Involvement of miRNAs in placental alterations mediated by oxidative stress.

Abstract:

:Oxidative stress (OS) is known to be strongly involved in a large number of fetal, neonatal, and adult diseases, including placental disorders, leading to pregnancy loss and stillbirths. A growing body of research links OS to preeclampsia, gestational diabetes, obesity, spontaneous abortion, recurrent pregnancy, preterm labor, and intrauterine growth restriction. While a considerable number of miRNAs have been related to physiological functions and pathological conditions of the placenta, a direct link among these miRNAs, placental functions, and OS is still lacking. This review summarizes data describing the role of miRNAs in placental pathophysiological processes and their possible impact on OS damaging responses. As miRNAs can be found in circulation, improving our understanding on their role in the pathogenesis of pregnancy related disorders could have an important impact on the diagnosis and prognosis of these diseases.

journal_name

Oxid Med Cell Longev

authors

Rudov A,Balduini W,Carloni S,Perrone S,Buonocore G,Albertini MC

doi

10.1155/2014/103068

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

103068

eissn

1942-0900

issn

1942-0994

journal_volume

2014

pub_type

杂志文章,评审
  • Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia.

    abstract:Background/Aims:Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal hormone levels in peripheral blood and poor-quality oocytes. PCOS is a pathophysiological syndrome caused by chronic inflammation and oxidative stress. The aim of this study was to investigate the mechanism of melatonin ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/8218650

    authors: Yu K,Wang RX,Li MH,Sun TC,Zhou YW,Li YY,Sun LH,Zhang BL,Lian ZX,Xue SG,Liu YX,Deng SL

    更新日期:2019-10-20 00:00:00

  • Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration.

    abstract::With recent insight into the mechanisms involved in diseases, such as cardiovascular disease, cancer, stroke, neurodegenerative diseases, and diabetes, more efficient modes of treatment are now being assessed. Traditional medicine including the use of natural products is widely practiced around the world, assuming tha...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2015/181260

    authors: Shay J,Elbaz HA,Lee I,Zielske SP,Malek MH,Hüttemann M

    更新日期:2015-01-01 00:00:00

  • REGγ Contributes to Regulation of Hemoglobin and Hemoglobin δ Subunit.

    abstract::Hemoglobin (Hb) is a family of proteins in red blood cells responsible for oxygen transport and vulnerable for oxidative damage. Hemoglobin δ subunit (HBD), a member of Hb family, is normally expressed by cells of erythroid lineage. Expression of Hb genes has been previously reported in nonerythroid and hematopoietic ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/7295319

    authors: Zuo Q,Cheng S,Huang W,Bhatti MZ,Xue Y,Zhang Y,Zhang B,Li L,Wu L,Fu J,Chen J,Li X

    更新日期:2017-01-01 00:00:00

  • The Role of Reactive Oxygen Species and Nitric Oxide in the Inhibition of Trichophyton rubrum Growth by HaCaT Cells.

    abstract::Trichophyton rubrum (T. rubrum) is one of the most important agents of dermatophyte infection in humans. The aim of this experiment was to evaluate the effect of HaCaT cells on T. rubrum, investigate the responsible mechanism of action, and explore the role of reactive oxygen species (ROS) and nitric oxide (NO) in the...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/8548619

    authors: Huang M,Huang H,Lv W,Xiao H,Gao Y,Tang H

    更新日期:2020-02-12 00:00:00

  • Corrigendum to "Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress".

    abstract::[This corrects the article DOI: 10.1155/2017/3027109.]. ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 已发布勘误

    doi:10.1155/2017/1083618

    authors: Nawrocka D,Kornicka K,Szydlarska J,Marycz K

    更新日期:2017-01-01 00:00:00

  • Lack of HXK2 induces localization of active Ras in mitochondria and triggers apoptosis in the yeast Saccharomyces cerevisiae.

