当前位置： SCI文献检索 > Oxidative Medicine and Cellular Longevity期刊下所有文献 > NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib.

NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib.

Abstract：

:NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and progression. NRF2 and HERs confer cancers with resistance to several therapeutic agents. Nevertheless, there is limited understanding of the regulation of HER expression and activation and the link between NRF2 and HER signalling pathways. We show that NRF2 regulates both basal and inducible expression of HER1, as treatment of ovarian cancer cells (PEO1, OVCAR3, and SKOV3) with NRF2 activator tBHQ inducing HER1, while inhibition of NRF2 by siRNA knockdown or with retinoid represses HER1. Furthermore, treatment of cells with tBHQ increased total and phosphorylated NRF2, HER1, and AKT levels and compromised the cytotoxic effect of lapatinib or erlotinib. Treatment with siRNA or retinoid antagonised the effect of tBHQ on NRF2 and HER1 levels and enhanced the sensitivity of ovarian cancer cells to lapatinib or erlotinib. Pharmacological or genetic inhibition of NRF2 and/or treatment with lapatinib or erlotinib elevated cellular ROS and depleted glutathione. This extends the understanding of NRF2 and its regulation of HER family receptors and opens a strategic target for improving cancer therapy.

journal_name

Oxid Med Cell Longev

journal_title

Oxidative medicine and cellular longevity

authors

Kankia IH,Khalil HS,Langdon SP,Moult PR,Bown JL,Deeni YY

doi

10.1155/2017/1864578

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

1864578

eissn

1942-0900

issn

1942-0994

journal_volume

2017

pub_type

杂志文章

相关文献

Oxidative Medicine and Cellular Longevity文献大全
  • Inhibitory Effect of Ursolic Acid on Ultraviolet B Radiation-Induced Oxidative Stress and Proinflammatory Response-Mediated Senescence in Human Skin Dermal Fibroblasts.

    abstract：:Ultraviolet radiation is an environmental carcinogenic agent that enhances inflammation and immunological reactions in the exposed human skin cells leading to oxidative photoaging of the epidermal and dermal segment. In the present study, we investigated the protective role of ursolic acid (UA) against ultraviolet B (...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/1246510

    authors： Samivel R,Nagarajan RP,Subramanian U,Khan AA,Masmali A,Almubrad T,Akhtar S

    更新日期：2020-06-15 00:00:00

  • Oxidative Stress in Ischemic Heart Disease.

    abstract：:One of the novel interesting topics in the study of cardiovascular disease is the role of the oxidation system, since inflammation and oxidative stress are known to lead to cardiovascular diseases, their progression and complications. During decades of research, many complex interactions between agents of oxidative st...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2020/6627144

    authors： Kibel A,Lukinac AM,Dambic V,Juric I,Relatic KS

    更新日期：2020-12-28 00:00:00

  • Mitochondrial-targeted two-photon fluorescent probes for zinc ions, H2O2, and thiols in living tissues.

    abstract：:Mitochondria provide the energy of the cells and are the primary site of oxygen consumption and the major source of reactive oxygen species. In mitochondria, metal ions and glutathione play vital roles in maintaining their structure and the redox environment. To understand their roles in mitochondria, it is crucial to...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2013/323619

    authors： Kim HM,Cho BR

    更新日期：2013-01-01 00:00:00

  • The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression.

    abstract：:The active constituent profile in Cape gooseberry (Physalis peruviana L.) juice was determined by GC-MS. Quercetin and kaempferol were active components in the juice. In this study we have evaluated its potential protective effect on hepatic injury and fibrosis induced by carbon tetrachloride (CCl4). Twenty-eight rats...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/381413

    authors： Al-Olayan EM,El-Khadragy MF,Aref AM,Othman MS,Kassab RB,Abdel Moneim AE

    更新日期：2014-01-01 00:00:00

  • Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging.

    abstract：:Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and decreased mtDNA copy number. Current wisdom indicates that mt...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2020/9423593

    authors： Quan Y,Xin Y,Tian G,Zhou J,Liu X

    更新日期：2020-03-26 00:00:00

  • Reactive oxygen species in vascular formation and development.

