Abstract：
:Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, both RNS and ROS are commonly triggered by the pathogenic viruses and are famous for their dual roles in the clearance of viruses and pathological implications. Uncontrolled production of reactive species results in oxidative stress and causes damage in proteins, lipids, DNA, and cellular structures. In this review, we describe the production of RS, their detoxification by a cellular antioxidant system, and how these RS damage the proteins, lipids, and DNA. Given the widespread importance of RS in avian viral diseases, oxidative stress pathways are of utmost importance for targeted therapeutics. Therefore, a special focus is provided on avian virus-mediated oxidative stresses. Finally, future research perspectives are discussed on the exploitation of these pathways to treat viral diseases of poultry.
journal_name
Oxid Med Cell Longevjournal_title
Oxidative medicine and cellular longevityauthors
Rehman ZU,Meng C,Sun Y,Safdar A,Pasha RH,Munir M,Ding Cdoi
10.1155/2018/5123147subject
Has Abstractpub_date
2018-12-10 00:00:00pages
5123147eissn
1942-0900issn
1942-0994journal_volume
2018pub_type
杂志文章,评审abstract：:2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascu...
journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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更新日期：2018-07-22 00:00:00
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章
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journal_title：Oxidative medicine and cellular longevity
pub_type： 杂志文章,评审
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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journal_title：Oxidative medicine and cellular longevity
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