Critical Roles of Reactive Oxygen Species in Age-Related Impairment in Ischemia-Induced Neovascularization by Regulating Stem and Progenitor Cell Function.

abstract：:Background. Increased oxidative stress is a well described feature of patients in hemodialysis. Their need for multiple blood transfusions and supplemental iron causes a significant iron overload that has recently been associated with increased oxidation of polyunsaturated lipids and accelerated aging due to DNA damag...

journal_title：Oxidative medicine and cellular longevity

authors： Murillo-Ortiz B,Ramírez Emiliano J,Hernández Vázquez WI,Martínez-Garza S,Solorio-Meza S,Albarrán-Tamayo F,Ramos-Rodríguez E,Benítez-Bribiesca L

更新日期：2016-01-01 00:00:00

abstract：:The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin. Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months. At the end of 3-month SFN treatment, the diabeti...

journal_title：Oxidative medicine and cellular longevity

authors： Cui W,Bai Y,Miao X,Luo P,Chen Q,Tan Y,Rane MJ,Miao L,Cai L

更新日期：2012-01-01 00:00:00

abstract：:We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo...

journal_title：Oxidative medicine and cellular longevity

authors： Huang Y,Zhao H,Cao K,Sun D,Yang Y,Liu C,Cui J,Cheng Y,Li B,Cai J,Gao F

更新日期：2016-01-01 00:00:00

abstract：:The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a 2-phenylamino-1,4-naphthoquinone derivative, significantly increased oxidative stress and induced vascular...

journal_title：Oxidative medicine and cellular longevity

authors： Palacios J,Cifuentes F,Valderrama JA,Benites J,Ríos D,González C,Chiong M,Cartes-Saavedra B,Lafourcade C,Wyneken U,González P,Owen GI,Pardo F,Sobrevia L,Buc Calderon P

更新日期：2016-01-01 00:00:00

abstract：:In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomal β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of V...

journal_title：Oxidative medicine and cellular longevity

authors： Zarrouk A,Vejux A,Nury T,El Hajj HI,Haddad M,Cherkaoui-Malki M,Riedinger JM,Hammami M,Lizard G

更新日期：2012-01-01 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Cardiolipin interacts with many proteins of the mitochondrial inner membrane and, together with cytochrome C and creatine kinase, activates them. It can be considered as an integrating factor for components of the mitochondrial respiratory chain, which provides for an efficient transfer of electrons and protons. The m...

journal_title：Oxidative medicine and cellular longevity

authors： Shilovsky GA,Zverkov OA,Seliverstov AV,Ashapkin VV,Putyatina TS,Rubanov LI,Lyubetsky VA

更新日期：2019-10-24 00:00:00

abstract：:We have demonstrated that neural progenitor cells (NPCs) protect endothelial cells (ECs) from oxidative stress. Since exosomes (EXs) can convey the benefit of parent cells through their carried microRNAs (miRs) and miR-210 is ubiquitously expressed with versatile functions, we investigated the role of miR-210 in the e...

journal_title：Oxidative medicine and cellular longevity

authors： Liu H,Wang J,Chen Y,Chen Y,Ma X,Bihl JC,Yang Y

更新日期：2017-01-01 00:00:00

abstract：:Degradation of oxidized or oxidatively modified proteins is an essential part of the antioxidant defenses of cells. 4-Hydroxy-2-nonenal, a major reactive aldehyde formed by lipid peroxidation, causes many types of cellular damage. It has been reported that 4-hydroxy-2-nonenal-modified proteins are degraded by the ubiq...

journal_title：Oxidative medicine and cellular longevity

authors： Tsuchiya Y,Okada G,Kobayashi S,Chikuma T,Hojo H

更新日期：2011-01-01 00:00:00

abstract：:Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living specie...

journal_title：Oxidative medicine and cellular longevity

authors： Avila-Sosa R,Montero-Rodríguez AF,Aguilar-Alonso P,Vera-López O,Lazcano-Hernández M,Morales-Medina JC,Navarro-Cruz AR

更新日期：2019-02-17 00:00:00

abstract：:The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tes...

journal_title：Oxidative medicine and cellular longevity

authors： Dimić DS,Marković ZS,Saso L,Avdović EH,Đorović JR,Petrović IP,Stanisavljević DD,Stevanović MJ,Potočňák I,Samoľová E,Trifunović SR,Dimitrić Marković JM

更新日期：2019-02-13 00:00:00

abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

journal_title：Oxidative medicine and cellular longevity

authors： Kim HM,Cho BR

更新日期：2013-01-01 00:00:00

abstract：:Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results,...

journal_title：Oxidative medicine and cellular longevity

authors： Ashour AE,Sayed-Ahmed MM,Abd-Allah AR,Korashy HM,Maayah ZH,Alkhalidi H,Mubarak M,Alhaider A

更新日期：2012-01-01 00:00:00

abstract：:We examined in vitro antioxidant capacity of polyphenolic extract obtained from the wood of oak Quercus robur (QR), Robuvit, using TEAC (Trolox equivalent antioxidant capacity) method and the effect of its intake on markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity in plasma ...

journal_title：Oxidative medicine and cellular longevity

authors： Horvathova M,Orszaghova Z,Laubertova L,Vavakova M,Sabaka P,Rohdewald P,Durackova Z,Muchova J

更新日期：2014-01-01 00:00:00

abstract：:Diabetes is associated with vascular inflammation, endothelial dysfunction, and oxidative stress, promoting the development of cardiovascular diseases (CVD). Several studies showed that a carotenoid-rich diet is associated to a reduced cardiovascular risk in healthy and diabetic subjects, although the mechanisms of ac...

