Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury.

abstract：:Metabolic diseases, such as insulin resistance, type II diabetes, and obesity, are associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of metabolic diseases, agents and...

journal_title：Oxidative medicine and cellular longevity

authors： Son Y,Lee JH,Chung HT,Pae HO

更新日期：2013-01-01 00:00:00

abstract：:Calenduloside E (CE) is a natural triterpenoid saponin isolated from Aralia elata (Miq.) Seem., a well-known traditional Chinese medicine. Our previous studies have shown that CE exerts cardiovascular protective effects both in vivo and in vitro. However, its role in myocardial ischemia/reperfusion injury (MIRI) and t...

journal_title：Oxidative medicine and cellular longevity

authors： Wang M,Wang RY,Zhou JH,Xie XH,Sun GB,Sun XB

更新日期：2020-08-31 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) is an alpha- and gamma-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the gamma-secretase, presenilin, have been implicated in familial Alzheimer's dis...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang T,Mi Z,Schor NF

更新日期：2009-09-01 00:00:00

abstract：Background:Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure. Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury. Intravenous anesthetic propofol potent effects on free radical scaven...

journal_title：Oxidative medicine and cellular longevity

authors： Yao W,Han X,Zhang Y,Guan J,Ge M,Chen C,Wu S,Chen J,Luo G,Huang P,Hei Z

更新日期：2018-10-28 00:00:00

abstract：:As one of the major risks for urolithiasis, hyperoxaluria can be caused by genetic defect or dietary intake. And high oxalate induced renal epithelial cells injury is related to oxidative stress and mitochondrial dysfunction. Here, we investigated whether MitoTEMPO, a mitochondria-targeted antioxidant, could protect a...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Wang Q,Xu C,Lu Y,Hu H,Qin B,Wang Y,He D,Li C,Yu X,Wang S,Liu J

更新日期：2017-01-01 00:00:00

abstract：Objective:Chidamide has a broad spectrum of antitumor activity but its function on glioma remains unknown. The increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS) may control glioma risk by promoting its apoptosis and necrosis. Hedgehog pathway is crucial to glioma cell proliferation and contr...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou H,Han L,Wang H,Wei J,Guo Z,Li Z

更新日期：2020-03-11 00:00:00

abstract：:Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca2+-activated potassium channel (BKCaα), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the ou...

journal_title：Oxidative medicine and cellular longevity

authors： Brazier SP,Telezhkin V,Kemp PJ

更新日期：2016-01-01 00:00:00

abstract：:Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF-κB and TNF-α have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-κB and TNF-α remain unknown. Exosomes have been ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu B,Zhang L,Liang C,Liu B,Pan X,Wang Y,Zhang Y,Zhang Y,Xie W,Yan B,Liu F,Yip HK,Yu XY,Li Y

更新日期：2019-04-08 00:00:00

abstract：:Stroke is a leading cause of mortality worldwide, as well as a source of long-term disabilities and huge socioeconomic costs. This study investigates the effects of resveratrol, an antioxidant supplement, on blood pressure, weight status, glucose, and lipid profile in patients who had a stroke in the last 12 months. T...

journal_title：Oxidative medicine and cellular longevity

authors： Fodor K,Tit DM,Pasca B,Bustea C,Uivarosan D,Endres L,Iovan C,Abdel-Daim MM,Bungau S

更新日期：2018-03-18 00:00:00

abstract：:Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin ...

journal_title：Oxidative medicine and cellular longevity

authors： Ben Yehuda Greenwald M,Frušić-Zlotkin M,Soroka Y,Ben Sasson S,Bitton R,Bianco-Peled H,Kohen R

更新日期：2017-01-01 00:00:00

abstract：Background:Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The idea of therapeutic angiogenesis in ischemic myocardium is a promising strategy for MI patients. Buyang Huanwu decoction (BHD), a famous Chinese herbal prescription, exerted antioxidant, antiapoptotic, and ant...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu JZ,Bao XY,Zheng Q,Tong Q,Zhu PC,Zhuang Z,Wang Y

更新日期：2019-04-16 00:00:00

abstract：:Equisetum ramosissimum, a genus of Equisetaceae, is a medicinal plant that can be separated into ethyl acetate (EA), dichloromethane (DM), n-hexane (Hex), methanol (MeOH), and water extracts. EA extract was known to have potent antioxidative properties, reducing power, DPPH scavenging activity, and metal ion chelating...

journal_title：Oxidative medicine and cellular longevity

authors： Li PH,Chiu YP,Shih CC,Wen ZH,Ibeto LK,Huang SH,Chiu CC,Ma DL,Leung CH,Chang YN,Wang HM

更新日期：2016-01-01 00:00:00

abstract：:Benzene is a chemical contaminant widespread in industrial and living environments. The oxidative metabolites of benzene induce toxicity involving oxidative damage. Protecting cells and cell membranes from oxidative damage, glucose-6-phosphate dehydrogenase (G6PD) maintains the reduced state of glutathione (GSH). This...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Cao M,Yang W,Sun F,Xu C,Yin L,Pu Y

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress is crucially involved in the pathogenesis of neurological diseases such as stroke and degenerative diseases. We previously demonstrated that platelet-derived growth factors (PDGFs) protected neurons from H2O2-induced oxidative stress and indicated the involvement of PI3K-Akt and MAP kinases as an unde...

journal_title：Oxidative medicine and cellular longevity

authors： Zheng LS,Ishii Y,Zhao QL,Kondo T,Sasahara M

更新日期：2013-01-01 00:00:00

abstract：:The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation. Intense exercise (28 m/min at a ...

