Reactive oxygen species in vascular formation and development.

abstract：:Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its maintenance. Here we prop...

journal_title：Oxidative medicine and cellular longevity

authors： Farooq MA,Pracheil TM,Dong Z,Xiao F,Liu Z

更新日期：2013-01-01 00:00:00

abstract：:Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

更新日期：2016-01-01 00:00:00

abstract：:As the involvement of oxidative stress (OS) in autoimmune thrombocytopenia (AITP) has been reported, a fast and rapid test for the reliable measurement of OS and antioxidant capacities (AOCs) might be a useful tool in extending current diagnostic possibilities. The free oxygen radical test (FORT) and free oxygen radic...

journal_title：Oxidative medicine and cellular longevity

authors： Kamhieh-Milz J,Salama A

更新日期：2014-01-01 00:00:00

abstract：:Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

journal_title：Oxidative medicine and cellular longevity

authors： Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

更新日期：2019-02-17 00:00:00

abstract：:The role of altered redox status and high reactive oxygen species (ROS) is still controversial in cancer development and progression. Intracellular levels of ROS are elevated in cancer cells suggesting a role in cancer initiation and progression; on the contrary, ROS elevated levels may induce programmed cell death an...

journal_title：Oxidative medicine and cellular longevity

authors： Leone A,Roca MS,Ciardiello C,Costantini S,Budillon A

更新日期：2017-01-01 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:Obesity is a state of chronic low-level inflammation closely associated with oxidative stress. Childhood obesity is associated with endothelial dysfunction, inflammation, and oxidative stress markers individually. This study was aimed at determining the association between the biomarkers of inflammation, oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Selvaraju V,Ayine P,Fadamiro M,Babu JR,Brown M,Geetha T

更新日期：2019-10-16 00:00:00

abstract：:The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained ...

journal_title：Oxidative medicine and cellular longevity

authors： de Giffoni de Carvalho JT,da Silva Baldivia D,Leite DF,de Araújo LCA,de Toledo Espindola PP,Antunes KA,Rocha PS,de Picoli Souza K,Dos Santos EL

更新日期：2019-08-25 00:00:00

abstract：:Several of the most prevalent etiological factors which contribute towards global death rates are associated with cardiovascular diseases (CVDs), which include a range of conditions such as angina, rheumatic heart disease, and venous thrombosis. Extensive research has been conducted into the role played by oxidative s...

journal_title：Oxidative medicine and cellular longevity

authors： Chen S,Jiang H,Peng H,Wu X,Fang J

更新日期：2017-01-01 00:00:00

abstract：:The human apoptosis-inducing factor (hAIF) is a moonlight flavoprotein involved in mitochondrial respiratory complex assembly and caspase-independent programmed cell death. These functions might be modulated by its redox-linked structural transition that enables hAIF to act as a NAD(H/+) redox sensor. Upon reduction w...

journal_title：Oxidative medicine and cellular longevity

authors： Romero-Tamayo S,Laplaza R,Velazquez-Campoy A,Villanueva R,Medina M,Ferreira P

更新日期：2021-01-15 00:00:00

abstract：:Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and is caused by mutations in the gene that encodes the cytoskeletal protein dystrophin. The treatment f...

journal_title：Oxidative medicine and cellular longevity

authors： Kuno A,Horio Y

更新日期：2016-01-01 00:00:00

abstract：:Hypoxia, as one of the severe cellular stresses, can cause cellular injury and even cell death. Apoptosis is the main mechanism of regulating cell death and is closely related to the cell death caused by hypoxia. However, hypoxia-induced apoptosis is not entirely the result of direct hypoxic stimulus of cells. In rece...

journal_title：Oxidative medicine and cellular longevity

authors： Guo Y,Tan J,Miao Y,Sun Z,Zhang Q

更新日期：2019-04-17 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascu...

journal_title：Oxidative medicine and cellular longevity

authors： Ling S,Xu JW

更新日期：2016-01-01 00:00:00

abstract：:Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field. This study is aimed at exploring StAEW as a potential wound care agent and its mechanism. StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of...

journal_title：Oxidative medicine and cellular longevity

authors： Fadriquela A,Sajo MEJ,Bajgai J,Kim DH,Kim CS,Kim SK,Lee KJ

更新日期：2020-12-12 00:00:00

abstract：:The antiamnesic effect of 3,5-dicaffeoylquinic acid (3,5-diCQA) as the main phenolic compound in Artemisia argyi H. extract on cognitive dysfunction induced by trimethyltin (TMT) (7.1 μg/kg of body weight; intraperitoneal injection) was investigated in order to assess its ameliorating function in mice. In several beha...

journal_title：Oxidative medicine and cellular longevity

authors： Kang JY,Park SK,Guo TJ,Ha JS,Lee DS,Kim JM,Lee U,Kim DO,Heo HJ

更新日期：2016-01-01 00:00:00

abstract：:The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy f...

journal_title：Oxidative medicine and cellular longevity

authors： Barquilha CN,Santos NJ,Monção CCD,Barbosa IC,Lima FO,Justulin LA,Pértega-Gomes N,Felisbino SL

