Abstract：
:Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigated for their antioxidant properties and anticholinesterase activities. The antioxidant properties were evaluated by free radical scavenging and electroanalytical assays, which were further correlated with the total phenolic content and LC-MS results. The acetylcholinesterase and butyrylcholinesterase inhibitory activities were examined using Ellman's colorimetric method. The LC-MS analysis of EAF revealed the presence of gallic acid and quercetin. CHE and its fractions, EAF and BF, showed anticholinesterase and antioxidant activities, suggesting the association of both effects with the phenolic content. In addition, behavioral tests performed with CHE (10, 100, and 300 mg/kg) showed that it prevented mice memory impairment which resulted from aluminium intake. Moreover, CHE inhibited brain lipid peroxidation and acetyl and butyryl-cholinesterase activities and the extract's neuroprotective effect was reflected at the microscopic level. Therefore, the leaves of pequi are a potential source of phenolic antioxidants and can be potentially used in treatments of memory dysfunctions, such as those associated with neurodegenerative disorders.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
de Oliveira TS,Thomaz DV,da Silva Neri HF,Cerqueira LB,Garcia LF,Gil HPV,Pontarolo R,Campos FR,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PCdoi
10.1155/2018/9842908subject
Has Abstractpub_date
2018-10-21 00:00:00pages
9842908eissn
1942-0900issn
1942-0994journal_volume
2018pub_type
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