Abstract：
:We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20 mg/kg/day) immediately after a muscle-damaging exercise protocol (300 eccentric contractions) and for eight consecutive days. Blood sampling and performance assessments were performed before exercise, after exercise, and daily throughout recovery. NAC reduced the decline of reduced glutathione in erythrocytes and the increase of plasma protein carbonyls, serum TAC and erythrocyte oxidized glutathione, and TBARS and catalase activity during recovery thereby altering postexercise redox status. The rise of muscle damage and inflammatory markers (muscle strength, creatine kinase activity, CRP, proinflammatory cytokines, and adhesion molecules) was less pronounced in NAC during the first phase of recovery. The rise of leukocyte and neutrophil count was decreased by NAC after exercise. Results on immune cell subpopulations obtained by flow cytometry indicated that NAC ingestion reduced the exercise-induced rise of total macrophages, HLA+ macrophages, and 11B+ macrophages and abolished the exercise-induced upregulation of B lymphocytes. Natural killer cells declined only in PLA immediately after exercise. These results indicate that thiol-based antioxidant supplementation blunts immune cell mobilisation in response to exercise-induced inflammation suggesting that leukocyte mobilization may be under redox-dependent regulation.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
Sakelliou A,Fatouros IG,Athanailidis I,Tsoukas D,Chatzinikolaou A,Draganidis D,Jamurtas AZ,Liacos C,Papassotiriou I,Mandalidis D,Stamatelopoulos K,Dimopoulos MA,Mitrakou Adoi
10.1155/2016/2840643subject
Has Abstractpub_date
2016-01-01 00:00:00pages
2840643eissn
1942-0900issn
1942-0994journal_volume
2016pub_type
杂志文章abstract：:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2014/572430
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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abstract：:[This corrects the article DOI: 10.1155/2017/4824371.]. ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 已发布勘误
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更新日期：2019-08-06 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.4161/oxim.2.4.9745
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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更新日期：2020-11-12 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2017/6838921.]. ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,已发布勘误
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更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
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更新日期：2018-05-20 00:00:00
