NLRP3 Inflammasome and Inflammatory Diseases.

abstract：:Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional curcumin (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wis...

journal_title：Oxidative medicine and cellular longevity

authors： Boarescu PM,Chirilă I,Bulboacă AE,Bocșan IC,Pop RM,Gheban D,Bolboacă SD

更新日期：2019-05-07 00:00:00

abstract：:Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism ar...

journal_title：Oxidative medicine and cellular longevity

authors： Hou B,Zhao Y,Qiang G,Yang X,Xu C,Chen X,Liu C,Wang X,Zhang L,Du G

更新日期：2018-07-02 00:00:00

abstract：:The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear f...

journal_title：Oxidative medicine and cellular longevity

authors： Fuyuno Y,Uchi H,Yasumatsu M,Morino-Koga S,Tanaka Y,Mitoma C,Furue M

更新日期：2018-02-14 00:00:00

abstract：:There is accumulating evidence that blood pressure (BP) control significantly reduces the risk of future cardiovascular events in patients with essential hypertension. However, strict BP control is often difficult to maintain, and half of hypertensive patients fail to attain BP goals on single-drug therapy. Therefore,...

journal_title：Oxidative medicine and cellular longevity

authors： Bekki H,Yamamoto K,Sone M,Homma T,Nakata M,Nohara M,Fukami K,Okuda S,Yamagishi S

更新日期：2010-09-01 00:00:00

abstract：Background:The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS). Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects. Aims:To assess the effect of ileal transposition (IT) and sham types of ...

journal_title：Oxidative medicine and cellular longevity

authors： Skrzep-Poloczek B,Stygar D,Sawczyn T,Romuk E,Chełmecka E,Poloczek J,Dulska A,Kazura W,Karcz KW

更新日期：2018-11-11 00:00:00

abstract：:Several lines of investigation have implicated oxidative stress in Parkinson's disease (PD) pathogenesis, but the mechanisms involved are still unclear. In this study, we characterized the involvement of NADPH oxidase (Nox), a multisubunit enzyme that catalyzes the reduction of oxygen, in the 6-hydroxydopamine- (6-OHD...

journal_title：Oxidative medicine and cellular longevity

authors： Hernandes MS,Café-Mendes CC,Britto LR

更新日期：2013-01-01 00:00:00

abstract：:Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis that bone morphogenetic protein 4 (BMP4) m...

journal_title：Oxidative medicine and cellular longevity

authors： Yang X,Niu N,Liang C,Wu MM,Tang LL,Wang QS,Lou J,Song BL,Zheng WW,Ma HP,Zhang ZR

更新日期：2020-10-28 00:00:00

abstract：Background:Acute kidney injury (AKI) is one of the common complications of sepsis. Heretofore, there is no effective treatment for septic AKI. Recent studies have revealed that besides treating hematological malignancies, human umbilical cord blood mononuclear cells (hUCBMNCs) show good therapeutic effects on other dis...

journal_title：Oxidative medicine and cellular longevity

authors： Feng LX,Zhao F,Liu Q,Peng JC,Duan XJ,Yan P,Wu X,Wang HS,Deng YH,Duan SB

更新日期：2020-07-28 00:00:00

abstract：:Approximately 90% of male diabetes mellitus patients have varying degrees of testicular dysfunction. The molecular mechanism underlying diabetes-induced testicular damage has not been thoroughly elucidated. In this research, we sought to determine the influence of metformin (Met) on diabetes-induced testicular injury ...

journal_title：Oxidative medicine and cellular longevity

authors： Liu Y,Yang Z,Kong D,Zhang Y,Yu W,Zha W

更新日期：2019-11-28 00:00:00

abstract：:During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to "inflammaging," which is a state of chronic, systemic, sterility, low-grade i...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou YT,Zhu L,Yuan Y,Ling S,Xu JW

更新日期：2020-06-17 00:00:00

abstract：:Vagus nerve stimulation (VNS) has been shown to attenuate ischemia-reperfusion (I/R) injury in multiple organs. The present study aimed at investigating whether VNS could exert protective effects against I/R injury in the skeletal muscle. Male Sprague-Dawley rats were randomly divided into 3 groups: the control, I/R, ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang Y,Li H,Wang M,Meng G,Wang Z,Deng J,Wang M,Zhang Q,Yang S,Jiang H

更新日期：2019-02-28 00:00:00

abstract：:The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notab...

journal_title：Oxidative medicine and cellular longevity

authors： Li S,Hong M,Tan HY,Wang N,Feng Y

更新日期：2016-01-01 00:00:00

abstract：:Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of pl...

journal_title：Oxidative medicine and cellular longevity

authors： Lee MH,Kwon BJ,Seo HJ,Yoo KE,Kim MS,Koo MA,Park JC

更新日期：2014-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of...

journal_title：Oxidative medicine and cellular longevity

authors： Paiva AA,Raposo HF,Wanschel AC,Nardelli TR,Oliveira HC

更新日期：2017-01-01 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been...

journal_title：Oxidative medicine and cellular longevity

authors： Tatzber F,Pursch E,Resch U,Pfragner R,Holasek S,Lindschinger M,Cvirn G,Wonisch W

更新日期：2017-01-01 00:00:00

abstract：:Eugenia dysenterica ex DC Mart. (Myrtaceae), popularly known as "cagaita," is a Brazilian plant rich in polyphenols and other antioxidant compounds. Aiming to evaluate the potential use of cagaita in pathologies involving oxidative stress, such as neurodegenerative disorders, this study investigated its antioxidant po...

