Abstract：
:A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular mechanisms through which impaired lipid metabolism causes lipotoxicity and elicits different forms of regulated cell death. Here, we discuss mechanisms of the "liponecrotic" mode of regulated cell death in S. cerevisiae. This mode of regulated cell death can be initiated in response to a brief treatment of yeast with exogenous palmitoleic acid. Such treatment prompts the incorporation of exogenously added palmitoleic acid into phospholipids and neutral lipids. This orchestrates a global remodeling of lipid metabolism and transfer in the endoplasmic reticulum, mitochondria, lipid droplets, and the plasma membrane. Certain features of such remodeling play essential roles either in committing yeast to liponecrosis or in executing this mode of regulated cell death. We also outline four processes through which yeast cells actively resist liponecrosis by adapting to the cellular stress imposed by palmitoleic acid and maintaining viability. These prosurvival cellular processes are confined in the endoplasmic reticulum, lipid droplets, peroxisomes, autophagosomes, vacuoles, and the cytosol.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VIdoi
10.1155/2018/3074769subject
Has Abstractpub_date
2018-01-31 00:00:00pages
3074769eissn
1942-0900issn
1942-0994journal_volume
2018pub_type
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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更新日期：2019-10-09 00:00:00
