Use of Carnosine for Oxidative Stress Reduction in Different Pathologies.

abstract：:Copper, a transition metal with essential cellular functions, exerts neurotoxic effects when present in excess by promoting production of reactive oxygen species (ROS). The aim of the present study was to investigate potential benefits of flavonoid quercetin against copper-induced toxicity. Results obtained with MTT a...

journal_title：Oxidative medicine and cellular longevity

authors： Zubčić K,Radovanović V,Vlainić J,Hof PR,Oršolić N,Šimić G,Jazvinšćak Jembrek M

更新日期：2020-07-11 00:00:00

abstract：:Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) i...

journal_title：Oxidative medicine and cellular longevity

authors： Carreira BP,Santos DF,Santos AI,Carvalho CM,Araújo IM

更新日期：2015-01-01 00:00:00

abstract：Aims:The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in db/db mice and to identify the protective mechanisms of this therapy. Methods:db/db mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously...

journal_title：Oxidative medicine and cellular longevity

authors： Papinska AM,Rodgers KE

更新日期：2018-10-23 00:00:00

abstract：:Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death. Mitochondrial functions can be...

journal_title：Oxidative medicine and cellular longevity

authors： Picone P,Nuzzo D,Caruana L,Scafidi V,Di Carlo M

更新日期：2014-01-01 00:00:00

abstract：:The study aimed to evaluate whether the treatment of primary cultured human endothelial cells with native low-density lipoprotein (nLDL) could induce their senescence and to uncover some of the putative mechanisms involved. For this purpose, human umbilical vein endothelial cells (HUVECs) were subcultured and/or conti...

journal_title：Oxidative medicine and cellular longevity

authors： Oh ST,Park H,Yoon HJ,Yang SY

更新日期：2017-01-01 00:00:00

abstract：:Tea polyphenols are of great benefit to the treatment of several neurodegenerative diseases. In order to explore the neuroprotective effects of tea polyphenols and their potential mechanisms, an established in vivo subarachnoid hemorrhage (SAH) model was used and alterations of mitochondrial function, ATP content, and...

journal_title：Oxidative medicine and cellular longevity

authors： Mo H,Chen Y,Huang L,Zhang H,Li J,Zhou W

更新日期：2013-01-01 00:00:00

abstract：:Mitochondrial dysfunction is associated with macrophage damage, but the role of mitochondrial fission in macrophage cholesterol metabolism is not fully understood. In this study, we explored the influences of miR-9 and mitochondrial fission on macrophage viability and cholesterol metabolism. Macrophages were incubated...

journal_title：Oxidative medicine and cellular longevity

authors： Xin T,Lu C,Zhang J,Wen J,Yan S,Li C,Zhang F,Zhang J

更新日期：2020-11-01 00:00:00

abstract：:Sarcopenia is a syndrome characterized by a progressive and generalized skeletal muscle mass and strength loss, as well as a poor physical performance, which as strongly been associated with aging. Sedentary lifestyle in the elderly contributes to this condition; however, physical activity improves health, reducing mo...

journal_title：Oxidative medicine and cellular longevity

authors： Hernández-Álvarez D,Mena-Montes B,Toledo-Pérez R,Pedraza-Vázquez G,López-Cervantes SP,Morales-Salazar A,Hernández-Cruz E,Lazzarini-Lechuga R,Vázquez-Cárdenas RR,Vilchis-DeLaRosa S,Posadas-Rodríguez P,Santín-Márquez R,Rosas-Carras

更新日期：2019-11-11 00:00:00

abstract：:Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence. CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well...

journal_title：Oxidative medicine and cellular longevity

authors： Dando I,Cordani M,Dalla Pozza E,Biondani G,Donadelli M,Palmieri M

更新日期：2015-01-01 00:00:00

abstract：:Our previous studies have shown Leptomycin B (LMB) is a promising antilung cancer drug. Epigallocatechin-3-gallate (EGCG) has antitumor properties but a debatable clinical application. The objective of this study is to evaluate the combination therapeutic effect of LMB and EGCG and its molecular mechanisms in human lu...

journal_title：Oxidative medicine and cellular longevity

authors： Cromie MM,Gao W

更新日期：2015-01-01 00:00:00

abstract：:Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

journal_title：Oxidative medicine and cellular longevity

authors： Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of endothelial dysfunction, which is found to precede the development of diverse cardiovascular diseases (CVDs). The aim of this study was to observe the protective effects of PD against H2O2-induced oxidative stress injury (OSI) in human umbilical vein endo...

journal_title：Oxidative medicine and cellular longevity

authors： Qiao H,Chen H,Dong Y,Ma H,Zhao G,Tang F,Li Z

更新日期：2016-01-01 00:00:00

abstract：:At present, little research has been done on the metabolic phenotype of the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. In this study, the effect of astaxanthin on improving osteogenic differentiation potential of mesenchymal stem cells was studied by metabolomics. Results showed that L-methioni...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao G,Zhong H,Rao T,Pan Z

