Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity.

abstract：:Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of Commiphora molmol resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH4Cl-) induced hyperammonemic rats, with an emphasis on the glutama...

journal_title：Oxidative medicine and cellular longevity

authors： Mahmoud AM,Alqahtani S,Othman SI,Germoush MO,Hussein OE,Al-Basher G,Khim JS,Al-Qaraawi MA,Al-Harbi HM,Fadel A,Allam AA

更新日期：2017-01-01 00:00:00

abstract：:Depression is an inflammatory-related condition, with the progression in neuronal damage resulting in major depression disorder. Ginsenoside-Rg1, a sterol extract from the herb Panax ginseng, has been shown to exert neuroprotective effects upon neurodegeneration disorders. However, whether ginsenoside-Rg1 confers anti...

journal_title：Oxidative medicine and cellular longevity

authors： Li Y,Wang L,Wang P,Fan C,Zhang P,Shen J,Yu SY

更新日期：2020-03-18 00:00:00

abstract：:Exercise induced skeletal muscle phenotype change involves a complex interplay between signaling pathways and downstream regulators. This study aims to investigate the effect of acute exercise on mitochondrial H2O2 production and its association with p(66Shc), FOXO3a, and antioxidant enzymes. Male ICR/CD-1 mice were s...

journal_title：Oxidative medicine and cellular longevity

authors： Wang P,Li CG,Qi Z,Cui D,Ding S

更新日期：2015-01-01 00:00:00

abstract：:Curcumin is a bifunctional antioxidant derived from Curcuma longa. This study identifies curcumin as a neuroprotectant against hemin-induced damage in primary cultures of cerebellar granule neurons (CGNs) of rats. Hemin, the oxidized form of heme, is a highly reactive compound that induces cellular injury. Pretreatmen...

journal_title：Oxidative medicine and cellular longevity

authors： González-Reyes S,Guzmán-Beltrán S,Medina-Campos ON,Pedraza-Chaverri J

更新日期：2013-01-01 00:00:00

abstract：:The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities...

journal_title：Oxidative medicine and cellular longevity

authors： Andreicuț AD,Fischer-Fodor E,Pârvu AE,Ţigu AB,Cenariu M,Pârvu M,Cătoi FA,Irimie A

更新日期：2019-12-14 00:00:00

abstract：:Endothelial injury plays a critical role in the pathogenesis of cardiovascular disorders and metabolic-associated vascular complications which are the leading cause of death worldwide. However, the mechanism underlying endothelial dysfunction is not completely understood. The study is aimed at investigating the role o...

journal_title：Oxidative medicine and cellular longevity

authors： Liu N,Li Y,Nan W,Zhou W,Huang J,Li R,Zhou L,Hu R

更新日期：2020-10-02 00:00:00

abstract：:Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign lipid storage to so-called second hit of inflammation activation. Isoquercitrin (IQ) is widely present flavonoid but its effects on hepatic lipid metabolism remain unknown. We used free fatty acids (FFA) induced lipid overl...

journal_title：Oxidative medicine and cellular longevity

authors： Hassan W,Rongyin G,Daoud A,Ding L,Wang L,Liu J,Shang J

更新日期：2014-01-01 00:00:00

abstract：:Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba Cistanche with a variety of biological attributes such as antiox...

journal_title：Oxidative medicine and cellular longevity

authors： Gu C,Li L,Huang Y,Qian D,Liu W,Zhang C,Luo Y,Zhou Z,Kong F,Zhao X,Liu H,Gao P,Chen J,Yin G

更新日期：2020-07-23 00:00:00

abstract：:Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipa...

journal_title：Oxidative medicine and cellular longevity

authors： Alonazi M,Horchani H,Alwhibi M,Ben Bacha A

更新日期：2020-10-29 00:00:00

abstract：:Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae. The animals received either 10 μL of saline or a S. pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis...

journal_title：Oxidative medicine and cellular longevity

authors： Barichello T,Santos AL,Silvestre C,Generoso JS,Cipriano AL,Petronilho F,Dal-Pizzol F,Comim CM,Quevedo J

更新日期：2011-01-01 00:00:00

abstract：:Reversible myocardial ischemia/reperfusion (I/R) or ischemic preconditioning (IPC) is associated with an immediate genomic response; IPC-induced immediate early genes are associated with reduced infarct size. Because the immediate early response gene X-1 (IEX-1) plays a central role in cell apoptosis, we examine wheth...

journal_title：Oxidative medicine and cellular longevity

authors： Xu MJ,Cai Y,Qu A,Shyy JY,Li W,Wang X

更新日期：2017-01-01 00:00:00

abstract：:Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms of ac...

journal_title：Oxidative medicine and cellular longevity

authors： Ucci M,Di Tomo P,Tritschler F,Cordone VGP,Lanuti P,Bologna G,Di Silvestre S,Di Pietro N,Pipino C,Mandatori D,Formoso G,Pandolfi A

更新日期：2019-01-30 00:00:00

abstract：:Introduction. Aerodigestive squamous cell carcinomas (ASCC) constitute a major source of global cancer deaths. Patients typically present with advanced, incurable disease, so new means of detecting early disease are a research priority. Metabolite quantitation is amenable to point-of-care analysis and can be performed...