    abstract：:Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduc...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2013/374963

    authors： Zhou Y,Yan H,Guo M,Zhu J,Xiao Q,Zhang L

    更新日期：2013-01-01 00:00:00

  • Oxidative stress contributes to endothelial dysfunction in mouse models of hereditary hemorrhagic telangiectasia.

    abstract：:Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia caused by mutations in endoglin (ENG; HHT1) or activin receptor-like kinase (ALK1; HHT2) genes, coding for transforming growth factor-β (TGF-β) superfamily receptors. We demonstrated previously that endoglin and ALK1 interact with endothelial NO synth...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2012/686972

    authors： Jerkic M,Sotov V,Letarte M

    更新日期：2012-01-01 00:00:00

  • Long-Term Administration of Angiotensin (1-7) to db/db Mice Reduces Oxidative Stress Damage in the Kidneys and Prevents Renal Dysfunction.

    abstract：Aims:The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in db/db mice and to identify the protective mechanisms of this therapy. Methods:db/db mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/1841046

    authors： Papinska AM,Rodgers KE

    更新日期：2018-10-23 00:00:00

  • Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation.

    abstract：:Some iron chelators display significant anticancer activity that may involve ferritin degradation either in proteasomes or in lysosomes, and the latter might involve ferritinophagy with a period. However, the correlation of ferritinophagy with anticancer activity of iron chelator was not fully determined. Revealing th...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/4928703

    authors： Huang T,Sun Y,Li Y,Wang T,Fu Y,Li C,Li C

    更新日期：2018-08-05 00:00:00

  • Chidamide Inhibits Glioma Cells by Increasing Oxidative Stress via the miRNA-338-5p Regulation of Hedgehog Signaling.

    abstract：Objective:Chidamide has a broad spectrum of antitumor activity but its function on glioma remains unknown. The increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS) may control glioma risk by promoting its apoptosis and necrosis. Hedgehog pathway is crucial to glioma cell proliferation and contr...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/7126976

    authors： Zhou H,Han L,Wang H,Wei J,Guo Z,Li Z

    更新日期：2020-03-11 00:00:00

  • Anticonvulsant and antioxidant effects of Tilia americana var. mexicana and flavonoids constituents in the pentylenetetrazole-induced seizures.

    abstract：:Tilia genus is commonly used around the world for its central nervous system properties; it is prepared as tea and used as tranquilizing, anticonvulsant, and analgesic. In this study, anticonvulsant activity of the Tilia americana var. mexicana inflorescences and leaves was investigated by evaluating organic and aqueo...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/329172

    authors： Cárdenas-Rodríguez N,González-Trujano ME,Aguirre-Hernández E,Ruíz-García M,Sampieri A 3rd,Coballase-Urrutia E,Carmona-Aparicio L

    更新日期：2014-01-01 00:00:00

  • Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway.

    abstract：:Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2016/2153745

    authors： Hu M,Zou W,Wang CY,Chen X,Tan HY,Zeng HY,Zhang P,Gu HF,Tang XQ

    更新日期：2016-01-01 00:00:00

  • Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells.

    abstract：:Hydroquinone (HQ) is widely used in food stuffs and is an occupational and environmental pollutant. Although the hepatotoxicity of HQ has been demonstrated both in vitro and in vivo, the prevention of HQ-induced hepatotoxicity has yet to be elucidated. In this study, we focused on the intervention effect of aqueous ex...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/4528581

    authors： Gao Y,Tang H,Xiong L,Zou L,Dai W,Liu H,Hu G

    更新日期：2018-11-18 00:00:00

  • The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats.

    abstract：:N-Acetyl-p-aminophenol (APAP) or acetaminophen is the most common drug ingredient worldwide. It is found in more than 600 different over-the-counter and prescription medicines. Its long-term and overdose use is highly toxic and may result in liver injury. Thus, this study was designed to assess the preventive effects ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/2745352

    authors： Ahmed OM,Fahim HI,Ahmed HY,Al-Muzafar HM,Ahmed RR,Amin KA,El-Nahass ES,Abdelazeem WH