更新日期：2020-03-25 00:00:00

abstract：:Previous studies have shown that metformin not only is a hypoglycemic agent but also has neuroprotective effects. However, the mechanism of action of metformin in ischemic stroke is unclear. Oxidative stress is an important factor in the pathogenesis of cerebral ischemia-reperfusion injury. It has been reported that m...

journal_title：Oxidative medicine and cellular longevity

authors： Zeng J,Zhu L,Liu J,Zhu T,Xie Z,Sun X,Zhang H

更新日期：2019-12-16 00:00:00

abstract：:This research paper is aimed at evaluating the predictive role of a default panel of oxidative stress (OS) biomarkers for the early identification of infants at high risk of HIE and their validation through the correlation with MRI findings. A multicenter prospective observational study was performed between March 201...

journal_title：Oxidative medicine and cellular longevity

authors： Negro S,Benders MJNL,Tataranno ML,Coviello C,de Vries LS,van Bel F,Groenendaal F,Longini M,Proietti F,Belvisi E,Buonocore G,Perrone S

更新日期：2018-06-28 00:00:00

abstract：:In metabolic diseases, the increased reactive oxygen species (ROS) represents one of the pathogenic mechanisms for vascular disease probably by promoting vascular smooth muscle cell (SMC) proliferation that contributes to the development of arterial remodeling and stenosis, hypertension, and atherosclerosis. Therefore...

journal_title：Oxidative medicine and cellular longevity

authors： López-Acosta O,de Los Angeles Fortis-Barrera M,Barrios-Maya MA,Ramírez AR,Aguilar FJA,El-Hafidi M

更新日期：2018-12-23 00:00:00

abstract：:Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, prete...

journal_title：Oxidative medicine and cellular longevity

authors： Rudov A,Balduini W,Carloni S,Perrone S,Buonocore G,Albertini MC

更新日期：2014-01-01 00:00:00

abstract：:Hemolytic diseases are characterized by an accelerated breakdown of red blood cells (RBCs) and the release of hemoglobin (Hb). Following, RBC lysis Hb oxidation occurs with the formation of different redox states of Hb (metHb and ferrylHb) and the release of heme. ferrylHb is unstable and decomposes to metHb with the ...

journal_title：Oxidative medicine and cellular longevity

authors： Nyakundi BB,Erdei J,Tóth A,Balogh E,Nagy A,Nagy B Jr,Novák L,Bognár L,Paragh G,Kappelmayer J,Jeney V

更新日期：2020-04-25 00:00:00

abstract：:Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its maintenance. Here we prop...

journal_title：Oxidative medicine and cellular longevity

authors： Farooq MA,Pracheil TM,Dong Z,Xiao F,Liu Z

更新日期：2013-01-01 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：:The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin. Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months. At the end of 3-month SFN treatment, the diabeti...

journal_title：Oxidative medicine and cellular longevity

authors： Cui W,Bai Y,Miao X,Luo P,Chen Q,Tan Y,Rane MJ,Miao L,Cai L

更新日期：2012-01-01 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric ox...

journal_title：Oxidative medicine and cellular longevity

authors： Jung J,Na C,Huh Y

更新日期：2012-01-01 00:00:00

abstract：:Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66Shc adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis by providing oxidativ...

journal_title：Oxidative medicine and cellular longevity

authors： Pérez H,Finocchietto PV,Alippe Y,Rebagliati I,Elguero ME,Villalba N,Poderoso JJ,Carreras MC

更新日期：2018-03-12 00:00:00

abstract：:In recent decades, localized tissue oxidative stress has been implicated as a key component in the development of diabetic retinopathy (DR). Increasing evidence shows that oxidative stress caused by diabetes-induced metabolic abnormalities is the most common mechanism associated with the pathogenesis of DR for both ty...

journal_title：Oxidative medicine and cellular longevity

authors： Wu Y,Tang L,Chen B

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in the cognitive domains associated with orientation, recording, and memory. This pathology results from an abnormal deposition of the β-amyloid (Aβ) peptide and the intracellular accumulation of neurofibrillary tangles. Mitochondria...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos SM,Romeiro CFR,Rodrigues CA,Cerqueira ARL,Monteiro MC

更新日期：2019-11-30 00:00:00

abstract：Objective:Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated in...

journal_title：Oxidative medicine and cellular longevity

authors： Gericke A,Mann C,Zadeh JK,Musayeva A,Wolff I,Wang M,Pfeiffer N,Daiber A,Li H,Xia N,Prokosch V

更新日期：2019-12-29 00:00:00

abstract：:Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba Cistanche with a variety of biological attributes such as antiox...

journal_title：Oxidative medicine and cellular longevity

authors： Gu C,Li L,Huang Y,Qian D,Liu W,Zhang C,Luo Y,Zhou Z,Kong F,Zhao X,Liu H,Gao P,Chen J,Yin G

更新日期：2020-07-23 00:00:00

abstract：:A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular ...

journal_title：Oxidative medicine and cellular longevity

authors： Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VI

更新日期：2018-01-31 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00