Roles of TRP Channels in Neurological Diseases.

abstract：:NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and progression. NRF2 and HERs confer cancers with resistance to several t...

journal_title：Oxidative medicine and cellular longevity

authors： Kankia IH,Khalil HS,Langdon SP,Moult PR,Bown JL,Deeni YY

更新日期：2017-01-01 00:00:00

abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

journal_title：Oxidative medicine and cellular longevity

authors： Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

更新日期：2020-02-12 00:00:00

abstract：:Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose ...

journal_title：Oxidative medicine and cellular longevity

authors： Gun A,Ozer MK,Bilgic S,Kocaman N,Ozan G

更新日期：2016-01-01 00:00:00

abstract：:We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apopto...

journal_title：Oxidative medicine and cellular longevity

authors： Sergeeva VA,Ershova ES,Veiko NN,Malinovskaya EM,Kalyanov AA,Kameneva LV,Stukalov SV,Dolgikh OA,Konkova MS,Ermakov AV,Veiko VP,Izhevskaya VL,Kutsev SI,Kostyuk SV

更新日期：2017-01-01 00:00:00

abstract：:Recent reports indicate that oxidative stress is involved in the pathobiology of acute spinal cord injury or compression myelopathy. We conducted an observational study to determine levels of oxidative stress markers in serum from 80 patients who underwent spinal surgery to treat neurological symptoms related to lumba...

journal_title：Oxidative medicine and cellular longevity

authors： Takahashi H,Aoki Y,Saito J,Nakajima A,Sonobe M,Akatsu Y,Taniguchi S,Yamada M,Koyama K,Akiyama Y,Shiga Y,Inage K,Orita S,Eguchi Y,Maki S,Furuya T,Akazawa T,Koda M,Yamazaki M,Ohtori S,Nakagawa K

更新日期：2020-12-24 00:00:00

abstract：:The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation. Intense exercise (28 m/min at a ...

journal_title：Oxidative medicine and cellular longevity

authors： Tang Y,Li J,Gao C,Xu Y,Li Y,Yu X,Wang J,Liu L,Yao P

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/4824371.]. ...

journal_title：Oxidative medicine and cellular longevity

authors： Song TY,Yang NC,Chen CL,Thi TLV

更新日期：2019-08-06 00:00:00

abstract：:The liver is a central organ that performs a wide range of functions such as detoxification and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly susceptible to oxidative stress. It is well documented that liver diseases including hepatitis, fibrosis, cirrhosis, and hepatocellular ...

journal_title：Oxidative medicine and cellular longevity

authors： Shin SM,Yang JH,Ki SH

更新日期：2013-01-01 00:00:00

abstract：:As a core member of p38 MAPK signal transduction pathway, p38 regulated/activated kinase (PRAK) is activated by cellular stresses. However, the function of PRAK and its downstream interacting partner remain undefined. Using a yeast two-hybrid system, we identified DJ-1 as a potential PRAK interacting protein. We furth...

journal_title：Oxidative medicine and cellular longevity

authors： Tang J,Liu J,Li X,Zhong Y,Zhong T,Liu Y,Wang JH,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Oxidative stress plays an important role in the pathogenesis of endothelial dysfunction, which is found to precede the development of diverse cardiovascular diseases (CVDs). The aim of this study was to observe the protective effects of PD against H2O2-induced oxidative stress injury (OSI) in human umbilical vein endo...

journal_title：Oxidative medicine and cellular longevity

authors： Qiao H,Chen H,Dong Y,Ma H,Zhao G,Tang F,Li Z

更新日期：2016-01-01 00:00:00

abstract：:Azadirachta indica A. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randoml...

journal_title：Oxidative medicine and cellular longevity

authors： Dkhil MA,Al-Quraishy S,Aref AM,Othman MS,El-Deib KM,Abdel Moneim AE

更新日期：2013-01-01 00:00:00

abstract：:The total lifespan of the yeast Saccharomyces cerevisiae may be divided into two phases: the reproductive phase, during which the cell undergoes mitosis cycles to produce successive buds, and the postreproductive phase, which extends from the last division to cell death. These phases may be regulated by a common mecha...

