PDGF suppresses oxidative stress induced Ca2+ overload and calpain activation in neurons.

abstract：:Hyperthyroidism is an endocrine disorder characterized by excessive secretion of thyroid hormones T3 and T4. Thyroid hormones exert pleiotropic actions on numerous tissues and induce an overall increase in metabolism, with an increase in energy demand and oxygen consumption. Therefore, the purpose of this study was to...

journal_title：Oxidative medicine and cellular longevity

authors： Costilla M,Macri Delbono R,Klecha A,Cremaschi GA,Barreiro Arcos ML

更新日期：2019-06-02 00:00:00

abstract：:Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly's health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The ...

journal_title：Oxidative medicine and cellular longevity

authors： Posadas-Rodríguez P,Posadas-Rodríguez NE,González-Puertos VY,Toledo-Pérez R,Ventura-Gallegos JL,Zentella A,Gómez-Quiroz LE,Königsberg M,Luna-López A

更新日期：2020-05-16 00:00:00

abstract：BACKGROUND:It has been known that cardiac surgery induces an oxidative stress. The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support. Total antioxidant capacity...

journal_title：Oxidative medicine and cellular longevity

authors： Kunt AS,Andac MH

更新日期：2012-01-01 00:00:00

abstract：:Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application is limited by its cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) the chemical composition and antioxidant capacity of aqu...

journal_title：Oxidative medicine and cellular longevity

authors： Dos Santos JM,Alfredo TM,Antunes KÁ,da Cunha JDSM,Costa EMA,Lima ES,Silva DB,Carollo CA,Schmitz WO,Boleti APA,Dos Santos EL,de Picoli Souza K

更新日期：2018-06-28 00:00:00

abstract：Background:Zinc plays a role in mitophagy and protects cardiomyocytes from ischemia/reperfusion injury. This study is aimed at investigating whether SUMOylation of Drp1 is involved in the protection of zinc ion on cardiac I/R injury. Methods:Mouse hearts were subjected to 30 minutes of regional ischemia followed by 2 ...

journal_title：Oxidative medicine and cellular longevity

authors： Bian X,Xu J,Zhao H,Zheng Q,Xiao X,Ma X,Li Y,Du X,Liu X

更新日期：2019-07-22 00:00:00

abstract：:Mono-(2-ethylhexyl) phthalate (MEHP) and genistein have been classified as endocrine-disrupting chemicals (EDCs) which interfere with the differentiation and development of the male reproductive system. However, how these two EDCs would affect fetal rat testis development at a low dose was rarely studied. In this stud...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang TD,Ma YB,Li HC,Chong T,Wang ZM,Zhang LD

更新日期：2020-05-27 00:00:00

abstract：:This study aims at investigating the radioprotective effect of ethanol extract from Ji-Xue-Teng (JXT, Spatholobus suberectus) on radiation-induced hematopoietic alteration and oxidative stress in the liver. Mice were exposed to a single acute γ-radiation for the whole body at the dose of 6.0 Gy, then subjected to admi...

journal_title：Oxidative medicine and cellular longevity

authors： Dong XZ,Wang YN,Tan X,Liu P,Guo DH,Yan C

更新日期：2018-10-28 00:00:00

abstract：:Reversible myocardial ischemia/reperfusion (I/R) or ischemic preconditioning (IPC) is associated with an immediate genomic response; IPC-induced immediate early genes are associated with reduced infarct size. Because the immediate early response gene X-1 (IEX-1) plays a central role in cell apoptosis, we examine wheth...

journal_title：Oxidative medicine and cellular longevity

authors： Xu MJ,Cai Y,Qu A,Shyy JY,Li W,Wang X

更新日期：2017-01-01 00:00:00

abstract：:There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessa...

journal_title：Oxidative medicine and cellular longevity

authors： Rosales-Corral S,Tan DX,Manchester L,Reiter RJ

更新日期：2015-01-01 00:00:00

abstract：:Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the su...

journal_title：Oxidative medicine and cellular longevity

authors： Kang M,Cho JH,Kim TJ,Lee SM,Kim HJ,Coronado I,Yi DK,Kim DY

更新日期：2020-04-25 00:00:00

abstract：:Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans. However, the mechanism underlying this effec...

journal_title：Oxidative medicine and cellular longevity

authors： Meng F,Li J,Rao Y,Wang W,Fu Y

更新日期：2018-02-18 00:00:00

abstract：:Flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide (NAD) are two redox cofactors of pivotal importance for mitochondrial functionality and cellular redox balance. Despite their relevance, the mechanism by which intramitochondrial NAD(H) and FAD levels are maintained remains quite unclear in Saccha...

journal_title：Oxidative medicine and cellular longevity

authors： Giancaspero TA,Locato V,Barile M

更新日期：2013-01-01 00:00:00

abstract：:Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have be...

journal_title：Oxidative medicine and cellular longevity

authors： Aquila G,Marracino L,Martino V,Calabria D,Campo G,Caliceti C,Rizzo P

更新日期：2019-05-02 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2020/9250512.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang X,Fu Q,Xu L,Yang Y,Zhao W,Zhang Y,Mi W,Li H

更新日期：2020-08-24 00:00:00

abstract：:Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation. However, there are few studies on the anticancer action of taurine. Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human na...