    abstract::We recently showed that activated Ras proteins are localized to the plasma membrane and in the nucleus in wild-type cells growing exponentially on glucose, while in the hxk2Δ strain they accumulated mainly in mitochondria. An aberrant accumulation of activated Ras in these organelles was previously reported and correl...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2013/678473

    authors: Amigoni L,Martegani E,Colombo S

    更新日期:2013-01-01 00:00:00

  • Evaluation of Binding of Rosmarinic Acid with Human Transferrin and Its Impact on the Protein Structure: Targeting Polyphenolic Acid-Induced Protection of Neurodegenerative Disorders.

    abstract::Rosmarinic acid (RA) is a natural compound that is gaining wide popularity owing to its broad-spectrum biological activities. RA is known for its wide range of medicinal properties and therapeutic applications in a vast range of neurodegenerative disorders thus making it a vital natural compound. Human transferrin (hT...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/1245875

    authors: Shamsi A,Anwar S,Shahbaaz M,Mohammad T,Alajmi MF,Hussain A,Hassan I,Ahmad F,Islam A

    更新日期:2020-11-05 00:00:00

  • Formation and Detection of Highly Oxidized Hemoglobin Forms in Biological Fluids during Hemolytic Conditions.

    abstract::Hemolytic diseases are characterized by an accelerated breakdown of red blood cells (RBCs) and the release of hemoglobin (Hb). Following, RBC lysis Hb oxidation occurs with the formation of different redox states of Hb (metHb and ferrylHb) and the release of heme. ferrylHb is unstable and decomposes to metHb with the ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/8929020

    authors: Nyakundi BB,Erdei J,Tóth A,Balogh E,Nagy A,Nagy B Jr,Novák L,Bognár L,Paragh G,Kappelmayer J,Jeney V

    更新日期:2020-04-25 00:00:00

  • Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties.

    abstract::Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigat...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/9842908

    authors: de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

    更新日期:2018-10-21 00:00:00

  • Modulations of Histone Deacetylase 2 Offer a Protective Effect through the Mitochondrial Apoptosis Pathway in Acute Liver Failure.

    abstract::The purpose of this study was to investigate the modulation of histone deacetylase 2 (HDAC2) on mitochondrial apoptosis in acute liver failure (ALF). The cellular model was established with LO2 cells stimulated by tumor necrosis factor alpha (TNF-α)/D-galactosamine (D-gal). Rats were administrated by lipopolysaccharid...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/8173016

    authors: Wang Y,Yang F,Jiao FZ,Chen Q,Zhang WB,Wang LW,Gong ZJ

    更新日期:2019-04-28 00:00:00

  • Identification of Potential Inhibitors of Calcium/Calmodulin-Dependent Protein Kinase IV from Bioactive Phytoconstituents.

    abstract::Calcium/calmodulin-dependent protein kinase IV (CaMKIV) is an upstream regulator of CaMKK-CaMKIV signaling cascade that activates various transcription factors, thereby regulating several cellular activities including, neuronal communication and immune response. Owing to the abnormal expression in cancer and neurodege...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/2094635

    authors: Gupta P,Khan S,Fakhar Z,Hussain A,Rehman MT,AlAjmi MF,Islam A,Ahmad F,Hassan MI

    更新日期:2020-07-16 00:00:00

  • Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis.

    abstract::The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). This cross-sectional study included 270 subjects (control group, n = 97) and RA patients (n = 173). RA patients were...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/8962763

    authors: Costa NT,Veiga Iriyoda TM,Kallaur AP,Delongui F,Alfieri DF,Lozovoy MA,Amin RB,Delfino VD,Dichi I,Simão AN

    更新日期:2016-01-01 00:00:00

  • It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.

    abstract::Free radical-mediated damage to macromolecules and the resulting oxidative modification of different cellular components are a common feature of aging, and this process becomes much more pronounced in age-associated pathologies, including Alzheimer disease (AD). In particular, proteins are particularly sensitive to ox...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2016/2756068

    authors: Tramutola A,Di Domenico F,Barone E,Perluigi M,Butterfield DA

    更新日期:2016-01-01 00:00:00

  • Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regu...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/4825949

    authors: Chu Q,Zhang S,Chen M,Han W,Jia R,Chen W,Zheng X

    更新日期:2019-02-25 00:00:00

  • Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease.