journal_title：Oxidative medicine and cellular longevity

authors： Thomaz DV,Peixoto LF,de Oliveira TS,Fajemiroye JO,da Silva Neri HF,Xavier CH,Costa EA,Dos Santos FCA,de Souza Gil E,Ghedini PC

更新日期：2018-09-19 00:00:00

abstract：:We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo...

journal_title：Oxidative medicine and cellular longevity

authors： Huang Y,Zhao H,Cao K,Sun D,Yang Y,Liu C,Cui J,Cheng Y,Li B,Cai J,Gao F

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to investigate the modulation of histone deacetylase 2 (HDAC2) on mitochondrial apoptosis in acute liver failure (ALF). The cellular model was established with LO2 cells stimulated by tumor necrosis factor alpha (TNF-α)/D-galactosamine (D-gal). Rats were administrated by lipopolysaccharid...

journal_title：Oxidative medicine and cellular longevity

authors： Wang Y,Yang F,Jiao FZ,Chen Q,Zhang WB,Wang LW,Gong ZJ

更新日期：2019-04-28 00:00:00

abstract：:Many groups of Gram-negative bacteria cause diseases that are harmful to sheep. Toll-like receptor 4 (TLR4), which is critical for detecting Gram-negative bacteria by the innate immune system, is activated by lipopolysaccharide (LPS) to initiate inflammatory responses and oxidative stress. Oxidation intermediates are ...

journal_title：Oxidative medicine and cellular longevity

authors： Deng S,Yu K,Zhang B,Yao Y,Wang Z,Zhang J,Zhang X,Liu G,Li N,Liu Y,Lian Z

更新日期：2015-01-01 00:00:00

abstract：Background:The mechanisms of crosstalk between depression and gastric cancer (GC) remain ill defined. Given that reactive oxygen species (ROS) is involved in the pathophysiology of both GC and depression, we try to explore the activities of ROS in the development of GC and GC-related depression. Methods:110 patients w...

journal_title：Oxidative medicine and cellular longevity

authors： Huang T,Zhou F,Yuan X,Yang T,Liang X,Wang Y,Tu H,Chang J,Nan K,Wei Y

更新日期：2019-07-15 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascu...

journal_title：Oxidative medicine and cellular longevity

authors： Ling S,Xu JW

更新日期：2016-01-01 00:00:00

abstract：:Glucocorticoid (GC) production is physiologically regulated through a negative feedback loop mediated by the GC, which appear disrupted in several pathological conditions. The inability to perform negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in several diseases is associated with an overproductio...

journal_title：Oxidative medicine and cellular longevity

authors： Prevatto JP,Torres RC,Diaz BL,Silva PMRE,Martins MA,Carvalho VF

更新日期：2017-01-01 00:00:00

abstract：:Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated w...

journal_title：Oxidative medicine and cellular longevity

authors： Baldim JL,de Alcântara BGV,Domingos ODS,Soares MG,Caldas IS,Novaes RD,Oliveira TB,Lago JHG,Chagas-Paula DA

更新日期：2017-01-01 00:00:00

abstract：:Choroidal neovascularization (CNV) is a sight-threatening disease and is characterized by the formation of pathological neovascularization in the choroid which extends into the subretinal space. Exudative age-related macular degeneration (AMD) is the formation of CNV in the macular area which leads to irreversible bli...

journal_title：Oxidative medicine and cellular longevity

authors： Xi L

更新日期：2020-03-06 00:00:00

abstract：:Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation. However, there are few studies on the anticancer action of taurine. Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human na...

journal_title：Oxidative medicine and cellular longevity

authors： Wang G,Ma N,He F,Kawanishi S,Kobayashi H,Oikawa S,Murata M

更新日期：2020-05-20 00:00:00

abstract：:Human skeletal muscle is a vital organ involved in movement and force generation. It suffers from deterioration in mass, strength, and regenerative capacity in sarcopenia. Skeletal muscle satellite cells are involved in the regeneration process in response to muscle loss. Tocotrienol, an isomer of vitamin E, was repor...

journal_title：Oxidative medicine and cellular longevity

authors： Lim JJ,Wan Zurinah WN,Mouly V,Norwahidah AK

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND AND AIMS:Metabolic syndrome (MetS) has been associated with occurrence and prognosis of ischemic stroke. This study aimed to evaluate whether an association exists between MetS and early neurological deterioration (END) following acute ischemic stroke and the possible role inflammatory biomarkers play. METH...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang X,Sun Z,Ding C,Tang Y,Jiang X,Xie Y,Li C,Zhang L,Hu D,Li T,Xu G,Sheng L

更新日期：2016-01-01 00:00:00

abstract：Methods:The expression of CD86, CD206, and HIF-1α in the gastric mucosa was evaluated through immunohistochemistry. RAW 264.7 cells were cocultured with H. pylori at various multiplicities of infection (MOIs), and iNOS, CD86, Arg-1, CD206, and HIF-1α expression was detected by Western blot, PCR, and ELISA analyses. ROS...

journal_title：Oxidative medicine and cellular longevity

authors： Lu Y,Rong J,Lai Y,Tao L,Yuan X,Shu X

更新日期：2020-12-08 00:00:00