Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis.

abstract：:Cardiac fibroblasts (CFs) are a critical cell population responsible for myocardial extracellular matrix homeostasis. After stimulation by myocardial infarction (MI), CFs transdifferentiate into cardiac myofibroblasts (CMFs) and play a fundamental role in the fibrotic healing response. Transient receptor potential ank...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Sun X,Wu H,Yu P,Wang X,Jiang Z,Gao E,Chen J,Li,Qiu C,Song B,Chen K,He K,Yang D,Yang Y

更新日期：2019-05-14 00:00:00

abstract：:Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca2+-activated potassium channel (BKCaα), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the ou...

journal_title：Oxidative medicine and cellular longevity

authors： Brazier SP,Telezhkin V,Kemp PJ

更新日期：2016-01-01 00:00:00

abstract：:Many groups of Gram-negative bacteria cause diseases that are harmful to sheep. Toll-like receptor 4 (TLR4), which is critical for detecting Gram-negative bacteria by the innate immune system, is activated by lipopolysaccharide (LPS) to initiate inflammatory responses and oxidative stress. Oxidation intermediates are ...

journal_title：Oxidative medicine and cellular longevity

authors： Deng S,Yu K,Zhang B,Yao Y,Wang Z,Zhang J,Zhang X,Liu G,Li N,Liu Y,Lian Z

更新日期：2015-01-01 00:00:00

abstract：:In an attempt to better understand the pathogen-host interaction between invading Mycoplasma ovipneumoniae (M. ovipneumoniae) and sheep airway epithelial cells, biological effects and possible molecular mechanism of capsular polysaccharide of M. ovipneumoniae (CPS) in the induction of cell apoptosis were explored usin...

journal_title：Oxidative medicine and cellular longevity

authors： Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

更新日期：2017-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) production in hepatic ischemia-reperfusion injury (IRI) is a complex process where multiple cellular and molecular pathways are involved. Few of those molecular pathways are under the direct influence of SIRT3 and its downstream mediators. SIRT3 plays a major role in the mechanism of IRI,...

journal_title：Oxidative medicine and cellular longevity

authors： Katwal G,Baral D,Fan X,Weiyang H,Zhang X,Ling L,Xiong Y,Ye Q,Wang Y

更新日期：2018-11-13 00:00:00

abstract：:Calenduloside E (CE) is a natural triterpenoid saponin isolated from Aralia elata (Miq.) Seem., a well-known traditional Chinese medicine. Our previous studies have shown that CE exerts cardiovascular protective effects both in vivo and in vitro. However, its role in myocardial ischemia/reperfusion injury (MIRI) and t...

journal_title：Oxidative medicine and cellular longevity

authors： Wang M,Wang RY,Zhou JH,Xie XH,Sun GB,Sun XB

更新日期：2020-08-31 00:00:00

abstract：:Our previous study showed that proteasomal inhibitor MG132 can prevent diabetic nephropathy (DN) along with upregulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). The present study was to investigate whether MG132 can prevent DN in wild-type and Nrf2-KO mice. Type 1 diabetes was induced in wild-type and N...

journal_title：Oxidative medicine and cellular longevity

authors： Kong L,Wang Y,Luo M,Tan Y,Cui W,Miao L

更新日期：2017-01-01 00:00:00

abstract：:Endothelial injury plays a critical role in the pathogenesis of cardiovascular disorders and metabolic-associated vascular complications which are the leading cause of death worldwide. However, the mechanism underlying endothelial dysfunction is not completely understood. The study is aimed at investigating the role o...

journal_title：Oxidative medicine and cellular longevity

authors： Liu N,Li Y,Nan W,Zhou W,Huang J,Li R,Zhou L,Hu R

更新日期：2020-10-02 00:00:00

abstract：:In plasma medicine, cold physical plasma delivers a delicate mixture of reactive components to cells and tissues. Recent studies suggested a beneficial role of cold plasma in wound healing. Yet, the biological processes related to the redox modulation via plasma are not fully understood. We here used the monocytic cel...

journal_title：Oxidative medicine and cellular longevity

authors： Bekeschus S,Schmidt A,Bethge L,Masur K,von Woedtke T,Hasse S,Wende K

更新日期：2016-01-01 00:00:00

abstract：:Surgical intervention is currently the only option for an abdominal aortic aneurysm (AAA), preventing its rupture and sudden death of a patient. Therefore, it is crucial to determine the pathogenic mechanisms of this disease for the development of effective pharmacological therapies. Oxidative stress is said to be one...

journal_title：Oxidative medicine and cellular longevity

authors： Kopacz A,Werner E,Grochot-Przęczek A,Klóska D,Hajduk K,Neumayer C,Józkowicz A,Piechota-Polanczyk A

更新日期：2020-06-16 00:00:00

abstract：:Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses an antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results,...

journal_title：Oxidative medicine and cellular longevity

authors： Ashour AE,Sayed-Ahmed MM,Abd-Allah AR,Korashy HM,Maayah ZH,Alkhalidi H,Mubarak M,Alhaider A

更新日期：2012-01-01 00:00:00

abstract：:The present study discusses about the effects of a combination of probiotics able to stimulate the immune system of patients affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To this purpose, patients diagnosed according to Fukuda's criteria and treated with probiotics were analyzed by means of ...