    abstract::Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been recognized as a toxic gas and environment pollutant. However, increasing evidence suggests that H2S acts as a novel gasotransmitter and plays important roles in a variety of physiological and pathological processes in mammals. H2S is involve...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2019/3831713

    authors: Wu DD,Wang DY,Li HM,Guo JC,Duan SF,Ji XY

    更新日期:2019-01-20 00:00:00

  • Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects.

    abstract::The advanced glycation end products (AGEs) are organic molecules formed in any living organisms with a great variety of structural and functional properties. They are considered organic markers of the glycation process. Due to their great heterogeneity, there is no specific test for their operational measurement. In t...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3818196

    authors: Perrone A,Giovino A,Benny J,Martinelli F

    更新日期:2020-03-18 00:00:00

  • Enhancement of Antioxidant Mechanisms and Reduction of Oxidative Stress in Chickens after the Administration of Drinking Water Enriched with Polyphenolic Powder from Olive Mill Waste Waters.

    abstract::The aim of the study was to examine the effects of a polyphenolic powder from olive mill wastewater (OMWW) administered through drinking water, on chickens' redox status. Thus, 75 chickens were divided into three groups. Group A was given just drinking water, while groups B and C were given drinking water containing 2...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2017/8273160

    authors: Papadopoulou A,Petrotos K,Stagos D,Gerasopoulos K,Maimaris A,Makris H,Kafantaris I,Makri S,Kerasioti E,Halabalaki M,Brieudes V,Ntasi G,Kokkas S,Tzimas P,Goulas P,Zakharenko AM,Golokhvast KS,Tsatsakis A,Kouretas D

    更新日期:2017-01-01 00:00:00

  • Cardiolipin, Perhydroxyl Radicals, and Lipid Peroxidation in Mitochondrial Dysfunctions and Aging.

    abstract::Mitochondrial dysfunctions caused by oxidative stress are currently regarded as the main cause of aging. Accumulation of mutations and deletions of mtDNA is a hallmark of aging. So far, however, there is no evidence that most studied oxygen radicals are directly responsible for mutations of mtDNA. Oxidative damages to...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1323028

    authors: Panov AV,Dikalov SI

    更新日期:2020-09-08 00:00:00

  • Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells.

    abstract::Benzene is a chemical contaminant widespread in industrial and living environments. The oxidative metabolites of benzene induce toxicity involving oxidative damage. Protecting cells and cell membranes from oxidative damage, glucose-6-phosphate dehydrogenase (G6PD) maintains the reduced state of glutathione (GSH). This...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/3912515

    authors: Zhang J,Cao M,Yang W,Sun F,Xu C,Yin L,Pu Y

    更新日期:2016-01-01 00:00:00

  • NADPH Oxidase Deficiency: A Multisystem Approach.

    abstract::The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes. The generation and release of ROS in the fo...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2017/4590127

    authors: Giardino G,Cicalese MP,Delmonte O,Migliavacca M,Palterer B,Loffredo L,Cirillo E,Gallo V,Violi F,Pignata C

    更新日期:2017-01-01 00:00:00

  • Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway.

    abstract:Background:The mechanisms of crosstalk between depression and gastric cancer (GC) remain ill defined. Given that reactive oxygen species (ROS) is involved in the pathophysiology of both GC and depression, we try to explore the activities of ROS in the development of GC and GC-related depression. Methods:110 patients w...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/5813985

    authors: Huang T,Zhou F,Yuan X,Yang T,Liang X,Wang Y,Tu H,Chang J,Nan K,Wei Y

    更新日期:2019-07-15 00:00:00

  • Chemical Composition and Antioxidant Activities of Polysaccharides from Yingshan Cloud Mist Tea.

    abstract::The study was designed to investigate the chemical composition and antioxidant activities of polysaccharides from Yingshan Cloud Mist Tea. The chemical composition of green tea polysaccharides (GTPS) was analyzed by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscope (SEM), thermogravimetric ...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/1915967

    authors: Li X,Chen S,Li JE,Wang N,Liu X,An Q,Ye XM,Zhao ZT,Zhao M,Han Y,Ouyang KH,Wang WJ

