Alterations in nitric oxide synthase in the aged CNS.

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of...

journal_title：Oxidative medicine and cellular longevity

authors： Paiva AA,Raposo HF,Wanschel AC,Nardelli TR,Oliveira HC

更新日期：2017-01-01 00:00:00

abstract：Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

journal_title：Oxidative medicine and cellular longevity

authors： Hsueh CY,Shao M,Cao W,Li S,Zhou L

更新日期：2019-04-16 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder characterized by movement alterations caused by reduced dopaminergic neurotransmission in the nigrostriatal pathway, presumably by oxidative stress (OS). MPP(+) intrastriatal injection leads to the overproduction of free radicals (FR). The increasing formation of FR ...

journal_title：Oxidative medicine and cellular longevity

authors： Rubio-Osornio M,Gorostieta-Salas E,Montes S,Pérez-Severiano F,Rubio C,Gómez C,Ríos C,Guevara J

更新日期：2015-01-01 00:00:00

abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

更新日期：2016-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible lung disease of unknown etiology with limited survival. IPF incidence and prevalence increase significantly with aging, which is associated with an age-related accumulation of oxidative DNA damage. The Mutyh gene is involved in the base excision repair...

journal_title：Oxidative medicine and cellular longevity

authors： Sun Q,Chen J,Xu L,Kang J,Wu X,Ren Y,Nakabeppu Y,Wang Y

更新日期：2020-10-16 00:00:00

abstract：:Aluminum ions are especially toxic to plants in acidic soils. Here we present evidences that SO2 protects germinating wheat grains against aluminum stress. SO2 donor (NaHSO3/Na2SO3) pretreatment at 1.2 mM reduced the accumulation of superoxide anion, hydrogen peroxide, and malondialdehyde, enhanced the activities of g...

journal_title：Oxidative medicine and cellular longevity

authors： Zhu DB,Hu KD,Guo XK,Liu Y,Hu LY,Li YH,Wang SH,Zhang H

更新日期：2015-01-01 00:00:00

abstract：:Andrographolide (Andro), a major bioactive component obtained from Andrographis paniculata Nees, has exerted wide antioxidant as well as cytoprotective properties. However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) remains unknown. In this study, we evaluated the effects of And...

journal_title：Oxidative medicine and cellular longevity

authors： Liang E,Liu X,Du Z,Yang R,Zhao Y

更新日期：2018-06-25 00:00:00

abstract：:We recently showed that activated Ras proteins are localized to the plasma membrane and in the nucleus in wild-type cells growing exponentially on glucose, while in the hxk2Δ strain they accumulated mainly in mitochondria. An aberrant accumulation of activated Ras in these organelles was previously reported and correl...

journal_title：Oxidative medicine and cellular longevity

authors： Amigoni L,Martegani E,Colombo S

更新日期：2013-01-01 00:00:00

abstract：Background:Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure. Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury. Intravenous anesthetic propofol potent effects on free radical scaven...

journal_title：Oxidative medicine and cellular longevity

authors： Yao W,Han X,Zhang Y,Guan J,Ge M,Chen C,Wu S,Chen J,Luo G,Huang P,Hei Z

更新日期：2018-10-28 00:00:00

abstract：:Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant s...

journal_title：Oxidative medicine and cellular longevity

authors： Gunawardena HP,Silva R,Sivakanesan R,Ranasinghe P,Katulanda P

更新日期：2019-08-05 00:00:00

abstract：:Serine-threonine kinase receptor-associated protein (STRAP) is a transforming growth factor β (TGF-β) receptor-interacting protein that has been implicated in both cell proliferation and cell death in response to various stresses. However, the precise roles of STRAP in these cellular processes are still unclear. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Manoharan R,Seong HA,Ha H

更新日期：2018-04-19 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the su...

