Relationship between Oxidative Stress, Circadian Rhythms, and AMD.

abstract：:Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear. Accumulating studies also indicate that uric acid has both pro- and antioxidant properties. We postulated that hyperuricemia impairs the function of glomerular podocytes, resulting in albuminuria. Hyperuricemic model w...

journal_title：Oxidative medicine and cellular longevity

authors： Asakawa S,Shibata S,Morimoto C,Shiraishi T,Nakamura T,Tamura Y,Kumagai T,Hosoyamada M,Uchida S

更新日期：2017-01-01 00:00:00

abstract：:The widely used herbicide atrazine (ATR) can cause many adverse effects including immunotoxicity, but the underlying mechanisms are not fully understood. The current study investigated the role of oxidative stress and calcium homeostasis in ATR-induced immunotoxicity in mice. ATR at doses of 0, 100, 200, or 400 mg/kg ...

journal_title：Oxidative medicine and cellular longevity

authors： Gao S,Wang Z,Zhang C,Jia L,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:Accumulating evidence has demonstrated that oxidative stress is associated with depression. Our present study aimed at investigating the antidepressant effect and the possible mechanisms of curcumin (CUR) in chronic unpredictable mild stress- (CUMS-) induced depression model in rats. After exposure to CUMS for four we...

journal_title：Oxidative medicine and cellular longevity

authors： Liao D,Lv C,Cao L,Yao D,Wu Y,Long M,Liu N,Jiang P

更新日期：2020-09-17 00:00:00

abstract：:We conducted quantitative cellular respiration analysis on samples taken from human breast cancer (HBC) and human colorectal cancer (HCC) patients. Respiratory capacity is not lost as a result of tumor formation and even though, functionally, complex I in HCC was found to be suppressed, it was not evident on the prote...

journal_title：Oxidative medicine and cellular longevity

authors： Koit A,Shevchuk I,Ounpuu L,Klepinin A,Chekulayev V,Timohhina N,Tepp K,Puurand M,Truu L,Heck K,Valvere V,Guzun R,Kaambre T

更新日期：2017-01-01 00:00:00

abstract：:Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD). The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature m...

journal_title：Oxidative medicine and cellular longevity

authors： Luca M,Luca A,Calandra C

更新日期：2013-01-01 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00

abstract：:In some inflammatory diseases of bone, osteogenesis and osteoclasis are uncoupled and the balance is usually tipped resulting in bone destruction. The underlying mechanism of osteogenic dysfunction in inflammation still needs further study. This study is aimed at investigating the effects of cyclosporine A (CsA) on bo...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Y,Gao J,Zhang Y,Gan X,Yu H

更新日期：2021-01-07 00:00:00

abstract：:Essential oils of some aromatic plants provide an effective nonmedicinal option to control liver fibrosis. Mentha piperita L. essential oil (MPEO) have been reported to possess protective effects against hepatotoxicity. However, its effect against liver fibrosis remains unknown. The present study investigated the anti...

journal_title：Oxidative medicine and cellular longevity

authors： Ogaly HA,Eltablawy NA,Abd-Elsalam RM

更新日期：2018-04-19 00:00:00

abstract：:Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field. This study is aimed at exploring StAEW as a potential wound care agent and its mechanism. StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of...

journal_title：Oxidative medicine and cellular longevity

authors： Fadriquela A,Sajo MEJ,Bajgai J,Kim DH,Kim CS,Kim SK,Lee KJ

更新日期：2020-12-12 00:00:00

abstract：:The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 wee...

journal_title：Oxidative medicine and cellular longevity

authors： Jorgačević B,Mladenović D,Ninković M,Vesković M,Dragutinović V,Vatazević A,Vučević D,Ješić Vukićević R,Radosavljević T

更新日期：2015-01-01 00:00:00

abstract：:Obesity is a state of chronic low-level inflammation closely associated with oxidative stress. Childhood obesity is associated with endothelial dysfunction, inflammation, and oxidative stress markers individually. This study was aimed at determining the association between the biomarkers of inflammation, oxidative str...

journal_title：Oxidative medicine and cellular longevity

authors： Selvaraju V,Ayine P,Fadamiro M,Babu JR,Brown M,Geetha T

更新日期：2019-10-16 00:00:00

abstract：:Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca2+-activated potassium channel (BKCaα), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the ou...

journal_title：Oxidative medicine and cellular longevity

authors： Brazier SP,Telezhkin V,Kemp PJ

更新日期：2016-01-01 00:00:00

abstract：:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

更新日期：2020-06-17 00:00:00

abstract：:Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

journal_title：Oxidative medicine and cellular longevity

authors： Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

更新日期：2017-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) regulate bone marrow microenvironment for stem and progenitor cells functions including self-renewal, differentiation, and cell senescence. In response to ischemia, ROS also play a critical role in mediating the mobilization of endothelial progenitor cells (EPCs) from the bone marrow to t...

journal_title：Oxidative medicine and cellular longevity

authors： Lam YT

更新日期：2015-01-01 00:00:00

abstract：:Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y,...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos KC,Cury SS,Ferraz APCR,Corrente JE,Gonçalves BM,de Araújo Machado LH,Carvalho RF,de Melo Stevanato Nakamune AC,Fabro AT,Freire PP,Corrêa CR

更新日期：2018-04-10 00:00:00

abstract：:Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccha...