journal_title：Oxidative medicine and cellular longevity

authors： Venturini L,Bacchi S,Capelli E,Lorusso L,Ricevuti G,Cusa C

更新日期：2019-11-23 00:00:00

abstract：:Accumulation of advanced glycation end products (AGEs) contributes to ageing and age-related diseases, especially type 2 diabetes. The NLRP3 inflammasome, as a vital component of the innate immune system, is implicated in the pathogenesis of type 2 diabetes. However, the role of the NLRP3 inflammasome in AGE-induced p...

journal_title：Oxidative medicine and cellular longevity

authors： Kong X,Lu AL,Yao XM,Hua Q,Li XY,Qin L,Zhang HM,Meng GX,Su Q

更新日期：2017-01-01 00:00:00

abstract：:Endothelial microparticles are effectors of endothelial damage; however mechanisms involved are unclear. We examined the effects of eMPs on cultured endothelial cells (ECs) and isolated vessels and investigated the role of eMP-derived reactive oxygen species (ROS) and redox signaling in these processes. eMPs were isol...

journal_title：Oxidative medicine and cellular longevity

authors： Burger D,Turner M,Munkonda MN,Touyz RM

更新日期：2016-01-01 00:00:00

abstract：:Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone gro...

journal_title：Oxidative medicine and cellular longevity

authors： You Z,Sun J,Xie F,Chen Z,Zhang S,Chen H,Liu F,Li L,Chen G,Song Y,Xuan Y,Zheng G,Xin Y

更新日期：2017-01-01 00:00:00

abstract：:In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomal β-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of V...

journal_title：Oxidative medicine and cellular longevity

authors： Zarrouk A,Vejux A,Nury T,El Hajj HI,Haddad M,Cherkaoui-Malki M,Riedinger JM,Hammami M,Lizard G

更新日期：2012-01-01 00:00:00

abstract：:The human apoptosis-inducing factor (hAIF) is a moonlight flavoprotein involved in mitochondrial respiratory complex assembly and caspase-independent programmed cell death. These functions might be modulated by its redox-linked structural transition that enables hAIF to act as a NAD(H/+) redox sensor. Upon reduction w...

journal_title：Oxidative medicine and cellular longevity

authors： Romero-Tamayo S,Laplaza R,Velazquez-Campoy A,Villanueva R,Medina M,Ferreira P

更新日期：2021-01-15 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/3027109.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Nawrocka D,Kornicka K,Szydlarska J,Marycz K

更新日期：2017-01-01 00:00:00

abstract：:Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women. Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development. Contrariwise, the human studies on this topic are still scarce and inconclusive....

journal_title：Oxidative medicine and cellular longevity

authors： Cervellati C,Romani A,Cremonini E,Bergamini CM,Fila E,Squerzanti M,Greco P,Massari L,Bonaccorsi G

更新日期：2016-01-01 00:00:00

abstract：:Respiratory diseases are accompanied by intensification of free radical processes at different levels of the biological body organization. Simultaneous stress and suppression of various parts of antioxidant protection lead to the development of oxidative stress (OS) and nitrosative stress (NS). The basic mechanisms of...

journal_title：Oxidative medicine and cellular longevity

authors： Soodaeva S,Kubysheva N,Klimanov I,Nikitina L,Batyrshin I

更新日期：2019-05-22 00:00:00

abstract：:Copper, a transition metal with essential cellular functions, exerts neurotoxic effects when present in excess by promoting production of reactive oxygen species (ROS). The aim of the present study was to investigate potential benefits of flavonoid quercetin against copper-induced toxicity. Results obtained with MTT a...

journal_title：Oxidative medicine and cellular longevity

authors： Zubčić K,Radovanović V,Vlainić J,Hof PR,Oršolić N,Šimić G,Jazvinšćak Jembrek M

更新日期：2020-07-11 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Cancer is the second leading cause of death and is becoming the leading one in old age. Vegetable and fruit consumption is inversely associated with cancer incidence and mortality. Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2015-01-01 00:00:00

abstract：Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

journal_title：Oxidative medicine and cellular longevity

authors： Hsueh CY,Shao M,Cao W,Li S,Zhou L

更新日期：2019-04-16 00:00:00

abstract：:Fungal immunomodulatory proteins (FIPs) are a class of small proteins that have been extensively studied for their immunomodulatory activities. In this study, two novel FIPs from Lentinus tigrinus were identified and named Fip-lti1 and Fip-lti2. The bioactive characteristics of Fip-lti1 and Fip-lti2 were compared to a...

journal_title：Oxidative medicine and cellular longevity

authors： Gao Y,Wáng Y,Wāng Y,Wu Y,Chen H,Yang R,Bao D

更新日期：2019-05-06 00:00:00

abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

journal_title：Oxidative medicine and cellular longevity

authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

更新日期：2019-03-26 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

journal_title：Oxidative medicine and cellular longevity

authors： Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

更新日期：2020-02-12 00:00:00

abstract：:Platelet-rich plasma (PRP) has grown as an attractive biologic instrument in regenerative medicine for its powerful healing properties. It is considered as a source of growth factors that may induce tissue repairing and improve fibrosis. This product has proven its efficacy in multiple studies, but its effect on cispl...

journal_title：Oxidative medicine and cellular longevity

authors： Salem N,Helmi N,Assaf N

更新日期：2018-07-18 00:00:00

abstract：:This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary ...

journal_title：Oxidative medicine and cellular longevity

authors： Moreto F,de Oliveira EP,Manda RM,Burini RC

更新日期：2014-01-01 00:00:00