

abstract：:Ischemia-reperfusion (IR) injury is directly related to the formation of reactive oxygen species (ROS), endothelial cell injury, increased vascular permeability, and the activation of neutrophils and platelets, cytokines, and the complement system. Several studies have confirmed the destructiveness of the toxic oxygen...

journal_title：Oxidative medicine and cellular longevity

authors： Ferrari RS,Andrade CF

更新日期：2015-01-01 00:00:00

abstract：:Rosmarinic acid (RA) is a natural compound that is gaining wide popularity owing to its broad-spectrum biological activities. RA is known for its wide range of medicinal properties and therapeutic applications in a vast range of neurodegenerative disorders thus making it a vital natural compound. Human transferrin (hT...

journal_title：Oxidative medicine and cellular longevity

authors： Shamsi A,Anwar S,Shahbaaz M,Mohammad T,Alajmi MF,Hussain A,Hassan I,Ahmad F,Islam A

更新日期：2020-11-05 00:00:00

abstract：:We have demonstrated that neural progenitor cells (NPCs) protect endothelial cells (ECs) from oxidative stress. Since exosomes (EXs) can convey the benefit of parent cells through their carried microRNAs (miRs) and miR-210 is ubiquitously expressed with versatile functions, we investigated the role of miR-210 in the e...

journal_title：Oxidative medicine and cellular longevity

authors： Liu H,Wang J,Chen Y,Chen Y,Ma X,Bihl JC,Yang Y

更新日期：2017-01-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both pa...

journal_title：Oxidative medicine and cellular longevity

authors： Ho YS,Zhao FY,Yeung WF,Wong GT,Zhang HQ,Chang RC

更新日期：2020-02-13 00:00:00

abstract：:Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been recognized as a toxic gas and environment pollutant. However, increasing evidence suggests that H2S acts as a novel gasotransmitter and plays important roles in a variety of physiological and pathological processes in mammals. H2S is involve...

journal_title：Oxidative medicine and cellular longevity

authors： Wu DD,Wang DY,Li HM,Guo JC,Duan SF,Ji XY

更新日期：2019-01-20 00:00:00

abstract：:Redox status changes during an annual training cycle in young and adult track and field athletes and possible differences between the two age groups were assessed. Forty-six individuals (24 children and 22 adults) were assigned to four groups: trained adolescents, (TAD, N = 13), untrained adolescents (UAD, N = 11), tr...

journal_title：Oxidative medicine and cellular longevity

authors： Zalavras A,Fatouros IG,Deli CK,Draganidis D,Theodorou AA,Soulas D,Koutsioras Y,Koutedakis Y,Jamurtas AZ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury. METHODS:36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (n = 12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-...

journal_title：Oxidative medicine and cellular longevity

authors： Chen X,Liu Q,Wang D,Feng S,Zhao Y,Shi Y,Liu Q

更新日期：2015-01-01 00:00:00

abstract：:Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-ED...

journal_title：Oxidative medicine and cellular longevity

authors： Chiazza F,Chegaev K,Rogazzo M,Cutrin JC,Benetti E,Lazzarato L,Fruttero R,Collino M

更新日期：2015-01-01 00:00:00