Functionalized Fullerene Increases NF-κB Activity and Blocks Genotoxic Effect of Oxidative Stress in Serum-Starving Human Embryo Lung Diploid Fibroblasts.

abstract：:Methanol extracts of Momordica charantia L. fruits are extensively studied for their antiaging activities. A new cucurbitane-type triterpenoid (1) and nine other known compounds (2-10) were isolated, and their structures were determined according to their spectroscopic characteristics and chemical derivatization. Biol...

journal_title：Oxidative medicine and cellular longevity

authors： Cao X,Sun Y,Lin Y,Pan Y,Farooq U,Xiang L,Qi J

更新日期：2018-03-25 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration. Pathogenetic mechanisms, triggered by β-amyloid (Aβ) accumulation, include oxidative stress, derived from energy homeostasis deregulation and involving mitochondria and peroxisomes. We here addressed the oxida...

journal_title：Oxidative medicine and cellular longevity

authors： Porcellotti S,Fanelli F,Fracassi A,Sepe S,Cecconi F,Bernardi C,Cimini A,Cerù MP,Moreno S

更新日期：2015-01-01 00:00:00

abstract：:We hypothesized that fibroblast growth factor-9 (FGF-9) would enhance angiogenesis via activating c-kit positive stem cells in the infarcted nondiabetic and diabetic heart. In brief, animals were divided into three groups: Sham, MI, and MI+FGF-9. Two weeks following MI or sham surgery, our data suggest that treatment ...

journal_title：Oxidative medicine and cellular longevity

authors： Singla D,Wang J

更新日期：2016-01-01 00:00:00

abstract：:This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephr...

journal_title：Oxidative medicine and cellular longevity

authors： Arellano-Buendía AS,Tostado-González M,García-Arroyo FE,Cristóbal-García M,Loredo-Mendoza ML,Tapia E,Sánchez-Lozada LG,Osorio-Alonso H

更新日期：2016-01-01 00:00:00

abstract：:This work reviews concepts regarding oxidative stress and the mechanisms by which endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys the relationships between oxidative stress, circadian rhythms, and retinal damage in humans, particularly those related to light and photodamage. In ...

journal_title：Oxidative medicine and cellular longevity

authors： Fanjul-Moles ML,López-Riquelme GO

更新日期：2016-01-01 00:00:00

abstract：:Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage. Unfortunately, no specific drugs have been found that effectively prevent and treat RIRI. Curcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities invol...

journal_title：Oxidative medicine and cellular longevity

authors： Wang ZH,Deng LH,Chi CW,Wang H,Huang YY,Zheng Q

更新日期：2020-11-12 00:00:00

abstract：:Advanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence. Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to ...

journal_title：Oxidative medicine and cellular longevity

authors： Buttari B,Profumo E,Facchiano F,Ozturk EI,Segoni L,Saso L,Riganò R

更新日期：2013-01-01 00:00:00

abstract：:Fungal immunomodulatory proteins (FIPs) are a class of small proteins that have been extensively studied for their immunomodulatory activities. In this study, two novel FIPs from Lentinus tigrinus were identified and named Fip-lti1 and Fip-lti2. The bioactive characteristics of Fip-lti1 and Fip-lti2 were compared to a...

journal_title：Oxidative medicine and cellular longevity

authors： Gao Y,Wáng Y,Wāng Y,Wu Y,Chen H,Yang R,Bao D

更新日期：2019-05-06 00:00:00

abstract：:The clinical and experimental postcardiac arrest treatment has not reached therapeutic success. The present study investigated the effect of PD98059 (PD) in rats subjected to cardiac arrest (CA)/cardiopulmonary resuscitation (CPR). Experimental rats were divided randomly into 3 groups: sham, CA, and PD. The rats excep...

