Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress Response.


:Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field. This study is aimed at exploring StAEW as a potential wound care agent and its mechanism. StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of hairless mice for seven days. Wound morphological and histological features and immune-redox markers were compared with saline- (Sal-) and alcohol- (Alc-) treated groups. Results showed that the StAEW group showed a significantly higher wound healing percentage than the Sal group on days 2, 4, 5, and 6 and the Alc group on day 4. The StAEW group also showed earlier mediation on proinflammatory cytokines such as tumor necrosis factor-α, interleukin- (IL-) 6, IL-1β, and keratinocyte chemoattractant. In addition, basic fibroblast growth factor and platelet-derived growth factor were found to be significantly changed in favor of the fibroblast synthesis and angiogenesis. In line, the StAEW group showed a controlled amount of ROS and significantly decreased compared to the Alc group. The StAEW group also favored oxidative stress balance through antioxidant responses. Additionally, matrix metalloproteinases (MMP) 9 and MMP1 were also modulated for keratinocyte and cell migration. Taken together, this study has proven the wound healing effect of StAEW and its earlier mediation through oxidative and inflammatory responses.


Oxid Med Cell Longev


Fadriquela A,Sajo MEJ,Bajgai J,Kim DH,Kim CS,Kim SK,Lee KJ




Has Abstract


2020-12-12 00:00:00










  • PD98059 Protects Brain against Cells Death Resulting from ROS/ERK Activation in a Cardiac Arrest Rat Model.

    abstract::The clinical and experimental postcardiac arrest treatment has not reached therapeutic success. The present study investigated the effect of PD98059 (PD) in rats subjected to cardiac arrest (CA)/cardiopulmonary resuscitation (CPR). Experimental rats were divided randomly into 3 groups: sham, CA, and PD. The rats excep...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Nguyen Thi PA,Chen MH,Li N,Zhuo XJ,Xie L

    更新日期:2016-01-01 00:00:00

  • Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats.

    abstract::Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes. This study sought to determine the effects of age and vitamin E supplementation in the form of tocotrienol-rich fraction (TRF) on brain arginine metabolism. Male Wistar rats at ages of 3 and 21 mon...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Mazlan M,Hamezah HS,Taridi NM,Jing Y,Liu P,Zhang H,Wan Ngah WZ,Damanhuri HA

    更新日期:2017-01-01 00:00:00

  • Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis.

    abstract::Mutations of mtDNA, due to their higher frequency of occurrence compared to nuclear DNA mutations, are the most promising biomarkers for assessing predisposition of the occurrence and development of atherogenesis. The aim of the present article was an analysis of correlation of several mitochondrial genome mutations w...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Sazonova MA,Sinyov VV,Ryzhkova AI,Galitsyna EV,Khasanova ZB,Postnov AY,Yarygina EI,Orekhov AN,Sobenin IA

    更新日期:2017-01-01 00:00:00

  • Reactive oxygen species in vascular formation and development.

    abstract::Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduc...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Zhou Y,Yan H,Guo M,Zhu J,Xiao Q,Zhang L

    更新日期:2013-01-01 00:00:00

  • Mitochondria-Targeted Antioxidants: A Step towards Disease Treatment.

    abstract::Mitochondria are the main organelles that produce adenosine 5'-triphosphate (ATP) and reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative damage. The irreversible oxidative damage in mitochondria has been implicated in various human diseases. Increasing evidence indicates the thera...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Jiang Q,Yin J,Chen J,Ma X,Wu M,Liu G,Yao K,Tan B,Yin Y

    更新日期:2020-12-03 00:00:00

  • Regulation on Calcium Oxalate Crystallization and Protection on HK-2 Cells of Tea Polysaccharides with Different Molecular Weights.

    abstract::The regulation on calcium oxalate (CaOx) crystallization and protective effect on human proximal tubular epithelial cells (HK-2) of four green tea polysaccharides (TPSs) with molecular weights of 10.88 (TPS0), 8.16 (TPS1), 4.82 (TPS2), and 2.3 kDa (TPS3) were comparatively studied. XRD, Fourier transform infrared spec...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Liu H,Sun XY,Wang FX,Ouyang JM

    更新日期:2020-05-12 00:00:00

  • Endothelial Microparticle-Derived Reactive Oxygen Species: Role in Endothelial Signaling and Vascular Function.

    abstract::Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Burger D,Turner M,Munkonda MN,Touyz RM

