Functional Interactions between BKCaα-Subunit and Annexin A5: Implications in Apoptosis.

abstract：:Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the ce...

journal_title：Oxidative medicine and cellular longevity

authors： Wang R,Tu S,Zhang J,Shao A

更新日期：2020-09-04 00:00:00

abstract：:The infiltration of red blood cells into atheromatous plaques is implicated in atherogenesis. Inside the lesion, hemoglobin (Hb) is oxidized to ferri- and ferrylHb which exhibit prooxidant and proinflammatory activities. Cystathione gamma-lyase- (CSE-) derived H2S has been suggested to possess various antiatherogenic ...

journal_title：Oxidative medicine and cellular longevity

authors： Potor L,Nagy P,Méhes G,Hendrik Z,Jeney V,Pethő D,Vasas A,Pálinkás Z,Balogh E,Gyetvai Á,Whiteman M,Torregrossa R,Wood ME,Olvasztó S,Nagy P,Balla G,Balla J

更新日期：2018-01-21 00:00:00

abstract：:OVE26 mice are a widely used transgenic model of early-onset type 1 diabetes. These mice overexpress calmodulin in their pancreatic β cells, develop severe diabetes within the first weeks of life, and progress to severe diabetic complications including diabetic nephropathy and diabetic cardiomyopathy (DCM). To date, d...

journal_title：Oxidative medicine and cellular longevity

authors： Tang X,Jiang S,Zhang J,Zhou S,Zheng Y

更新日期：2020-05-14 00:00:00

abstract：:NADPH oxidase (Nox) is considered a major source of reactive oxygen species (ROS) in the heart in normal and pathological conditions. However, the role of Nox in severe acute pancreatitis- (SAP-) associated cardiac injury remains unclear. Therefore, we aim to investigate the contribution of Nox to SAP-associated cardi...

journal_title：Oxidative medicine and cellular longevity

authors： Wen Y,Liu R,Lin N,Luo H,Tang J,Huang Q,Sun H,Tang L

更新日期：2019-05-09 00:00:00

abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

更新日期：2019-03-26 00:00:00

abstract：:Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone gro...

journal_title：Oxidative medicine and cellular longevity

authors： You Z,Sun J,Xie F,Chen Z,Zhang S,Chen H,Liu F,Li L,Chen G,Song Y,Xuan Y,Zheng G,Xin Y

更新日期：2017-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis that bone morphogenetic protein 4 (BMP4) m...

journal_title：Oxidative medicine and cellular longevity

authors： Yang X,Niu N,Liang C,Wu MM,Tang LL,Wang QS,Lou J,Song BL,Zheng WW,Ma HP,Zhang ZR

更新日期：2020-10-28 00:00:00

abstract：:This study was conducted to assess the protective effect of extract of match (EM) on high-fat diet- (HFD-) induced cognitive deficits in male C57BL/6 mice. It was found that EM improved glucose tolerance status by measuring OGTT and IPGTT with HFD-induced mice. EM protected behavioral and memory dysfunction in Y-maze,...

journal_title：Oxidative medicine and cellular longevity

authors： Kim JM,Lee U,Kang JY,Park SK,Kim JC,Heo HJ

更新日期：2020-11-28 00:00:00

abstract：:In chronic heart failure (HF), some parameters of oxidative stress are correlated with disease severity. The aim of this study was to evaluate the importance of oxidative stress biomarkers in prognostic risk stratification (death and combined endpoint: heart transplantation or death). In 774 patients, aged 48-59 years...

journal_title：Oxidative medicine and cellular longevity

authors： Romuk E,Wojciechowska C,Jacheć W,Zemła-Woszek A,Momot A,Buczkowska M,Rozentryt P

更新日期：2019-10-09 00:00:00

abstract：:Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The combination of siramesine, a lysosomotropic agent, and lapatinib, a dual tyrosine kinase inhibitor (TKI), synergistically induced cell death in breast cancer cells media...

journal_title：Oxidative medicine and cellular longevity

authors： Villalpando-Rodriguez GE,Blankstein AR,Konzelman C,Gibson SB

更新日期：2019-09-17 00:00:00

abstract：:We examined in vitro antioxidant capacity of polyphenolic extract obtained from the wood of oak Quercus robur (QR), Robuvit, using TEAC (Trolox equivalent antioxidant capacity) method and the effect of its intake on markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity in plasma ...

journal_title：Oxidative medicine and cellular longevity

authors： Horvathova M,Orszaghova Z,Laubertova L,Vavakova M,Sabaka P,Rohdewald P,Durackova Z,Muchova J

更新日期：2014-01-01 00:00:00

abstract：:This work reviews concepts regarding oxidative stress and the mechanisms by which endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys the relationships between oxidative stress, circadian rhythms, and retinal damage in humans, particularly those related to light and photodamage. In ...

journal_title：Oxidative medicine and cellular longevity

authors： Fanjul-Moles ML,López-Riquelme GO

更新日期：2016-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) has grown as an attractive biologic instrument in regenerative medicine for its powerful healing properties. It is considered as a source of growth factors that may induce tissue repairing and improve fibrosis. This product has proven its efficacy in multiple studies, but its effect on cispl...

journal_title：Oxidative medicine and cellular longevity

authors： Salem N,Helmi N,Assaf N

更新日期：2018-07-18 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration. Pathogenetic mechanisms, triggered by β-amyloid (Aβ) accumulation, include oxidative stress, derived from energy homeostasis deregulation and involving mitochondria and peroxisomes. We here addressed the oxida...