    更新日期:2019-08-21 00:00:00

  • Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase-1.

    abstract::Metabolic diseases, such as insulin resistance, type II diabetes, and obesity, are associated with a low-grade chronic inflammation (inflammatory stress), oxidative stress, and endoplasmic reticulum (ER) stress. Because the integration of these stresses is critical to the pathogenesis of metabolic diseases, agents and...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2013/639541

    authors: Son Y,Lee JH,Chung HT,Pae HO

    更新日期:2013-01-01 00:00:00

  • PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation.

    abstract::Autophagy is considered to be the primary degradative pathway that takes place in all eukaryotic cells. Morphologically, the autophagy pathway refers to a process by which cytoplasmic portions are delivered to double-membrane organelles, called autophagosomes, to fuse with lysosomes for bulk degradation. Autophagy, as...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2019/2641712

    authors: Rodríguez-Vargas JM,Oliver-Pozo FJ,Dantzer F

    更新日期:2019-06-09 00:00:00

  • Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity.

    abstract::Surgical intervention is currently the only option for an abdominal aortic aneurysm (AAA), preventing its rupture and sudden death of a patient. Therefore, it is crucial to determine the pathogenic mechanisms of this disease for the development of effective pharmacological therapies. Oxidative stress is said to be one...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2020/6340190

    authors: Kopacz A,Werner E,Grochot-Przęczek A,Klóska D,Hajduk K,Neumayer C,Józkowicz A,Piechota-Polanczyk A

    更新日期:2020-06-16 00:00:00

  • Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme.

    abstract::Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated mole...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2018/8753063

    authors: Fawzy MS,Badran DI,Al Ageeli E,Al-Qahtani SAM,Alghamdi SA,Helal GM,Toraih EA

    更新日期:2018-03-21 00:00:00

  • Dexamethasone treatment reverses cognitive impairment but increases brain oxidative stress in rats submitted to pneumococcal meningitis.

    abstract::Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae. The animals received either 10 μL of saline or a S. pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2011/173035

    authors: Barichello T,Santos AL,Silvestre C,Generoso JS,Cipriano AL,Petronilho F,Dal-Pizzol F,Comim CM,Quevedo J

    更新日期:2011-01-01 00:00:00

  • Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model.

    abstract::To date, it remains unclear whether mild form of acute pancreatitis (AP) may cause myocardial damage which may be asymptomatic for a long time. Pathogenesis of AP-related cardiac injury may be attributed in part to ROS/RNS overproduction. The aim of the present study was to evaluate the oxidative stress changes in bot...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2016/4139851

    authors: Marciniak A,Walczyna B,Rajtar G,Marciniak S,Wojtak A,Lasiecka K

    更新日期:2016-01-01 00:00:00

  • The Antiaggregative and Antiamyloidogenic Properties of Nanoparticles: A Promising Tool for the Treatment and Diagnostics of Neurodegenerative Diseases.

    abstract::Due to the progressive aging of the society, the prevalence and socioeconomic burden of neurodegenerative diseases are predicted to rise. The most common neurodegenerative disorders nowadays, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, can be classified as proteinopathies. They...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章,评审

    doi:10.1155/2020/3534570

    authors: Pichla M,Bartosz G,Sadowska-Bartosz I

    更新日期:2020-10-13 00:00:00

  • Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients.

    abstract::Glycaemic control is the main focus of managing diabetes and its complications. Hyperglycaemia induces oxidative stress favouring cellular damage and subsequent diabetic complications. The present study was conducted to compare the plasma total antioxidant capacity (TAC) and individual antioxidant marker antioxidant s...

    journal_title:Oxidative medicine and cellular longevity

    pub_type: 杂志文章

    doi:10.1155/2019/9471697

    authors: Gunawardena HP,Silva R,Sivakanesan R,Ranasinghe P,Katulanda P

    更新日期:2019-08-05 00:00:00