journal_title：Oxidative medicine and cellular longevity

authors： Kang M,Cho JH,Kim TJ,Lee SM,Kim HJ,Coronado I,Yi DK,Kim DY

更新日期：2020-04-25 00:00:00

abstract：:This study aims at investigating the radioprotective effect of ethanol extract from Ji-Xue-Teng (JXT, Spatholobus suberectus) on radiation-induced hematopoietic alteration and oxidative stress in the liver. Mice were exposed to a single acute γ-radiation for the whole body at the dose of 6.0 Gy, then subjected to admi...

journal_title：Oxidative medicine and cellular longevity

authors： Dong XZ,Wang YN,Tan X,Liu P,Guo DH,Yan C

更新日期：2018-10-28 00:00:00

abstract：:In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomal β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of V...

journal_title：Oxidative medicine and cellular longevity

authors： Zarrouk A,Vejux A,Nury T,El Hajj HI,Haddad M,Cherkaoui-Malki M,Riedinger JM,Hammami M,Lizard G

更新日期：2012-01-01 00:00:00

abstract：:Accumulating evidence has demonstrated that oxidative stress is associated with depression. Our present study aimed at investigating the antidepressant effect and the possible mechanisms of curcumin (CUR) in chronic unpredictable mild stress- (CUMS-) induced depression model in rats. After exposure to CUMS for four we...

journal_title：Oxidative medicine and cellular longevity

authors： Liao D,Lv C,Cao L,Yao D,Wu Y,Long M,Liu N,Jiang P

更新日期：2020-09-17 00:00:00

abstract：:Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p < 0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69...

journal_title：Oxidative medicine and cellular longevity

authors： Pristov JB,Spasojevic I,Mikovic Z,Mandic V,Cerovic N,Spasic M

更新日期：2009-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:Reactive oxygen species (ROS) regulate bone marrow microenvironment for stem and progenitor cells functions including self-renewal, differentiation, and cell senescence. In response to ischemia, ROS also play a critical role in mediating the mobilization of endothelial progenitor cells (EPCs) from the bone marrow to t...

journal_title：Oxidative medicine and cellular longevity

authors： Lam YT

更新日期：2015-01-01 00:00:00

abstract：:Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes. This study sought to determine the effects of age and vitamin E supplementation in the form of tocotrienol-rich fraction (TRF) on brain arginine metabolism. Male Wistar rats at ages of 3 and 21 mon...

journal_title：Oxidative medicine and cellular longevity

authors： Mazlan M,Hamezah HS,Taridi NM,Jing Y,Liu P,Zhang H,Wan Ngah WZ,Damanhuri HA

更新日期：2017-01-01 00:00:00

abstract：:Several of the most prevalent etiological factors which contribute towards global death rates are associated with cardiovascular diseases (CVDs), which include a range of conditions such as angina, rheumatic heart disease, and venous thrombosis. Extensive research has been conducted into the role played by oxidative s...

journal_title：Oxidative medicine and cellular longevity

authors： Chen S,Jiang H,Peng H,Wu X,Fang J

更新日期：2017-01-01 00:00:00

abstract：:Hemolytic diseases are characterized by an accelerated breakdown of red blood cells (RBCs) and the release of hemoglobin (Hb). Following, RBC lysis Hb oxidation occurs with the formation of different redox states of Hb (metHb and ferrylHb) and the release of heme. ferrylHb is unstable and decomposes to metHb with the ...

journal_title：Oxidative medicine and cellular longevity

authors： Nyakundi BB,Erdei J,Tóth A,Balogh E,Nagy A,Nagy B Jr,Novák L,Bognár L,Paragh G,Kappelmayer J,Jeney V

更新日期：2020-04-25 00:00:00

abstract：:Respiratory diseases are accompanied by intensification of free radical processes at different levels of the biological body organization. Simultaneous stress and suppression of various parts of antioxidant protection lead to the development of oxidative stress (OS) and nitrosative stress (NS). The basic mechanisms of...