    更新日期：2019-03-26 00:00:00

  • Enhancement of Antioxidant Mechanisms and Reduction of Oxidative Stress in Chickens after the Administration of Drinking Water Enriched with Polyphenolic Powder from Olive Mill Waste Waters.

    abstract：:The aim of the study was to examine the effects of a polyphenolic powder from olive mill wastewater (OMWW) administered through drinking water, on chickens' redox status. Thus, 75 chickens were divided into three groups. Group A was given just drinking water, while groups B and C were given drinking water containing 2...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/8273160

    authors： Papadopoulou A,Petrotos K,Stagos D,Gerasopoulos K,Maimaris A,Makris H,Kafantaris I,Makri S,Kerasioti E,Halabalaki M,Brieudes V,Ntasi G,Kokkas S,Tzimas P,Goulas P,Zakharenko AM,Golokhvast KS,Tsatsakis A,Kouretas D

    更新日期：2017-01-01 00:00:00

  • Cocoa polyphenols and their potential benefits for human health.

    abstract：:This paper compiles the beneficial effects of cocoa polyphenols on human health, especially with regard to cardiovascular and inflammatory diseases, metabolic disorders, and cancer prevention. Their antioxidant properties may be responsible for many of their pharmacological effects, including the inhibition of lipid p...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2012/906252

    authors： Andújar I,Recio MC,Giner RM,Ríos JL

    更新日期：2012-01-01 00:00:00

  • Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

    abstract：:In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria ar...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2012/740849

    authors： Li N,Stojanovski S,Maechler P

    更新日期：2012-01-01 00:00:00

  • Effects of paracetamol on NOS, COX, and CYP activity and on oxidative stress in healthy male subjects, rat hepatocytes, and recombinant NOS.

    abstract：:Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromb...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/212576

    authors： Trettin A,Böhmer A,Suchy MT,Probst I,Staerk U,Stichtenoth DO,Frölich JC,Tsikas D

    更新日期：2014-01-01 00:00:00

  • Nitric oxide synthetic pathway in patients with microvascular angina and its relations with oxidative stress.

    abstract：:A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies. As red blood cells (RBCs) participate in NO formation in the bloodstream, the aim of this study was to outline the metabolic profile of L-arginine (Arg)/NO pathway and of oxidati...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/726539

    authors： Porro B,Eligini S,Veglia F,Lualdi A,Squellerio I,Fiorelli S,Giovannardi M,Chiorino E,Dalla Cia A,Crisci M,Werba JP,Tremoli E,Cavalca V

    更新日期：2014-01-01 00:00:00

  • Lack of HXK2 induces localization of active Ras in mitochondria and triggers apoptosis in the yeast Saccharomyces cerevisiae.

    abstract：:We recently showed that activated Ras proteins are localized to the plasma membrane and in the nucleus in wild-type cells growing exponentially on glucose, while in the hxk2Δ strain they accumulated mainly in mitochondria. An aberrant accumulation of activated Ras in these organelles was previously reported and correl...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2013/678473

    authors： Amigoni L,Martegani E,Colombo S

    更新日期：2013-01-01 00:00:00

  • Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis.

    abstract：:Mutations of mtDNA, due to their higher frequency of occurrence compared to nuclear DNA mutations, are the most promising biomarkers for assessing predisposition of the occurrence and development of atherogenesis. The aim of the present article was an analysis of correlation of several mitochondrial genome mutations w...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/6934394

    authors： Sazonova MA,Sinyov VV,Ryzhkova AI,Galitsyna EV,Khasanova ZB,Postnov AY,Yarygina EI,Orekhov AN,Sobenin IA

    更新日期：2017-01-01 00:00:00

  • Effect of the French oak wood extract Robuvit on markers of oxidative stress and activity of antioxidant enzymes in healthy volunteers: a pilot study.