journal_title：Oxidative medicine and cellular longevity

authors： Ucci M,Di Tomo P,Tritschler F,Cordone VGP,Lanuti P,Bologna G,Di Silvestre S,Di Pietro N,Pipino C,Mandatori D,Formoso G,Pandolfi A

更新日期：2019-01-30 00:00:00

abstract：:Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid and is widely distributed among species. In addition to this housekeeping function, mammalian XOR is a physiological source of superoxide ion, hydrogen peroxide, and nitric oxide, which can fu...

journal_title：Oxidative medicine and cellular longevity

authors： Battelli MG,Polito L,Bortolotti M,Bolognesi A

更新日期：2016-01-01 00:00:00

abstract：:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

更新日期：2020-06-17 00:00:00

abstract：:Paraoxonase-1 (PON1) and lipoprotein phospholipase A2 (Lp-PLA2) may exert an important protective role by preventing the oxidative transformation of high- and low-density lipoproteins (HDL and LDL, respectively). The activity of both enzymes is influenced by lipidome and proteome of the lipoprotein carriers. T2DM typi...

journal_title：Oxidative medicine and cellular longevity

authors： Passaro A,Vigna GB,Romani A,Sanz JM,Cavicchio C,Bonaccorsi G,Valacchi G,Cervellati C

更新日期：2018-11-05 00:00:00

abstract：:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...

journal_title：Oxidative medicine and cellular longevity

authors： Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

更新日期：2014-01-01 00:00:00

abstract：:During pregnancy, the adaptive changes in uterine circulation and the formation of the placenta are essential for the growth of the fetus and the well-being of the mother. The steroid hormone estrogen plays a pivotal role in this adaptive process. An insufficient blood supply to the placenta due to uteroplacental dysf...

journal_title：Oxidative medicine and cellular longevity

authors： Hu XQ,Song R,Zhang L

更新日期：2019-02-10 00:00:00

abstract：:Benzene is a chemical contaminant widespread in industrial and living environments. The oxidative metabolites of benzene induce toxicity involving oxidative damage. Protecting cells and cell membranes from oxidative damage, glucose-6-phosphate dehydrogenase (G6PD) maintains the reduced state of glutathione (GSH). This...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Cao M,Yang W,Sun F,Xu C,Yin L,Pu Y

更新日期：2016-01-01 00:00:00

abstract：:This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B. serrata was perform...

journal_title：Oxidative medicine and cellular longevity

authors： Bertocchi M,Isani G,Medici F,Andreani G,Tubon Usca I,Roncada P,Forni M,Bernardini C

更新日期：2018-06-25 00:00:00

abstract：:Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

journal_title：Oxidative medicine and cellular longevity

authors： He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

更新日期：2020-11-05 00:00:00

abstract：:Some evidence indicated that chemoresistance associates with the acquisition of cancer stem-like properties. Recent studies suggested that chemokines can promote the chemoresistance and stem cell properties in various cancer cells, while the underling mechanism is still not completely illustrated. In our study, we fou...

journal_title：Oxidative medicine and cellular longevity

authors： Lu LL,Chen XH,Zhang G,Liu ZC,Wu N,Wang H,Qi YF,Wang HS,Cai SH,Du J

更新日期：2016-01-01 00:00:00

abstract：:In some inflammatory diseases of bone, osteogenesis and osteoclasis are uncoupled and the balance is usually tipped resulting in bone destruction. The underlying mechanism of osteogenic dysfunction in inflammation still needs further study. This study is aimed at investigating the effects of cyclosporine A (CsA) on bo...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Y,Gao J,Zhang Y,Gan X,Yu H

更新日期：2021-01-07 00:00:00

abstract：Objective:Chidamide has a broad spectrum of antitumor activity but its function on glioma remains unknown. The increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS) may control glioma risk by promoting its apoptosis and necrosis. Hedgehog pathway is crucial to glioma cell proliferation and contr...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou H,Han L,Wang H,Wei J,Guo Z,Li Z

更新日期：2020-03-11 00:00:00

abstract：:Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application is limited by its cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) the chemical composition and antioxidant capacity of aqu...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos JM,Alfredo TM,Antunes KÁ,da Cunha JDSM,Costa EMA,Lima ES,Silva DB,Carollo CA,Schmitz WO,Boleti APA,Dos Santos EL,de Picoli Souza K

更新日期：2018-06-28 00:00:00

abstract：:Recent studies have found that propofol may protect brain from cerebral ischemic-reperfusion injury. However, the underlying mechanism remains unclear. The effects of propofol were evaluated in HBVSMC after hypoxia/reoxygenation (H/R). Cell viability and levels of SOD, LDH, and MDA were measured. Apoptosis was detecte...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang J,Xia Y,Xu Z,Deng X

更新日期：2016-01-01 00:00:00

abstract：:Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of ...

journal_title：Oxidative medicine and cellular longevity

authors： Maciejczyk M,Skutnik-Radziszewska A,Zieniewska I,Matczuk J,Domel E,Waszkiel D,Żendzian-Piotrowska M,Szarmach I,Zalewska A

更新日期：2019-03-10 00:00:00

abstract：:Mechanisms underlying hypertensive target organ damage (TOD) are not completely understood. The pathophysiological role of mitochondrial oxidative stress, resulting from mitochondrial dysfunction, in development of TOD is unclear. The stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable model of human hyp...

journal_title：Oxidative medicine and cellular longevity

authors： Rubattu S,Stanzione R,Volpe M

更新日期：2016-01-01 00:00:00