journal_title：Oxidative medicine and cellular longevity

authors： Giancaspero TA,Locato V,Barile M

更新日期：2013-01-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is a Ca+2-permeable channel expressed on neuronal and nonneuronal cells, known as an oxidative stress sensor. It plays a protective role in bacterial infection, and recent findings indicate that this receptor modulates monocyte populations in mice with malaria; however,...

journal_title：Oxidative medicine and cellular longevity

authors： Pereira DMS,Teixeira SA,Murillo O,Peixoto EPM,Araújo MC,Sousa NCF,Monteiro-Neto V,Calixto JB,Cunha TM,Marinho CRF,Muscará MN,Fernandes ES

更新日期：2019-05-16 00:00:00

abstract：:The neutrophil elastase inhibitor sivelestat (ONO-5046) possesses unknown mechanisms of cardioprotection when infused following global ischemia, even in the absence of neutrophils. Since myocardial ischemia-reperfusion injury is strongly associated with endothelial dysfunction and reactive oxygen species (ROS) generat...

journal_title：Oxidative medicine and cellular longevity

authors： Aune SE,Yeh ST,Kuppusamy P,Kuppusamy ML,Khan M,Angelos MG

更新日期：2013-01-01 00:00:00

abstract：:A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular ...

journal_title：Oxidative medicine and cellular longevity

authors： Mohammad K,Dakik P,Medkour Y,McAuley M,Mitrofanova D,Titorenko VI

更新日期：2018-01-31 00:00:00

abstract：:The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation. Intense exercise (28 m/min at a ...

journal_title：Oxidative medicine and cellular longevity

authors： Tang Y,Li J,Gao C,Xu Y,Li Y,Yu X,Wang J,Liu L,Yao P

更新日期：2016-01-01 00:00:00

abstract：:We examined in vitro antioxidant capacity of polyphenolic extract obtained from the wood of oak Quercus robur (QR), Robuvit, using TEAC (Trolox equivalent antioxidant capacity) method and the effect of its intake on markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity in plasma ...

journal_title：Oxidative medicine and cellular longevity

authors： Horvathova M,Orszaghova Z,Laubertova L,Vavakova M,Sabaka P,Rohdewald P,Durackova Z,Muchova J

更新日期：2014-01-01 00:00:00

abstract：:Endothelial dysfunction tends to be the initial indicator in proinflammatory state and macro- and microvascular complications, such as atherosclerosis and cardiovascular diseases. It has been shown that certain compounds in diet can generate beneficial effects on cardiovascular disease due to its interactions with end...

journal_title：Oxidative medicine and cellular longevity

authors： Stromsnes K,Mas-Bargues C,Gambini J,Gimeno-Mallench L

更新日期：2020-08-06 00:00:00

abstract：:Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigat...

journal_title：Oxidative medicine and cellular longevity

authors： de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

更新日期：2018-10-21 00:00:00

abstract：:2-[(2,6-Dichlorobenzylidene)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, 5TIO1, is a new 2-aminothiophene derivative with promising pharmacological activities. The aim of this study was to evaluate its antioxidant activity in different areas of mice central nervous system. Male Swiss adult mice were in...

journal_title：Oxidative medicine and cellular longevity

authors： Fortes AC,Almeida AA,Oliveira GA,Santos PS,De Lucca Junior W,Mendonça Junior FJ,Freitas RM,Soares-Sobrinho JL,Soares MF

更新日期：2013-01-01 00:00:00

abstract：:The World Health Organization estimates that 7 million people die every year due to pollution exposure. Among the different pollutants to which living organism are exposed, ozone (O3) represents one of the most toxic, because its location which is the skin is one of the direct tissues exposed to the outdoor environmen...

journal_title：Oxidative medicine and cellular longevity

authors： Pambianchi E,Ferrara F,Pecorelli A,Woodby B,Grace M,Therrien JP,Lila MA,Valacchi G

更新日期：2020-08-13 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/4824371.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Song TY,Yang NC,Chen CL,Thi TLV

更新日期：2019-08-06 00:00:00

abstract：:Edaravone (5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, EDV) is a free-radical scavenger reduces organ ischemic injury. Here we investigated whether the protective effects of EDV in renal ischemia/reperfusion (I/R) injury may be enhanced by an EDV derivative bearing a nitric oxide- (NO-) donor furoxan moiety (NO-ED...

journal_title：Oxidative medicine and cellular longevity

authors： Chiazza F,Chegaev K,Rogazzo M,Cutrin JC,Benetti E,Lazzarato L,Fruttero R,Collino M

更新日期：2015-01-01 00:00:00

abstract：:Simvastatin is a lipid-lowering agent used to treat hypercholesterolemia and to reduce the risk of heart disease. This study scrutinized the beneficial effects of simvastatin on experimental diabetic cardiomyopathy (DCM), pointing to the role of hyperglycemia-induced oxidative stress and inflammation. Diabetes was ind...

journal_title：Oxidative medicine and cellular longevity

authors： Al-Rasheed NM,Al-Rasheed NM,Hasan IH,Al-Amin MA,Al-Ajmi HN,Mohamad RA,Mahmoud AM

更新日期：2017-01-01 00:00:00

abstract：:Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans. However, the mechanism underlying this effec...

journal_title：Oxidative medicine and cellular longevity

authors： Meng F,Li J,Rao Y,Wang W,Fu Y

更新日期：2018-02-18 00:00:00