Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway.

abstract：:Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and is associated with high mortality and poor prognosis. Thus, the primary aim of the present study was to determine whether glycine could (1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and (2) downregulate mitochondria-mediated autop...

journal_title：Oxidative medicine and cellular longevity

authors： Cai CC,Zhu JH,Ye LX,Dai YY,Fang MC,Hu YY,Pan SL,Chen S,Li PJ,Fu XQ,Lin ZL

更新日期：2019-02-06 00:00:00

abstract：:Trichophyton rubrum (T. rubrum) is one of the most important agents of dermatophyte infection in humans. The aim of this experiment was to evaluate the effect of HaCaT cells on T. rubrum, investigate the responsible mechanism of action, and explore the role of reactive oxygen species (ROS) and nitric oxide (NO) in the...

journal_title：Oxidative medicine and cellular longevity

authors： Huang M,Huang H,Lv W,Xiao H,Gao Y,Tang H

更新日期：2020-02-12 00:00:00

abstract：:In metabolic diseases, the increased reactive oxygen species (ROS) represents one of the pathogenic mechanisms for vascular disease probably by promoting vascular smooth muscle cell (SMC) proliferation that contributes to the development of arterial remodeling and stenosis, hypertension, and atherosclerosis. Therefore...

journal_title：Oxidative medicine and cellular longevity

authors： López-Acosta O,de Los Angeles Fortis-Barrera M,Barrios-Maya MA,Ramírez AR,Aguilar FJA,El-Hafidi M

更新日期：2018-12-23 00:00:00

abstract：:We aimed to evaluate the cardioprotective effect and mechanism of propofol in anthracycline-induced cardiomyocyte apoptosis. We selected the rat myocardial cell line, H9c2, and primary cardiomyocytes for in vitro study. The cardiomyocytes were treated with vehicle, Adriamycin® (ADM), propofol, or a combination of ADM ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao H,Zhang X,Zheng Y,Li Y,Wang X,Hu N,Zhou P,Wang K

更新日期：2018-04-18 00:00:00

abstract：:In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole webs...

journal_title：Oxidative medicine and cellular longevity

authors： Liu M,Tang L,Liu X,Fang J,Zhan H,Wu H,Yang H

更新日期：2016-01-01 00:00:00

abstract：:Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy and is caused by mutations in the gene that encodes the cytoskeletal protein dystrophin. The treatment f...

journal_title：Oxidative medicine and cellular longevity

authors： Kuno A,Horio Y

更新日期：2016-01-01 00:00:00

abstract：:To evaluate RNA oxidation in the early stage of diabetic nephropathy, we applied an accurate method based on isotope dilution high-performance liquid chromatography-triple quadruple mass spectrometry to analyze the oxidatively generated guanine nucleosides in renal tissue and urine from db/db mice of different ages. W...

journal_title：Oxidative medicine and cellular longevity

authors： Wang WX,Luo SB,Jiang P,Xia MM,Hei AL,Mao YH,Li CB,Hu GX,Cai JP

更新日期：2017-01-01 00:00:00

abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

更新日期：2016-01-01 00:00:00

abstract：:Hydrogen sulfide (H2S), a toxic gaseous molecule, plays a physiological role in regulating homeostasis and cell signaling. H2S is produced from cysteine by enzymes, such as cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST). The...

journal_title：Oxidative medicine and cellular longevity

authors： Shefa U,Kim MS,Jeong NY,Jung J

更新日期：2018-02-04 00:00:00

abstract：:This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephr...

journal_title：Oxidative medicine and cellular longevity

authors： Arellano-Buendía AS,Tostado-González M,García-Arroyo FE,Cristóbal-García M,Loredo-Mendoza ML,Tapia E,Sánchez-Lozada LG,Osorio-Alonso H

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs are short (21-23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reporte...

journal_title：Oxidative medicine and cellular longevity

authors： Giudice A,D'Arena G,Crispo A,Tecce MF,Nocerino F,Grimaldi M,Rotondo E,D'Ursi AM,Scrima M,Galdiero M,Ciliberto G,Capunzo M,Franci G,Barbieri A,Bimonte S,Montella M

更新日期：2016-01-01 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:Several lines of investigation have implicated oxidative stress in Parkinson's disease (PD) pathogenesis, but the mechanisms involved are still unclear. In this study, we characterized the involvement of NADPH oxidase (Nox), a multisubunit enzyme that catalyzes the reduction of oxygen, in the 6-hydroxydopamine- (6-OHD...

journal_title：Oxidative medicine and cellular longevity

authors： Hernandes MS,Café-Mendes CC,Britto LR

更新日期：2013-01-01 00:00:00

abstract：:There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessa...

journal_title：Oxidative medicine and cellular longevity

authors： Rosales-Corral S,Tan DX,Manchester L,Reiter RJ

更新日期：2015-01-01 00:00:00

abstract：:Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP). The redox properties of both Hem12p and Tkl1p from Saccharomyces cerevisiae were investigated using proteom...

journal_title：Oxidative medicine and cellular longevity

authors： McDonagh B,Pedrajas JR,Padilla CA,Bárcena JA

更新日期：2013-01-01 00:00:00

abstract：:Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca2+-activated potassium channel (BKCaα), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the ou...

journal_title：Oxidative medicine and cellular longevity

authors： Brazier SP,Telezhkin V,Kemp PJ

更新日期：2016-01-01 00:00:00

abstract：:Fungal immunomodulatory proteins (FIPs) are a class of small proteins that have been extensively studied for their immunomodulatory activities. In this study, two novel FIPs from Lentinus tigrinus were identified and named Fip-lti1 and Fip-lti2. The bioactive characteristics of Fip-lti1 and Fip-lti2 were compared to a...