journal_title：Oxidative medicine and cellular longevity

authors： Porcellotti S,Fanelli F,Fracassi A,Sepe S,Cecconi F,Bernardi C,Cimini A,Cerù MP,Moreno S

更新日期：2015-01-01 00:00:00

abstract：:Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms of ac...

journal_title：Oxidative medicine and cellular longevity

authors： Ucci M,Di Tomo P,Tritschler F,Cordone VGP,Lanuti P,Bologna G,Di Silvestre S,Di Pietro N,Pipino C,Mandatori D,Formoso G,Pandolfi A

更新日期：2019-01-30 00:00:00

abstract：:Escherichia coli (E. coli) is one of pathogens causing nosocomial pneumonia and could induce pulmonary excessive apoptosis. Although much has been learned about metabolic diseases induced by obesity, the information linking bacterial pneumonia to obesity is limited. Accordingly, we investigated the apoptosis of normal...

journal_title：Oxidative medicine and cellular longevity

authors： Wang F,Zuo Z,Yang Z,Chen K,Fang J,Cui H,Shu G,Zhou Y,Geng Y,Ouyang P

更新日期：2019-10-22 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of endothelial dysfunction, which is found to precede the development of diverse cardiovascular diseases (CVDs). The aim of this study was to observe the protective effects of PD against H2O2-induced oxidative stress injury (OSI) in human umbilical vein endo...

journal_title：Oxidative medicine and cellular longevity

authors： Qiao H,Chen H,Dong Y,Ma H,Zhao G,Tang F,Li Z

更新日期：2016-01-01 00:00:00

abstract：:As a core member of p38 MAPK signal transduction pathway, p38 regulated/activated kinase (PRAK) is activated by cellular stresses. However, the function of PRAK and its downstream interacting partner remain undefined. Using a yeast two-hybrid system, we identified DJ-1 as a potential PRAK interacting protein. We furth...

journal_title：Oxidative medicine and cellular longevity

authors： Tang J,Liu J,Li X,Zhong Y,Zhong T,Liu Y,Wang JH,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear f...

journal_title：Oxidative medicine and cellular longevity

authors： Fuyuno Y,Uchi H,Yasumatsu M,Morino-Koga S,Tanaka Y,Mitoma C,Furue M

更新日期：2018-02-14 00:00:00

abstract：:The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environmen...

journal_title：Oxidative medicine and cellular longevity

authors： Pambianchi E,Ferrara F,Pecorelli A,Woodby B,Grace M,Therrien JP,Lila MA,Valacchi G

更新日期：2020-08-13 00:00:00

abstract：Background:The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects. Aims:To assess the effect of ileal transposition (IT) and sham types of ...

journal_title：Oxidative medicine and cellular longevity

authors： Skrzep-Poloczek B,Stygar D,Sawczyn T,Romuk E,Chełmecka E,Poloczek J,Dulska A,Kazura W,Karcz KW

更新日期：2018-11-11 00:00:00

abstract：:The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tes...

journal_title：Oxidative medicine and cellular longevity

authors： Dimić DS,Marković ZS,Saso L,Avdović EH,Đorović JR,Petrović IP,Stanisavljević DD,Stevanović MJ,Potočňák I,Samoľová E,Trifunović SR,Dimitrić Marković JM

更新日期：2019-02-13 00:00:00

abstract：:Traumatic brain injury (TBI) represents one of the major causes of mortality and disability in the world. TBI is characterized by primary damage resulting from the mechanical forces applied to the head as a direct result of the trauma and by the subsequent secondary injury due to a complex cascade of biochemical event...

journal_title：Oxidative medicine and cellular longevity

authors： Angeloni C,Prata C,Dalla Sega FV,Piperno R,Hrelia S

更新日期：2015-01-01 00:00:00

abstract：:Fruits, such as grapes, are essential food of the Mediterranean diet. Grape extracts have potent antioxidant and chemopreventive properties in vitro. Numerous studies have examined the effects of plant extract administration on redox status at rest in animals and humans but their results are controversial. However, th...

journal_title：Oxidative medicine and cellular longevity

authors： Veskoukis AS,Kyparos A,Nikolaidis MG,Stagos D,Aligiannis N,Halabalaki M,Chronis K,Goutzourelas N,Skaltsounis L,Kouretas D

更新日期：2012-01-01 00:00:00

abstract：:Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable model of human hyp...

journal_title：Oxidative medicine and cellular longevity

authors： Rubattu S,Stanzione R,Volpe M

更新日期：2016-01-01 00:00:00

abstract：:Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury. The liver has high capacity for producing glutathione and is a key organ in modulating local and ...

journal_title：Oxidative medicine and cellular longevity

authors： Shang Y,Siow YL,Isaak CK,O K

更新日期：2016-01-01 00:00:00

abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

journal_title：Oxidative medicine and cellular longevity

authors： Kim HM,Cho BR

更新日期：2013-01-01 00:00:00

abstract：:Virulence of enterohemorrhagic Escherichia coli (EHEC) strains depends on production of Shiga toxins. These toxins are encoded in genomes of lambdoid bacteriophages (Shiga toxin-converting phages), present in EHEC cells as prophages. The genes coding for Shiga toxins are silent in lysogenic bacteria, and prophage indu...

journal_title：Oxidative medicine and cellular longevity

authors： Licznerska K,Nejman-Faleńczyk B,Bloch S,Dydecka A,Topka G,Gąsior T,Węgrzyn A,Węgrzyn G

更新日期：2016-01-01 00:00:00