    更新日期:2016-01-01 00:00:00

  • Sulfur Dioxide Enhances Endogenous Hydrogen Sulfide Accumulation and Alleviates Oxidative Stress Induced by Aluminum Stress in Germinating Wheat Seeds.

    abstract::Aluminum ions are especially toxic to plants in acidic soils. Here we present evidences that SO2 protects germinating wheat grains against aluminum stress. SO2 donor (NaHSO3/Na2SO3) pretreatment at 1.2 mM reduced the accumulation of superoxide anion, hydrogen peroxide, and malondialdehyde, enhanced the activities of g...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Zhu DB,Hu KD,Guo XK,Liu Y,Hu LY,Li YH,Wang SH,Zhang H

    更新日期:2015-01-01 00:00:00

  • Effect of novel marine nutraceuticals on IL-1α-mediated TNF-α release from UVB-irradiated human melanocyte-derived cells.

    abstract::UV-induced inflammation and reactive oxygen species formation are involved in the development of melanoma. Natural products like 5β-scymnol and CO(2)-supercritical fluid extract (CO(2)-SFE) of mussel oil contain anti-inflammatory and antioxidant properties that may aid in reducing the deleterious effects of UV radiati...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Muthusamy V,Hodges LD,Macrides TA,Boyle GM,Piva TJ

    更新日期:2011-01-01 00:00:00

  • NADPH Oxidase Isoforms Are Involved in Glucocorticoid-Induced Preosteoblast Apoptosis.

    abstract::Oxidative stress induced by long-term glucocorticoid (GC) use weakens the repair capacity of bone tissue. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase (NOX) is a superoxide-generating enzyme that plays an important role in regulating bone metabolism. To clarify the role of nonphagocytic NO...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Bai SC,Xu Q,Li H,Qin YF,Song LC,Wang CG,Cui WH,Zheng Z,Yan DW,Li ZJ,Li D,Wan X,Zhang HF

    更新日期:2019-03-27 00:00:00

  • Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients.

    abstract::Ascorbate requiring Fe2+/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in the endomembranes of fibroblasts from arterial tortuosity syndrome (AT...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Németh CE,Nemoda Z,Lőw P,Szabó P,Horváth EZ,Willaert A,Boel A,Callewaert BL,Coucke PJ,Colombi M,Bánhegyi G,Margittai É

    更新日期:2019-01-13 00:00:00

  • Decrease of total antioxidative capacity in developed low cardiac output syndrome.

    abstract:BACKGROUND:It has been known that cardiac surgery induces an oxidative stress. The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support. Total antioxidant capacity...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Kunt AS,Andac MH

    更新日期:2012-01-01 00:00:00

  • Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.

    abstract::GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to evaluate how exercise-based lifestyle interventions modulate GlycA ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,随机对照试验


    authors: Bartlett DB,Slentz CA,Connelly MA,Piner LW,Willis LH,Bateman LA,Granville EO,Bales CW,Huffman KM,Kraus WE

    更新日期:2017-01-01 00:00:00

  • Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis.

    abstract::Haptoglobin (Hp) is a plasma protein involved in clearing extracellular haemoglobin and regulating inflammation; it exists as two genetic variants (Hp1 and Hp2). In a meta-analysis of six published studies, we confirm that Hp genotype affects short-term outcome (cerebral vasospasm and/or delayed cerebral ischemia) aft...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,meta分析


    authors: Gaastra B,Glazier J,Bulters D,Galea I

    更新日期:2017-01-01 00:00:00

  • Integrated Analysis of miRNA-mRNA Interaction Network in Porcine Granulosa Cells Undergoing Oxidative Stress.

    abstract::Oxidative stress (OS), a common intracellular phenomenon induced by excess reactive oxygen species (ROS) generation, has been shown to be associated with mammalian ovarian follicular development blockage and granulosa cell (GC) impairment. However, the mechanism involved in these effects remains unknown, and the effec...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Du X,Li Q,Cao Q,Wang S,Liu H,Li Q

    更新日期:2019-11-04 00:00:00

  • Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer.

    abstract::Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of genes necessary to circumvent to hypoxic (low oxygen level) environments. In carcinogenesis, HIFs play a critical role. Indeed, HIF-1α has been validated as a promising target for novel cancer therapeutics, even as clinical i...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Akanji MA,Rotimi D,Adeyemi OS

    更新日期:2019-08-14 00:00:00

  • Exposure to Ti4Al4V Titanium Alloy Leads to Redox Abnormalities, Oxidative Stress, and Oxidative Damage in Patients Treated for Mandible Fractures.