journal_title：Oxidative medicine and cellular longevity

authors： Soodaeva S,Kubysheva N,Klimanov I,Nikitina L,Batyrshin I

更新日期：2019-05-22 00:00:00

abstract：:Non-thermal plasma (NTP), an ionized gas generated at ambient pressure and temperature, has been an emerging technology for medical applications. Through controlled delivery of reactive oxygen and nitrogen species (ROS/RNS), NTP can elicit hormetic cellular responses, thus stimulating broad therapeutic effects. To ena...

journal_title：Oxidative medicine and cellular longevity

authors： Lin A,Biscop E,Breen C,Butler SJ,Smits E,Bogaerts A

更新日期：2020-12-03 00:00:00

abstract：:Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative su...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Q,Huang Y,Qin C,Liang M,Mao X,Li S,Zou Y,Jia W,Li H,Ma CW,Huang Z

更新日期：2016-01-01 00:00:00

abstract：:Ascorbate requiring Fe2+/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in the endomembranes of fibroblasts from arterial tortuosity syndrome (AT...

journal_title：Oxidative medicine and cellular longevity

authors： Németh CE,Nemoda Z,Lőw P,Szabó P,Horváth EZ,Willaert A,Boel A,Callewaert BL,Coucke PJ,Colombi M,Bánhegyi G,Margittai É

更新日期：2019-01-13 00:00:00

abstract：:Recent reports indicate that oxidative stress is involved in the pathobiology of acute spinal cord injury or compression myelopathy. We conducted an observational study to determine levels of oxidative stress markers in serum from 80 patients who underwent spinal surgery to treat neurological symptoms related to lumba...

journal_title：Oxidative medicine and cellular longevity

authors： Takahashi H,Aoki Y,Saito J,Nakajima A,Sonobe M,Akatsu Y,Taniguchi S,Yamada M,Koyama K,Akiyama Y,Shiga Y,Inage K,Orita S,Eguchi Y,Maki S,Furuya T,Akazawa T,Koda M,Yamazaki M,Ohtori S,Nakagawa K

更新日期：2020-12-24 00:00:00

abstract：Background:Acute kidney injury (AKI) is one of the common complications of sepsis. Heretofore, there is no effective treatment for septic AKI. Recent studies have revealed that besides treating hematological malignancies, human umbilical cord blood mononuclear cells (hUCBMNCs) show good therapeutic effects on other dis...

journal_title：Oxidative medicine and cellular longevity

authors： Feng LX,Zhao F,Liu Q,Peng JC,Duan XJ,Yan P,Wu X,Wang HS,Deng YH,Duan SB

更新日期：2020-07-28 00:00:00

abstract：:Escherichia coli (E. coli) is one of pathogens causing nosocomial pneumonia and could induce pulmonary excessive apoptosis. Although much has been learned about metabolic diseases induced by obesity, the information linking bacterial pneumonia to obesity is limited. Accordingly, we investigated the apoptosis of normal...

journal_title：Oxidative medicine and cellular longevity

authors： Wang F,Zuo Z,Yang Z,Chen K,Fang J,Cui H,Shu G,Zhou Y,Geng Y,Ouyang P

更新日期：2019-10-22 00:00:00

abstract：:Oxidative stress induced by long-term glucocorticoid (GC) use weakens the repair capacity of bone tissue. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase (NOX) is a superoxide-generating enzyme that plays an important role in regulating bone metabolism. To clarify the role of nonphagocytic NO...

journal_title：Oxidative medicine and cellular longevity

authors： Bai SC,Xu Q,Li H,Qin YF,Song LC,Wang CG,Cui WH,Zheng Z,Yan DW,Li ZJ,Li D,Wan X,Zhang HF

更新日期：2019-03-27 00:00:00

abstract：:Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense. Tanshinone IIA has been recently revealed to act directly on neutrophils. Hence, we aimed at investigating whether Tanshinone IIA can protec...

journal_title：Oxidative medicine and cellular longevity

authors： Liu X,He H,Huang T,Lei Z,Liu F,An G,Wen T

更新日期：2016-01-01 00:00:00