journal_title：Oxidative medicine and cellular longevity

authors： Nguyen Thi PA,Chen MH,Li N,Zhuo XJ,Xie L

更新日期：2016-01-01 00:00:00

abstract：Objective:Oxidized cholesterol derivatives are compounds with proven atherogenic and mutagenic effects. However, little is known about the effect of oxidized plant sterol derivatives (oxyphytosterols), whose structure is similar to the one of oxycholesterols. Our previous studies indicate that they have a similar profi...

journal_title：Oxidative medicine and cellular longevity

authors： Wielkoszyński T,Zalejska-Fiolka J,Strzelczyk JK,Owczarek AJ,Cholewka A,Kokoszczyk K,Stanek A

更新日期：2020-06-08 00:00:00

abstract：:Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD). The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature m...

journal_title：Oxidative medicine and cellular longevity

authors： Luca M,Luca A,Calandra C

更新日期：2013-01-01 00:00:00

abstract：:Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccha...

journal_title：Oxidative medicine and cellular longevity

authors： Giancaspero TA,Locato V,Barile M

更新日期：2013-01-01 00:00:00

abstract：:The neuroendocrine functions of the pineal affect a wide variety of glandular and nervous system processes. Beside melatonin (MEL), the pineal gland secretes and expresses certain proteins essential for various physiological functions. It has been suggested that the pineal gland may also have an antioxidant role due t...

journal_title：Oxidative medicine and cellular longevity

authors： Bharti VK,Srivastava RS

更新日期：2009-04-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both pa...

journal_title：Oxidative medicine and cellular longevity

authors： Ho YS,Zhao FY,Yeung WF,Wong GT,Zhang HQ,Chang RC

更新日期：2020-02-13 00:00:00

abstract：:Inhibition of either P2Y12 receptor or the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome provides cardioprotective effects. Here, we investigate whether direct NLRP3 inflammasome inhibition exerts additive effects on myocardial protection induced by the ...

journal_title：Oxidative medicine and cellular longevity

authors： Penna C,Aragno M,Cento AS,Femminò S,Russo I,Bello FD,Chiazza F,Collotta D,Alves GF,Bertinaria M,Zicola E,Mercurio V,Medana C,Collino M,Pagliaro P

更新日期：2020-08-03 00:00:00

abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

更新日期：2016-01-01 00:00:00

abstract：:Detection of free radicals in tissues is challenging. Most approaches rely on incubating excised sections or homogenates with reagents, typically at supraphysiologic oxygen tensions, to finally detect surrogate, nonspecific end products. In the present work, we explored the potential of using intravenously (i.v.) inje...

journal_title：Oxidative medicine and cellular longevity

authors： Proniewski B,Kij A,Sitek B,Kelley EE,Chlopicki S

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and...

journal_title：Oxidative medicine and cellular longevity

authors： Longato L,Ripp K,Setshedi M,Dostalek M,Akhlaghi F,Branda M,Wands JR,de la Monte SM

更新日期：2012-01-01 00:00:00

abstract：:Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typi...

journal_title：Oxidative medicine and cellular longevity

authors： Passaro A,Vigna GB,Romani A,Sanz JM,Cavicchio C,Bonaccorsi G,Valacchi G,Cervellati C

更新日期：2018-11-05 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results from the death of upper and lower motor neurons. Due to a lack of effective treatment, it is imperative to understand the underlying mechanisms and processes involved in disease progression. Regulations in cellular reduction/oxidation (red...

journal_title：Oxidative medicine and cellular longevity

authors： Parakh S,Spencer DM,Halloran MA,Soo KY,Atkin JD

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/4824371.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Song TY,Yang NC,Chen CL,Thi TLV

更新日期：2019-08-06 00:00:00

abstract：:Low back pain (LBP) is the leading cause of disability in the elderly. Intervertebral disc degeneration (IDD) was considered as the main cause for LBP. Degeneration of cartilaginous endplate was a crucial harmful factor during the initiation and development of IDD. Oxidative stress was implicated in IDD. However, the ...