journal_title：Oxidative medicine and cellular longevity

authors： Wang G,Ma N,He F,Kawanishi S,Kobayashi H,Oikawa S,Murata M

更新日期：2020-05-20 00:00:00

abstract：:The p75 neurotrophin receptor (p75NTR) is an alpha- and gamma-secretase substrate expressed preferentially in the cholinergic neurons of the nucleus basalis of Meynert, the hippocampus, and the cerebellum of the adult brain. Mutations of the gamma-secretase, presenilin, have been implicated in familial Alzheimer's dis...

journal_title：Oxidative medicine and cellular longevity

authors： Zhang T,Mi Z,Schor NF

更新日期：2009-09-01 00:00:00

abstract：:Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence. CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well...

journal_title：Oxidative medicine and cellular longevity

authors： Dando I,Cordani M,Dalla Pozza E,Biondani G,Donadelli M,Palmieri M

更新日期：2015-01-01 00:00:00

abstract：:As a core member of p38 MAPK signal transduction pathway, p38 regulated/activated kinase (PRAK) is activated by cellular stresses. However, the function of PRAK and its downstream interacting partner remain undefined. Using a yeast two-hybrid system, we identified DJ-1 as a potential PRAK interacting protein. We furth...

journal_title：Oxidative medicine and cellular longevity

authors： Tang J,Liu J,Li X,Zhong Y,Zhong T,Liu Y,Wang JH,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Uroporphyrinogen decarboxylase (Hem12p) and transketolase (Tkl1p) are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP). The redox properties of both Hem12p and Tkl1p from Saccharomyces cerevisiae were investigated using proteom...

journal_title：Oxidative medicine and cellular longevity

authors： McDonagh B,Pedrajas JR,Padilla CA,Bárcena JA

更新日期：2013-01-01 00:00:00

abstract：:The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained ...

journal_title：Oxidative medicine and cellular longevity

authors： de Giffoni de Carvalho JT,da Silva Baldivia D,Leite DF,de Araújo LCA,de Toledo Espindola PP,Antunes KA,Rocha PS,de Picoli Souza K,Dos Santos EL

更新日期：2019-08-25 00:00:00

abstract：:Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and in vitro measurement of vascular tone to test a hypothesis that bone morphogenetic protein 4 (BMP4) m...

journal_title：Oxidative medicine and cellular longevity

authors： Yang X,Niu N,Liang C,Wu MM,Tang LL,Wang QS,Lou J,Song BL,Zheng WW,Ma HP,Zhang ZR

更新日期：2020-10-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly malignant, recurrent, drug-resistant, and often diagnosed in the advanced stage. It is clear that early diagnosis and a better understanding of molecular mechanisms contributing to HCC progression is clinically urgent. Metabolic a...

journal_title：Oxidative medicine and cellular longevity

authors： De Matteis S,Ragusa A,Marisi G,De Domenico S,Casadei Gardini A,Bonafè M,Giudetti AM

更新日期：2018-11-04 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the ce...

journal_title：Oxidative medicine and cellular longevity

authors： Wang R,Tu S,Zhang J,Shao A

更新日期：2020-09-04 00:00:00

abstract：:Background. Oxidative stress plays an important role in the pathogenesis of contrast-induced nephropathy (CIN). The aim of this study was to investigate the antioxidant effects of sulforaphane (SFN) in a rat model of CIN and a cell model of oxidative stress in HK2 cells. Methods. Rats were randomized into four groups ...

journal_title：Oxidative medicine and cellular longevity

authors： Zhao Z,Liao G,Zhou Q,Lv D,Holthfer H,Zou H

更新日期：2016-01-01 00:00:00

abstract：:Patients with triple negative breast cancer (TNBC) often suffer relapse, and clinical improvements offered by radiotherapy and chemotherapy are modest. Although targeted therapy and immunotherapy have been a topic of significant research in recent years, scientific developments have not yet translated to significant i...

journal_title：Oxidative medicine and cellular longevity

authors： He Z,Zhang H,Li H,Wang Y,Qian J,Cai X,Sun L,Huang J

更新日期：2020-11-05 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of...

journal_title：Oxidative medicine and cellular longevity

authors： Paiva AA,Raposo HF,Wanschel AC,Nardelli TR,Oliveira HC

更新日期：2017-01-01 00:00:00

abstract：:The ability to produce cold plasma at atmospheric pressure conditions was the basis for the rapid growth of plasma-related application areas in biomedicine. Plasma comprises a multitude of active components such as charged particles, electric current, UV radiation, and reactive gas species which can act synergisticall...

journal_title：Oxidative medicine and cellular longevity

authors： Bernhardt T,Semmler ML,Schäfer M,Bekeschus S,Emmert S,Boeckmann L

更新日期：2019-09-03 00:00:00

abstract：:We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle microtrauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either plac...

journal_title：Oxidative medicine and cellular longevity

authors： Sakelliou A,Fatouros IG,Athanailidis I,Tsoukas D,Chatzinikolaou A,Draganidis D,Jamurtas AZ,Liacos C,Papassotiriou I,Mandalidis D,Stamatelopoulos K,Dimopoulos MA,Mitrakou A

更新日期：2016-01-01 00:00:00

abstract：:An increasing number of studies have proposed a strong correlation between reactive oxygen species (ROS)-induced oxidative stress (OS) and the pathogenesis of Alzheimer's disease (AD). With over five million people diagnosed in the United States alone, AD is the most common type of dementia worldwide. AD includes prog...

journal_title：Oxidative medicine and cellular longevity

authors： Zuo L,Hemmelgarn BT,Chuang CC,Best TM

更新日期：2015-01-01 00:00:00