journal_title：Oxidative medicine and cellular longevity

authors： Zadrag-Tecza R,Kwolek-Mirek M,Alabrudzińska M,Skoneczna A

更新日期：2018-03-20 00:00:00

abstract：:Objectives. Oxidative stress contributes to Parkinson's disease (PD) pathophysiology and progression. The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity. Methods. 58 otherwise healthy individuals ...

journal_title：Oxidative medicine and cellular longevity

authors： Mischley LK,Standish LJ,Weiss NS,Padowski JM,Kavanagh TJ,White CC,Rosenfeld ME

更新日期：2016-01-01 00:00:00

abstract：:Detection of free radicals in tissues is challenging. Most approaches rely on incubating excised sections or homogenates with reagents, typically at supraphysiologic oxygen tensions, to finally detect surrogate, nonspecific end products. In the present work, we explored the potential of using intravenously (i.v.) inje...

journal_title：Oxidative medicine and cellular longevity

authors： Proniewski B,Kij A,Sitek B,Kelley EE,Chlopicki S

更新日期：2019-05-22 00:00:00

abstract：:Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly malignant, recurrent, drug-resistant, and often diagnosed in the advanced stage. It is clear that early diagnosis and a better understanding of molecular mechanisms contributing to HCC progression is clinically urgent. Metabolic a...

journal_title：Oxidative medicine and cellular longevity

authors： De Matteis S,Ragusa A,Marisi G,De Domenico S,Casadei Gardini A,Bonafè M,Giudetti AM

更新日期：2018-11-04 00:00:00

abstract：:Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromb...

journal_title：Oxidative medicine and cellular longevity

authors： Trettin A,Böhmer A,Suchy MT,Probst I,Staerk U,Stichtenoth DO,Frölich JC,Tsikas D

更新日期：2014-01-01 00:00:00

abstract：Background:Oxidized human DNA or plasmid DNAs containing human ribosomal genes can easily penetrate into the breast cancer cells MCF7 and stimulate the adaptive response induction. Plasmid DNA containing a CMV promoter, gene EGFP, and the insertion of the human ribosomal genes can be expressed. A hypothesis is proposed...

journal_title：Oxidative medicine and cellular longevity

authors： Kozhina EA,Ershova ES,Okorokova NA,Veiko VP,Malinovskaya EM,Sergeeva VA,Konkova MS,Kutsev SI,Veiko NN,Kostyuk SV

更新日期：2019-11-03 00:00:00

abstract：:Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks...

journal_title：Oxidative medicine and cellular longevity

authors： Othman MS,Fareid MA,Abdel Hameed RS,Abdel Moneim AE

更新日期：2020-10-19 00:00:00

abstract：:The in vitro ability of polyphenols, extracted from red grape, to modulate peripheral blood mononuclear cell responses has been evaluated in 20 obese (Ob) people. With regard to cytokine release in response to phorbol myristate acetate (PMA), levels of interleukin-2 (IL-2), interferon-γ (IFN-γ), IL-4, IL-10, and IL-17...

journal_title：Oxidative medicine and cellular longevity

authors： Magrone T,Jirillo E,Spagnoletta A,Magrone M,Russo MA,Fontana S,Laforgia F,Donvito I,Campanella A,Silvestris F,De Pergola G

更新日期：2017-01-01 00:00:00

abstract：:Galectin-3 is an important modulator of several biological functions. It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic eff...

journal_title：Oxidative medicine and cellular longevity

authors： Menini S,Iacobini C,Blasetti Fantauzzi C,Pesce CM,Pugliese G

更新日期：2016-01-01 00:00:00

abstract：:The present study discusses about the effects of a combination of probiotics able to stimulate the immune system of patients affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To this purpose, patients diagnosed according to Fukuda's criteria and treated with probiotics were analyzed by means of ...