journal_title：Oxidative medicine and cellular longevity

authors： Gao Y,Wáng Y,Wāng Y,Wu Y,Chen H,Yang R,Bao D

更新日期：2019-05-06 00:00:00

abstract：:Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation. However, there are few studies on the anticancer action of taurine. Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human na...

journal_title：Oxidative medicine and cellular longevity

authors： Wang G,Ma N,He F,Kawanishi S,Kobayashi H,Oikawa S,Murata M

更新日期：2020-05-20 00:00:00

abstract：:Hormone replacement therapy (HRT) can alleviate estrogen deficiency symptoms especially during menopause. The present study aimed at investigating the effect of soy isoflavones as HRT on immunological and bone health-related parameters with a special focus on the interactions between immunological status and metabolis...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelrazek HMA,Mahmoud MMA,Tag HM,Greish SM,Eltamany DA,Soliman MTA

更新日期：2019-01-10 00:00:00

abstract：:We explored whether pu-erh tea consumption ameliorates atherosclerosis and the possible mechanism for its effects in apolipoprotein E-deficient (ApoE-/-) mice. Our data showed that pu-erh tea consumption markedly reduced early fatty streak formation and the advanced fibrofatty plaque sizes. Additionally, the mean prop...

journal_title：Oxidative medicine and cellular longevity

authors： Xiao Y,He M,Liang X,She J,He L,Liu Y,Zou J,Yuan Z

更新日期：2018-08-23 00:00:00

abstract：:Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative su...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Q,Huang Y,Qin C,Liang M,Mao X,Li S,Zou Y,Jia W,Li H,Ma CW,Huang Z

更新日期：2016-01-01 00:00:00

abstract：:Degradation of oxidized or oxidatively modified proteins is an essential part of the antioxidant defenses of cells. 4-Hydroxy-2-nonenal, a major reactive aldehyde formed by lipid peroxidation, causes many types of cellular damage. It has been reported that 4-hydroxy-2-nonenal-modified proteins are degraded by the ubiq...

journal_title：Oxidative medicine and cellular longevity

authors： Tsuchiya Y,Okada G,Kobayashi S,Chikuma T,Hojo H

更新日期：2011-01-01 00:00:00

abstract：:Neutrophils play a critical role in the initiation and maintenance of intestinal inflammation. However, conventional neutrophil-targeted therapies can impair normal host defense. Tanshinone IIA has been recently revealed to act directly on neutrophils. Hence, we aimed at investigating whether Tanshinone IIA can protec...

journal_title：Oxidative medicine and cellular longevity

authors： Liu X,He H,Huang T,Lei Z,Liu F,An G,Wen T

更新日期：2016-01-01 00:00:00

abstract：:Known for centuries throughout the world, Plantago species have long been used as traditional herbal remedies for many diseases related to inflammatory conditions of the skin, respiratory and digestive tract, or even malignancy. This study is aimed first at investigating the in vitro antioxidant and regenerative effec...

journal_title：Oxidative medicine and cellular longevity

authors： Farcaș AD,Moț AC,Pârvu AE,Toma VA,Popa MA,Mihai MC,Sevastre B,Roman I,Vlase L,Pârvu M

更新日期：2019-06-02 00:00:00

abstract：:The generation of reactive oxygen and nitrogen species (RONS) has been found to occur during inflammatory procedures, during cell ischemia, and in various crucial developmental processes such as cell differentiation and along cell signaling pathways. The most common sources of intracellular RONS are the mitochondrial ...

journal_title：Oxidative medicine and cellular longevity

authors： Jha N,Ryu JJ,Choi EH,Kaushik NK

更新日期：2017-01-01 00:00:00

abstract：:As a pair of differential isomers, Kaji-ichigoside F1 and Rosamultin are both pentacyclic triterpenoids isolated from the subterranean root of Potentilla anserina L., a plant used in folk medicine in western China as antihypoxia and anti-inflammatory treatments. We demonstrated that Kaji-ichigoside F1 and Rosamultin e...

journal_title：Oxidative medicine and cellular longevity

authors： Shi C,Zhan L,Wu Y,Li Z,Li J,Li Y,Wei J,Zhang Y,Li L

更新日期：2020-04-12 00:00:00

abstract：:The regulation on calcium oxalate (CaOx) crystallization and protective effect on human proximal tubular epithelial cells (HK-2) of four green tea polysaccharides (TPSs) with molecular weights of 10.88 (TPS0), 8.16 (TPS1), 4.82 (TPS2), and 2.3 kDa (TPS3) were comparatively studied. XRD, Fourier transform infrared spec...

journal_title：Oxidative medicine and cellular longevity

authors： Liu H,Sun XY,Wang FX,Ouyang JM

更新日期：2020-05-12 00:00:00

abstract：:Mono-(2-ethylhexyl) phthalate (MEHP) and genistein have been classified as endocrine-disrupting chemicals (EDCs) which interfere with the differentiation and development of the male reproductive system. However, how these two EDCs would affect fetal rat testis development at a low dose was rarely studied. In this stud...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang TD,Ma YB,Li HC,Chong T,Wang ZM,Zhang LD

更新日期：2020-05-27 00:00:00

abstract：:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AE

更新日期：2014-01-01 00:00:00

abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

更新日期：2019-03-26 00:00:00