journal_title：Oxidative medicine and cellular longevity

authors： Chen K,Lv X,Li W,Yu F,Lin J,Ma J,Xiao D

更新日期：2017-01-01 00:00:00

abstract：:Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPRmt in the cardiac muscle are yet to be elucidated. The aim of this study was to determ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang B,Tan Y,Zhang Z,Feng P,Ding W,Wang Q,Liang H,Duan W,Wang X,Yu S,Liu J,Yi D,Sun Y,Yi W

更新日期：2020-12-26 00:00:00

abstract：:Oxidative stress-mediated endothelial injury is considered to be involved in the pathogenesis of various cardiovascular diseases. Farrerol, a typical natural flavanone from the medicinal plant Rhododendron dauricum L., has been reported to show protective effects against oxidative stress-induced endothelial injuries i...

journal_title：Oxidative medicine and cellular longevity

authors： Yan C,Zhang X,Miao J,Yuan H,Liu E,Liang T,Li Q

更新日期：2020-01-28 00:00:00

abstract：:There is accumulating evidence that blood pressure (BP) control significantly reduces the risk of future cardiovascular events in patients with essential hypertension. However, strict BP control is often difficult to maintain, and half of hypertensive patients fail to attain BP goals on single-drug therapy. Therefore,...

journal_title：Oxidative medicine and cellular longevity

authors： Bekki H,Yamamoto K,Sone M,Homma T,Nakata M,Nohara M,Fukami K,Okuda S,Yamagishi S

更新日期：2010-09-01 00:00:00

abstract：Background:Mitochondrial dynamics (mtDYN) has been proposed as a bridge between mitochondrial dysfunction and insulin resistance (IR), which is involved in the pathogenesis of type 2 diabetes (T2D). Our previous study has identified that mitochondrial DNA (mtDNA) haplogroup B4 is a T2D-susceptible genotype. Using trans...

journal_title：Oxidative medicine and cellular longevity

authors： Lin HY,Weng SW,Chang YH,Su YJ,Chang CM,Tsai CJ,Shen FC,Chuang JH,Lin TK,Liou CW,Lin CY,Wang PW

更新日期：2018-09-30 00:00:00

abstract：:The ability to produce cold plasma at atmospheric pressure conditions was the basis for the rapid growth of plasma-related application areas in biomedicine. Plasma comprises a multitude of active components such as charged particles, electric current, UV radiation, and reactive gas species which can act synergisticall...

journal_title：Oxidative medicine and cellular longevity

authors： Bernhardt T,Semmler ML,Schäfer M,Bekeschus S,Emmert S,Boeckmann L

更新日期：2019-09-03 00:00:00

abstract：:Aging leads to a number of disadvantageous changes in the cardiovascular system. Deterioration of vascular homoeostasis with increase in oxidative stress, chronic low-grade inflammation, and impaired nitric oxide bioavailability results in endothelial dysfunction, increased vascular stiffness, and compromised arterial...

journal_title：Oxidative medicine and cellular longevity

authors： Rammos C,Totzeck M,Deenen R,Köhrer K,Kelm M,Rassaf T,Hendgen-Cotta UB

更新日期：2015-01-01 00:00:00

abstract：:Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randoml...

journal_title：Oxidative medicine and cellular longevity

authors： Dkhil MA,Al-Quraishy S,Aref AM,Othman MS,El-Deib KM,Abdel Moneim AE

更新日期：2013-01-01 00:00:00

abstract：:Three cosmetically important skin lightening agents, hydroquinone (HQ), kojic acid (KA), and niacinamide (NA), consume the bulk of successful skin lightening ingredients in cosmetic applications. However, the mechanisms by which these ingredients work are still unclear. In this study, melanocytes and keratinocytes wer...

journal_title：Oxidative medicine and cellular longevity

authors： Gruber JV,Holtz R

更新日期：2013-01-01 00:00:00