Abstract：
:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats divided into 4 groups: Group I served as control group, and Group II received weekly i.p. injection of 2 mL CCl4/kg bwt for 12 weeks. Group III were supplemented with Physalis juice via the drinking water. The animals of Group IV received Physalis juice as Group III and also were intraperitoneally injected weekly with 2 mL CCl4/kg bwt for 12 weeks. Hepatoprotective effect was evaluated by improvement in liver enzymes serum levels, reduction in collagen areas, downregulation in expression of the fibrotic marker MMP-9, reduction in the peroxidative marker malonaldehyde and the inflammatory marker nitric oxide, and restoration of the activity of antioxidant enzymatic and nonenzymatic systems, namely, glutathione content, superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase activities. The results show that the potential hepatoprotective effects of Physalis peruviana may be due to physalis acts by promotion of processes that restore hepatolobular architecture and through the inhibition of oxidative stress pathway.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AEdoi
10.1155/2014/381413subject
Has Abstractpub_date
2014-01-01 00:00:00pages
381413eissn
1942-0900issn
1942-0994journal_volume
2014pub_type
杂志文章abstract：:Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. R...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2019/9426368
更新日期：2019-11-11 00:00:00
abstract：:Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randoml...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2013/741817
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abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
doi：10.1155/2016/4234061
更新日期：2016-01-01 00:00:00
abstract：:This work reviews concepts regarding oxidative stress and the mechanisms by which endogenous and exogenous factors produce reactive oxygen species (ROS). It also surveys the relationships between oxidative stress, circadian rhythms, and retinal damage in humans, particularly those related to light and photodamage. In ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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journal_title：Oxidative medicine and cellular longevity
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更新日期：2015-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,随机对照试验
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更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2012/821936
更新日期：2012-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2017/4674918
更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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更新日期：2018-03-22 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2013/702120
更新日期：2013-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2015/217304
更新日期：2015-01-01 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2017/6838921.]. ...
journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,已发布勘误
doi：10.1155/2017/3575348
更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
doi：10.1155/2017/8584930
更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2016/2853543
更新日期：2016-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
doi：10.1155/2017/6109061
更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
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更新日期：2017-01-01 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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更新日期：2018-07-18 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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更新日期：2019-05-22 00:00:00
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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更新日期：2018-06-25 00:00:00
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journal_title：Oxidative medicine and cellular longevity
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abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...
journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2018-01-31 00:00:00
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