    abstract：:We examined in vitro antioxidant capacity of polyphenolic extract obtained from the wood of oak Quercus robur (QR), Robuvit, using TEAC (Trolox equivalent antioxidant capacity) method and the effect of its intake on markers of oxidative stress, activity of antioxidant enzymes, and total antioxidant capacity in plasma ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2014/639868

    authors： Horvathova M,Orszaghova Z,Laubertova L,Vavakova M,Sabaka P,Rohdewald P,Durackova Z,Muchova J

    更新日期：2014-01-01 00:00:00

  • Effects of Redox Disturbances on Intestinal Contractile Reactivity in Rats Fed with a Hypercaloric Diet.

    abstract：:Few studies have associated the effects of changes in caloric intake and redox disturbances in the gastrointestinal tract. Therefore, the present study aimed at evaluating the hypercaloric diet consumption influence on the contractile reactivity of intestinal smooth muscle, morphology, and oxidative stress of rat ileu...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/6364821

    authors： de Souza ILL,Ferreira EDS,Diniz AFA,Carvalho MTL,Queiroga FR,Toscano LT,Silva AS,da Silva PM,Cavalcante FA,da Silva BA

    更新日期：2018-10-25 00:00:00

  • Fish Scale Collagen Peptides Protect against CoCl2/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.

    abstract：:Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl2-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is th...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2017/9703609

    authors： Subhan F,Kang HY,Lim Y,Ikram M,Baek SY,Jin S,Jeong YH,Kwak JY,Yoon S

    更新日期：2017-01-01 00:00:00

  • The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes.

    abstract：:UVA irradiation induced ROS-mediated photo damage to the human skin leading to coarseness, wrinkling, pigmentation, and cutaneous malignancies. We investigated the dermatoprotective efficacies of submicromolar concentrations of ergothioneine (EGT, 0.125-0.5 μM), which occurs naturally as a sulfur-containing amino acid...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2020/2576823

    authors： Hseu YC,Vudhya Gowrisankar Y,Chen XZ,Yang YC,Yang HL

    更新日期：2020-02-12 00:00:00

  • An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia.

    abstract：:In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole webs...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2016/9162074

    authors： Liu M,Tang L,Liu X,Fang J,Zhan H,Wu H,Yang H

    更新日期：2016-01-01 00:00:00

  • Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway.

    abstract：:Approximately 90% of male diabetes mellitus patients have varying degrees of testicular dysfunction. The molecular mechanism underlying diabetes-induced testicular damage has not been thoroughly elucidated. In this research, we sought to determine the influence of metformin (Met) on diabetes-induced testicular injury ...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/5681701

    authors： Liu Y,Yang Z,Kong D,Zhang Y,Yu W,Zha W

    更新日期：2019-11-28 00:00:00

  • Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study.

    abstract：Purpose:Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Meth...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2019/1821969

    authors： Hsueh CY,Shao M,Cao W,Li S,Zhou L

    更新日期：2019-04-16 00:00:00

  • Oxidative and Antioxidative Status of Children with Celiac Disease Treated with a Gluten Free-Diet.

    abstract：Aims:Oxidative stress is a factor involved in the pathogenesis of celiac disease (CD), possibly affecting the course of the disease and celiac-related complications. We assessed the intensity of oxidative processes and the efficiency of antioxidant defense in children with celiac disease. Methods. Group I (n = 32) cons...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章

    doi：10.1155/2018/1324820

    authors： Rowicka G,Czaja-Bulsa G,Chełchowska M,Riahi A,Strucińska M,Weker H,Ambroszkiewicz J

    更新日期：2018-05-02 00:00:00

  • Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System.

    abstract：:Oxidative stress is involved in pathophysiology and pathological conditions of numerous human diseases. Thus, understanding the mechanisms underlying the redox homeostasis in cells and organs is valuable for discovery of therapeutic drugs for oxidative stress-related diseases. Recently, by applying chemical biology ap...

    journal_title：Oxidative medicine and cellular longevity

    pub_type： 杂志文章,评审

    doi：10.1155/2017/8584930

    authors： Yukitake H,Takizawa M,Kimura H

    更新日期：2017-01-01 00:00:00