journal_title：Oxidative medicine and cellular longevity

authors： Goh YM,Antonowicz SS,Boshier P,Hanna GB

更新日期：2020-02-21 00:00:00

abstract：:Previous studies have shown that metformin not only is a hypoglycemic agent but also has neuroprotective effects. However, the mechanism of action of metformin in ischemic stroke is unclear. Oxidative stress is an important factor in the pathogenesis of cerebral ischemia-reperfusion injury. It has been reported that m...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng J,Zhu L,Liu J,Zhu T,Xie Z,Sun X,Zhang H

更新日期：2019-12-16 00:00:00

abstract：:Apigenin is a natural flavonoid found in several dietary plant foods as vegetables and fruits. To investigate potential anti-ischemia/reperfusion injury properties of apigenin in vitro, cell proliferation assay, tube formation, cell migration, apoptosis, and autophagy were performed in human brain microvascular endoth...

journal_title：Oxidative medicine and cellular longevity

authors： Pang Q,Zhao Y,Chen X,Zhao K,Zhai Q,Tu F

更新日期：2018-12-03 00:00:00

abstract：:We conducted quantitative cellular respiration analysis on samples taken from human breast cancer (HBC) and human colorectal cancer (HCC) patients. Respiratory capacity is not lost as a result of tumor formation and even though, functionally, complex I in HCC was found to be suppressed, it was not evident on the prote...

journal_title：Oxidative medicine and cellular longevity

authors： Koit A,Shevchuk I,Ounpuu L,Klepinin A,Chekulayev V,Timohhina N,Tepp K,Puurand M,Truu L,Heck K,Valvere V,Guzun R,Kaambre T

更新日期：2017-01-01 00:00:00

abstract：:Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant s...

journal_title：Oxidative medicine and cellular longevity

authors： Gunawardena HP,Silva R,Sivakanesan R,Ranasinghe P,Katulanda P

更新日期：2019-08-05 00:00:00

abstract：:Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus ...

journal_title：Oxidative medicine and cellular longevity

authors： Liu J,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccha...

journal_title：Oxidative medicine and cellular longevity

authors： Giancaspero TA,Locato V,Barile M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and...

journal_title：Oxidative medicine and cellular longevity

authors： Longato L,Ripp K,Setshedi M,Dostalek M,Akhlaghi F,Branda M,Wands JR,de la Monte SM

更新日期：2012-01-01 00:00:00

abstract：:Eugenia dysenterica ex DC Mart. (Myrtaceae), popularly known as "cagaita," is a Brazilian plant rich in polyphenols and other antioxidant compounds. Aiming to evaluate the potential use of cagaita in pathologies involving oxidative stress, such as neurodegenerative disorders, this study investigated its antioxidant po...

journal_title：Oxidative medicine and cellular longevity

authors： Thomaz DV,Peixoto LF,de Oliveira TS,Fajemiroye JO,da Silva Neri HF,Xavier CH,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

更新日期：2018-09-19 00:00:00

abstract：:Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be...

journal_title：Oxidative medicine and cellular longevity

authors： Picone P,Nuzzo D,Caruana L,Scafidi V,Di Carlo M

更新日期：2014-01-01 00:00:00

abstract：:Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF-κB and TNF-α have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-κB and TNF-α remain unknown. Exosomes have been ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu B,Zhang L,Liang C,Liu B,Pan X,Wang Y,Zhang Y,Zhang Y,Xie W,Yan B,Liu F,Yip HK,Yu XY,Li Y

更新日期：2019-04-08 00:00:00

abstract：:Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism ar...

journal_title：Oxidative medicine and cellular longevity

authors： Hou B,Zhao Y,Qiang G,Yang X,Xu C,Chen X,Liu C,Wang X,Zhang L,Du G

更新日期：2018-07-02 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Considering the various pharmacological activities of epigallocatechin-3-O-gallate (EGCG) including anticancer, and anti-inflammatory, antidiabetic, and so forth, relatively less attention has been paid to the antiaging effect of EGCG on primary cells. In this study, the preventive effects of EGCG against serial passa...

journal_title：Oxidative medicine and cellular longevity

authors： Han DW,Lee MH,Kim B,Lee JJ,Hyon SH,Park JC

更新日期：2012-01-01 00:00:00

abstract：:In plasma medicine, cold physical plasma delivers a delicate mixture of reactive components to cells and tissues. Recent studies suggested a beneficial role of cold plasma in wound healing. Yet, the biological processes related to the redox modulation via plasma are not fully understood. We here used the monocytic cel...

journal_title：Oxidative medicine and cellular longevity

authors： Bekeschus S,Schmidt A,Bethge L,Masur K,von Woedtke T,Hasse S,Wende K

更新日期：2016-01-01 00:00:00

abstract：:Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y,...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos KC,Cury SS,Ferraz APCR,Corrente JE,Gonçalves BM,de Araújo Machado LH,Carvalho RF,de Melo Stevanato Nakamune AC,Fabro AT,Freire PP,Corrêa CR

更新日期：2018-04-10 00:00:00

abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2015-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is a common inflammatory bowel disease that can destroy the integrity of the colon and increase the risk of colorectal cancer. Oxidative stress is one of the critical pathogenic factors for UC, further impairing the entire affected colon. The Nrf2-ARE signaling pathway plays an important role i...

journal_title：Oxidative medicine and cellular longevity

authors： Xu LL,Liu T,Wang L,Li L,Wu YF,Li CC,Di B,You QD,Jiang ZY

更新日期：2018-05-20 00:00:00