Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats.

Abstract:

:Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes. This study sought to determine the effects of age and vitamin E supplementation in the form of tocotrienol-rich fraction (TRF) on brain arginine metabolism. Male Wistar rats at ages of 3 and 21 months were supplemented with TRF orally for 3 months prior to the dissection of tissue from five brain regions. The tissue concentrations of L-arginine and its nine downstream metabolites were quantified using high-performance liquid chromatography and liquid chromatography tandem mass spectrometry. We found age-related alterations in L-arginine metabolites in the chemical- and region-specific manners. Moreover, TRF supplementation reversed age-associated changes in arginine metabolites in the entorhinal cortex and cerebellum. Multiple regression analysis revealed a number of significant neurochemical-behavioral correlations, indicating the beneficial effects of TRF supplementation on memory and motor function.

journal_name

Oxid Med Cell Longev

authors

Mazlan M,Hamezah HS,Taridi NM,Jing Y,Liu P,Zhang H,Wan Ngah WZ,Damanhuri HA

doi

10.1155/2017/6019796

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

6019796

eissn

1942-0900

issn

1942-0994

journal_volume

2017

pub_type

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