journal_title：Oxidative medicine and cellular longevity

authors： Tang Y,Li J,Gao C,Xu Y,Li Y,Yu X,Wang J,Liu L,Yao P

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and decreased mtDNA copy number. Current wisdom indicates that mt...

journal_title：Oxidative medicine and cellular longevity

authors： Quan Y,Xin Y,Tian G,Zhou J,Liu X

更新日期：2020-03-26 00:00:00

abstract：:A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected toxicities that become apparent only after the launch of new drug entities. Circumstantial evidence suggests that, in most cases, reactive metabolites are responsible for these unexpected toxicities. In this...

journal_title：Oxidative medicine and cellular longevity

authors： Attia SM

更新日期：2010-07-01 00:00:00

abstract：:The in vitro ability of polyphenols, extracted from red grape, to modulate peripheral blood mononuclear cell responses has been evaluated in 20 obese (Ob) people. With regard to cytokine release in response to phorbol myristate acetate (PMA), levels of interleukin-2 (IL-2), interferon-γ (IFN-γ), IL-4, IL-10, and IL-17...

journal_title：Oxidative medicine and cellular longevity

authors： Magrone T,Jirillo E,Spagnoletta A,Magrone M,Russo MA,Fontana S,Laforgia F,Donvito I,Campanella A,Silvestris F,De Pergola G

更新日期：2017-01-01 00:00:00

abstract：SCOPE:To determine whether doses of quercetin in the range of serum concentrations exert any effect on triacylglycerol accumulation in maturing preadipocytes and mature adipocytes. The influence on the expression of adipogenic markers as well as on gene expression and activity of enzymes involved in triacylglycerol met...

journal_title：Oxidative medicine and cellular longevity

authors： Eseberri I,Miranda J,Lasa A,Churruca I,Portillo MP

更新日期：2015-01-01 00:00:00

abstract：:The study aimed to evaluate whether the treatment of primary cultured human endothelial cells with native low-density lipoprotein (nLDL) could induce their senescence and to uncover some of the putative mechanisms involved. For this purpose, human umbilical vein endothelial cells (HUVECs) were subcultured and/or conti...

journal_title：Oxidative medicine and cellular longevity

authors： Oh ST,Park H,Yoon HJ,Yang SY

更新日期：2017-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduc...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou Y,Yan H,Guo M,Zhu J,Xiao Q,Zhang L

更新日期：2013-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have shown beneficial effects in the treatment of abdominal aortic aneurysm (AAA). Nonetheless, the biological properties of adipose-derived MSCs (ASCs) from patients with AAA (AAA-ASCs) remain unclear. This study is aimed at investigating the properties of cell phenotype and function of ...

journal_title：Oxidative medicine and cellular longevity

authors： Huang X,Zhang H,Liang X,Hong Y,Mao M,Han Q,He H,Tao W,Jiang G,Zhang Y,Li X

更新日期：2019-11-25 00:00:00

abstract：:We aimed to evaluate the cardioprotective effect and mechanism of propofol in anthracycline-induced cardiomyocyte apoptosis. We selected the rat myocardial cell line, H9c2, and primary cardiomyocytes for in vitro study. The cardiomyocytes were treated with vehicle, Adriamycin® (ADM), propofol, or a combination of ADM ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao H,Zhang X,Zheng Y,Li Y,Wang X,Hu N,Zhou P,Wang K

更新日期：2018-04-18 00:00:00

abstract：:Oxidative stress reflects an imbalance between oxidants and antioxidants in favor of the oxidants capable of evoking tissue damage. Like hydrogen sulfide (H2S) and nitric oxide (NO), carbon monoxide (CO) is an endogenous gaseous mediator recently implicated in the physiology of the gastrointestinal (GI) tract. CO is p...

journal_title：Oxidative medicine and cellular longevity

authors： Korbut E,Brzozowski T,Magierowski M

更新日期：2020-04-15 00:00:00

abstract：:Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries i...

journal_title：Oxidative medicine and cellular longevity

authors： Yan C,Zhang X,Miao J,Yuan H,Liu E,Liang T,Li Q

更新日期：2020-01-28 00:00:00

abstract：:Oxidative stress (OS) and neuronal apoptosis are major pathological processes after hypoxic-ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to CSF1 receptor (CSF1R), has been shown to reduce neuronal loss after hypoxic-ischemia- (HI-) induced brain injury. In the present study, we hypothesiz...

journal_title：Oxidative medicine and cellular longevity

authors： Hu X,Li S,Doycheva DM,Huang L,Lenahan C,Liu R,Huang J,Gao L,Tang J,Zuo G,Zhang JH

更新日期：2020-10-07 00:00:00

abstract：:Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,He Z,Shen X,Xu X,Fan J,Wu S,Zhang D

更新日期：2012-01-01 00:00:00

abstract：:Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-ED...

journal_title：Oxidative medicine and cellular longevity

authors： Chiazza F,Chegaev K,Rogazzo M,Cutrin JC,Benetti E,Lazzarato L,Fruttero R,Collino M

更新日期：2015-01-01 00:00:00

abstract：:Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its maintenance. Here we prop...

journal_title：Oxidative medicine and cellular longevity

authors： Farooq MA,Pracheil TM,Dong Z,Xiao F,Liu Z

更新日期：2013-01-01 00:00:00

abstract：:Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H2O2 production and its association with p(66Shc), FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were s...

journal_title：Oxidative medicine and cellular longevity

authors： Wang P,Li CG,Qi Z,Cui D,Ding S

更新日期：2015-01-01 00:00:00