    abstract::Due to the high biotolerance, favourable mechanical properties, and osseointegration ability, titanium is the basic biomaterial used in maxillofacial surgery. The passive layer of titanium dioxide on the surface of the implant effectively provides anticorrosive properties, but it can be damaged, resulting in the relea...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Borys J,Maciejczyk M,Antonowicz B,Krętowski A,Waszkiel D,Bortnik P,Czarniecka-Bargłowska K,Kocisz M,Szulimowska J,Czajkowski M,Waszkiewicz N,Zalewska A

    更新日期:2018-06-14 00:00:00

  • A novel contrast-induced acute kidney injury model based on the 5/6-nephrectomy rat and nephrotoxicological evaluation of iohexol and iodixanol in vivo.

    abstract::Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media. Proper animal models of CI-AKI can help understand the mechanisms involved and prevent the disorder. We used the 5/6-nephrectomized (NE) rat to develop a CI-AKI model and to evaluate di...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Liu TQ,Luo WL,Tan X,Fang Y,Chen J,Zhang H,Yu XF,Cai JR,Ding XQ

    更新日期:2014-01-01 00:00:00

  • Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model.

    abstract::To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in bot...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Marciniak A,Walczyna B,Rajtar G,Marciniak S,Wojtak A,Lasiecka K

    更新日期:2016-01-01 00:00:00

  • Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer.

    abstract::The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy f...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Barquilha CN,Santos NJ,Monção CCD,Barbosa IC,Lima FO,Justulin LA,Pértega-Gomes N,Felisbino SL

    更新日期:2020-01-20 00:00:00

  • Kaji-Ichigoside F1 and Rosamultin Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via the PI3K/AKT or ERK1/2 Signaling Pathway.

    abstract::As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

    更新日期:2020-04-12 00:00:00

  • Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging.

    abstract::Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and decreased mtDNA copy number. Current wisdom indicates that mt...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Quan Y,Xin Y,Tian G,Zhou J,Liu X

    更新日期:2020-03-26 00:00:00

  • Long-Term Moderate Exercise Combined with Metformin Treatment Induces an Hormetic Response That Prevents Strength and Muscle Mass Loss in Old Female Wistar Rats.

    abstract::Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing mo...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Hernández-Álvarez D,Mena-Montes B,Toledo-Pérez R,Pedraza-Vázquez G,López-Cervantes SP,Morales-Salazar A,Hernández-Cruz E,Lazzarini-Lechuga R,Vázquez-Cárdenas RR,Vilchis-DeLaRosa S,Posadas-Rodríguez P,Santín-Márquez R,Rosas-Carras

    更新日期:2019-11-11 00:00:00

  • The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats.

    abstract::Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

    更新日期:2020-10-19 00:00:00

  • Mitochondrial-targeted two-photon fluorescent probes for zinc ions, H2O2, and thiols in living tissues.

    abstract::Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Kim HM,Cho BR

    更新日期:2013-01-01 00:00:00

  • Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties.

    abstract::Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigat...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

    更新日期:2018-10-21 00:00:00

  • 3-Amino-1,2,4-Triazole Induces Quick and Strong Fat Loss in Mice with High Fat-Induced Metabolic Syndrome.

    abstract:Background:Obesity is a growing epidemic with limited effective treatments and an important risk factor for several diseases such as metabolic syndrome (MetS). In this study, we aimed to investigate the effect of 3-amino-1,2,4-triazole (ATZ), an inhibitor of catalase and heme synthesis, in a murine model for MetS. Met...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Nunes-Souza V,Dias-Júnior NM,Eleutério-Silva MA,Ferreira-Neves VP,Moura FA,Alenina N,Bader M,Rabelo LA

    更新日期:2020-04-13 00:00:00

  • Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives.

    abstract::Undiminishing actuality of enzyme modification for therapeutic purposes has been confirmed by application of modified enzymes in clinical practice and numerous research data on them. Intravenous injection of the superoxide dismutase-chondroitin sulfate-catalase (SOD-CHS-CAT) conjugate in preventive and medicative regi...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审


    authors: Maksimenko AV

    更新日期:2016-01-01 00:00:00

  • Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme.

    abstract::Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated mole...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Fawzy MS,Badran DI,Al Ageeli E,Al-Qahtani SAM,Alghamdi SA,Helal GM,Toraih EA

    更新日期:2018-03-21 00:00:00

  • Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study.

    abstract:Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章


    authors: Hsueh CY,Shao M,Cao W,Li S,Zhou L

    更新日期:2019-04-16 00:00:00