更新日期：2020-01-20 00:00:00

abstract：:Organic cations (OCs) are substances of endogenous (e.g. dopamine, choline) or exogenous (e.g. drugs like cimetidine) origin that are positively charged at physiological pH. Since many of these compounds can not pass the cell membrane freely, their transport in our out of cells must be mediated by specific transport s...

journal_title：Oxidative medicine and cellular longevity

authors： Faria A,Monteiro R,Pestana D,Freitas Vd,Mateus N,Azevedo I,Calhau C

更新日期：2009-11-01 00:00:00

abstract：:Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Gaspar RS,Trostchansky A,Paes AM

更新日期：2016-01-01 00:00:00

abstract：:Our previous studies have shown Leptomycin B (LMB) is a promising antilung cancer drug. Epigallocatechin-3-gallate (EGCG) has antitumor properties but a debatable clinical application. The objective of this study is to evaluate the combination therapeutic effect of LMB and EGCG and its molecular mechanisms in human lu...

journal_title：Oxidative medicine and cellular longevity

authors： Cromie MM,Gao W

更新日期：2015-01-01 00:00:00

abstract：Objective:Cholesterol oxidation products have an established proatherogenic and cytotoxic effect. An increased exposure to these substances may be associated with the development of atherosclerosis and cancers. Relatively little, though, is known about the effect of phytosterol oxidation products, although phytosterols...

journal_title：Oxidative medicine and cellular longevity

authors： Wielkoszyński T,Zalejska-Fiolka J,Strzelczyk JK,Owczarek AJ,Cholewka A,Krawczyk A,Stanek A

更新日期：2019-11-15 00:00:00

abstract：:This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation with MRI findings. A multicenter prospective observational study was performed between March 201...

journal_title：Oxidative medicine and cellular longevity

authors： Negro S,Benders MJNL,Tataranno ML,Coviello C,de Vries LS,van Bel F,Groenendaal F,Longini M,Proietti F,Belvisi E,Buonocore G,Perrone S

更新日期：2018-06-28 00:00:00

abstract：:The ability to produce cold plasma at atmospheric pressure conditions was the basis for the rapid growth of plasma-related application areas in biomedicine. Plasma comprises a multitude of active components such as charged particles, electric current, UV radiation, and reactive gas species which can act synergisticall...

journal_title：Oxidative medicine and cellular longevity

authors： Bernhardt T,Semmler ML,Schäfer M,Bekeschus S,Emmert S,Boeckmann L

更新日期：2019-09-03 00:00:00

abstract：:We examined in vitro antioxidant capacity of polyphenolic extract obtained from the wood of oak Quercus robur (QR), Robuvit, using TEAC (Trolox equivalent antioxidant capacity) method and the effect of its intake on markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity in plasma ...

journal_title：Oxidative medicine and cellular longevity

authors： Horvathova M,Orszaghova Z,Laubertova L,Vavakova M,Sabaka P,Rohdewald P,Durackova Z,Muchova J

更新日期：2014-01-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) is an alpha- and gamma-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the gamma-secretase, presenilin, have been implicated in familial Alzheimer's dis...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang T,Mi Z,Schor NF

更新日期：2009-09-01 00:00:00

abstract：:The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generat...

journal_title：Oxidative medicine and cellular longevity

authors： Aune SE,Yeh ST,Kuppusamy P,Kuppusamy ML,Khan M,Angelos MG

更新日期：2013-01-01 00:00:00

abstract：:The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin. Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months. At the end of 3-month SFN treatment, the diabeti...

journal_title：Oxidative medicine and cellular longevity

authors： Cui W,Bai Y,Miao X,Luo P,Chen Q,Tan Y,Rane MJ,Miao L,Cai L

更新日期：2012-01-01 00:00:00

abstract：:Ischemia-reperfusion (I/R) injury caused by acute myocardial infarction (AMI) can initiate a strong inflammatory response. Polymorphonuclear cells (PMNs) are the most important inflammatory cells. Our previous studies found that the calcium-sensing receptor (CaSR) regulates the proinflammatory effects of PMNs. However...

journal_title：Oxidative medicine and cellular longevity

authors： Zhai TY,Cui BH,Zhou Y,Xu XY,Zou L,Lin X,Zhu XS,Zhang SW,Xie WL,Cheng YY,Sun YH

更新日期：2021-01-12 00:00:00

abstract：:Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its ...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Z,Zhang S,Xiao Y,Zhang W,Wu S,Qin T,Yue Y,Qian W,Li L

更新日期：2020-02-17 00:00:00

abstract：:Over 50% of end-stage renal disease (ESRD) patients die of cardiovascular disease. ESRD patients treated with maintenance hemodialysis are repeatedly exposed to oxidative stress. The aim of the study was to find the relationship between lifestyle factors, nutritional status, calcium-phosphate metabolism, and selected ...

journal_title：Oxidative medicine and cellular longevity

authors： Maraj M,Kuśnierz-Cabala B,Dumnicka P,Gawlik K,Pawlica-Gosiewska D,Gala-Błądzińska A,Ząbek-Adamska A,Ceranowicz P,Kuźniewski M

更新日期：2019-09-05 00:00:00

abstract：:Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify ...

journal_title：Oxidative medicine and cellular longevity

authors： Malaguti M,Angeloni C,Hrelia S

更新日期：2013-01-01 00:00:00