journal_title：Oxidative medicine and cellular longevity

authors： Venturini L,Bacchi S,Capelli E,Lorusso L,Ricevuti G,Cusa C

更新日期：2019-11-23 00:00:00

abstract：:The effects of zinc oxide nanoparticles (ZnONPs) on antioxidants in Nile tilapia muscles and the protective role of vitamins C and E were examined. Two hundred males of Nile tilapia were held in aquaria (10 fishes/aquarium). Fishes were divided into 5 groups: 40 fishes in each group; the first group was the control; t...

journal_title：Oxidative medicine and cellular longevity

authors： Abdelazim AM,Saadeldin IM,Swelum AA,Afifi MM,Alkaladi A

更新日期：2018-04-05 00:00:00

abstract：:Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticanc...

journal_title：Oxidative medicine and cellular longevity

authors： Li K,Zheng Q,Chen X,Wang Y,Wang D,Wang J

更新日期：2018-10-16 00:00:00

abstract：Objectives:Our previous study showed that aldose reductase (AR) played key roles in fatty liver ischemia-reperfusion (IR) injury by regulating inflammatory response and energy metabolism. Here, we aim to investigate the role and mechanism of AR in the regeneration of normal and fatty livers after liver surgery. Method...

journal_title：Oxidative medicine and cellular longevity

authors： Li CX,Wang HW,Jiang WJ,Li GC,Zhang YD,Luo CH,Li XC

更新日期：2020-02-27 00:00:00

abstract：Objective:The aim of this study was to establish a 3T3-L1 adipocyte model and ApoE-/- mouse model of intermittent hypoxia (IH) composite abnormal glucose metabolism (AGM) in vitro and in vivo and explore their synergistic damage effect leading to atherosclerosis (AS) and the influence of SREBP-1 signaling molecule-rela...

journal_title：Oxidative medicine and cellular longevity

authors： Ma L,Zhang J,Qiao Y,Sun X,Mao T,Lei S,Zheng Q,Liu Y

更新日期：2019-02-04 00:00:00

abstract：:Although hyperuricemia is shown to accelerate chronic kidney disease, the mechanisms remain unclear. Accumulating studies also indicate that uric acid has both pro- and antioxidant properties. We postulated that hyperuricemia impairs the function of glomerular podocytes, resulting in albuminuria. Hyperuricemic model w...

journal_title：Oxidative medicine and cellular longevity

authors： Asakawa S,Shibata S,Morimoto C,Shiraishi T,Nakamura T,Tamura Y,Kumagai T,Hosoyamada M,Uchida S

更新日期：2017-01-01 00:00:00

abstract：:Chrysanthellum americanum L. (Vatke) is a medicinal plant from the Compositae family used in west-African traditional medicine, known for its flavonoid and saponin richness and for its strong antioxidant potential. In the present study, we assessed the effects of Chrysanthellum americanum polyphenolic extract in the p...

journal_title：Oxidative medicine and cellular longevity

authors： Cojocariu R,Ciobica A,Balmus IM,Guenne S,Trifan A,Stanciu C,Hrițcu L,Lefter R

更新日期：2019-08-14 00:00:00

abstract：Purpose:Oxidative stress induced by reduced blood circulation is a critical pathological damage to retinal ganglion cells (RGCs) in glaucoma. We previously showed that green tea extract (GTE) and its catechin constituents alleviate sodium iodate-induced retinal degeneration in rats. Here, we investigated the therapeuti...

journal_title：Oxidative medicine and cellular longevity

authors： Yang Y,Xu C,Chen Y,Liang JJ,Xu Y,Chen SL,Huang S,Yang Q,Cen LP,Pang CP,Sun XH,Ng TK

更新日期：2019-07-09 00:00:00

abstract：:The advanced glycation end products (AGEs) are organic molecules formed in any living organisms with a great variety of structural and functional properties. They are considered organic markers of the glycation process. Due to their great heterogeneity, there is no specific test for their operational measurement. In t...

journal_title：Oxidative medicine and cellular longevity

authors： Perrone A,Giovino A,Benny J,Martinelli F

更新日期：2020-03-18 00:00:00

abstract：:Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduc...

journal_title：Oxidative medicine and cellular longevity

authors： Zhou Y,Yan H,Guo M,Zhu J,Xiao Q,Zhang L

更新日期：2013-01-01 00:00:00